메뉴 건너뛰기




Volumn 13, Issue 6, 2012, Pages 829-841

To cardiovascular disease and beyond: New therapeutic perspectives of statins in autoimmune diseases and cancer

Author keywords

Atherosclerosis; Autoimmune diseases; Cancer; Cardiovascular disease; Inflammation; Statins

Indexed keywords

ATORVASTATIN; CETUXIMAB; CISPLATIN; CYTARABINE; EZETIMIBE; FLUINDOSTATIN; FLUOROURACIL; FOLINIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IDARUBICIN; IRINOTECAN; METHOTREXATE; MEVINOLIN; NITRIC OXIDE; PRAVASTATIN; PREDNISONE; RETINOIC ACID; ROSUVASTATIN; SIMVASTATIN; TRASTUZUMAB; VASCULOTROPIN C;

EID: 84860820321     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/138945012800564112     Document Type: Review
Times cited : (15)

References (139)
  • 1
    • 78249272288 scopus 로고    scopus 로고
    • Influence of statins on effector and regulatory immune mechanisms and their potential clinical relevance in treating autoimmune disorders
    • Chalubinski M, Broncel M. Influence of statins on effector and regulatory immune mechanisms and their potential clinical relevance in treating autoimmune disorders. Med Sci Monit 2010; 16: RA245-RA251.
    • (2010) Med Sci Monit , vol.16
    • Chalubinski, M.1    Broncel, M.2
  • 2
    • 69249219178 scopus 로고    scopus 로고
    • Targeting the mevalonate pathway for improved anticancer therapy
    • Fritz G. Targeting the mevalonate pathway for improved anticancer therapy. Curr Cancer Drug Targets 2009; 9: 626-638.
    • (2009) Curr Cancer Drug Targets , vol.9 , pp. 626-638
    • Fritz, G.1
  • 3
    • 38049034068 scopus 로고    scopus 로고
    • Pleiotropic effects of statin therapy: Molecular mchanisms and clinical results
    • Wang CY, Liu PY, Liao JK. Pleiotropic effects of statin therapy: molecular mchanisms and clinical results. Trends Mol Med 2008; 14: 37-44.
    • (2008) Trends Mol Med , vol.14 , pp. 37-44
    • Wang, C.Y.1    Liu, P.Y.2    Liao, J.K.3
  • 4
    • 33646354412 scopus 로고    scopus 로고
    • Statin therapy and autoimmune disease: From protein prenylation to immunomodulation
    • Greenwood J, Steinman L, Zamvil SS. Statin therapy and autoimmune disease: from protein prenylation to immunomodulation. Nat Rev Immunol 2006; 6: 358-370.
    • (2006) Nat Rev Immunol , vol.6 , pp. 358-370
    • Greenwood, J.1    Steinman, L.2    Zamvil, S.S.3
  • 7
    • 0035876928 scopus 로고    scopus 로고
    • Cutting edge: Lipid raft integrity affects the efficiency of MHC class I tetramer binding and cell surface TCR arrangement on CD8+ T cells
    • rd, Braciale TJ. Cutting edge: lipid raft integrity affects the efficiency of MHC class I tetramer binding and cell surface TCR arrangement on CD8+ T cells. J Immunol 2001; 166: 7009-7013.
    • (2001) J Immunol , vol.166 , pp. 7009-7013
    • Drake, D.R.1    Braciale, T.J.2
  • 8
    • 0033431772 scopus 로고    scopus 로고
    • A role for lipid rafts in B cell antigen receptor signaling and antigen targeting
    • Cheng PC, Dykstra ML, Mitchell MN, Pierce SK. A role for lipid rafts in B cell antigen receptor signaling and antigen targeting. J Exp Med 1999; 190: 1549-1560.
    • (1999) J Exp Med , vol.190 , pp. 1549-1560
    • Cheng, P.C.1    Dykstra, M.L.2    Mitchell, M.N.3    Pierce, S.K.4
  • 9
    • 0036775527 scopus 로고    scopus 로고
    • Lipid rafts, major histocompatibility complex molecules, and immune regulation
    • Goebel J, Forrest K, Flynn D, Rao R, Roszman TL. Lipid rafts, major histocompatibility complex molecules, and immune regulation. Hum Immunol 2002; 63: 813-820.
    • (2002) Hum Immunol , vol.63 , pp. 813-820
    • Goebel, J.1    Forrest, K.2    Flynn, D.3    Rao, R.4    Roszman, T.L.5
  • 11
    • 0036305114 scopus 로고    scopus 로고
    • Atorvastatin and thrombogenicity of the carotid atherosclerotic plaque: The ATROCAP study
    • Cortellaro M, Cofrancesco E, Arbustini E, et al. Atorvastatin and thrombogenicity of the carotid atherosclerotic plaque: the ATROCAP study. Thromb Haemost 2002; 88: 41-47.
    • (2002) Thromb Haemost , vol.88 , pp. 41-47
    • Cortellaro, M.1    Cofrancesco, E.2    Arbustini, E.3
  • 12
    • 63649095045 scopus 로고    scopus 로고
    • Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: A prospective study of the JUPITER trial
    • JUPITER Trial Study Group
    • Ridker PM, Danielson E, Fonseca FA, et al. JUPITER Trial Study Group. Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial. Lancet 2009; 373: 1175-1182.
    • (2009) Lancet , vol.373 , pp. 1175-1182
    • Ridker, P.M.1    Danielson, E.2    Fonseca, F.A.3
  • 13
    • 65449138698 scopus 로고    scopus 로고
    • A randomized trial of rosuvastatin in the prevention of venous thromboembolism
    • Glynn RJ, Danielson E, Fonseca FA, et al. A randomized trial of rosuvastatin in the prevention of venous thromboembolism. N Engl J Med 2009; 360: 1851-1861.
    • (2009) N Engl J Med , vol.360 , pp. 1851-1861
    • Glynn, R.J.1    Danielson, E.2    Fonseca, F.A.3
  • 15
    • 33751246181 scopus 로고    scopus 로고
    • Simvastatin inhibits the MHC class II pathway of antigen presentation by impairing Ras superfamily GTPases
    • Ghittoni R, Napolitani G, Benati D, et al. Simvastatin inhibits the MHC class II pathway of antigen presentation by impairing Ras superfamily GTPases. Eur J Immunol 2006; 36: 2885-2893.
    • (2006) Eur J Immunol , vol.36 , pp. 2885-2893
    • Ghittoni, R.1    Napolitani, G.2    Benati, D.3
  • 16
    • 2142734914 scopus 로고    scopus 로고
    • Function and regulation of MHC class II molecules in T-lymphocytes: Of mice and men
    • Holling TM, Schooten E, van den Elsen PJ. Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. Hum Immunol 2004; 65: 282-290.
    • (2004) Hum Immunol , vol.65 , pp. 282-290
    • Holling, T.M.1    Schooten, E.2    van den Elsen, P.J.3
  • 17
    • 21544482024 scopus 로고    scopus 로고
    • Statins affect T cell-surface expression of major histocompatibility complex class II molecules by disrupting cholesterol-containing microdomains
    • Kuipers HF, Biesta PJ, Groothuis TA, et al. Statins affect T cell-surface expression of major histocompatibility complex class II molecules by disrupting cholesterol-containing microdomains. Hum Immunol 2005; 66: 653-665.
    • (2005) Hum Immunol , vol.66 , pp. 653-665
    • Kuipers, H.F.1    Biesta, P.J.2    Groothuis, T.A.3
  • 18
    • 16344370063 scopus 로고    scopus 로고
    • Simvastatin inhibits T-cell activation by selectively impairing the function of Ras superfamily GTPases
    • Ghittoni R, Patrussi L, Pirozzi K, et al. Simvastatin inhibits T-cell activation by selectively impairing the function of Ras superfamily GTPases. FASEB J 2005; 19: 605-607.
    • (2005) FASEB J , vol.19 , pp. 605-607
    • Ghittoni, R.1    Patrussi, L.2    Pirozzi, K.3
  • 19
    • 33344475402 scopus 로고    scopus 로고
    • Isoprenoids determine Th1/Th2 fate in pathogenic T cells providing a mechanism of modulation of autoimmunity by atorvastatin
    • Dunn SE, Youssef S, Goldstein MJ, et al. Isoprenoids determine Th1/Th2 fate in pathogenic T cells providing a mechanism of modulation of autoimmunity by atorvastatin. J Exp Med 2006; 203: 401-412.
