Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease

Toxicology and Applied Pharmacology

Volumn 254, Issue 2, 2011, Pages 72-85

  Yao, Hongwei ^a   Rahman, Irfan ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

COPD; Epigenetics; Inflammation; NF B; Oxidants; SIRT1; Smokers

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; ANTIOXIDANT; ANTISENSE OLIGONUCLEOTIDE; CHEMOKINE; CIGARETTE SMOKE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOKINE; EARLY GROWTH RESPONSE FACTOR 1; GLUCOCORTICOID; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE T1; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HISTONE; HISTONE DEACETYLASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; REACTIVE OXYGEN METABOLITE; SIRTUIN 1; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; TRANSFORMING GROWTH FACTOR BETA; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TUMOR NECROSIS FACTOR ALPHA;

ADAPTIVE IMMUNITY; ARTICLE; AUTOPHAGY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CORTICOSTEROID THERAPY; DNA METHYLATION; ENZYME ACTIVITY; EPIGENETICS; HUMAN; INFLAMMATION; INNATE IMMUNITY; LIPID PEROXIDATION; LUNG; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PROTEIN FOLDING; PROTEIN PROCESSING; UNFOLDED PROTEIN RESPONSE;

ANIMALS; ANTIOXIDANTS; EPIGENESIS, GENETIC; HUMANS; INFLAMMATION; OXIDATIVE STRESS; PROTEIN CARBONYLATION; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SIGNAL TRANSDUCTION; SMOKING;

EID: 79957900741     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.10.022     Document Type: Article

References (229)

