메뉴 건너뛰기




Volumn 34, Issue 3, 2013, Pages 167-177

The promise of N-acetylcysteine in neuropsychiatry

Author keywords

addiction; Alzheimer's; anxiety; autism; bipolar disorder; cannabis; depression; glutamate; glutathione; mania; neurodegeneration; obsessive compulsive disorder; Parkinson's; psychosis; schizophrenia; trichotillomania

Indexed keywords

ACETYLCYSTEINE; DOPAMINE; GLUTAMIC ACID; GLUTATHIONE; INTERLEUKIN 1BETA; INTERLEUKIN 6; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NALTREXONE; NUTRACEUTICAL; PLACEBO; SEROTONIN UPTAKE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA;

EID: 84874652458     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2013.01.001     Document Type: Review
Times cited : (371)

References (121)
  • 1
    • 57649148545 scopus 로고    scopus 로고
    • N-Acetylcysteine for antioxidant therapy: Pharmacology and clinical utility
    • S. Dodd N-Acetylcysteine for antioxidant therapy: pharmacology and clinical utility Expert Opin. Biol. Ther. 8 2008 1955 1962
    • (2008) Expert Opin. Biol. Ther. , vol.8 , pp. 1955-1962
    • Dodd, S.1
  • 2
    • 84861040626 scopus 로고    scopus 로고
    • Translating the rosetta stone of N-acetylcysteine
    • O.M. Dean Translating the rosetta stone of N-acetylcysteine Biol. Psychiatry 71 2012 935 936
    • (2012) Biol. Psychiatry , vol.71 , pp. 935-936
    • Dean, O.M.1
  • 3
    • 79953111745 scopus 로고    scopus 로고
    • N-Acetylcysteine in psychiatry: Current therapeutic evidence and potential mechanisms of action
    • O. Dean N-Acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action J. Psychiatry Neurosci. 36 2011 78 86
    • (2011) J. Psychiatry Neurosci. , vol.36 , pp. 78-86
    • Dean, O.1
  • 4
    • 36549029828 scopus 로고    scopus 로고
    • N-acetylcysteine and neurodegenerative diseases: Basic and clinical pharmacology
    • DOI 10.1080/14734220601142878, PII 770199349
    • M. Arakawa, and Y. Ito N-Acetylcysteine and neurodegenerative diseases: basic and clinical pharmacology Cerebellum 6 2007 308 314 (Pubitemid 350179062)
    • (2007) Cerebellum , vol.6 , Issue.4 , pp. 308-314
    • Arakawa, M.1    Ito, Y.2
  • 5
    • 49349104661 scopus 로고    scopus 로고
    • Blunted cysteine-glutamate antiporter function in the nucleus accumbens promotes cocaine-induced drug seeking
    • K.S. Kau Blunted cysteine-glutamate antiporter function in the nucleus accumbens promotes cocaine-induced drug seeking Neuroscience 155 2008 530 537
    • (2008) Neuroscience , vol.155 , pp. 530-537
    • Kau, K.S.1
  • 6
    • 84869110746 scopus 로고    scopus 로고
    • Glutathione homeostasis and functions: Potential targets for medical interventions
    • V.I. Lushchak Glutathione homeostasis and functions: potential targets for medical interventions J. Amino Acids 2012 2012 736837
    • (2012) J. Amino Acids , vol.2012 , pp. 736837
    • Lushchak, V.I.1
  • 7
    • 84855534956 scopus 로고    scopus 로고
    • Glutamatergic medications for the treatment of drug and behavioral addictions
    • M.F. Olive Glutamatergic medications for the treatment of drug and behavioral addictions Pharmacol. Biochem. Behav. 100 2012 801 810
    • (2012) Pharmacol. Biochem. Behav. , vol.100 , pp. 801-810
    • Olive, M.F.1
  • 8
    • 77956648156 scopus 로고    scopus 로고
    • N-Methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: The final common pathway on the road to schizophrenia?
    • J.T. Kantrowitz, and D.C. Javitt N-Methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: the final common pathway on the road to schizophrenia? Brain Res. Bull. 83 2010 108 121
    • (2010) Brain Res. Bull. , vol.83 , pp. 108-121
    • Kantrowitz, J.T.1    Javitt, D.C.2
  • 9
    • 21844443565 scopus 로고    scopus 로고
    • Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking
    • DOI 10.1523/JNEUROSCI.1007-05.2005
    • M.M. Moran Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking J. Neurosci. 25 2005 6389 6393 (Pubitemid 40962534)
    • (2005) Journal of Neuroscience , vol.25 , Issue.27 , pp. 6389-6393
    • Moran, M.M.1    McFarland, K.2    Melendez, R.I.3    Kalivas, P.W.4    Seamans, J.K.5
  • 10
    • 0035693680 scopus 로고    scopus 로고
    • Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death
    • DOI 10.1385/MN:24:1-3:107
    • R. Sattler, and M. Tymianski Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death Mol. Neurobiol. 24 2001 107 129 (Pubitemid 34066681)
    • (2001) Molecular Neurobiology , vol.24 , Issue.1-3 , pp. 107-129
    • Sattler, R.1    Tymianski, M.2
  • 14
    • 0026038428 scopus 로고
    • 2+ in cultured rat forebrain neurons
    • 2+ in cultured rat forebrain neurons Neurosci. Lett. 133 1991 11 14
    • (1991) Neurosci. Lett. , vol.133 , pp. 11-14
    • Gilbert, K.R.1
  • 15
    • 0026532925 scopus 로고
    • Stimulation of N-methyl-d-aspartate receptor-mediated calcium entry into dissociated neurons by reduced and oxidized glutathione
    • S.W. Leslie Stimulation of N-methyl-d-aspartate receptor-mediated calcium entry into dissociated neurons by reduced and oxidized glutathione Mol. Pharmacol. 41 1992 308 314
    • (1992) Mol. Pharmacol. , vol.41 , pp. 308-314