    • (2006) J Exp Med , vol.203 , pp. 401-412
    • Dunn, S.E.1    Youssef, S.2    Goldstein, M.J.3
  • 20
    • 79953848180 scopus 로고    scopus 로고
    • Participation of Mac-1, LFA-1 and VLA-4 integrins in the in vitro adhesion of sickle cell disease neutrophils to endothelial layers, and reversal of adhesion by simvastatin
    • Canalli AA, Proença RF, Franco-Penteado CF, et al. Participation of Mac-1, LFA-1 and VLA-4 integrins in the in vitro adhesion of sickle cell disease neutrophils to endothelial layers, and reversal of adhesion by simvastatin. Haematologica 2011; 96:526-533.
    • (2011) Haematologica , vol.96 , pp. 526-533
    • Canalli, A.A.1    Proença, R.F.2    Franco-Penteado, C.F.3
  • 21
    • 35748945752 scopus 로고    scopus 로고
    • Atorvastatin inhibits T cell activation through 3-hydroxy-3-methylglutaryl coenzyme A reductase without decreasing cholesterol synthesis
    • Blank N, Schiller M, Krienke S, et al. Atorvastatin inhibits T cell activation through 3-hydroxy-3-methylglutaryl coenzyme A reductase without decreasing cholesterol synthesis. J Immunol 2007; 179:3613-3621.
    • (2007) J Immunol , vol.179 , pp. 3613-3621
    • Blank, N.1    Schiller, M.2    Krienke, S.3
  • 22
    • 0027935309 scopus 로고
    • Leukocyte-endothelial adhesion molecules
    • Carlos TM, Harlan JM. Leukocyte-endothelial adhesion molecules. Blood 1994; 84: 2068-2101.
    • (1994) Blood , vol.84 , pp. 2068-2101
    • Carlos, T.M.1    Harlan, J.M.2
  • 23
    • 0024443411 scopus 로고
    • T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1
    • Dustin ML, Springer TA. T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature 1989; 341: 619-624.
    • (1989) Nature , vol.341 , pp. 619-624
    • Dustin, M.L.1    Springer, T.A.2
  • 24
    • 0038322504 scopus 로고    scopus 로고
    • Lovastatin inhibits brain endothelial Rho-dependent lymphocyte migration and attenuates experimental autoimmune encephalomyelitis
    • Greenwood J, Walters CE, Pryce G, et al. Lovastatin inhibits brain endothelial Rho-dependent lymphocyte migration and attenuates experimental autoimmune encephalomyelitis. FASEB J 2003; 17: 905-907.
    • (2003) FASEB J , vol.17 , pp. 905-907
    • Greenwood, J.1    Walters, C.E.2    Pryce, G.3
  • 25
    • 0035723275 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitor modulates monocyte-endothelial cell interaction under physiological flow conditions in vitro: Involvement of Rho GTPase-dependent mechanism
    • Yoshida M, Sawada T, Ishii H, et al. HMG-CoA reductase inhibitor modulates monocyte-endothelial cell interaction under physiological flow conditions in vitro: involvement of Rho GTPase-dependent mechanism. Arterioscler Thromb Vasc Biol 2001; 21: 1165-1171.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1165-1171
    • Yoshida, M.1    Sawada, T.2    Ishii, H.3
  • 26
    • 0037339680 scopus 로고    scopus 로고
    • Simvastatin reduces the expression of adhesion molecules in circulating monocytes from hypercholesterolemic patients
    • Rezaie-Majd A, Prager GW, Bucek RA, et al. Simvastatin reduces the expression of adhesion molecules in circulating monocytes from hypercholesterolemic patients. Arterioscler Thromb Vasc Biol 2003; 23: 397-403.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 397-403
    • Rezaie-Majd, A.1    Prager, G.W.2    Bucek, R.A.3
  • 27
    • 18144418144 scopus 로고    scopus 로고
    • Simvastatin inhibits MMP-9 secretion from human saphenous vein smooth muscle cells by inhibiting the RhoA/ROCK pathway and reducing MMP-9 mRNA levels
    • Turner NA, O'Regan DJ, Ball SG, Porter KE. Simvastatin inhibits MMP-9 secretion from human saphenous vein smooth muscle cells by inhibiting the RhoA/ROCK pathway and reducing MMP-9 mRNA levels. FASEB J 2005; 19: 804-806.
    • (2005) FASEB J , vol.19 , pp. 804-806
    • Turner, N.A.1    O'Regan, D.J.2    Ball, S.G.3    Porter, K.E.4
  • 28
    • 79961031512 scopus 로고    scopus 로고
    • Rapid, Direct Effects of Statin Treatment on Arterial Redox State and Nitric Oxide Bioavailability in Human Atherosclerosis via Tetrahydrobiopterin-Mediated Endothelial Nitric Oxide Synthase Coupling
    • Antoniades C, Bakogiannis C, Leeson P, et al. Rapid, Direct Effects of Statin Treatment on Arterial Redox State and Nitric Oxide Bioavailability in Human Atherosclerosis via Tetrahydrobiopterin-Mediated Endothelial Nitric Oxide Synthase Coupling. Circulation. 2011; 124: 335-345.
    • (2011) Circulation , vol.124 , pp. 335-345
    • Antoniades, C.1    Bakogiannis, C.2    Leeson, P.3
  • 29
    • 0026059986 scopus 로고
    • Nitric oxide and prostacyclin: Divergence of inhibitory effects on monocyte chemotaxis and adhesion to endothelium in vitro
    • Bath PMW, Hassall DG, Gladwin AM, Palmer RMJ, Martin JF. Nitric oxide and prostacyclin: divergence of inhibitory effects on monocyte chemotaxis and adhesion to endothelium in vitro. Arterioscler Thromb Vasc Biol 1991; 11: 254-260.
    • (1991) Arterioscler Thromb Vasc Biol , vol.11 , pp. 254-260
    • Bath, P.M.W.1    Hassall, D.G.2    Gladwin, A.M.3    Palmer, R.M.J.4    Martin, J.F.5
  • 30
    • 0025731835 scopus 로고
    • Nitric oxide: An endogenous modulator of leukocyte adhesion
    • Kubes P, Suzuki M, Granger DN. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 1991; 88: 4651-4655.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 4651-4655
    • Kubes, P.1    Suzuki, M.2    Granger, D.N.3
  • 31
    • 0030295229 scopus 로고    scopus 로고
    • Nitric oxide attenuates adhesion molecule expression in human endothelial cells
    • Takahashi M, Ikeda U, Masuyama J, Funayama H, Kano S, Shimada K. Nitric oxide attenuates adhesion molecule expression in human endothelial cells. Cytokine 1996; 8: 817-821.
    • (1996) Cytokine , vol.8 , pp. 817-821
    • Takahashi, M.1    Ikeda, U.2    Masuyama, J.3    Funayama, H.4    Kano, S.5    Shimada, K.6
  • 32
    • 0030667160 scopus 로고    scopus 로고
    • Inhibition of endothelial vascular cell adhesion molecule-1 expression by nitric oxide involves the induction and nuclear translocation of IκBα
    • Spiecker M, Peng HB, Liao JK. Inhibition of endothelial vascular cell adhesion molecule-1 expression by nitric oxide involves the induction and nuclear translocation of IκBα. J Biol Chem 1997; 272: 30969-30974.
    • (1997) J Biol Chem , vol.272 , pp. 30969-30974
    • Spiecker, M.1    Peng, H.B.2    Liao, J.K.3
  • 33
    • 0029159779 scopus 로고
    • Nitric oxide decreases cytokine induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines
    • De Caterina R, Libby P, Peng HB, et al. Nitric oxide decreases cytokine induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Invest 1995; 96: 60-68.
    • (1995) J Clin Invest , vol.96 , pp. 60-68
    • de Caterina, R.1    Libby, P.2    Peng, H.B.3
  • 34
    • 0037038402 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease
    • Youssef SO, Stuve JC, Patarroyo PJ, et al. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Nature 2002; 420: 78-84.
    • (2002) Nature , vol.420 , pp. 78-84
    • Youssef, S.O.1    Stuve, J.C.2    Patarroyo, P.J.3
  • 35
    • 45549102525 scopus 로고    scopus 로고
    • Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes
    • Zhang X, Jin J, Peng X, Ramgolam VS, Markovic-Plese S. Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. J Immunol 2008; 180: 6988-6996.