1. Adenuga D., March T.H., Seagrave J., Rahman I. Cigarette smoke-induced loss of nuclear HDAC2 is associated with chronic inflammation and emphysema in A/J mice. Am. J. Respir. Crit. Care Med. 2008, 177:A866.
2. Adenuga D., Yang S.R., Rajendrasozhan S., Rahman I. HDAC2 degradation is associated with increased hyperphosphorylation and a proteasome-dependent mechanism in response to cigarette smoke in macrophages. Am. J. Respir. Crit. Care Med. 2008, 177:A866.
3. Adenuga D., Yao H., March T.H., Seagrave J., Rahman I. Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke. Am. J. Respir. Cell Mol. Biol. 2009, 40:464-473.
4. Adenuga D., Caito S., Yao H., Sundar I.K., Hwang J.W., Chung S., Rahman I. Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction. Biochem. Biophys. Res. Commun. 2010, 403:452-456.
5. Algood H.M., Flynn J.L. CCR5-deficient mice control Mycobacterium tuberculosis infection despite increased pulmonary lymphocytic infiltration. J. Immunol. 2004, 173:3287-3296.
6. Allison M.E., Fearon D.T. Enhanced immunogenicity of aldehyde-bearing antigens: a possible link between innate and adaptive immunity. Eur. J. Immunol. 2000, 30:2881-2887.
7. Andersson D.A., Gentry C., Moss S., Bevan S. Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress. J. Neurosci. 2008, 28:2485-2494.
8. Andre E., Campi B., Materazzi S., Trevisani M., Amadesi S., Massi D., Creminon C., Vaksman N., Nassini R., Civelli M., Baraldi P.G., Poole D.P., Bunnett N.W., Geppetti P., Patacchini R. Cigarette smoke-induced neurogenic inflammation is mediated by alpha, beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J. Clin. Invest. 2008, 118:2574-2582.
9. Anest V., Hanson J.L., Cogswell P.C., Steinbrecher K.A., Strahl B.D., Baldwin A.S. A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression. Nature 2003, 423:659-663.
10. Arunachalam G., Yao H., Sundar I.K., Caito S., Rahman I. SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: role of resveratrol. Biochem. Biophys. Res. Commun. 2010, 393:66-72.
11. Bannister A.J., Kouzarides T. Reversing histone methylation. Nature 2005, 436:1103-1106.
12. Barnes P.J., Ito K., Adcock I.M. Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase. Lancet 2004, 363:731-733.
13. Beeh K.M., Kornmann O., Buhl R., Culpitt S.V., Giembycz M.A., Barnes P.J. Neutrophil chemotactic activity of sputum from patients with COPD: role of interleukin 8 and leukotriene B4. Chest 2003, 123:1240-1247.
14. Bertolotti A., Wang X., Novoa I., Jungreis R., Schlessinger K., Cho J.H., West A.B., Ron D. Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice. J. Clin. Invest. 2001, 107:585-593.
15. Bessac B.F., Sivula M., von Hehn C.A., Escalera J., Cohn L., Jordt S.E. TRPA1 is a major oxidant sensor in murine airway sensory neurons. J. Clin. Invest. 2008, 118:1899-1910.
16. Biswal S., Rangasamy T., Sussan T.E., Yates M., Sporn M., Kensler T., Tuder R.M. NRF2 protects mice from cigarette smoke-induced emphysema. FASEB J. 2008, 22:7.
17. Blake D.J., Singh A., Kombairaju P., Malhotra D., Mariani T.J., Tuder R.M., Gabrielson E., Biswal S. Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation. Am. J. Respir. Cell Mol. Biol. 2010, 42:524-536.
18. Borchers M.T., Wesselkamper S.C., Curull V., Ramirez-Sarmiento A., Sanchez-Font A., Garcia-Aymerich J., Coronell C., Lloreta J., Agusti A.G., Gea J., Howington J.A., Reed M.F., Starnes S.L., Harris N.L., Vitucci M., Eppert B.L., Motz G.T., Fogel K., McGraw D.W., Tichelaar J.W., Orozco-Levi M. Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease. J. Clin. Invest. 2009, 119:636-649.
19. Borchers M.T., Wesselkamper S.C., Eppert B.L., Motz G.T., Sartor M.A., Tomlinson C.R., Medvedovic M., Tichelaar J.W. Nonredundant functions of alphabeta and gammadelta T cells in acrolein-induced pulmonary pathology. Toxicol. Sci. 2008, 105:188-199.
20. Borchers M.T., Wesselkamper S.C., Harris N.L., Deshmukh H., Beckman E., Vitucci M., Tichelaar J.W., Leikauf G.D. CD8+ T cells contribute to macrophage accumulation and airspace enlargement following repeated irritant exposure. Exp. Mol. Pathol. 2007, 83:301-310.
21. Bowie A., O'Neill L.A. Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries. Biochem. Pharmacol. 2000, 59:13-23.
22. Bracke K.R., D'Hulst A.I., Maes T., Demedts I.K., Moerloose K.B., Kuziel W.A., Joos G.F., Brusselle G.G. Cigarette smoke-induced pulmonary inflammation, but not airway remodelling, is attenuated in chemokine receptor 5-deficient mice. Clin. Exp. Allergy 2007, 37:1467-1479.
