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Volumn 36, Issue 2, 2011, Pages 78-86

N-acetylcysteine in psychiatry: Current therapeutic evidence and potential mechanisms of action

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; DOPAMINE; FLUVOXAMINE; GLUTAMIC ACID; GLUTATHIONE; GLUTATHIONE PEROXIDASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; PLACEBO; SEROTONIN UPTAKE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA;

EID: 79953111745     PISSN: 11804882     EISSN: 14882434     Source Type: Journal    
DOI: 10.1503/jpn.100057     Document Type: Review
Times cited : (393)

References (87)
  • 1
    • 0018099851 scopus 로고
    • Acetaminophen poisoning: A case report of the use of acetylcysteine
    • Scalley RD, Conner CS. Acetaminophen poisoning: a case report of the use of acetylcysteine. Am J Hosp Pharm 1978;35:964-967.
    • (1978) Am J Hosp Pharm , vol.35 , pp. 964-967
    • Scalley, R.D.1    Conner, C.S.2
  • 2
    • 57649148545 scopus 로고    scopus 로고
    • N-acetylcysteine for antioxidant therapy: Pharmacology and clinical utility
    • Dodd S, Dean O, Copolov DL, et al. N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility. Expert Opin Biol Ther 2008;8:1955-1962.
    • (2008) Expert Opin Biol Ther , vol.8 , pp. 1955-1962
    • Dodd, S.1    Dean, O.2    Copolov, D.L.3
  • 3
    • 0035940625 scopus 로고    scopus 로고
    • Controlled trial of N-acetylcysteine for patients with probable Alzheimer's disease
    • Adair JC, Knoefel JE, Morgan N. Controlled trial of N-acetylcysteine for patients with probable Alzheimer's disease. Neurology 2001;57: 1515-7.
    • (2001) Neurology , vol.57 , pp. 1515-1517
    • Adair, J.C.1    Knoefel, J.E.2    Morgan, N.3
  • 4
    • 0038636003 scopus 로고    scopus 로고
    • Glutathione pathways in the brain
    • Dringen R, Hirrlinger J. Glutathione pathways in the brain. Biol Chem 2003;384:505-516.
    • (2003) Biol Chem , vol.384 , pp. 505-516
    • Dringen, R.1    Hirrlinger, J.2
  • 5
    • 0028273316 scopus 로고
    • Glutathione, ascorbate, and cellular protection
    • Meister A. Glutathione, ascorbate, and cellular protection. Cancer Res 1994;54(Suppl):1969s-75s.
    • (1994) Cancer Res , vol.54 , Issue.SUPPL.
    • Meister, A.1
  • 6
    • 0024394697 scopus 로고
    • The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid
    • Aruoma OI, Halliwell B, Hoey BM, et al. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med 1989;6:593-597.
    • (1989) Free Radic Biol Med , vol.6 , pp. 593-597
    • Aruoma, O.I.1    Halliwell, B.2    Hoey, B.M.3
  • 7
    • 0026448043 scopus 로고
    • The systemic availability of oral glutathione
    • Witschi A, Reddy S, Stofer B, et al. The systemic availability of oral glutathione. Eur J Clin Pharmacol 1992;43:667-669.
    • (1992) Eur J Clin Pharmacol , vol.43 , pp. 667-669
    • Witschi, A.1    Reddy, S.2    Stofer, B.3
  • 8
    • 0017817730 scopus 로고
    • Maintenance of glutathione content in isolated hepatocytes
    • Vina J, Reginald H, Krebs HA. Maintenance of glutathione content in isolated hepatocytes. Biochem J 1978;170:627-630.
    • (1978) Biochem J , vol.170 , pp. 627-630
    • Vina, J.1    Reginald, H.2    Krebs, H.A.3
  • 9
    • 0024331933 scopus 로고
    • Metabolism of N-acetyl-L-cysteine. Some structural requirements for the deacetylation and consequences for the oral bioavailability
    • Sjodin K, Nilsson E, Hallberg A, et al. Metabolism of N-acetyl-L-cysteine. Some structural requirements for the deacetylation and consequences for the oral bioavailability. Biochem Pharmacol 1989;38: 3981-3985.
    • (1989) Biochem Pharmacol , vol.38 , pp. 3981-3985
    • Sjodin, K.1    Nilsson, E.2    Hallberg, A.3
  • 10
    • 0025288044 scopus 로고
    • Dose dependent pharmacokinetics of N-acetylcysteine after oral dosing to man
    • Borgström L, Kågedal B. Dose dependent pharmacokinetics of N-acetylcysteine after oral dosing to man. Biopharm Drug Dispos 1990;11:131-136.
    • (1990) Biopharm Drug Dispos , vol.11 , pp. 131-136
    • Borgström, L.1    Kågedal, B.2
  • 11
    • 0025959339 scopus 로고
    • Clinical pharmokinetics of N-acetylcysteine
    • Holdiness MR. Clinical pharmokinetics of N-acetylcysteine. Clin Pharmacokinet 1991;20:123-134.