    • Leslie, S.W.1
  • 16
    • 0030876671 scopus 로고    scopus 로고
    • Glutathione is an endogenous ligand of rat brain N-methyl-D-aspartate (NMDA) and 2-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors
    • DOI 10.1023/A:1027377605054
    • V. Varga Glutathione is an endogenous ligand of rat brain N-methyl-d-aspartate (NMDA) and 2-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors Neurochem. Res. 22 1997 1165 1171 (Pubitemid 27327944)
    • (1997) Neurochemical Research , vol.22 , Issue.9 , pp. 1165-1171
    • Varga, V.1    Jenaei, Zs.2    Janaky, R.3    Saransaari, P.4    Oja, S.S.5
  • 17
    • 30144435733 scopus 로고    scopus 로고
    • Synaptic plasticity impairment and hypofunction of NMDA receptors induced by glutathione deficit: Relevance to schizophrenia
    • DOI 10.1016/j.neuroscience.2005.10.014, PII S0306452205011589
    • P. Steullet Synaptic plasticity impairment and hypofunction of NMDA receptors induced by glutathione deficit: relevance to schizophrenia Neuroscience 137 2006 807 819 (Pubitemid 43053945)
    • (2006) Neuroscience , vol.137 , Issue.3 , pp. 807-819
    • Steullet, P.1    Neijt, H.C.2    Cuenod, M.3    Do, K.Q.4
  • 19
    • 67651214391 scopus 로고    scopus 로고
    • The effect of N-acetylcysteine on amphetamine-mediated dopamine release in rat brain striatal slices by ion-pair reversed-phase high performance liquid chromatography
    • E. Gere-Paszti, and J. Jakus The effect of N-acetylcysteine on amphetamine-mediated dopamine release in rat brain striatal slices by ion-pair reversed-phase high performance liquid chromatography Biomed. Chromatogr. 23 2009 658 664
    • (2009) Biomed. Chromatogr. , vol.23 , pp. 658-664
    • Gere-Paszti, E.1    Jakus, J.2
  • 20
    • 76949108822 scopus 로고    scopus 로고
    • The role of dopamine oxidation in mitochondrial dysfunction: Implications for Parkinson's disease
    • T.G. Hastings The role of dopamine oxidation in mitochondrial dysfunction: implications for Parkinson's disease J. Bioenerg. Biomembr. 41 2009 469 472
    • (2009) J. Bioenerg. Biomembr. , vol.41 , pp. 469-472
    • Hastings, T.G.1
  • 21
    • 8444225810 scopus 로고    scopus 로고
    • Protective effects of N-acetyl-L-cysteine on the reduction of dopamine transporters in the striatum of monkeys treated with methamphetamine
    • DOI 10.1038/sj.npp.1300512
    • K. Hashimoto Protective effects of N-acetyl-l-cysteine on the reduction of dopamine transporters in the striatum of monkeys treated with methamphetamine Neuropsychopharmacology 29 2004 2018 2023 (Pubitemid 39486553)
    • (2004) Neuropsychopharmacology , vol.29 , Issue.11 , pp. 2018-2023
    • Hashimoto, K.1    Tsukada, H.2    Nishiyama, S.3    Fukumoto, D.4    Kakiuchi, T.5    Shimizu, E.6    Iyo, M.7
  • 22
    • 84857407923 scopus 로고    scopus 로고
    • AC927, a sigma receptor ligand, blocks methamphetamine-induced release of dopamine and generation of reactive oxygen species in NG108-15 cells
    • N. Kaushal AC927, a sigma receptor ligand, blocks methamphetamine-induced release of dopamine and generation of reactive oxygen species in NG108-15 cells Mol. Pharmacol. 81 2012 299 308
    • (2012) Mol. Pharmacol. , vol.81 , pp. 299-308
    • Kaushal, N.1
  • 23
    • 0036682171 scopus 로고    scopus 로고
    • Glutathione release from cultured brain cells: Multidrug resistance protein 1 mediates the release of GSH from rat astroglial cells
    • DOI 10.1002/jnr.10308
    • J. Hirrlinger Glutathione release from cultured brain cells: multidrug resistance protein 1 mediates the release of GSH from rat astroglial cells J. Neurosci. Res. 69 2002 318 326 (Pubitemid 34809481)
    • (2002) Journal of Neuroscience Research , vol.69 , Issue.3 , pp. 318-326
    • Hirrlinger, J.1    Schulz, J.B.2    Dringen, R.3
  • 25
    • 79952309760 scopus 로고    scopus 로고
    • Scaling of brain metabolism with a fixed energy budget per neuron: Implications for neuronal activity, plasticity and evolution
    • S. Herculano-Houzel Scaling of brain metabolism with a fixed energy budget per neuron: implications for neuronal activity, plasticity and evolution PLoS ONE 6 2011 e17514
    • (2011) PLoS ONE , vol.6 , pp. 17514
    • Herculano-Houzel, S.1
  • 28
    • 67749122382 scopus 로고    scopus 로고
    • Increased oxidative stress in the anterior cingulate cortex of subjects with bipolar disorder and schizophrenia
    • J.F. Wang Increased oxidative stress in the anterior cingulate cortex of subjects with bipolar disorder and schizophrenia Bipolar Disord. 11 2009 523 529
    • (2009) Bipolar Disord. , vol.11 , pp. 523-529
    • Wang, J.F.1
  • 29
    • 51349132292 scopus 로고    scopus 로고
    • Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in different phases of bipolar disorder and in schizophrenia
    • M. Kunz Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in different phases of bipolar disorder and in schizophrenia Prog. Neuropsychopharmacol. Biol Psychiatry 32 2008 1677 1681
    • (2008) Prog. Neuropsychopharmacol. Biol Psychiatry , vol.32 , pp. 1677-1681
    • Kunz, M.1
  • 30
    • 34249326931 scopus 로고    scopus 로고