    • (2008) J Immunol , vol.180 , pp. 6988-6996
    • Zhang, X.1    Jin, J.2    Peng, X.3    Ramgolam, V.S.4    Markovic-Plese, S.5
  • 36
    • 0036091606 scopus 로고    scopus 로고
    • Role of nuclear factor-kappa B activation in metalloproteinase-1, -3, and -9 secretion by human macrophages in vitro and rabbit foam cells produced in vivo
    • Chase AJ, Bond M, Crook MF, Newby AC. Role of nuclear factor-kappa B activation in metalloproteinase-1, -3, and -9 secretion by human macrophages in vitro and rabbit foam cells produced in vivo. Arterioscler Thromb Vasc Biol 2002; 22: 765-771.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 765-771
    • Chase, A.J.1    Bond, M.2    Crook, M.F.3    Newby, A.C.4
  • 37
    • 33751171940 scopus 로고    scopus 로고
    • Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes
    • Cuccurullo C, Lezzi A, Fazia ML, et al. Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes. Arterioscler Thromb Vasc Biol 2006; 26: 2716-2723.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 2716-2723
    • Cuccurullo, C.1    Lezzi, A.2    Fazia, M.L.3
  • 38
    • 0037682113 scopus 로고    scopus 로고
    • Different effect induced by treatment with several statins on monocyte tissue factor expression in hypercholesterolemic subjects
    • Bruni F, Puccetti L, Pasqui AL, et al. Different effect induced by treatment with several statins on monocyte tissue factor expression in hypercholesterolemic subjects. Clin Exp Med 2003; 3: 45-53.
    • (2003) Clin Exp Med , vol.3 , pp. 45-53
    • Bruni, F.1    Puccetti, L.2    Pasqui, A.L.3
  • 40
    • 1842413134 scopus 로고    scopus 로고
    • Thrombosis in primary antiphospholipid syndrome: A pivotal role for monocyte tissue factor expression
    • Cuadrado MJ, López-Pedrera C, Khamashta MA, et al. Thrombosis in primary antiphospholipid syndrome: a pivotal role for monocyte tissue factor expression. Arthritis Rheum 1997; 40: 834-841.
    • (1997) Arthritis Rheum , vol.40 , pp. 834-841
    • Cuadrado, M.J.1    López-Pedrera, C.2    Khamashta, M.A.3
  • 41
    • 31044449865 scopus 로고    scopus 로고
    • Antiphospholipid antibodies from patients with the antiphospholipid syndrome induce monocyte tissue factor expression through the simultaneous activation of NF-kappaB/Rel proteins via the p38 mitogen-activated protein kinase pathway, and of the MEK-1/ERK pathway
    • López-Pedrera C, Buendía P, Cuadrado MJ, et al. Antiphospholipid antibodies from patients with the antiphospholipid syndrome induce monocyte tissue factor expression through the simultaneous activation of NF-kappaB/Rel proteins via the p38 mitogen-activated protein kinase pathway, and of the MEK-1/ERK pathway. Arthritis Rheum 2006; 54: 301-311.
    • (2006) Arthritis Rheum , vol.54 , pp. 301-311
    • López-Pedrera, C.1    Buendía, P.2    Cuadrado, M.J.3
  • 42
    • 8344267910 scopus 로고    scopus 로고
    • The p38 mitogen-activated protein kinase (MAPK) pathway mediates induction of the tissue factor gene in monocytes stimulated with human monoclonal anti-beta2Glycoprotein I antibodies
    • Bohgaki M, Atsumi T, Yamashita Y, et al. The p38 mitogen-activated protein kinase (MAPK) pathway mediates induction of the tissue factor gene in monocytes stimulated with human monoclonal anti-beta2Glycoprotein I antibodies. Int Immunol 2004; 16: 1633-1641.
    • (2004) Int Immunol , vol.16 , pp. 1633-1641
    • Bohgaki, M.1    Atsumi, T.2    Yamashita, Y.3
  • 43
    • 55849112296 scopus 로고    scopus 로고
    • Neutrophil activation by the tissue factor/factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome
    • Redecha P, Franzke CW, Ruf W, et al. Neutrophil activation by the tissue factor/factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome. J Clin Invest 2008; 118: 3453-3461.
    • (2008) J Clin Invest , vol.118 , pp. 3453-3461
    • Redecha, P.1    Franzke, C.W.2    Ruf, W.3
  • 44
    • 77649099693 scopus 로고    scopus 로고
    • Differential expression of proteaseactivated receptors in monocytes from patients with primary Antiphospholipid syndrome
    • López-Pedrera C, Aguirre MA, Buendía P, et al. Differential expression of proteaseactivated receptors in monocytes from patients with primary Antiphospholipid syndrome. Arthritis Rheum 2010; 62: 869-877.
    • (2010) Arthritis Rheum , vol.62 , pp. 869-877
    • López-Pedrera, C.1    Aguirre, M.A.2    Buendía, P.3
  • 46
    • 23744503066 scopus 로고    scopus 로고
    • Tissue factor mediates infl ammation
    • Chu AJ. Tissue factor mediates infl ammation. Arch Biochem Biophys 2005; 440: 123-132.
    • (2005) Arch Biochem Biophys , vol.440 , pp. 123-132
    • Chu, A.J.1
  • 47
    • 0032547763 scopus 로고    scopus 로고
    • Vascular endothelial growth factor upregulates the expression of matrix metalloproteinases in vascular smooth muscle cells: Role of flit-1
    • Wang H, Keiser JA. Vascular endothelial growth factor upregulates the expression of matrix metalloproteinases in vascular smooth muscle cells: role of flit-1. Circ Res 1998; 83: 832-840.
    • (1998) Circ Res , vol.83 , pp. 832-840
    • Wang, H.1    Keiser, J.A.2
  • 48
    • 33750091036 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression in monocytes from patients with primary antiphospholipid syndrome
    • Cuadrado MJ, Buendía P, Velasco F, et al. Vascular endothelial growth factor expression in monocytes from patients with primary antiphospholipid syndrome. J Thromb Haemost 2006; 4: 2461-2469.
    • (2006) J Thromb Haemost , vol.4 , pp. 2461-2469
    • Cuadrado, M.J.1    Buendía, P.2    Velasco, F.3
  • 49
    • 3042677724 scopus 로고    scopus 로고
    • Thrombin induces angiogenesis and vascular endothelial growth factor expression in human endothelial cells: Possible relevance to HIF-1alpha
    • Dupuy E, Habib A, Lebret M, et al. Thrombin induces angiogenesis and vascular endothelial growth factor expression in human endothelial cells: possible relevance to HIF-1alpha. J Thromb Haemost 2003; 1: 1096-1102.
    • (2003) J Thromb Haemost , vol.1 , pp. 1096-1102
    • Dupuy, E.1    Habib, A.2    Lebret, M.3
  • 50
    • 0035893021 scopus 로고    scopus 로고
    • Identification of anti-thrombin antibodies in the antiphospholipid syndrome that interfere with the inactivation of thrombin by antithrombin
    • Hwang KK, Grossman JM, Visvanathan S, et al. Identification of anti-thrombin antibodies in the antiphospholipid syndrome that interfere with the inactivation of thrombin by antithrombin. J Immunol 2001; 167: 7192-7198.
    • (2001) J Immunol , vol.167 , pp. 7192-7198
    • Hwang, K.K.1    Grossman, J.M.2    Visvanathan, S.3
  • 51
    • 1842607575 scopus 로고    scopus 로고
    • Role of thrombin in angiogenesis and tumor progression
    • Tsopanoglou NE, Maragoudakis ME. Role of thrombin in angiogenesis and tumor progression. Semin Thromb Hemost 2004; 30: 63-69.
    • (2004) Semin Thromb Hemost , vol.30 , pp. 63-69
    • Tsopanoglou, N.E.1    Maragoudakis, M.E.2
  • 52
    • 51849152401 scopus 로고    scopus 로고
    • Proteomic analysis in monocytes of antiphospholipid syndrome patients: Deregulation of proteins related to the development of thrombosis
    • López-Pedrera C, Cuadrado MJ, Hernández V, et al. Proteomic analysis in monocytes of antiphospholipid syndrome patients: deregulation of proteins related to the development of thrombosis. Arthritis Rheum 2008; 58: 2835-2844.