    • (1991) Clin Pharmacokinet , vol.20 , pp. 123-134
    • Holdiness, M.R.1
  • 12
    • 47249165587 scopus 로고    scopus 로고
    • Glutathione precursor, N-acetyl-cysteine, improves mismatch negativity in schizophrenia patients
    • Lavoie S, Murray MM, Deppen P, et al. Glutathione precursor, N-acetyl-cysteine, improves mismatch negativity in schizophrenia patients. Neuropsychopharmacology 2008;33:2187-2199.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 2187-2199
    • Lavoie, S.1    Murray, M.M.2    Deppen, P.3
  • 13
    • 0035503798 scopus 로고    scopus 로고
    • Therapeutic efficacy of aortic administration of N-acetylcysteine as a chemoprotectant against bone marrow toxicity after intracarotid administration of alkylators, with or without glutathione depletion in a rat model
    • Neuwelt EA, Pagel MA, Hasler BP, et al. Therapeutic efficacy of aortic administration of N-acetylcysteine as a chemoprotectant against bone marrow toxicity after intracarotid administration of alkylators, with or without glutathione depletion in a rat model. Cancer Res 2001;61:7868-7874.
    • (2001) Cancer Res , vol.61 , pp. 7868-7874
    • Neuwelt, E.A.1    Pagel, M.A.2    Hasler, B.P.3
  • 14
    • 38949218189 scopus 로고    scopus 로고
    • N-acetylcysteine inhibits depletion of brain glutathione levels in rats: Implications for schizophrenia [abstract]
    • Dean O, van den Buuse M, Copolov D, et al. N-acetylcysteine inhibits depletion of brain glutathione levels in rats: implications for schizophrenia [abstract]. Int J Neuropsychopharmacol 2004; 7(S1):262.
    • (2004) Int J Neuropsychopharmacol , vol.7 , Issue.S1 , pp. 262
    • Dean, O.1    van den Buuse, M.2    Copolov, D.3
  • 15
    • 0037342554 scopus 로고    scopus 로고
    • The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice
    • Farr SA, Poon HF, Dogrukolak D, et al. The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice. J Neurochem 2003;84: 1173-1183.
    • (2003) J Neurochem , vol.84 , pp. 1173-1183
    • Farr, S.A.1    Poon, H.F.2    Dogrukolak, D.3
  • 16
    • 74949090006 scopus 로고    scopus 로고
    • The mononuclear phagocyte system and its cytokine inflammatory networks in schizophrenia and bipolar disorder
    • Drexhage RC, Knijff EM, Padmos RC, et al. The mononuclear phagocyte system and its cytokine inflammatory networks in schizophrenia and bipolar disorder. Expert Rev Neurother 2010;10:59-76.
    • (2010) Expert Rev Neurother , vol.10 , pp. 59-76
    • Drexhage, R.C.1    Knijff, E.M.2    Padmos, R.C.3
  • 17
    • 57749193787 scopus 로고    scopus 로고
    • Inflammatory markers in depression
    • Dinan TG. Inflammatory markers in depression. Curr Opin Psychiatry 2009;22:32-36.
    • (2009) Curr Opin Psychiatry , vol.22 , pp. 32-36
    • Dinan, T.G.1
  • 18
    • 77957678999 scopus 로고    scopus 로고
    • Effect of oral N-acetylcysteine treatment on plasma inflammatory and oxidative stress markers in peritoneal dialysis patients: A placebo-controlled study
    • Nascimento MM, Suliman ME, Silva M et al. Effect of oral N-acetylcysteine treatment on plasma inflammatory and oxidative stress markers in peritoneal dialysis patients: a placebo-controlled study. Perit Dial Int 2010;30:336-342.
    • (2010) Perit Dial Int , vol.30 , pp. 336-342
    • Nascimento, M.M.1    Suliman, M.E.2    Silva, M.3
  • 19
    • 45549089322 scopus 로고    scopus 로고
    • Inhibitory effect on cerebral inflammatory response following traumatic brain injury in rats: A potential neuroprotective mechanism of N-acetylcysteine
    • Chen G, Shi J, Hu Z et al. Inhibitory effect on cerebral inflammatory response following traumatic brain injury in rats: a potential neuroprotective mechanism of N-acetylcysteine. Mediators Inflamm 2008;2008:716458.
    • (2008) Mediators Inflamm , pp. 716458
    • Chen, G.1    Shi, J.2    Hu, Z.3
  • 20
    • 2342562573 scopus 로고    scopus 로고
    • Administration of N-acetyl -cysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke
    • Khan M, Sekhon B, Jatana M, et al. Administration of N-acetyl -cysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke. J Neurosci Res 2004;76:519-527.
    • (2004) J Neurosci Res , vol.76 , pp. 519-527
    • Khan, M.1    Sekhon, B.2    Jatana, M.3
  • 21
    • 45149090560 scopus 로고    scopus 로고
    • Late N-acetylcysteine treatment prevents the deficits induced in the offspring of dams exposed to an immune stress during gestation
    • Lante F, Meunier J, Guiramand J, et al. Late N-acetylcysteine treatment prevents the deficits induced in the offspring of dams exposed to an immune stress during gestation. Hippocampus 2008;18: 602-609.
    • (2008) Hippocampus , vol.18 , pp. 602-609
    • Lante, F.1    Meunier, J.2    Guiramand, J.3
  • 22
    • 42449118547 scopus 로고    scopus 로고
    • Modulation of peroxisome proliferator-activated receptor-alpha activity by N-acetyl cysteine attenuates inhibition of oligodendrocyte development in lipo -polysaccharide stimulated mixed glial cultures
    • Paintlia MK, Paintlia AS, Khan M, et al. Modulation of peroxisome proliferator-activated receptor-alpha activity by N-acetyl cysteine attenuates inhibition of oligodendrocyte development in lipo -polysaccharide stimulated mixed glial cultures. J Neurochem 2008; 105:956-970.