    • DNA fragmentation is increased in non-GABAergic neurons in bipolar disorder but not in schizophrenia
    • DOI 10.1016/j.schres.2007.01.030, PII S0920996407000722
    • N. Buttner DNA fragmentation is increased in non-GABAergic neurons in bipolar disorder but not in schizophrenia Schizophr. Res. 93 2007 33 41 (Pubitemid 46817926)
    • (2007) Schizophrenia Research , vol.93 , Issue.1-3 , pp. 33-41
    • Buttner, N.1    Bhattacharyya, S.2    Walsh, J.3    Benes, F.M.4
  • 32
    • 77956549615 scopus 로고    scopus 로고
    • Oxidative damage to RNA but not DNA in the hippocampus of patients with major mental illness
    • Y. Che Oxidative damage to RNA but not DNA in the hippocampus of patients with major mental illness J. Psychiatry Neurosci. 35 2010 296 302
    • (2010) J. Psychiatry Neurosci. , vol.35 , pp. 296-302
    • Che, Y.1
  • 34
    • 33745463205 scopus 로고    scopus 로고
    • Downregulation in components of the mitochondrial electron transport chain in the postmortem frontal cortex of subjects with bipolar disorder
    • X. Sun Downregulation in components of the mitochondrial electron transport chain in the postmortem frontal cortex of subjects with bipolar disorder J. Psychiatry Neurosci. 31 2006 189 196 (Pubitemid 43954738)
    • (2006) Journal of Psychiatry and Neuroscience , vol.31 , Issue.3 , pp. 189-196
    • Sun, X.1    Wang, J.-F.2    Tseng, M.3    Young, L.T.4
  • 35
    • 84870839107 scopus 로고    scopus 로고
    • Mitochondrial mutations and polymorphisms in psychiatric disorders
    • A. Sequeira Mitochondrial mutations and polymorphisms in psychiatric disorders Front. Genet. 3 2012 103
    • (2012) Front. Genet. , vol.3 , pp. 103
    • Sequeira, A.1
  • 36
    • 84860594239 scopus 로고    scopus 로고
    • The psychiatric manifestations of mitochondrial disorders: A case and review of the literature
    • R.E. Anglin The psychiatric manifestations of mitochondrial disorders: a case and review of the literature J. Clin. Psychiatry 73 2012 506 512
    • (2012) J. Clin. Psychiatry , vol.73 , pp. 506-512
    • Anglin, R.E.1
  • 37
    • 70449274750 scopus 로고
    • Blood glutathione and eosinophil levels and hospital adjustment scale in chronic schizophrenia
    • M.D. Altschule Blood glutathione and eosinophil levels and hospital adjustment scale in chronic schizophrenia Arch. Gen. Psychiatry 1 1959 358 365
    • (1959) Arch. Gen. Psychiatry , vol.1 , pp. 358-365
    • Altschule, M.D.1
  • 38
    • 0034499731 scopus 로고    scopus 로고
    • Erythrocyte superoxide dismutase and glutathione peroxidase activities, and malondialdehyde and reduced glutathione levels in schizophrenic patients
    • DOI 10.1515/CCLM.2001.201
    • I. Altuntas Erythrocyte superoxide dismutase and glutathione peroxidase activities, and malondialdehyde and reduced glutathione levels in schizophrenic patients Clin. Chem. Lab. Med. 38 2000 1277 1281 (Pubitemid 32094401)
    • (2000) Clinical Chemistry and Laboratory Medicine , vol.38 , Issue.12 , pp. 1277-1281
    • Altuntas, I.1    Aksoy, H.2    Coskun, I.3    Caykoylu, A.4    Akcay, F.5
  • 39
    • 34447645974 scopus 로고
    • The lactic acid and glutathione content of the blood of schizophrenic patients
    • J.M. Looney, and H.M. Childs The lactic acid and glutathione content of the blood of schizophrenic patients J. Clin. Invest. 13 1934 963 968
    • (1934) J. Clin. Invest. , vol.13 , pp. 963-968
    • Looney, J.M.1    Childs, H.M.2
  • 40
    • 26444576548 scopus 로고
    • Blood glutathione level in mental disease before and after treatment
    • M.D. Altschule Blood glutathione level in mental disease before and after treatment AMA Arch. Neurol. Psychiatry 67 1952 64 68
    • (1952) AMA Arch. Neurol. Psychiatry , vol.67 , pp. 64-68
    • Altschule, M.D.1
  • 41
    • 1542299043 scopus 로고    scopus 로고
    • Antioxidant enzyme activities and oxidative stress in affective disorders
    • M. Erkan Ozcan Antioxidant enzyme activities and oxidative stress in affective disorders Int. Clin. Psychopharmacol. 19 2004 89 95
    • (2004) Int. Clin. Psychopharmacol. , vol.19 , pp. 89-95
    • Erkan Ozcan, M.1
  • 42
    • 0035065919 scopus 로고    scopus 로고
    • Antioxidative enzyme activities and lipid peroxidation in major depression: Alterations by antidepressant treatments
    • DOI 10.1016/S0165-0327(00)00199-3, PII S0165032700001993
    • M. Bilici Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments J. Affect. Disord. 64 2001 43 51 (Pubitemid 32268670)
    • (2001) Journal of Affective Disorders , vol.64 , Issue.1 , pp. 43-51
    • Bilici, M.1    Efe, H.2    Koroglu, M.A.3    Uydu, H.A.4    Bekaroglu, M.5    Deger, O.6
  • 43
    • 70149115047 scopus 로고    scopus 로고
    • 3-Nitrotyrosine and glutathione antioxidant system in patients in the early and late stages of bipolar disorder
    • A.C. Andreazza 3-Nitrotyrosine and glutathione antioxidant system in patients in the early and late stages of bipolar disorder J. Psychiatry Neurosci. 34 2009 263 271
    • (2009) J. Psychiatry Neurosci. , vol.34 , pp. 263-271
    • Andreazza, A.C.1
  • 44
    • 79955909679 scopus 로고    scopus 로고