    • (2008) Arthritis Rheum , vol.58 , pp. 2835-2844
    • López-Pedrera, C.1    Cuadrado, M.J.2    Hernández, V.3
  • 53
    • 33644839601 scopus 로고    scopus 로고
    • Cardiovascular risk and rheumatoid arthritis: From mechanisms of atherosclerosis to therapeutic approach
    • Jurcut C, Jurcut R, Tanasescu C. Cardiovascular risk and rheumatoid arthritis: from mechanisms of atherosclerosis to therapeutic approach. Rom J Int Med 2004; 42: 659-669.
    • (2004) Rom J Int Med , vol.42 , pp. 659-669
    • Jurcut, C.1    Jurcut, R.2    Tanasescu, C.3
  • 54
    • 24344499558 scopus 로고    scopus 로고
    • Cardiovascular disease in lupus patients: Should all patients be treated with statins and aspirin
    • Bruce IN. Cardiovascular disease in lupus patients: should all patients be treated with statins and aspirin. Best Pract Res Clin Rheumatol 2005; 19: 823-838.
    • (2005) Best Pract Res Clin Rheumatol , vol.19 , pp. 823-838
    • Bruce, I.N.1
  • 55
    • 0344490278 scopus 로고    scopus 로고
    • Evaluation of clinical and laboratory features of antiphospholipid syndrome: A retrospective study of 637 patients
    • Soltesz P, Veres K, Lakos G, Kiss E, Muszbek L, Szegedi G. Evaluation of clinical and laboratory features of antiphospholipid syndrome: a retrospective study of 637 patients. Lupus 2003; 12: 302-307.
    • (2003) Lupus , vol.12 , pp. 302-307
    • Soltesz, P.1    Veres, K.2    Lakos, G.3    Kiss, E.4    Muszbek, L.5    Szegedi, G.6
  • 56
    • 24944496938 scopus 로고    scopus 로고
    • Preclinical vascular disease in systemic lupus erythematosus and primary antiphospholipid syndrome
    • Jimenez S, García-Criado MA, Tassies D, et al. Preclinical vascular disease in systemic lupus erythematosus and primary antiphospholipid syndrome. Rheumatology 2005; 44: 756-761.
    • (2005) Rheumatology , vol.44 , pp. 756-761
    • Jimenez, S.1    García-Criado, M.A.2    Tassies, D.3
  • 57
    • 0034496732 scopus 로고    scopus 로고
    • Autoantibodies associated with atherosclerosis
    • Shoenfeld Y, Sherer Y, George J, Harats D. Autoantibodies associated with atherosclerosis. Ann Med 2000; 32(Suppl. I): 37-40.
    • (2000) Ann Med , vol.32 , Issue.SUPPL. I , pp. 37-40
    • Shoenfeld, Y.1    Sherer, Y.2    George, J.3    Harats, D.4
  • 58
    • 0029830512 scopus 로고    scopus 로고
    • Antiphospholipid antibodies and atherosclerosis
    • Vaarala O. Antiphospholipid antibodies and atherosclerosis. Lupus 1996; 5: 442-447.
    • (1996) Lupus , vol.5 , pp. 442-447
    • Vaarala, O.1
  • 59
    • 3142672076 scopus 로고    scopus 로고
    • Antiphospholipid antibodies in acute coronary syndrome
    • Veres K, Lakos G, Kerenyi A, et al. Antiphospholipid antibodies in acute coronary syndrome. Lupus 2004; 13: 423-427.
    • (2004) Lupus , vol.13 , pp. 423-427
    • Veres, K.1    Lakos, G.2    Kerenyi, A.3
  • 60
    • 3042668784 scopus 로고    scopus 로고
    • New nonlipid effects of statins and their clinical relevance in cardiovascular disease
    • Undas A, Celiska-Lowenhoff M, Kaczor M, Musial J. New nonlipid effects of statins and their clinical relevance in cardiovascular disease. Thromb Haemost 2004; 91: 1065-1077.
    • (2004) Thromb Haemost , vol.91 , pp. 1065-1077
    • Undas, A.1    Celiska-Lowenhoff, M.2    Kaczor, M.3    Musial, J.4
  • 61
    • 0042833280 scopus 로고    scopus 로고
    • Effects of HMG-CoA reductase inhibitors on coagulation and fibrinolysis processes
    • Krysiak R, Okopien B, Herman ZS. Effects of HMG-CoA reductase inhibitors on coagulation and fibrinolysis processes. Drugs 2003; 63: 1821-1854.
    • (2003) Drugs , vol.63 , pp. 1821-1854
    • Krysiak, R.1    Okopien, B.2    Herman, Z.S.3
  • 63
    • 0035673283 scopus 로고    scopus 로고
    • Statins prevent endothelial cell activation induced by antiphospholipid (anti-beta2-glycoprotein I) antibodies: Effect on the proadhesive and proinflammatory phenotype
    • Meroni PL, Raschi E, Testoni C, et al. Statins prevent endothelial cell activation induced by antiphospholipid (anti-beta2-glycoprotein I) antibodies: effect on the proadhesive and proinflammatory phenotype. Arthritis Rheum 2001; 44: 2870-2878.
    • (2001) Arthritis Rheum , vol.44 , pp. 2870-2878
    • Meroni, P.L.1    Raschi, E.2    Testoni, C.3
  • 64
    • 0242721975 scopus 로고    scopus 로고
    • Inhibition of the thrombogenic and inflammatory properties of antiphospholipid antibodies by fluvastatin in an in vivo animal model
    • Ferrara DE, Liu X, Espinola RG, et al. Inhibition of the thrombogenic and inflammatory properties of antiphospholipid antibodies by fluvastatin in an in vivo animal model. Arthritis Rheum 2003; 48: 3272-3279.
    • (2003) Arthritis Rheum , vol.48 , pp. 3272-3279
    • Ferrara, D.E.1    Liu, X.2    Espinola, R.G.3
  • 65
    • 7244237671 scopus 로고    scopus 로고
    • Fluvastatin inhibits up-regulation of tissue factor expression by antiphospholipid antibodies on endothelial cells
    • Ferrara DE, Swerlick R, Casper K, et al. Fluvastatin inhibits up-regulation of tissue factor expression by antiphospholipid antibodies on endothelial cells. J Thromb Haemost 2004; 2: 1558-1563.
    • (2004) J Thromb Haemost , vol.2 , pp. 1558-1563
    • Ferrara, D.E.1    Swerlick, R.2    Casper, K.3
  • 66
    • 62849125725 scopus 로고    scopus 로고
    • Effect of rosuvastatin on VCAM-1 expression by HUVEC exposed to APS serum in an in vitro model
    • Martínez-Martínez LA, Amigo MC, Orozco A, et al. Effect of rosuvastatin on VCAM-1 expression by HUVEC exposed to APS serum in an in vitro model. Clin Exp Rheumatol 2007; 25: 18-19.
    • (2007) Clin Exp Rheumatol , vol.25 , pp. 18-19
    • Martínez-Martínez, L.A.1    Amigo, M.C.2    Orozco, A.3
  • 67
    • 79952362255 scopus 로고    scopus 로고
    • Global effects of fluvastatin on the prothrombotic status of patients with antiphospholipid syndrome
    • López-Pedrera C, Ruiz-Limón P, Aguirre MA, et al. Global effects of fluvastatin on the prothrombotic status of patients with antiphospholipid syndrome. Ann Rheum Dis 2011; 70: 675-682.
    • (2011) Ann Rheum Dis , vol.70 , pp. 675-682
    • López-Pedrera, C.1    Ruiz-Limón, P.2    Aguirre, M.A.3
  • 68
    • 55849112296 scopus 로고    scopus 로고
    • Neutrophil activation by the tissue factor/factor VIIa/PAR2 axis mediates foetal death in a mouse model of antiphospholipid syndrome
    • Redecha P, Franzke CW, Ruf W, et al. Neutrophil activation by the tissue factor/factor VIIa/PAR2 axis mediates foetal death in a mouse model of antiphospholipid syndrome. J Clin Invest 2008; 118: 3453-3461.
    • (2008) J Clin Invest , vol.118 , pp. 3453-3461
    • Redecha, P.1    Franzke, C.W.2    Ruf, W.3
  • 69
    • 70049117028 scopus 로고    scopus 로고
    • Statins for the treatment of antiphospholipid syndrome?
    • Jajoria P, Murthy V, Papalardo E, et al. Statins for the treatment of antiphospholipid syndrome? Ann NY Acad Sci 2009; 1173: 736-745.
    • (2009) Ann NY Acad Sci , vol.1173 , pp. 736-745
    • Jajoria, P.1    Murthy, V.2    Papalardo, E.3
  • 70
    • 56749106312 scopus 로고    scopus 로고
    • Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
    • Ridker PM, Danielson E, Fonseca FA. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med 2008; 20: 2195-2107.