    • (2008) J Neurochem , vol.105 , pp. 956-970
    • Paintlia, M.K.1    Paintlia, A.S.2    Khan, M.3
  • 23
    • 34250796230 scopus 로고    scopus 로고
    • Modulation of [3H]dopamine release by glutathione in mouse striatal slices
    • Janaky R, Dohovics R, Saransaari P, et al. Modulation of [3H]dopamine release by glutathione in mouse striatal slices. Neurochem Res 2007;32:1357-1364.
    • (2007) Neurochem Res , vol.32 , pp. 1357-1364
    • Janaky, R.1    Dohovics, R.2    Saransaari, P.3
  • 24
    • 0037373041 scopus 로고    scopus 로고
    • Oxidative neuronal death caused by glutamate uptake inhibition in cultured hippocampal neurons
    • Himi T, Ikeda M, Yasuhara T, et al. Oxidative neuronal death caused by glutamate uptake inhibition in cultured hippocampal neurons. J Neurosci Res 2003;71:679-688.
    • (2003) J Neurosci Res , vol.71 , pp. 679-688
    • Himi, T.1    Ikeda, M.2    Yasuhara, T.3
  • 25
    • 0037109669 scopus 로고    scopus 로고
    • The origin and neuronal function of in vivo nonsynaptic glutamate
    • Baker DA, Xi ZX, Shen H, et al. The origin and neuronal function of in vivo nonsynaptic glutamate. J Neurosci 2002;22:9134-9141.
    • (2002) J Neurosci , vol.22 , pp. 9134-9141
    • Baker, D.A.1    Xi, Z.X.2    Shen, H.3
  • 26
    • 21844443565 scopus 로고    scopus 로고
    • Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking
    • Moran MM, McFarland K, Melendez RI, et al. Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking. J Neurosci 2005;25:6389-6393.
    • (2005) J Neurosci , vol.25 , pp. 6389-6393
    • Moran, M.M.1    McFarland, K.2    Melendez, R.I.3
  • 27
    • 0023037563 scopus 로고
    • Glutathione-induced in hibition of Na+-independent and -dependent bindings of L- [3H]glutamate in rat brain
    • Ogita K, Kitago T, Nakamuta H, et al. Glutathione-induced in hibition of Na+-independent and -dependent bindings of L- [3H]glutamate in rat brain. Life Sci 1986;39:2411-2418.
    • (1986) Life Sci , vol.39 , pp. 2411-2418
    • Ogita, K.1    Kitago, T.2    Nakamuta, H.3
  • 28
    • 0030876671 scopus 로고    scopus 로고
    • Glutathione is an endogenous lig-and of rat brain N-methyl-D-aspartate (NMDA) and 2-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors
    • Varga V, Jenei Z, Janaky R, et al. Glutathione is an endogenous lig-and of rat brain N-methyl-D-aspartate (NMDA) and 2-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors. Neurochem Res 1997;22:1165-1171.
    • (1997) Neurochem Res , vol.22 , pp. 1165-1171
    • Varga, V.1    Jenei, Z.2    Janaky, R.3
  • 29
    • 67651214391 scopus 로고    scopus 로고
    • The effect of N-acetylcysteine on amphetamine-mediated dopamine release in rat brain striatal slices by ion-pair reversed-phase high performance liquid chromatography
    • Gere-Paszti E, Jakus J. The effect of N-acetylcysteine on amphetamine-mediated dopamine release in rat brain striatal slices by ion-pair reversed-phase high performance liquid chromatography. Biomed Chromatogr 2009;23:658-664.
    • (2009) Biomed Chromatogr , vol.23 , pp. 658-664
    • Gere-Paszti, E.1    Jakus, J.2
  • 30
    • 10444275649 scopus 로고    scopus 로고
    • Effects of N-acetyl-L-cysteine on the reduction of brain dopamine transporters in monkey treated with methamphetamine
    • Hashimoto K, Tsukada H, Nishiyama S, et al. Effects of N-acetyl-L-cysteine on the reduction of brain dopamine transporters in monkey treated with methamphetamine. Ann N Y Acad Sci 2004;1025: 231-235.
    • (2004) Ann N Y Acad Sci , vol.1025 , pp. 231-235
    • Hashimoto, K.1    Tsukada, H.2    Nishiyama, S.3
  • 31
    • 77149167604 scopus 로고    scopus 로고
    • N-acetylcysteine (NAC) in young marijuana users: An open-label pilot study
    • Gray KM, Watson NL, Carpenter MJ, et al. N-acetylcysteine (NAC) in young marijuana users: an open-label pilot study. Am J Addict 2010;19:187-189.
    • (2010) Am J Addict , vol.19 , pp. 187-189
    • Gray, K.M.1    Watson, N.L.2    Carpenter, M.J.3
  • 32
    • 65049088707 scopus 로고    scopus 로고
    • The role of cystine-glutamate exchange in nicotine dependence in rats and humans
    • Knackstedt LA, LaRowe S, Mardikian P, et al. The role of cystine-glutamate exchange in nicotine dependence in rats and humans. Biol Psychiatry 2009;65:841-845.