    • Glutamate cysteine ligase (GCL) and self reported depression: An association study from the HUNT
    • M. Berk Glutamate cysteine ligase (GCL) and self reported depression: an association study from the HUNT J. Affect. Disord. 131 2011 207 213
    • (2011) J. Affect. Disord. , vol.131 , pp. 207-213
    • Berk, M.1
  • 46
    • 79952775531 scopus 로고    scopus 로고
    • Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders
    • J.W. Gawryluk Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders Int. J. Neuropsychopharmacol. 14 2011 123 130
    • (2011) Int. J. Neuropsychopharmacol. , vol.14 , pp. 123-130
    • Gawryluk, J.W.1
  • 47
    • 81355138985 scopus 로고    scopus 로고
    • Behavioral phenotyping of glutathione-deficient mice: Relevance to schizophrenia and bipolar disorder
    • A. Kulak Behavioral phenotyping of glutathione-deficient mice: relevance to schizophrenia and bipolar disorder Behav. Brain Res. 226 2012 563 570
    • (2012) Behav. Brain Res. , vol.226 , pp. 563-570
    • Kulak, A.1
  • 49
    • 78049286777 scopus 로고    scopus 로고
    • Effects of N-acetyl-cysteine treatment on glutathione depletion and a short-term spatial memory deficit in 2-cyclohexene-1-one-treated rats
    • K.H. Choy Effects of N-acetyl-cysteine treatment on glutathione depletion and a short-term spatial memory deficit in 2-cyclohexene-1-one-treated rats Eur. J. Pharmacol. 649 2010 224 228
    • (2010) Eur. J. Pharmacol. , vol.649 , pp. 224-228
    • Choy, K.H.1
  • 50
    • 38949218189 scopus 로고    scopus 로고
    • N-Acetyl cysteine inhibits depletion of brain glutathione levels in rats: Implications for schizophrenia
    • O. Dean N-Acetyl cysteine inhibits depletion of brain glutathione levels in rats: implications for schizophrenia Int. J. Neuropsychopharmacol. 7 2004 262
    • (2004) Int. J. Neuropsychopharmacol. , vol.7 , pp. 262
    • Dean, O.1
  • 51
    • 67749130818 scopus 로고    scopus 로고
    • Reactive oxygen species-induced cell death of rat primary astrocytes through mitochondria-mediated mechanism
    • C.C. Wang Reactive oxygen species-induced cell death of rat primary astrocytes through mitochondria-mediated mechanism J. Cell. Biochem. 107 2009 933 943
    • (2009) J. Cell. Biochem. , vol.107 , pp. 933-943
    • Wang, C.C.1
  • 52
    • 80052708116 scopus 로고    scopus 로고
    • N-Acetyl cysteine treatment rescues cognitive deficits induced by mitochondrial dysfunction in G72/G30 transgenic mice
    • D.M. Otte N-Acetyl cysteine treatment rescues cognitive deficits induced by mitochondrial dysfunction in G72/G30 transgenic mice Neuropsychopharmacology 36 2011 2233 2243
    • (2011) Neuropsychopharmacology , vol.36 , pp. 2233-2243
    • Otte, D.M.1
  • 53
    • 58149342069 scopus 로고    scopus 로고
    • Oxidation of plasma cysteine/cystine redox state in endotoxin-induced lung injury
    • S.S. Iyer Oxidation of plasma cysteine/cystine redox state in endotoxin-induced lung injury Am. J. Respir. Cell Mol. Biol. 40 2009 90 98
    • (2009) Am. J. Respir. Cell Mol. Biol. , vol.40 , pp. 90-98
    • Iyer, S.S.1
  • 55
    • 80053037896 scopus 로고    scopus 로고
    • The cystine/cysteine cycle and GSH are independent and crucial antioxidant systems in malignant melanoma cells and represent druggable targets
    • R. Vene The cystine/cysteine cycle and GSH are independent and crucial antioxidant systems in malignant melanoma cells and represent druggable targets Antioxid. Redox Signal. 15 2011 2439 2453
    • (2011) Antioxid. Redox Signal. , vol.15 , pp. 2439-2453
    • Vene, R.1
  • 56
    • 0030298025 scopus 로고    scopus 로고
    • Leukocytes and organ-nonspecific autoantibodies in schizophrenics and their siblings: Markers of vulnerability or disease?
    • DOI 10.1016/0006-3223(95)00598-6
    • E.P. Zorrilla Leukocytes and organ-nonspecific autoantibodies in schizophrenics and their siblings: markers of vulnerability or disease? Biol. Psychiatry 40 1996 825 833 (Pubitemid 26356716)
    • (1996) Biological Psychiatry , vol.40 , Issue.9 , pp. 825-833
    • Zorrilla, E.P.1    Cannon, T.D.2    Gur, R.E.3    Kessler, J.4
  • 57
    • 75849155537 scopus 로고    scopus 로고
    • A meta-analysis of cytokines in major depression
    • Y. Dowlati A meta-analysis of cytokines in major depression Biol. Psychiatry 67 2010 446 457
    • (2010) Biol. Psychiatry , vol.67 , pp. 446-457
    • Dowlati, Y.1
  • 58
    • 65649152524 scopus 로고    scopus 로고
    • Associations of depression with C-reactive protein, IL-1, and IL-6: A meta-analysis
    • M.B. Howren Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis Psychosom. Med. 71 2009 171 186
    • (2009) Psychosom. Med. , vol.71 , pp. 171-186
    • Howren, M.B.1
  • 59
    • 0023190469 scopus 로고
    • The neuropsychiatric effects of treatment with interleukin-2 and lymphokine-activated killer cells
    • K.D. Denicoff The neuropsychiatric effects of treatment with interleukin-2 and lymphokine-activated killer cells Ann. Intern. Med. 107 1987 293 300 (Pubitemid 17136929)
    • (1987) Annals of Internal Medicine , vol.107 , Issue.3 , pp. 293-300
    • Denicoff, K.D.1    Rubinow, D.R.2    Papa, M.Z.3