    • (2008) N Engl J Med , vol.20 , pp. 2195-2207
    • Ridker, P.M.1    Danielson, E.2    Fonseca, F.A.3
  • 71
    • 78349245587 scopus 로고    scopus 로고
    • Accelerated atherosclerosis in systemic lupus erythematosus: Role of proinflammatory cytokines and therapeutic approaches
    • doi: 10.1155/2010/607084
    • Lopez-Pedrera Ch, Aguirre MA, Barbarroja N, Cuadrado MJ. Accelerated atherosclerosis in systemic lupus erythematosus: role of proinflammatory cytokines and therapeutic approaches. J Biomed Biotech 2010; doi: 10.1155/2010/607084.
    • (2010) J Biomed Biotech
    • Lopez-Pedrera, C.1    Aguirre, M.A.2    Barbarroja, N.3    Cuadrado, M.J.4
  • 72
    • 34848831197 scopus 로고    scopus 로고
    • Atorvastatin therapy improves endothelialdependent vasodilation in patients with systemic lupus erythematosus: An 8 weeks controlled trial
    • Ferreira GA, Navarro TP, Telles RW, et al. Atorvastatin therapy improves endothelialdependent vasodilation in patients with systemic lupus erythematosus: an 8 weeks controlled trial. Rheumatology 2007; 46: 1560-1565.
    • (2007) Rheumatology , vol.46 , pp. 1560-1565
    • Ferreira, G.A.1    Navarro, T.P.2    Telles, R.W.3
  • 73
    • 33751019456 scopus 로고    scopus 로고
    • TNF- α as a potential target in the treatment of systemic lupus erythematosus: A role for the HMG-CoA reductase inhibitor simvastatin
    • Kotyla PJ, Sliwinska-Kotyla B, Kucharz EJ. TNF- α as a potential target in the treatment of systemic lupus erythematosus: a role for the HMG-CoA reductase inhibitor simvastatin. Journal of Rheumatology 2006; 33: 2361-2363.
    • (2006) Journal of Rheumatology , vol.33 , pp. 2361-2363
    • Kotyla, P.J.1    Sliwinska-Kotyla, B.2    Kucharz, E.J.3
  • 74
    • 78751704400 scopus 로고    scopus 로고
    • Effects of ezetimibe plus pravastatin on endothelial dysfunction in patients with systemic lupus erythematosus (pilot study) [abstract]
    • Vera-Lastra O, Mendez OL, Jara LJ, et al. Effects of ezetimibe plus pravastatin on endothelial dysfunction in patients with systemic lupus erythematosus (pilot study) [abstract]. Arthritis Rheum 2009; 60(Suppl 10):1564.
    • (2009) Arthritis Rheum , vol.60 , Issue.SUPPL. 10 , pp. 1564
    • Vera-Lastra, O.1    Mendez, O.L.2    Jara, L.J.3
  • 76
    • 65249180649 scopus 로고    scopus 로고
    • Effect of fluvastatin on cardiac outcomes in kidney transplant patients with systemic lupus erythematosus a randomized placebo controlled study
    • Norby GE, Holme I, Fellström B, et al. Effect of fluvastatin on cardiac outcomes in kidney transplant patients with systemic lupus erythematosus a randomized placebo controlled study. Arthritis and Rheumatism 2009; 60: 1060-1064.
    • (2009) Arthritis and Rheumatism , vol.60 , pp. 1060-1064
    • Norby, G.E.1    Holme, I.2    Fellström, B.3
  • 78
    • 34547770769 scopus 로고    scopus 로고
    • Statin-induced Ro/SSa-positive subacute cutaneous lupus erythematosus
    • Suchak R, Benson K, Swale V. Statin-induced Ro/SSa-positive subacute cutaneous lupus erythematosus. Clin. Exp. Dermatol 2007; 32: 589-591.
    • (2007) Clin. Exp. Dermatol , vol.32 , pp. 589-591
    • Suchak, R.1    Benson, K.2    Swale, V.3
  • 80
    • 79960015053 scopus 로고    scopus 로고
    • Epidemiology of CVD in rheumatic disease, with a focus on RA and SLE
    • Symmons DPM, Gabriel SE. Epidemiology of CVD in rheumatic disease, with a focus on RA and SLE. Nat Rev Rheumatol 2011; 7:399-408.
    • (2011) Nat Rev Rheumatol , vol.7 , pp. 399-408
    • Symmons, D.P.M.1    Gabriel, S.E.2
  • 81
    • 0037432305 scopus 로고    scopus 로고
    • Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis
    • Solomon DH, Karlson EW, Rimm EB, et al. Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis. Circulation 2003; 107: 1303-1307.
    • (2003) Circulation , vol.107 , pp. 1303-1307
    • Solomon, D.H.1    Karlson, E.W.2    Rimm, E.B.3
  • 82
    • 34447651227 scopus 로고    scopus 로고
    • Precocious atherosclerosis in rheumatoid arthritis: Role of traditional and disease-related cardiovascular risk factors
    • Gerli R, Sherer Y, Bocci EB, et al. Precocious atherosclerosis in rheumatoid arthritis: Role of traditional and disease-related cardiovascular risk factors. Ann NY Acad Sci 2007; 1108: 372-381.
    • (2007) Ann NY Acad Sci , vol.1108 , pp. 372-381
    • Gerli, R.1    Sherer, Y.2    Bocci, E.B.3
  • 83
    • 27744521598 scopus 로고    scopus 로고
    • Relative contribution of cardiovascular risk factors and rheumatoid arthritis clinical manifestations to atherothrombosis
    • del Rincón I, Freeman GL, Haas RW, et al. Relative contribution of cardiovascular risk factors and rheumatoid arthritis clinical manifestations to atherothrombosis. Arthritis Rheum 2005; 52: 3413-3423.
    • (2005) Arthritis Rheum , vol.52 , pp. 3413-3423
    • del Rincón, I.1    Freeman, G.L.2    Haas, R.W.3
  • 84
    • 41749125475 scopus 로고    scopus 로고
    • Rheumatoid arthritis and cardiovascular disease
    • Dhawan SS, Quyyumi AA. Rheumatoid arthritis and cardiovascular disease. Curr Atheroscler Rep 2008; 10: 128-133.
    • (2008) Curr Atheroscler Rep , vol.10 , pp. 128-133
    • Dhawan, S.S.1    Quyyumi, A.A.2
  • 85
    • 32644437182 scopus 로고    scopus 로고
    • Mechanisms of disease: Atherosclerosis in autoimmune diseases
    • Sherer Y, Shoenfeld Y. Mechanisms of disease: Atherosclerosis in autoimmune diseases. Nat Clin Pract Rheumatol 2006; 2: 99-106.
    • (2006) Nat Clin Pract Rheumatol , vol.2 , pp. 99-106
    • Sherer, Y.1    Shoenfeld, Y.2
  • 86
    • 12144287983 scopus 로고    scopus 로고
    • Heat-shok protein 60-reactive CD41CD28null T cells in patients with acute coronary syndrome
    • Zal B, Kaski JC, Arno G, et al. Heat-shok protein 60-reactive CD41CD28null T cells in patients with acute coronary syndrome. Circulation 2004; 109: 1230-1235.
    • (2004) Circulation , vol.109 , pp. 1230-1235
    • Zal, B.1    Kaski, J.C.2    Arno, G.3
  • 87
    • 34948903757 scopus 로고    scopus 로고
    • Accelerated atherosclerosis in rheumatoid arthritis
    • Szekanecz Z, Kerekes G, Dér H, et al. Accelerated atherosclerosis in rheumatoid arthritis. Ann NY Acad Sci 2007; 1108: 349-358.
    • (2007) Ann NY Acad Sci , vol.1108 , pp. 349-358
    • Szekanecz, Z.1    Kerekes, G.2    Dér, H.3
  • 88
    • 2942670131 scopus 로고    scopus 로고
    • Trial of Atorvastatin in Rheumatoid Arthritis (TARA): Double-blind, randomised placebo controlled trial
    • McCarey DW, McInnes IB, Madhok R, et al. Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo controlled trial. Lancet 2004; 363: 2015-2021.