    • (2009) Biol Psychiatry , vol.65 , pp. 841-845
    • Knackstedt, L.A.1    Larowe, S.2    Mardikian, P.3
  • 33
    • 0036195556 scopus 로고    scopus 로고
    • Effects of oral administration of N-acetyl-L-cysteine: A multi-biomarker study in smokers
    • Van Schooten FJ, Besaratinia A, De Flora S, et al. Effects of oral administration of N-acetyl-L-cysteine: a multi-biomarker study in smokers. Cancer Epidemiol Biomarkers Prev 2002;11:167-175.
    • (2002) Cancer Epidemiol Biomarkers Prev , vol.11 , pp. 167-175
    • van Schooten, F.J.1    Besaratinia, A.2    de Flora, S.3
  • 34
    • 32144454852 scopus 로고    scopus 로고
    • Safety and tolerability of N-acetylcysteine in cocaine-dependent individuals
    • LaRowe SD, Mardikian P, Malcolm R, et al. Safety and tolerability of N-acetylcysteine in cocaine-dependent individuals. Am J Addict 2006;15:105-110.
    • (2006) Am J Addict , vol.15 , pp. 105-110
    • Larowe, S.D.1    Mardikian, P.2    Malcolm, R.3
  • 35
    • 34547199417 scopus 로고    scopus 로고
    • Is cocaine desire reduced by N-acetylcysteine?
    • LaRowe SD, Myrick H, Hedden S, et al. Is cocaine desire reduced by N-acetylcysteine? Am J Psychiatry 2007;164:1115-1117.
    • (2007) Am J Psychiatry , vol.164 , pp. 1115-1117
    • Larowe, S.D.1    Myrick, H.2    Hedden, S.3
  • 36
    • 33846811306 scopus 로고    scopus 로고
    • An open-label trial of N-acetylcysteine for the treatment of cocaine dependence: A pilot study
    • Mardikian PN, LaRowe SD, Hedden S, et al. An open-label trial of N-acetylcysteine for the treatment of cocaine dependence: a pilot study. Prog Neuropsychopharmacol Biol Psychiatry 2007;31:389-394.
    • (2007) Prog Neuropsychopharmacol Biol Psychiatry , vol.31 , pp. 389-394
    • Mardikian, P.N.1    Larowe, S.D.2    Hedden, S.3
  • 37
    • 34548150512 scopus 로고    scopus 로고
    • N-acetyl cysteine, a glutamate-modulating agent, in the treatment of pathological gambling: A pilot study
    • Grant JE, Kim SW, Odlaug BL. N-acetyl cysteine, a glutamate-modulating agent, in the treatment of pathological gambling: a pilot study. Biol Psychiatry 2007;62:652-657.
    • (2007) Biol Psychiatry , vol.62 , pp. 652-657
    • Grant, J.E.1    Kim, S.W.2    Odlaug, B.L.3
  • 38
    • 30644478253 scopus 로고    scopus 로고
    • N-acetylcysteine augmentation in serotonin reuptake inhibitor refractory obsessive-compulsive disorder
    • Lafleur DL, Pittenger C, Kelmendi B, et al. N-acetylcysteine augmentation in serotonin reuptake inhibitor refractory obsessive-compulsive disorder. Psychopharmacology (Berl) 2006;184:254-256.
    • (2006) Psychopharmacology (Berl) , vol.184 , pp. 254-256
    • Lafleur, D.L.1    Pittenger, C.2    Kelmendi, B.3
  • 39
    • 34247170051 scopus 로고    scopus 로고
    • N-acetyl cysteine in the treatment of grooming disorders
    • Odlaug BL, Grant JE. N-acetyl cysteine in the treatment of grooming disorders. J Clin Psychopharmacol 2007;27:227-229.
    • (2007) J Clin Psychopharmacol , vol.27 , pp. 227-229
    • Odlaug, B.L.1    Grant, J.E.2
  • 40
    • 67650483697 scopus 로고    scopus 로고
    • N-acetylcysteine, a glutamate modulator, in the treatment of trichotillomania: A double-blind, placebo-controlled study
    • Grant JE, Odlaug BL, Kim SW. N-acetylcysteine, a glutamate modulator, in the treatment of trichotillomania: a double-blind, placebo-controlled study. Arch Gen Psychiatry 2009;66:756-763.
    • (2009) Arch Gen Psychiatry , vol.66 , pp. 756-763
    • Grant, J.E.1    Odlaug, B.L.2    Kim, S.W.3
  • 41
    • 70350445015 scopus 로고    scopus 로고
    • Nail-biting stuff? The effect of N-acetyl cysteine on nail-biting
    • Berk M, Jeavons S, Dean O, et al. Nail-biting stuff? The effect of N-acetyl cysteine on nail-biting. CNS Spectr 2009;14:357-360.
    • (2009) CNS Spectr , vol.14 , pp. 357-360
    • Berk, M.1    Jeavons, S.2    Dean, O.3
  • 42
    • 48749112603 scopus 로고    scopus 로고
    • N-acetyl cysteine as a glu-tathione precursor for schizophrenia-a double-blind, randomized, placebo-controlled trial
    • Berk M, Copolov D, Dean O, et al. N-acetyl cysteine as a glu-tathione precursor for schizophrenia-a double-blind, randomized, placebo-controlled trial. Biol Psychiatry 2008;64:361-368.