  • 61
    • 0034079672 scopus 로고    scopus 로고
    • Early depressive symptoms in cancer patients receiving interleukin 2 and/or interferon alfa-2b therapy
    • L. Capuron Early depressive symptoms in cancer patients receiving interleukin 2 and/or interferon α-2b therapy J. Clin. Oncol. 18 2000 2143 2151 (Pubitemid 30324368)
    • (2000) Journal of Clinical Oncology , vol.18 , Issue.10 , pp. 2143-2151
    • Capuron, L.1    Ravaud, A.2    Dantzer, R.3
  • 62
    • 57749179191 scopus 로고    scopus 로고
    • The inflammatory & neurodegenerative (I&ND) hypothesis of depression: Leads for future research and new drug developments in depression
    • M. Maes The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression Metab. Brain Dis. 24 2009 27 53
    • (2009) Metab. Brain Dis. , vol.24 , pp. 27-53
    • Maes, M.1
  • 63
    • 63449122724 scopus 로고    scopus 로고
    • Inflammation and its discontents: The role of cytokines in the pathophysiology of major depression
    • A.H. Miller Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression Biol. Psychiatry 65 2009 732 741
    • (2009) Biol. Psychiatry , vol.65 , pp. 732-741
    • Miller, A.H.1
  • 64
    • 77957678999 scopus 로고    scopus 로고
    • Effect of oral N-acetylcysteine treatment on plasma inflammatory and oxidative stress markers in peritoneal dialysis patients: A placebo-controlled study
    • M.M. Nascimento Effect of oral N-acetylcysteine treatment on plasma inflammatory and oxidative stress markers in peritoneal dialysis patients: a placebo-controlled study Perit. Dial. Int. 30 2010 336 342
    • (2010) Perit. Dial. Int. , vol.30 , pp. 336-342
    • Nascimento, M.M.1
  • 65
    • 80052294229 scopus 로고    scopus 로고
    • Effect of N-acetylcysteine on cardiac injury and oxidative stress after abdominal aortic aneurysm repair: A randomized controlled trial
    • K.M. Mahmoud, and A.S. Ammar Effect of N-acetylcysteine on cardiac injury and oxidative stress after abdominal aortic aneurysm repair: a randomized controlled trial Acta Anaesthesiol. Scand. 55 2011 1015 1021
    • (2011) Acta Anaesthesiol. Scand. , vol.55 , pp. 1015-1021
    • Mahmoud, K.M.1    Ammar, A.S.2
  • 66
    • 84858082210 scopus 로고    scopus 로고
    • Effect of N-acetylcysteine treatment on oxidative stress and inflammation after severe burn
    • C. Csontos Effect of N-acetylcysteine treatment on oxidative stress and inflammation after severe burn Burns 38 2012 428 437
    • (2012) Burns , vol.38 , pp. 428-437
    • Csontos, C.1
  • 67
    • 45549089322 scopus 로고    scopus 로고
    • Inhibitory effect on cerebral inflammatory response following traumatic brain injury in rats: A potential neuroprotective mechanism of N-acetylcysteine
    • G. Chen Inhibitory effect on cerebral inflammatory response following traumatic brain injury in rats: a potential neuroprotective mechanism of N-acetylcysteine Mediators Inflamm. 2008 2008 716458
    • (2008) Mediators Inflamm. , vol.2008 , pp. 716458
    • Chen, G.1
  • 68
  • 69
    • 84878145540 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX(3)CR1)-deficient mice
    • 10.1016/j.bbi.2012.08.008
    • A.W. Corona Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX(3)CR1)-deficient mice Brain Behav. Immun. 2012 10.1016/j.bbi.2012.08.008
    • (2012) Brain Behav. Immun.
    • Corona, A.W.1
  • 70
    • 84863860942 scopus 로고    scopus 로고
    • Maternal N-acetyl-cysteine (NAC) protects the rat fetal brain from inflammatory cytokine responses to lipopolysaccharide (LPS)
    • R. Beloosesky Maternal N-acetyl-cysteine (NAC) protects the rat fetal brain from inflammatory cytokine responses to lipopolysaccharide (LPS) J. Matern. Fetal Neonatal. Med. 25 2012 1324 1328
    • (2012) J. Matern. Fetal Neonatal. Med. , vol.25 , pp. 1324-1328
    • Beloosesky, R.1
  • 74
    • 65449157994 scopus 로고    scopus 로고
    • Effect of N-acetylcysteine on the early expression of inflammatory markers in the retina and plasma of diabetic rats
    • G.Y. Tsai Effect of N-acetylcysteine on the early expression of inflammatory markers in the retina and plasma of diabetic rats Clin. Exp. Ophthalmol. 37 2009 223 231
    • (2009) Clin. Exp. Ophthalmol. , vol.37 , pp. 223-231
    • Tsai, G.Y.1
  • 75
    • 84856225531 scopus 로고    scopus 로고
    • System x(c)(-) regulates microglia and macrophage glutamate excitotoxicity in vivo
    • K.A. Kigerl System x(c)(-) regulates microglia and macrophage glutamate excitotoxicity in vivo Exp. Neurol. 233 2012 333 341
    • (2012) Exp. Neurol. , vol.233 , pp. 333-341
    • Kigerl, K.A.1
  • 76
    • 58149099399 scopus 로고    scopus 로고
    • Glutamate transmission in addiction
    • P.W. Kalivas Glutamate transmission in addiction Neuropharmacology 56 Suppl. 1 2009 169 173
    • (2009) Neuropharmacology , vol.56 , Issue.SUPPL. 1 , pp. 169-173
    • Kalivas, P.W.1
  • 77
    • 0024390333 scopus 로고
    • Blockade of 'reverse tolerance' to cocaine and amphetamine by MK-801
    • DOI 10.1016/0024-3205(89)90045-3
    • R. Karler Blockade of "reverse tolerance" to cocaine and amphetamine by MK-801 Life Sci. 45 1989 599 606 (Pubitemid 19198546)