    • (2004) Lancet , vol.363 , pp. 2015-2021
    • McCarey, D.W.1    McInnes, I.B.2    Madhok, R.3
  • 89
    • 61649093065 scopus 로고    scopus 로고
    • Changes in disease activity, cytokine production, and proliferation of peripheral blood mononuclear cells in patients with rheumatoid arthritis after simvastatin treatment
    • Shirinsky IV, Zheltova OI, Solovyova NY, Kozlov VA, Shirinsky VS. Changes in disease activity, cytokine production, and proliferation of peripheral blood mononuclear cells in patients with rheumatoid arthritis after simvastatin treatment. Scand J Rheumatol 2009; 38: 23-27.
    • (2009) Scand J Rheumatol , vol.38 , pp. 23-27
    • Shirinsky, I.V.1    Zheltova, O.I.2    Solovyova, N.Y.3    Kozlov, V.A.4    Shirinsky, V.S.5
  • 90
    • 79551708938 scopus 로고    scopus 로고
    • Effect of atorvastatin on inflammation and modification of vascular risk factors in rheumatoid arthritis
    • El-Barbary AM, Hussein MS, Rageh EM, Hamouda HE, Wagih AA, Ismail RG. Effect of atorvastatin on inflammation and modification of vascular risk factors in rheumatoid arthritis. J Rheumatol 2011; 38: 229-235.
    • (2011) J Rheumatol , vol.38 , pp. 229-235
    • El-Barbary, A.M.1    Hussein, M.S.2    Rageh, E.M.3    Hamouda, H.E.4    Wagih, A.A.5    Ismail, R.G.6
  • 91
    • 27744547021 scopus 로고    scopus 로고
    • Effects of Angiotensin-converting enzyme inhibition and statin treatment on inflammatory markers and endothelial functions in patients with long term rheumatoid arthritis
    • Tikiz C, Utuk O, Pirildar T, et al. Effects of Angiotensin-converting enzyme inhibition and statin treatment on inflammatory markers and endothelial functions in patients with long term rheumatoid arthritis. J Rheumatol 2005; 32: 2095-2101.
    • (2005) J Rheumatol , vol.32 , pp. 2095-2101
    • Tikiz, C.1    Utuk, O.2    Pirildar, T.3
  • 92
    • 34248669556 scopus 로고    scopus 로고
    • Beneficial action of statins in patients with rheumatoid arthritis in a large observational cohort
    • Okamoto H, Koizumi K, Kamitsuji S, et al. Beneficial action of statins in patients with rheumatoid arthritis in a large observational cohort. J Rheumatol 2007; 34: 964-968.
    • (2007) J Rheumatol , vol.34 , pp. 964-968
    • Okamoto, H.1    Koizumi, K.2    Kamitsuji, S.3
  • 93
    • 34547950892 scopus 로고    scopus 로고
    • Ezetimibe and simvastatin reduce inflammation, disease activity, and aortic stiffness and improve endothelial function in rheumatoid arthritis
    • Maki-Petaja KM, Booth AD, Hall FC, et al. Ezetimibe and simvastatin reduce inflammation, disease activity, and aortic stiffness and improve endothelial function in rheumatoid arthritis. J Am Coll Cardiol 2007; 50: 852-858.
    • (2007) J Am Coll Cardiol , vol.50 , pp. 852-858
    • Maki-Petaja, K.M.1    Booth, A.D.2    Hall, F.C.3
  • 94
    • 77950325065 scopus 로고    scopus 로고
    • Statin use in rheumatoid arthritis in relation to actual cardiovascular risk: Evidence for substancial Ander treatment of lipid associated cardiovascular risk?
    • Toms TE, Panoulas VF, Douglas KM, et al. Statin use in rheumatoid arthritis in relation to actual cardiovascular risk: evidence for substancial Ander treatment of lipid associated cardiovascular risk? Ann Rheum Dis 2009; 69:683-688.
    • (2009) Ann Rheum Dis , vol.69 , pp. 683-688
    • Toms, T.E.1    Panoulas, V.F.2    Douglas, K.M.3
  • 96
    • 79955026310 scopus 로고    scopus 로고
    • Death pathways triggered by activated Ras in cancer cells
    • Overmeyer JH, Maltese WA. Death pathways triggered by activated Ras in cancer cells. Front Biosci 2011; 16: 1693-1613.
    • (2011) Front Biosci , vol.16 , pp. 1693-1713
    • Overmeyer, J.H.1    Maltese, W.A.2
  • 97
    • 44449178868 scopus 로고    scopus 로고
    • Rho GTPases in cancer cell biology
    • Vega FM, Ridley AJ. Rho GTPases in cancer cell biology. FEBS Lett 2008; 582: 2093-2101.
    • (2008) FEBS Lett , vol.582 , pp. 2093-2101
    • Vega, F.M.1    Ridley, A.J.2
  • 98
    • 33751523611 scopus 로고    scopus 로고
    • Pravastatin reduces lung metastasis of rat hepatocellular carcinoma via a coordinated decrease of MMP expression and activity
    • Taras D, Blanc JF, Rullier A, et al. Pravastatin reduces lung metastasis of rat hepatocellular carcinoma via a coordinated decrease of MMP expression and activity. J Hepatol 2007; 46: 69-76.
    • (2007) J Hepatol , vol.46 , pp. 69-76
    • Taras, D.1    Blanc, J.F.2    Rullier, A.3
  • 99
    • 77956565365 scopus 로고    scopus 로고
    • Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway
    • Kidera Y, Tsubaki M, Yamazoe Y, et al. Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway. J Exp Clin Cancer Res 2010; 29: 127.
    • (2010) J Exp Clin Cancer Res , vol.29 , pp. 127
    • Kidera, Y.1    Tsubaki, M.2    Yamazoe, Y.3
  • 100
    • 79952010116 scopus 로고    scopus 로고
    • Simvastatin modulates the adhesion and growth of hepatocellular carcinoma cells via decrease of integrin expression and ROCK
    • Relja B, Meder F, Wang M, et al. Simvastatin modulates the adhesion and growth of hepatocellular carcinoma cells via decrease of integrin expression and ROCK. Int J Oncol 2011; 38: 879-885.
    • (2011) Int J Oncol , vol.38 , pp. 879-885
    • Relja, B.1    Meder, F.2    Wang, M.3
  • 101
    • 79953217743 scopus 로고    scopus 로고
    • Simvastatin prevents skeletal metastasis of breast cancer by an antagonistic interplay between p53 and CD44
    • Mandal CC, Ghosh-Choudhury N, Yoneda T, Choudhury GG and Ghosh-Choudhury N. Simvastatin prevents skeletal metastasis of breast cancer by an antagonistic interplay between p53 and CD44. J Biol Chem 2011; 286: 11314-11327.
    • (2011) J Biol Chem , vol.286 , pp. 11314-11327
    • Mandal, C.C.1    Ghosh-Choudhury, N.2    Yoneda, T.3    Choudhury, G.G.4    Ghosh-Choudhury, N.5
  • 102
    • 57649217290 scopus 로고    scopus 로고
    • Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion
    • Fromigue O, Hamidouche Z, Marie PJ. Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. J Biol Chem 2008; 283: 30549-30556.
    • (2008) J Biol Chem , vol.283 , pp. 30549-30556
    • Fromigue, O.1    Hamidouche, Z.2    Marie, P.J.3
  • 103
    • 79959507266 scopus 로고    scopus 로고
    • CYR61 downregulation reduces osteosarcoma cell invasion, migration, and metastasis
    • Fromigue O, Hamidouche Z, Vaudin P, et al. CYR61 downregulation reduces osteosarcoma cell invasion, migration, and metastasis. J Bone Miner Res 2011; 26: 1533-1542.
    • (2011) J Bone Miner Res , vol.26 , pp. 1533-1542
    • Fromigue, O.1    Hamidouche, Z.2    Vaudin, P.3
  • 104
    • 77957367974 scopus 로고    scopus 로고
    • Inhibition of autophagy enhances anticancer effects of atorvastatin in digestive malignancies
    • Yang PM, Liu YL, Lin YC, Shun CT, Wu MS, Chen CC. Inhibition of autophagy enhances anticancer effects of atorvastatin in digestive malignancies. Cancer Res 2010; 70: 7699-7709.
    • (2010) Cancer Res , vol.70 , pp. 7699-7709
    • Yang, P.M.1    Liu, Y.L.2    Lin, Y.C.3    Shun, C.T.4    Wu, M.S.5    Chen, C.C.6
  • 105
    • 77952933689 scopus 로고    scopus 로고
    • Statin-induced autophagy by inhibition of geranylgeranyl biosynthesis in prostate cancer PC3 cells
    • Parikh A, Childress C, Deitrick K, Lin Q, Rukstalis D, Yang W. Statin-induced autophagy by inhibition of geranylgeranyl biosynthesis in prostate cancer PC3 cells. Prostate 2010; 70: 971-981.