    • (2008) Biol Psychiatry , vol.64 , pp. 361-368
    • Berk, M.1    Copolov, D.2    Dean, O.3
  • 43
    • 77449155361 scopus 로고    scopus 로고
    • Beneficial effects of N-acetylcysteine in treatment resistant schizophrenia
    • Bulut M, Savas HA, Altindag A, et al. Beneficial effects of N-acetylcysteine in treatment resistant schizophrenia. World J Biol Psychiatry 2009;10:626-628.
    • (2009) World J Biol Psychiatry , vol.10 , pp. 626-628
    • Bulut, M.1    Savas, H.A.2    Altindag, A.3
  • 44
    • 49749109893 scopus 로고    scopus 로고
    • N-acetyl cysteine for depressive symptoms in bipolar disorder-a double-blind randomized placebo-controlled trial
    • Berk M, Copolov DL, Dean O, et al. N-acetyl cysteine for depressive symptoms in bipolar disorder-a double-blind randomized placebo-controlled trial. Biol Psychiatry 2008;64:468-475.
    • (2008) Biol Psychiatry , vol.64 , pp. 468-475
    • Berk, M.1    Copolov, D.L.2    Dean, O.3
  • 45
    • 45849098291 scopus 로고    scopus 로고
    • Glutathione: A novel treatment target in psychiatry
    • Berk M, Ng F, Dean O, et al. Glutathione: a novel treatment target in psychiatry. Trends Pharmacol Sci 2008;29:346-351.
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 346-351
    • Berk, M.1    Ng, F.2    Dean, O.3
  • 46
    • 51349132292 scopus 로고    scopus 로고
    • Elevated serum super -oxide dismutase and thiobarbituric acid reactive substances in different phases of bipolar disorder and in schizophrenia
    • Kunz M, Gama CS, Andreazza AC, et al. Elevated serum super -oxide dismutase and thiobarbituric acid reactive substances in different phases of bipolar disorder and in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 2008;32:1677-1681.
    • (2008) Prog Neuropsychopharmacol Biol Psychiatry , vol.32 , pp. 1677-1681
    • Kunz, M.1    Gama, C.S.2    Andreazza, A.C.3
  • 48
    • 0037743546 scopus 로고    scopus 로고
    • Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse
    • Baker DA, McFarland K, Lake RW, et al. Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse. Nat Neurosci 2003;6:743-749.
    • (2003) Nat Neurosci , vol.6 , pp. 743-749
    • Baker, D.A.1    McFarland, K.2    Lake, R.W.3
  • 49
    • 45549108542 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psycho -stimulant drugs
    • Cunha-Oliveira T, Rego AC, Oliveira CR. Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psycho -stimulant drugs. Brain Res Rev 2008;58:192-208.
    • (2008) Brain Res Rev , vol.58 , pp. 192-208
    • Cunha-Oliveira, T.1    Rego, A.C.2    Oliveira, C.R.3
  • 50
    • 58149352369 scopus 로고    scopus 로고
    • The correlation between early alcohol withdrawal severity and oxidative stress in patients with alcohol dependence
    • Huang MC, Chen CC, Peng FC, et al. The correlation between early alcohol withdrawal severity and oxidative stress in patients with alcohol dependence. Prog Neuropsychopharmacol Biol Psychiatry 2009;33:66-69.
    • (2009) Prog Neuropsychopharmacol Biol Psychiatry , vol.33 , pp. 66-69
    • Huang, M.C.1    Chen, C.C.2    Peng, F.C.3
  • 51
    • 41449095227 scopus 로고    scopus 로고
    • Prooxidative/antioxidative homeostasis in heroin addiction and detoxification
    • Pereska Z, Dejanova B, Bozinovska C, et al. Prooxidative/antioxidative homeostasis in heroin addiction and detoxification. Bratisl Lek Listy 2007;108:393-398.
    • (2007) Bratisl Lek Listy , vol.108 , pp. 393-398
    • Pereska, Z.1    Dejanova, B.2    Bozinovska, C.3
  • 52
    • 38449086396 scopus 로고    scopus 로고
    • Repeated N-acetylcysteine administration alters plasticity-dependent effects of cocaine
    • Madayag A, Lobner D, Kau KS, et al. Repeated N-acetylcysteine administration alters plasticity-dependent effects of cocaine. J Neurosci 2007;27:13968-13976.
    • (2007) J Neurosci , vol.27 , pp. 13968-13976
    • Madayag, A.1    Lobner, D.2    Kau, K.S.3
  • 53
    • 77953290416 scopus 로고    scopus 로고
    • The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice
    • Chen HH, Stoker A, Markou A. The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice. Psychopharmacology (Berl) 2010;209:343-350.
    • (2010) Psychopharmacology (Berl) , vol.209 , pp. 343-350
    • Chen, H.H.1    Stoker, A.2    Markou, A.3
  • 54
    • 61849151380 scopus 로고    scopus 로고
    • A psychological and neuroanatomical model of obsessive-compulsive disorder
    • Huey ED, Zahn R, Krueger F, et al. A psychological and neuroanatomical model of obsessive-compulsive disorder. J Neuropsychiatry Clin Neurosci 2008;20:390-408.