    • (1989) Life Sciences , vol.45 , Issue.7 , pp. 599-606
    • Karler, R.1    Calder, L.D.2    Chaudhry, I.A.3    Turkanis, S.A.4
  • 78
    • 84863987616 scopus 로고    scopus 로고
    • N-Acetylcysteine normalizes glutamate levels in cocaine-dependent patients: A randomized crossover magnetic resonance spectroscopy study
    • L. Schmaal N-Acetylcysteine normalizes glutamate levels in cocaine-dependent patients: a randomized crossover magnetic resonance spectroscopy study Neuropsychopharmacology 37 2012 2143 2152
    • (2012) Neuropsychopharmacology , vol.37 , pp. 2143-2152
    • Schmaal, L.1
  • 79
    • 84859996055 scopus 로고    scopus 로고
    • Protective effects of the antioxidant sulforaphane on behavioral changes and neurotoxicity in mice after the administration of methamphetamine
    • H. Chen Protective effects of the antioxidant sulforaphane on behavioral changes and neurotoxicity in mice after the administration of methamphetamine Psychopharmacology 222 2012 37 45
    • (2012) Psychopharmacology , vol.222 , pp. 37-45
    • Chen, H.1
  • 80
    • 80054021719 scopus 로고    scopus 로고
    • Molecular adaptations of apoptotic pathways and signaling partners in the cerebral cortex of human cocaine addicts and cocaine-treated rats
    • M. Alvaro-Bartolome Molecular adaptations of apoptotic pathways and signaling partners in the cerebral cortex of human cocaine addicts and cocaine-treated rats Neuroscience 196 2011 1 15
    • (2011) Neuroscience , vol.196 , pp. 1-15
    • Alvaro-Bartolome, M.1
  • 82
    • 79960985577 scopus 로고    scopus 로고
    • D-Amphetamine-induced cytotoxicity and oxidative stress in isolated rat hepatocytes
    • O.S. El-Tawil d-Amphetamine-induced cytotoxicity and oxidative stress in isolated rat hepatocytes Pathophysiology 18 2011 279 285
    • (2011) Pathophysiology , vol.18 , pp. 279-285
    • El-Tawil, O.S.1
  • 83
    • 77954338704 scopus 로고    scopus 로고
    • Cocaine causes memory and learning impairments in rats: Involvement of nuclear factor κb and oxidative stress, and prevention by topiramate
    • M. Muriach Cocaine causes memory and learning impairments in rats: involvement of nuclear factor κB and oxidative stress, and prevention by topiramate J. Neurochem. 114 2010 675 684
    • (2010) J. Neurochem. , vol.114 , pp. 675-684
    • Muriach, M.1
  • 84
    • 65049088707 scopus 로고    scopus 로고
    • The role of cysteine-glutamate exchange in nicotine dependence in rats and humans
    • L.A. Knackstedt The role of cysteine-glutamate exchange in nicotine dependence in rats and humans Biol. Psychiatry 65 2009 841 845
    • (2009) Biol. Psychiatry , vol.65 , pp. 841-845
    • Knackstedt, L.A.1
  • 85
    • 77957020829 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled study of N-acetyl cysteine plus naltrexone for methamphetamine dependence
    • J.E. Grant A double-blind, placebo-controlled study of N-acetyl cysteine plus naltrexone for methamphetamine dependence Eur. Neuropsychopharmacol. 20 2010 823 828
    • (2010) Eur. Neuropsychopharmacol. , vol.20 , pp. 823-828
    • Grant, J.E.1
  • 86
    • 77149167604 scopus 로고    scopus 로고
    • N-Acetylcysteine (NAC) in young marijuana users: An open-label pilot study
    • K.M. Gray N-Acetylcysteine (NAC) in young marijuana users: an open-label pilot study Am. J. Addict. 19 2010 187 189
    • (2010) Am. J. Addict. , vol.19 , pp. 187-189
    • Gray, K.M.1
  • 87
    • 84864794946 scopus 로고    scopus 로고
    • A double-blind randomized controlled trial of N-acetylcysteine in cannabis-dependent adolescents
    • K.M. Gray A double-blind randomized controlled trial of N-acetylcysteine in cannabis-dependent adolescents Am. J. Psychiatry 169 2012 805 812
    • (2012) Am. J. Psychiatry , vol.169 , pp. 805-812
    • Gray, K.M.1
  • 89
    • 32144454852 scopus 로고    scopus 로고
    • Safety and tolerability of N-acetylcysteine in cocaine-dependent individuals
    • S.D. Larowe Safety and tolerability of N-acetylcysteine in cocaine-dependent individuals Am. J. Addict. 15 2006 105 110
    • (2006) Am. J. Addict. , vol.15 , pp. 105-110
    • Larowe, S.D.1
  • 92
    • 34548150512 scopus 로고    scopus 로고
    • N-Acetyl Cysteine, a Glutamate-Modulating Agent, in the Treatment of Pathological Gambling: A Pilot Study
    • DOI 10.1016/j.biopsych.2006.11.021, PII S0006322306015101
    • J.E. Grant N-Acetyl cysteine, a glutamate-modulating agent, in the treatment of pathological gambling: a pilot study Biol. Psychiatry 62 2007 652 657 (Pubitemid 47314380)
    • (2007) Biological Psychiatry , vol.62 , Issue.6 , pp. 652-657
    • Grant, J.E.1    Kim, S.W.2    Odlaug, B.L.3
  • 93
    • 61849151380 scopus 로고    scopus 로고
    • A psychological and neuroanatomical model of obsessive-compulsive disorder
    • E.D. Huey A psychological and neuroanatomical model of obsessive-compulsive disorder J. Neuropsychiatry Clin. Neurosci. 20 2008 390 408
    • (2008) J. Neuropsychiatry Clin. Neurosci. , vol.20 , pp. 390-408
    • Huey, E.D.1
  • 95
    • 58149347324 scopus 로고    scopus 로고
    • Serum selenium and plasma malondialdehyde levels and antioxidant enzyme activities in patients with obsessive-compulsive disorder