    • (2010) Prostate , vol.70 , pp. 971-981
    • Parikh, A.1    Childress, C.2    Deitrick, K.3    Lin, Q.4    Rukstalis, D.5    Yang, W.6
  • 106
    • 10744220087 scopus 로고    scopus 로고
    • Statins differentially regulate vascular endothelial growth factor synthesis in endothelial and vascular smooth muscle cells
    • Frick M, Dulak J, Cisowski J, et al. Statins differentially regulate vascular endothelial growth factor synthesis in endothelial and vascular smooth muscle cells. Atherosclerosis 2003; 170: 229-236.
    • (2003) Atherosclerosis , vol.170 , pp. 229-236
    • Frick, M.1    Dulak, J.2    Cisowski, J.3
  • 108
    • 0344948143 scopus 로고    scopus 로고
    • Lovastatin and tumor necrosis factor-alpha exhibit potentiated antitumor effects against Ha-ras-transformed murine tumor via inhibition of tumor-induced angiogenesis
    • Feleszko W, Balkowiec EZ, Sieberth E, et al. Lovastatin and tumor necrosis factor-alpha exhibit potentiated antitumor effects against Ha-ras-transformed murine tumor via inhibition of tumor-induced angiogenesis. Int J Cancer 1999; 81: 560-567.
    • (1999) Int J Cancer , vol.81 , pp. 560-567
    • Feleszko, W.1    Balkowiec, E.Z.2    Sieberth, E.3
  • 109
    • 77958520300 scopus 로고    scopus 로고
    • Lovastatin inhibits VEGFR and AKT activation: Synergistic cytotoxicity in combination with VEGFR inhibitors
    • Zhao TT, Trinh D, Addison CL, Dimitroulakos J. Lovastatin inhibits VEGFR and AKT activation: synergistic cytotoxicity in combination with VEGFR inhibitors. PLoS One 2010; 5:e12563.
    • (2010) PLoS One , vol.5
    • Zhao, T.T.1    Trinh, D.2    Addison, C.L.3    Dimitroulakos, J.4
  • 111
    • 4644261860 scopus 로고    scopus 로고
    • Blocking the Raf/MEK/ERK pathway sensitizes acute myelogenous leukemia cells to lovastatin-induced apoptosis
    • Wu J, Wong WW, Khosravi F, Minden MD, Penn LZ. Blocking the Raf/MEK/ERK pathway sensitizes acute myelogenous leukemia cells to lovastatin-induced apoptosis. Cancer Res 2004; 64: 6461-6468.
    • (2004) Cancer Res , vol.64 , pp. 6461-6468
    • Wu, J.1    Wong, W.W.2    Khosravi, F.3    Minden, M.D.4    Penn, L.Z.5
  • 112
    • 0035048749 scopus 로고    scopus 로고
    • Lovastatin induced control of blast cell growth in an elderly patient with acute myeloblastic leukemia
    • Minden MD, Dimitroulakos J, Nohynek D, Penn LZ. Lovastatin induced control of blast cell growth in an elderly patient with acute myeloblastic leukemia. Leuk Lymphoma 2001; 40: 659-662.
    • (2001) Leuk Lymphoma , vol.40 , pp. 659-662
    • Minden, M.D.1    Dimitroulakos, J.2    Nohynek, D.3    Penn, L.Z.4
  • 113
    • 0033557949 scopus 로고    scopus 로고
    • Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: A potential therapeutic approach
    • Dimitroulakos J, Nohynek D, Backway KL, et al. Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: a potential therapeutic approach. Blood 1999; 93: 1308-1318.
    • (1999) Blood , vol.93 , pp. 1308-1318
    • Dimitroulakos, J.1    Nohynek, D.2    Backway, K.L.3
  • 115
    • 38849127391 scopus 로고    scopus 로고
    • Statins induce lethal effects in acute myeloblastic leukemia [corrected] cells within 72 hours
    • Burke LP, Kukoly CA. Statins induce lethal effects in acute myeloblastic leukemia [corrected] cells within 72 hours. Leuk Lymphoma 2008; 49: 322-330.
    • (2008) Leuk Lymphoma , vol.49 , pp. 322-330
    • Burke, L.P.1    Kukoly, C.A.2
  • 116
    • 0034773582 scopus 로고    scopus 로고
    • Effect of simvastatin alone and in combination with cytosine arabinoside on the proliferation of myeloid leukemia cell lines
    • Lishner M, Bar-Sef A, Elis A, Fabian I. Effect of simvastatin alone and in combination with cytosine arabinoside on the proliferation of myeloid leukemia cell lines. J Investig Med 2001; 49: 319-324.
    • (2001) J Investig Med , vol.49 , pp. 319-324
    • Lishner, M.1    Bar-Sef, A.2    Elis, A.3    Fabian, I.4
  • 117
    • 65649104695 scopus 로고    scopus 로고
    • Combining simvastatin with the farnesyltransferase inhibitor tipifarnib results in an enhanced cytotoxic effect in a subset of primary CD34+ acute myeloid leukemia samples
    • Van der WK, de Jonge-Peeters SD, Kuipers F, de Vries EG, Vellenga E. Combining simvastatin with the farnesyltransferase inhibitor tipifarnib results in an enhanced cytotoxic effect in a subset of primary CD34+ acute myeloid leukemia samples. Clin Cancer Res 2009; 15: 3076-3083.
    • (2009) Clin Cancer Res , vol.15 , pp. 3076-3083
    • van der, W.K.1    de Jonge-Peeters, S.D.2    Kuipers, F.3    de Vries, E.G.4    Vellenga, E.5
  • 118
    • 33947594969 scopus 로고    scopus 로고
    • Blockade of adaptive defensive changes in cholesterol uptake and synthesis in AML by the addition of pravastatin to idarubicin + high-dose Ara-C: A phase 1 study
    • Kornblau SM, Banker DE, Stirewalt D, et al. Blockade of adaptive defensive changes in cholesterol uptake and synthesis in AML by the addition of pravastatin to idarubicin + high-dose Ara-C: a phase 1 study. Blood 2007; 109: 2999-3006.
    • (2007) Blood , vol.109 , pp. 2999-3006
    • Kornblau, S.M.1    Banker, D.E.2    Stirewalt, D.3
  • 119
    • 34249324822 scopus 로고    scopus 로고
    • Suppressive effects of statins on acute promyelocytic leukemia cells
    • Sassano A, Katsoulidis E, Antico G, et al. Suppressive effects of statins on acute promyelocytic leukemia cells. Cancer Res 2007; 67: 4524-4532.
    • (2007) Cancer Res , vol.67 , pp. 4524-4532
    • Sassano, A.1    Katsoulidis, E.2    Antico, G.3
  • 120
    • 41149118896 scopus 로고    scopus 로고
    • The possibility of simvastatin as a chemotherapeutic agent for all-trans retinoic acid-resistant promyelocytic leukemia
    • Tomiyama N, Matzno S, Kitada C, Nishiguchi E, Okamura N, Mat-suyama K. The possibility of simvastatin as a chemotherapeutic agent for all-trans retinoic acid-resistant promyelocytic leukemia. Biol Pharm Bull 2008; 31: 369-374.
    • (2008) Biol Pharm Bull , vol.31 , pp. 369-374
    • Tomiyama, N.1    Matzno, S.2    Kitada, C.3    Nishiguchi, E.4    Okamura, N.5    Mat-Suyama, K.6
  • 121
    • 0032766426 scopus 로고    scopus 로고
    • Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells
    • Agarwal B, Bhendwal S, Halmos B, Moss SF, Ramey WG, Holt PR. Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells. Clin Cancer Res 1999; 5: 2223-2229.
    • (1999) Clin Cancer Res , vol.5 , pp. 2223-2229
    • Agarwal, B.1    Bhendwal, S.2    Halmos, B.3    Moss, S.F.4    Ramey, W.G.5    Holt, P.R.6
  • 122
    • 0037145831 scopus 로고    scopus 로고
    • Cerivastatin enhances the cytotoxicity of 5-fluorouracil on chemosensitive and resistant colorectal cancer cell lines
    • Wang W, Collie-Duguid E, Cassidy J. Cerivastatin enhances the cytotoxicity of 5-fluorouracil on chemosensitive and resistant colorectal cancer cell lines. FEBS Lett 2002; 531: 415-420.