    • (2008) J Neuropsychiatry Clin Neurosci , vol.20 , pp. 390-408
    • Huey, E.D.1    Zahn, R.2    Krueger, F.3
  • 56
    • 0036036511 scopus 로고    scopus 로고
    • Antioxidant enzyme activities and malondialdehyde levels in patients with obsessive-compulsive disorder
    • Kuloglu M, Atmaca M, Tezcan E, et al. Antioxidant enzyme activities and malondialdehyde levels in patients with obsessive-compulsive disorder. Neuropsychobiology 2002;46:27-32.
    • (2002) Neuropsychobiology , vol.46 , pp. 27-32
    • Kuloglu, M.1    Atmaca, M.2    Tezcan, E.3
  • 57
    • 60049086948 scopus 로고    scopus 로고
    • Correlation between lipid peroxidation-induced TBARS level and disease severity in obsessive-compulsive disorder
    • Chakraborty S, Singh OP, Dasgupta A, et al. Correlation between lipid peroxidation-induced TBARS level and disease severity in obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry 2009;33:363-366.
    • (2009) Prog Neuropsychopharmacol Biol Psychiatry , vol.33 , pp. 363-366
    • Chakraborty, S.1    Singh, O.P.2    Dasgupta, A.3
  • 58
    • 33745241877 scopus 로고    scopus 로고
    • Examination of free radical metabolism and antioxidant defence system elements in patients with obsessive-compulsive disorder
    • Ersan S, Bakir S, Erdal Ersan E, et al. Examination of free radical metabolism and antioxidant defence system elements in patients with obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry 2006;30:1039-1042.
    • (2006) Prog Neuropsychopharmacol Biol Psychiatry , vol.30 , pp. 1039-1042
    • Ersan, S.1    Bakir, S.2    Erdal Ersan, E.3
  • 59
    • 58149347324 scopus 로고    scopus 로고
    • Serum selenium and plasma malondialdehyde levels and antioxidant enzyme activities in patients with obsessive-compulsive disorder
    • Ozdemir E, Cetinkaya S, Ersan S, et al. Serum selenium and plasma malondialdehyde levels and antioxidant enzyme activities in patients with obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry 2009;33:62-65.
    • (2009) Prog Neuropsychopharmacol Biol Psychiatry , vol.33 , pp. 62-65
    • Ozdemir, E.1    Cetinkaya, S.2    Ersan, S.3
  • 60
    • 38849205585 scopus 로고    scopus 로고
    • Oxidative imbalance in obsessive compulsive disorder patients: A total evaluation of oxidant-antioxidant status
    • Selek S, Herken H, Bulut M, et al. Oxidative imbalance in obsessive compulsive disorder patients: a total evaluation of oxidant-antioxidant status. Prog Neuropsychopharmacol Biol Psychiatry 2008;32:487-491.
    • (2008) Prog Neuropsychopharmacol Biol Psychiatry , vol.32 , pp. 487-491
    • Selek, S.1    Herken, H.2    Bulut, M.3
  • 61
    • 77955663523 scopus 로고    scopus 로고
    • Meta-analysis of the dose-response relationship of SSRI in obsessive-compulsive disorder
    • Bloch MH, McGuire J, Landeros-Weisenberger A, et al. Meta-analysis of the dose-response relationship of SSRI in obsessive-compulsive disorder. Mol Psychiatry 2010;15:850-855.
    • (2010) Mol Psychiatry , vol.15 , pp. 850-855
    • Bloch, M.H.1    McGuire, J.2    Landeros-Weisenberger, A.3
  • 62
    • 0035115622 scopus 로고    scopus 로고
    • On the role of prefrontal cortex glutamate for the antithetical phenomenology of obsessive compulsive disorder and attention deficit hyperactivity disorder
    • Carlsson ML. On the role of prefrontal cortex glutamate for the antithetical phenomenology of obsessive compulsive disorder and attention deficit hyperactivity disorder. Prog Neuropsychopharmacol Biol Psychiatry 2001;25:5-26.
    • (2001) Prog Neuropsychopharmacol Biol Psychiatry , vol.25 , pp. 5-26
    • Carlsson, M.L.1
  • 63
    • 33745214485 scopus 로고    scopus 로고
    • Epidemiologic and clinical updates on impulse control disorders: A critical review
    • Dell'Osso B, Altamura AC, Allen A, et al. Epidemiologic and clinical updates on impulse control disorders: a critical review. Eur Arch Psychiatry Clin Neurosci 2006;256:464-475.
    • (2006) Eur Arch Psychiatry Clin Neurosci , vol.256 , pp. 464-475
    • Dell'osso, B.1    Altamura, A.C.2    Allen, A.3
  • 66
    • 34047118144 scopus 로고    scopus 로고
    • Addicted to hair pulling? How an alternate model of trichotillomania may improve treatment outcome
    • Grant JE, Odlaug BL, Potenza MN. Addicted to hair pulling? How an alternate model of trichotillomania may improve treatment outcome. Harv Rev Psychiatry 2007;15:80-85.
    • (2007) Harv Rev Psychiatry , vol.15 , pp. 80-85
    • Grant, J.E.1    Odlaug, B.L.2    Potenza, M.N.3
  • 67
    • 0035028512 scopus 로고    scopus 로고
    • Interactions between monoamines, glutamate, and GABA in schizophrenia: New evidence
    • Carlsson A, Waters N, Holm-Waters S, et al. Interactions between monoamines, glutamate, and GABA in schizophrenia: new evidence. Annu Rev Pharmacol Toxicol 2001;41:237-260.