    • E. Ozdemir Serum selenium and plasma malondialdehyde levels and antioxidant enzyme activities in patients with obsessive-compulsive disorder Prog. Neuropsychopharmacol. Biol. Psychiatry 33 2009 62 65
    • (2009) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.33 , pp. 62-65
    • Ozdemir, E.1
  • 96
    • 33745241877 scopus 로고    scopus 로고
    • Examination of free radical metabolism and antioxidant defence system elements in patients with obsessive-compulsive disorder
    • DOI 10.1016/j.pnpbp.2006.03.034, PII S027858460600131X
    • S. Ersan Examination of free radical metabolism and antioxidant defence system elements in patients with obsessive-compulsive disorder Prog. Neuropsychopharmacol. Biol. Psychiatry 30 2006 1039 1042 (Pubitemid 43928217)
    • (2006) Progress in Neuro-Psychopharmacology and Biological Psychiatry , vol.30 , Issue.6 , pp. 1039-1042
    • Ersan, S.1    Bakir, S.2    Erdal Ersan, E.3    Dogan, O.4
  • 97
    • 79956004865 scopus 로고    scopus 로고
    • Nutraceuticals in the treatment of obsessive compulsive disorder (OCD): A review of mechanistic and clinical evidence
    • D.A. Camfield Nutraceuticals in the treatment of obsessive compulsive disorder (OCD): a review of mechanistic and clinical evidence Prog. Neuropsychopharmacol. Biol. Psychiatry 35 2011 887 895
    • (2011) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.35 , pp. 887-895
    • Camfield, D.A.1
  • 100
    • 34047118144 scopus 로고    scopus 로고
    • Addicted to hair pulling? How an alternate model of trichotillomania may improve treatment outcome
    • DOI 10.1080/10673220701298407, PII 776091816
    • J.E. Grant Addicted to hair pulling? How an alternate model of trichotillomania may improve treatment outcome Harv. Rev. Psychiatry 15 2007 80 85 (Pubitemid 46514891)
    • (2007) Harvard Review of Psychiatry , vol.15 , Issue.2 , pp. 80-85
    • Grant, J.E.1    Odlaug, B.L.2    Potenza, M.N.3
  • 101
    • 34247170051 scopus 로고    scopus 로고
    • N-acetyl cysteine in the treatment of grooming disorders [14]
    • DOI 10.1097/01.jcp.0000264976.86990.00, PII 0000471420070400000028
    • B.L. Odlaug, and J.E. Grant N-Acetyl cysteine in the treatment of grooming disorders J. Clin. Psychopharmacol. 27 2007 227 229 (Pubitemid 46594953)
    • (2007) Journal of Clinical Psychopharmacology , vol.27 , Issue.2 , pp. 227-229
    • Odlaug, B.L.1    Grant, J.E.2
  • 102
    • 67650483697 scopus 로고    scopus 로고
    • N-Acetylcysteine, a glutamate modulator, in the treatment of trichotillomania: A double-blind, placebo-controlled study
    • J.E. Grant N-Acetylcysteine, a glutamate modulator, in the treatment of trichotillomania: a double-blind, placebo-controlled study Arch. Gen. Psychiatry 66 2009 756 763
    • (2009) Arch. Gen. Psychiatry , vol.66 , pp. 756-763
    • Grant, J.E.1
  • 103
    • 70350445015 scopus 로고    scopus 로고
    • Nail-biting stuff? the effect of N-acetyl cysteine on nail-biting
    • M. Berk Nail-biting stuff? The effect of N-acetyl cysteine on nail-biting CNS Spectr. 14 2009 357 360
    • (2009) CNS Spectr. , vol.14 , pp. 357-360
    • Berk, M.1
  • 104
    • 77149138329 scopus 로고    scopus 로고
    • Glutamatergic (N-methyl-d-aspartate receptor) hypofrontality in schizophrenia: Too little juice or a miswired brain?
    • G.J. Marek Glutamatergic (N-methyl-d-aspartate receptor) hypofrontality in schizophrenia: too little juice or a miswired brain? Mol. Pharmacol. 77 2010 317 326
    • (2010) Mol. Pharmacol. , vol.77 , pp. 317-326
    • Marek, G.J.1
  • 105
    • 70349404318 scopus 로고    scopus 로고
    • A role for glutathione in the pathophysiology of bipolar disorder and schizophrenia? Animal models and relevance to clinical practice
    • O.M. Dean A role for glutathione in the pathophysiology of bipolar disorder and schizophrenia? Animal models and relevance to clinical practice Curr. Med. Chem. 16 2009 2965 2976
    • (2009) Curr. Med. Chem. , vol.16 , pp. 2965-2976
    • Dean, O.M.1
  • 106
    • 48749112603 scopus 로고    scopus 로고
    • N-Acetyl cysteine as a glutathione precursor for schizophrenia-a double-blind, randomized, placebo-controlled trial
    • M. Berk N-Acetyl cysteine as a glutathione precursor for schizophrenia-a double-blind, randomized, placebo-controlled trial Biol. Psychiatry 64 2008 361 368
    • (2008) Biol. Psychiatry , vol.64 , pp. 361-368
    • Berk, M.1
  • 107
    • 78249290706 scopus 로고    scopus 로고
    • Qualitative methods in early-phase drug trials: Broadening the scope of data and methods from an RCT of N-acetylcysteine in schizophrenia
    • M. Berk Qualitative methods in early-phase drug trials: broadening the scope of data and methods from an RCT of N-acetylcysteine in schizophrenia J. Clin. Psychiatry 72 2011 909 913
    • (2011) J. Clin. Psychiatry , vol.72 , pp. 909-913
    • Berk, M.1
  • 108
    • 77449155361 scopus 로고    scopus 로고
    • Beneficial effects of N-acetylcysteine in treatment resistant schizophrenia
    • M. Bulut Beneficial effects of N-acetylcysteine in treatment resistant schizophrenia World J. Biol. Psychiatry 10 2009 626 628