    • (2002) FEBS Lett , vol.531 , pp. 415-420
    • Wang, W.1    Collie-Duguid, E.2    Cassidy, J.3
  • 124
    • 68149131593 scopus 로고    scopus 로고
    • Simvastatin plus irinotecan, 5-fluorouracil, and leucovorin (FOLFIRI) as first-line chemotherapy in metastatic colorectal patients: A multicenter phase II study
    • Lee J, Jung KH, Park YS, et al. Simvastatin plus irinotecan, 5-fluorouracil, and leucovorin (FOLFIRI) as first-line chemotherapy in metastatic colorectal patients: a multicenter phase II study. Cancer Chemother Pharmacol 2009; 64: 657-663.
    • (2009) Cancer Chemother Pharmacol , vol.64 , pp. 657-663
    • Lee, J.1    Jung, K.H.2    Park, Y.S.3
  • 125
    • 79955486467 scopus 로고    scopus 로고
    • A phase 2 study of irinotecan, cisplatin, and simvastatin for untreated extensive-disease small cell lung cancer
    • Han JY, Lim KY, Yu SY, Yun T, Kim HT, Lee JS. A phase 2 study of irinotecan, cisplatin, and simvastatin for untreated extensive-disease small cell lung cancer. Cancer 2011; 117: 2178-2185.
    • (2011) Cancer , vol.117 , pp. 2178-2185
    • Han, J.Y.1    Lim, K.Y.2    Yu, S.Y.3    Yun, T.4    Kim, H.T.5    Lee, J.S.6
  • 126
    • 77951182123 scopus 로고    scopus 로고
    • Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: Potential therapeutic relevance
    • Martirosyan A, Clendening JW, Goard CA, Penn LZ. Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance. BMC Cancer 2010; 10:103.
    • (2010) BMC Cancer , vol.10 , pp. 103
    • Martirosyan, A.1    Clendening, J.W.2    Goard, C.A.3    Penn, L.Z.4
  • 127
    • 78149359469 scopus 로고    scopus 로고
    • Fluvastatin and cisplatin demonstrate synergistic cytotoxicity in epithelial ovarian cancer cells
    • Taylor-Harding B, Orsulic S, Karlan BY, Li AJ. Fluvastatin and cisplatin demonstrate synergistic cytotoxicity in epithelial ovarian cancer cells. Gynecol Oncol 2010; 119: 549-556.
    • (2010) Gynecol Oncol , vol.119 , pp. 549-556
    • Taylor-Harding, B.1    Orsulic, S.2    Karlan, B.Y.3    Li, A.J.4
  • 128
    • 79960020540 scopus 로고    scopus 로고
    • Statins induce apoptosis and inhibit proliferation in cholangiocarcinoma cells
    • Kamigaki M, Sasaki T, Serikawa M, et al. Statins induce apoptosis and inhibit proliferation in cholangiocarcinoma cells. Int J Oncol 2011; 39: 561-568.
    • (2011) Int J Oncol , vol.39 , pp. 561-568
    • Kamigaki, M.1    Sasaki, T.2    Serikawa, M.3
  • 129
    • 79955364441 scopus 로고    scopus 로고
    • Effect of simvastatin on cetuximab resistance in human colorectal cancer with KRAS mutations
    • Lee J, Lee I, Han B, et al. Effect of simvastatin on cetuximab resistance in human colorectal cancer with KRAS mutations. J Natl Cancer Inst 2011; 103: 674-688.
    • (2011) J Natl Cancer Inst , vol.103 , pp. 674-688
    • Lee, J.1    Lee, I.2    Han, B.3
  • 130
    • 27544497021 scopus 로고    scopus 로고
    • EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer
    • Huether A, Hopfner M, Baradari V, Schuppan D, Scherubl H. EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer. Biochem Pharmacol 2005; 70: 1568-1578.
    • (2005) Biochem Pharmacol , vol.70 , pp. 1568-1578
    • Huether, A.1    Hopfner, M.2    Baradari, V.3    Schuppan, D.4    Scherubl, H.5
  • 131
    • 34250818154 scopus 로고    scopus 로고
    • Fluvastatin enhancement of trastuzumab and classical cytotoxic agents in defined breast cancer cell lines in vitro
    • Budman DR, Tai J, Calabro A. Fluvastatin enhancement of trastuzumab and classical cytotoxic agents in defined breast cancer cell lines in vitro. Breast Cancer Res Treat 2007; 104: 93-101.
    • (2007) Breast Cancer Res Treat , vol.104 , pp. 93-101
    • Budman, D.R.1    Tai, J.2    Calabro, A.3
  • 132
    • 3042661957 scopus 로고    scopus 로고
    • Role of cell cycle in mediating sensitivity to radiotherapy
    • Pawlik TM, Keyomarsi K. Role of cell cycle in mediating sensitivity to radiotherapy. Int J Radiat Oncol Biol Phys 2004; 59: 928-942.
    • (2004) Int J Radiat Oncol Biol Phys , vol.59 , pp. 928-942
    • Pawlik, T.M.1    Keyomarsi, K.2
  • 133
    • 23044508571 scopus 로고    scopus 로고
    • Oncogenic H-Ras up-regulates expression of Ku80 to protect cells from gamma-ray irradiation in NIH3T3 cells
    • Chang IY, Youn CK, Kim HB, et al. Oncogenic H-Ras up-regulates expression of Ku80 to protect cells from gamma-ray irradiation in NIH3T3 cells. Cancer Res 2005; 65: 6811-619.
    • (2005) Cancer Res , vol.65 , pp. 6811-6819
    • Chang, I.Y.1    Youn, C.K.2    Kim, H.B.3
  • 134
    • 0027473872 scopus 로고
    • Increased radioresistance of EJras-transformed human osteosarcoma cells and its modulation by lovastatin, an inhibitor of p21ras isoprenylation
    • Miller AC, Kariko K, Myers CE, Clark EP, Samid D. Increased radioresistance of EJras-transformed human osteosarcoma cells and its modulation by lovastatin, an inhibitor of p21ras isoprenylation. Int J Cancer 1993; 53: 302-307.
    • (1993) Int J Cancer , vol.53 , pp. 302-307
    • Miller, A.C.1    Kariko, K.2    Myers, C.E.3    Clark, E.P.4    Samid, D.5
  • 135
    • 79951768538 scopus 로고    scopus 로고
    • Lovastatin sensitizes lung cancer cells to ionizing radiation: Modulation of molecular pathways of radioresistance and tumor suppression
    • Sanli T, Liu C, Rashid A, et al. Lovastatin sensitizes lung cancer cells to ionizing radiation: modulation of molecular pathways of radioresistance and tumor suppression. J Thorac Oncol 2011; 6: 439-450.
    • (2011) J Thorac Oncol , vol.6 , pp. 439-450
    • Sanli, T.1    Liu, C.2    Rashid, A.3
  • 136
    • 77954479865 scopus 로고    scopus 로고
    • Improved biochemical outcomes with statin use in patients with high-risk localized prostate cancer treated with radiotherapy
    • Kollmeier MA, Katz MS, Mak K, et al. Improved biochemical outcomes with statin use in patients with high-risk localized prostate cancer treated with radiotherapy. Int J Radiat Oncol Biol Phys 2011; 79: 713-718.
    • (2011) Int J Radiat Oncol Biol Phys , vol.79 , pp. 713-718
    • Kollmeier, M.A.1    Katz, M.S.2    Mak, K.3
  • 137
    • 57849132574 scopus 로고    scopus 로고
    • No effect of statins on biochemical outcomes after radiotherapy for localized prostate cancer
    • Soto DE, Daignault S, Sandler HM, Ray ME. No effect of statins on biochemical outcomes after radiotherapy for localized prostate cancer. Urology 2009; 73: 158-162.
    • (2009) Urology , vol.73 , pp. 158-162
    • Soto, D.E.1    Daignault, S.2    Sandler, H.M.3    Ray, M.E.4
  • 138
    • 77549087054 scopus 로고    scopus 로고
    • Statins and risk of incident diabetes: A collaborative meta-analysis of randomised statins trials
    • Sattar N, Preiss D, Murray HM, et al. Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statins trials. Lancet 2010; 375:735-742.
    • (2010) Lancet , vol.375 , pp. 735-742
    • Sattar, N.1    Preiss, D.2    Murray, H.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.