    • (2001) Annu Rev Pharmacol Toxicol , vol.41 , pp. 237-260
    • Carlsson, A.1    Waters, N.2    Holm-Waters, S.3
  • 68
    • 77149138329 scopus 로고    scopus 로고
    • Glutamatergic (N-methyl-D-aspartate receptor) hypofrontality in schizophrenia: Too little juice or a miswired brain?
    • Marek GJ, Behl B, Bespalov AY, et al. Glutamatergic (N-methyl-D-aspartate receptor) hypofrontality in schizophrenia: Too little juice or a miswired brain? Mol Pharmacol 2010;77:317-326.
    • (2010) Mol Pharmacol , vol.77 , pp. 317-326
    • Marek, G.J.1    Behl, B.2    Bespalov, A.Y.3
  • 69
    • 17744413269 scopus 로고    scopus 로고
    • Modulation of glutamate receptor functions by glutathione
    • Oja SS, Janaky R, Varga V, et al. Modulation of glutamate receptor functions by glutathione. Neurochem Int 2000;37:299-306.
    • (2000) Neurochem Int , vol.37 , pp. 299-306
    • Oja, S.S.1    Janaky, R.2    Varga, V.3
  • 70
    • 33644827689 scopus 로고    scopus 로고
    • The neurochemical circuitry of schizophrenia
    • Carlsson A. The neurochemical circuitry of schizophrenia. Pharmacopsychiatry 2006;39(Suppl 1):S10-14.
    • (2006) Pharmacopsychiatry , vol.39 , Issue.SUPPL. 1
    • Carlsson, A.1
  • 71
    • 70349404318 scopus 로고    scopus 로고
    • A role for glutathione in the pathophysiology of bipolar disorder and schizophrenia? Animal models and relevance to clinical practice
    • Dean OM, van den Buuse M, Bush AI, et al. A role for glutathione in the pathophysiology of bipolar disorder and schizophrenia? Animal models and relevance to clinical practice. Curr Med Chem 2009; 16:2965-2976.
    • (2009) Curr Med Chem , vol.16 , pp. 2965-2976
    • Dean, O.M.1    van den Buuse, M.2    Bush, A.I.3
  • 72
    • 69549129391 scopus 로고    scopus 로고
    • Decreased glutathione levels and antioxidant enzyme activities in untreated and treated schizophrenic patients
    • Raffa M, Mechri A, Othman LB, et al. Decreased glutathione levels and antioxidant enzyme activities in untreated and treated schizophrenic patients. Prog Neuropsychopharmacol Biol Psychiatry 2009;33: 1178-1183.
    • (2009) Prog Neuropsychopharmacol Biol Psychiatry , vol.33 , pp. 1178-1183
    • Raffa, M.1    Mechri, A.2    Othman, L.B.3
  • 73
    • 70349303526 scopus 로고    scopus 로고
    • Oxidative mechanisms in schizophrenia and their relationship with illness subtype and symptom profile
    • Pazvantoglu O, Selek S, Okay IT, et al. Oxidative mechanisms in schizophrenia and their relationship with illness subtype and symptom profile. Psychiatry Clin Neurosci 2009;63:693-700.
    • (2009) Psychiatry Clin Neurosci , vol.63 , pp. 693-700
    • Pazvantoglu, O.1    Selek, S.2    Okay, I.T.3
  • 74
    • 50849139232 scopus 로고    scopus 로고
    • Oxidative stress in psychiatric disorders: Evidence base and therapeutic implications
    • Ng F, Berk M, Dean O, et al. Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int J Neuropsychopharmacol 2008;11:851-876.
    • (2008) Int J Neuropsychopharmacol , vol.11 , pp. 851-876
    • Ng, F.1    Berk, M.2    Dean, O.3
  • 75
    • 33747193538 scopus 로고    scopus 로고
    • Schizophrenia susceptibility genes converge on interlinked pathways related to glutamatergic transmission and long-term potentiation, oxidative stress and oligodendrocyte viability
    • Carter CJ. Schizophrenia susceptibility genes converge on interlinked pathways related to glutamatergic transmission and long-term potentiation, oxidative stress and oligodendrocyte viability. Schizophr Res 2006;86:1-14.
    • (2006) Schizophr Res , vol.86 , pp. 1-14
    • Carter, C.J.1
  • 76
    • 85031258279 scopus 로고    scopus 로고
    • Qualitative methods in early-phase drug trials: Data and methods from a trial of N-acetyl cys-teine in schizophrenia
    • Sep. 1 [Epub ahead of print
    • Berk M, Munib A, Dean O et al. Qualitative methods in early-phase drug trials: data and methods from a trial of N-acetyl cys-teine in schizophrenia. J Clin Psychiatry 2010 Sep. 1 [Epub ahead of print].
    • (2010) J Clin Psychiatry
    • Berk, M.1    Munib, A.2    Dean, O.3
  • 77
    • 51349085199 scopus 로고    scopus 로고
    • Oxidative stress markers in bipolar disorder: A meta-analysis
    • Andreazza AC, Kauer-Sant'anna M, Frey BN, et al. Oxidative stress markers in bipolar disorder: a meta-analysis. J Affect Disord 2008;111:135-144.