    • (2009) World J. Biol. Psychiatry , vol.10 , pp. 626-628
    • Bulut, M.1
  • 109
    • 49749109893 scopus 로고    scopus 로고
    • N-Acetyl cysteine for depressive symptoms in bipolar disorder-a double-blind randomized placebo-controlled trial
    • M. Berk N-Acetyl cysteine for depressive symptoms in bipolar disorder-a double-blind randomized placebo-controlled trial Biol. Psychiatry 64 2008 468 475
    • (2008) Biol. Psychiatry , vol.64 , pp. 468-475
    • Berk, M.1
  • 110
    • 84855821800 scopus 로고    scopus 로고
    • N-Acetylcysteine for major depressive episodes in bipolar disorder
    • P.V. Magalhaes N-Acetylcysteine for major depressive episodes in bipolar disorder Rev. Bras. Psiquiatr. 33 2011 374 378
    • (2011) Rev. Bras. Psiquiatr. , vol.33 , pp. 374-378
    • Magalhaes, P.V.1
  • 111
    • 79851512462 scopus 로고    scopus 로고
    • N-Acetyl cysteine add-on treatment for bipolar II disorder: A subgroup analysis of a randomized placebo-controlled trial
    • P.V. Magalhaes N-Acetyl cysteine add-on treatment for bipolar II disorder: a subgroup analysis of a randomized placebo-controlled trial J. Affect. Disord. 129 2011 317 320
    • (2011) J. Affect. Disord. , vol.129 , pp. 317-320
    • Magalhaes, P.V.1
  • 112
    • 78249244490 scopus 로고    scopus 로고
    • Oxidative pathways as a drug target for the treatment of autism
    • K.A. Villagonzalo Oxidative pathways as a drug target for the treatment of autism Expert Opin. Ther. Targets 14 2010 1301 1310
    • (2010) Expert Opin. Ther. Targets , vol.14 , pp. 1301-1310
    • Villagonzalo, K.A.1
  • 113
    • 84861019501 scopus 로고    scopus 로고
    • A Randomized Controlled Pilot Trial of Oral N-Acetylcysteine in Children with Autism
    • A.Y. Hardan A Randomized Controlled Pilot Trial of Oral N-Acetylcysteine in Children with Autism Biol. Psychiatry 71 2012 956 961
    • (2012) Biol. Psychiatry , vol.71 , pp. 956-961
    • Hardan, A.Y.1
  • 114
    • 84861455748 scopus 로고    scopus 로고
    • N-Acetyl-cysteine in the treatment of Parkinson's disease. What are we waiting for?
    • M.A. Martinez-Banaclocha N-Acetyl-cysteine in the treatment of Parkinson's disease. What are we waiting for? Med. Hypotheses 79 1999 8 12
    • (1999) Med. Hypotheses , vol.79 , pp. 8-12
    • Martinez-Banaclocha, M.A.1
  • 115
    • 0035940625 scopus 로고    scopus 로고
    • Controlled trial of N-acetylcysteine for patients with probable Alzheimer's disease
    • J.C. Adair Controlled trial of N-acetylcysteine for patients with probable Alzheimer's disease Neurology 57 2001 1515 1517 (Pubitemid 32995744)
    • (2001) Neurology , vol.57 , Issue.8 , pp. 1515-1517
    • Adair, J.C.1    Knoefel, J.E.2    Morgan, N.3
  • 116
    • 58149191631 scopus 로고    scopus 로고
    • Efficacy of a vitamin/nutriceutical formulation for early-stage Alzheimer's disease: A 1-year, open-label pilot study with an 16-month caregiver extension
    • A. Chan Efficacy of a vitamin/nutriceutical formulation for early-stage Alzheimer's disease: a 1-year, open-label pilot study with an 16-month caregiver extension Am. J. Alzheimers Dis. Other Demen. 23 2008 571 585
    • (2008) Am. J. Alzheimers Dis. Other Demen. , vol.23 , pp. 571-585
    • Chan, A.1
  • 117
    • 63349096757 scopus 로고    scopus 로고
    • Efficacy of a vitamin/nutriceutical formulation for moderate-stage to later-stage Alzheimer's disease: A placebo-controlled pilot study
    • R. Remington Efficacy of a vitamin/nutriceutical formulation for moderate-stage to later-stage Alzheimer's disease: a placebo-controlled pilot study Am. J. Alzheimers Dis. Other Demen. 24 2009 27 33
    • (2009) Am. J. Alzheimers Dis. Other Demen. , vol.24 , pp. 27-33
    • Remington, R.1
  • 119
    • 33646235152 scopus 로고    scopus 로고
    • Facilitation action of N-acetylcysteine on the anticonvulsant effect of sodium valproate in mice
    • P.U. Devi Facilitation action of N-acetylcysteine on the anticonvulsant effect of sodium valproate in mice Basic Clin. Pharmacol. Toxicol. 98 2006 521 522
    • (2006) Basic Clin. Pharmacol. Toxicol. , vol.98 , pp. 521-522
    • Devi, P.U.1
  • 120
    • 4544344727 scopus 로고    scopus 로고
    • Status epilepticus after a massive intravenous N-acetylcysteine overdose leading to intracranial hypertension and death
    • DOI 10.1016/j.annemergmed.2004.05.014, PII S0196064404005451
    • B. Bailey Status epilepticus after a massive intravenous N-acetylcysteine overdose leading to intracranial hypertension and death Ann. Emerg. Med. 44 2004 401 406 (Pubitemid 39237636)
    • (2004) Annals of Emergency Medicine , vol.44 , Issue.4 , pp. 401-406
    • Bailey, B.1    Blais, R.2    Letarte, A.3
  • 121
    • 80055010828 scopus 로고    scopus 로고
    • The efficacy of N-acetylcysteine as an adjunctive treatment in bipolar depression: An open label trial
    • M. Berk The efficacy of N-acetylcysteine as an adjunctive treatment in bipolar depression: an open label trial J. Affect. Disord. 135 2011 389 394
    • (2011) J. Affect. Disord. , vol.135 , pp. 389-394
    • Berk, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.