    • (2008) J Affect Disord , vol.111 , pp. 135-144
    • Andreazza, A.C.1    Kauer-Sant'anna, M.2    Frey, B.N.3
  • 78
    • 70149115047 scopus 로고    scopus 로고
    • 3-Nitrotyrosine and glutathione antioxidant system in patients in the early and late stages of bipolar disorder
    • Andreazza AC, Kapczinski F, Kauer-Sant'Anna M, et al. 3-Nitrotyrosine and glutathione antioxidant system in patients in the early and late stages of bipolar disorder. J Psychiatry Neurosci 2009;34:263-271.
    • (2009) J Psychiatry Neurosci , vol.34 , pp. 263-271
    • Andreazza, A.C.1    Kapczinski, F.2    Kauer-Sant'anna, M.3
  • 79
    • 34848881907 scopus 로고    scopus 로고
    • S-Nitrosothiols signal hypoxia- mimetic vascular pathology
    • Palmer LA, Doctor A, Chhabra P, et al. S-Nitrosothiols signal hypoxia- mimetic vascular pathology. J Clin Invest 2007;117:2592-2601.
    • (2007) J Clin Invest , vol.117 , pp. 2592-2601
    • Palmer, L.A.1    Doctor, A.2    Chhabra, P.3
  • 80
    • 33646235152 scopus 로고    scopus 로고
    • Facilitation action of N-acetylcysteine on the anticonvulsant effect of sodium valproate in mice
    • Devi PU, Pillai KK, Vohora D. Facilitation action of N-acetylcysteine on the anticonvulsant effect of sodium valproate in mice. Basic Clin Pharmacol Toxicol 2006;98:521-522.
    • (2006) Basic Clin Pharmacol Toxicol , vol.98 , pp. 521-522
    • Devi, P.U.1    Pillai, K.K.2    Vohora, D.3
  • 81
    • 4544344727 scopus 로고    scopus 로고
    • Status epilepticus after a massive intravenous N-acetylcysteine overdose leading to intracranial hypertension and death
    • Bailey B, Blais R, Letarte A. Status epilepticus after a massive intravenous N-acetylcysteine overdose leading to intracranial hypertension and death. Ann Emerg Med 2004;44:401-406.
    • (2004) Ann Emerg Med , vol.44 , pp. 401-406
    • Bailey, B.1    Blais, R.2    Letarte, A.3
  • 82
    • 49349104661 scopus 로고    scopus 로고
    • Blunted cystine-glutamate an-tiporter function in the nucleus accumbens promotes cocaine-induced drug seeking
    • Kau KS, Madayag A, Mantsch JR, et al. Blunted cystine-glutamate an-tiporter function in the nucleus accumbens promotes cocaine-induced drug seeking. Neuroscience 2008;155:530-537.
    • (2008) Neuroscience , vol.155 , pp. 530-537
    • Kau, K.S.1    Madayag, A.2    Mantsch, J.R.3
  • 83
    • 0347722441 scopus 로고    scopus 로고
    • N-acetyl cysteine-induced blockade of cocaine-induced reinstatement
    • Baker DA, McFarland K, Lake RW, et al. N-acetyl cysteine-induced blockade of cocaine-induced reinstatement. Ann N Y Acad Sci 2003; 1003: 349-351.
    • (2003) Ann N Y Acad Sci , vol.1003 , pp. 349-351
    • Baker, D.A.1    McFarland, K.2    Lake, R.W.3
  • 84
    • 58849166971 scopus 로고    scopus 로고
    • N-Acetylcysteine reverses cocaine-induced metaplasticity
    • Moussawi K, Pacchioni A, Moran M, et al. N-Acetylcysteine reverses cocaine-induced metaplasticity. Nat Neurosci 2009;12:182-189.
    • (2009) Nat Neurosci , vol.12 , pp. 182-189
    • Moussawi, K.1    Pacchioni, A.2    Moran, M.3
  • 85
    • 38349082684 scopus 로고    scopus 로고
    • The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon-gamma
    • Bian Q, Kato T, Monji A, et al. The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon-gamma. Prog Neuropsychopharmacol Biol Psychiatry 2008;32:42-48.
    • (2008) Prog Neuropsychopharmacol Biol Psychiatry , vol.32 , pp. 42-48
    • Bian, Q.1    Kato, T.2    Monji, A.3
  • 86
    • 0037215386 scopus 로고    scopus 로고
    • Expression of brain-derived neurotrophic factor mRNA in rat hippocampus after treatment with antipsychotic drugs
    • Bai O, Chlan-Fourney J, Bowen R, et al. Expression of brain-derived neurotrophic factor mRNA in rat hippocampus after treatment with antipsychotic drugs. J Neurosci Res 2003;71:127-131.
    • (2003) J Neurosci Res , vol.71 , pp. 127-131
    • Bai, O.1    Chlan-Fourney, J.2    Bowen, R.3
  • 87
    • 33846847640 scopus 로고    scopus 로고
    • Long-term antipsychotic treatments and crossover studies in rats: Differential effects of typ -ical and atypical agents on the expression of antioxidant enzymes and membrane lipid peroxidation in rat brain
    • Pillai A, Parikh V, Terry AV Jr, et al. Long-term antipsychotic treatments and crossover studies in rats: differential effects of typ -ical and atypical agents on the expression of antioxidant enzymes and membrane lipid peroxidation in rat brain. J Psychiatr Res 2007;41:372-386.
    • (2007) J Psychiatr Res , vol.41 , pp. 372-386
    • Pillai, A.1    Parikh, V.2    Terry Jr., A.V.3


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