23. Caito S., Cook S., Yang S.R., Rajendrasozhan S., Rahman I. Sirtuin 1, an oxidant sensitive deacetylase, is posttraslationally modified and degraded by the proteasome in response to cigarette smoke in lung epithelial cells. FASEB J. 2008, 22:747.
24. Caito S., Rajendrasozhan S., Cook S., Chung S., Yao H., Friedman A.E., Brookes P.S., Rahman I. SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress. FASEB J. 2010, 24:3145-3159.
25. Calabrese F., Baraldo S., Bazzan E., Lunardi F., Rea F., Maestrelli P., Turato G., Lokar-Oliani K., Papi A., Zuin R., Sfriso P., Balestro E., Dinarello C.A., Saetta M. IL-32, a novel proinflammatory cytokine in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2008, 178:894-901.
26. Capelli A., Di Stefano A., Gnemmi I., Balbo P., Cerutti C.G., Balbi B., Lusuardi M., Donner C.F. Increased MCP-1 and MIP-1beta in bronchoalveolar lavage fluid of chronic bronchitics. Eur. Respir. J. 1999, 14:160-165.
27. Carrero P., Okamoto K., Coumailleau P., O'Brien S., Tanaka H., Poellinger L. Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha. Mol. Cell. Biol. 2000, 20:402-415.
28. Carrozza M.J., Utley R.T., Workman J.L., Cote J. The diverse functions of histone acetyltransferase complexes. Trends Genet. 2003, 19:321-329.
29. Celedon J.C., Lange C., Raby B.A., Litonjua A.A., Palmer L.J., DeMeo D.L., Reilly J.J., Kwiatkowski D.J., Chapman H.A., Laird N., Sylvia J.S., Hernandez M., Speizer F.E., Weiss S.T., Silverman E.K. The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum. Mol. Genet. 2004, 13:1649-1656.
30. Chen L., Fischle W., Verdin E., Greene W.C. Duration of nuclear NF-kappaB action regulated by reversible acetylation. Science 2001, 293:1653-1657.
31. Chen L.F., Greene W.C. Shaping the nuclear action of NF-kappaB. Nat. Rev. Mol. Cell Biol. 2004, 5:392-401.
32. Chen L.F., Mu Y., Greene W.C. Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB. EMBO J. 2002, 21:6539-6548.
33. Chen Z.H., Kim H.P., Lee J., Ryter S., Choi A.M.K. Egr-1 in regulation of cigarette smoking induced autophagy: relevance to chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2008, 177:A865.
34. Chen Z.H., Lam H.C., Jin Y., Kim H.P., Cao J., Lee S.J., Ifedigbo E., Parameswaran H., Ryter S.W., Choi A.M. Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema. Proc. Natl. Acad. Sci. U S A. 2010, 107:18880-18885.
35. Cheung P., Lau P. Epigenetic regulation by histone methylation and histone variants. Mol. Endocrinol. 2005, 19:563-573.
36. Cho H.Y., Kleeberger S.R. Nrf2 protects against airway disorders. Toxicol. Appl. Pharmacol. 2010, 244:43-56.
37. Christman J.W., Sadikot R.T., Blackwell T.S. The role of nuclear factor-kappa B in pulmonary diseases. Chest 2000, 117:1482-1487.
38. Church D.F., Pryor W.A. Free-radical chemistry of cigarette smoke and its toxicological implications. Environ. Health Perspect. 1985, 64:111-126.
39. Combadiere C., Gao J., Tiffany H.L., Murphy P.M. Gene cloning, RNA distribution, and functional expression of mCX3CR1, a mouse chemotactic receptor for the CX3C chemokine fractalkine. Biochem. Biophys. Res. Commun. 1998, 253:728-732.
40. Combadiere C., Salzwedel K., Smith E.D., Tiffany H.L., Berger E.A., Murphy P.M. Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1. J. Biol. Chem. 1998, 273:23799-23804.
41. Cosio B.G., Tsaprouni L., Ito K., Jazrawi E., Adcock I.M., Barnes P.J. Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. J. Exp. Med. 2004, 200:689-695.
42. Costa C., Rufino R., Traves S.L., Lapa E.S.J.R., Barnes P.J., Donnelly L.E. CXCR3 and CCR5 chemokines in induced sputum from patients with COPD. Chest 2008, 133:26-33.
43. Csiszar A., Labinskyy N., Podlutsky A., Kaminski P.M., Wolin M.S., Zhang C., Mukhopadhyay P., Pacher P., Hu F., de Cabo R., Ballabh P., Ungvari Z. Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations. Am. J. Physiol. Heart Circ. Physiol. 2008, 294:H2721-H2735.
44. Cullinan S.B., Diehl J.A. PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress. J. Biol. Chem. 2004, 279:20108-20117.
45. Cullinan S.B., Zhang D., Hannink M., Arvisais E., Kaufman R.J., Diehl J.A. Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol. Cell. Biol. 2003, 23:7198-7209.
46. Dahl M., Bowler R.P., Juul K., Crapo J.D., Levy S., Nordestgaard B.G. Superoxide dismutase 3 polymorphism associated with reduced lung function in two large populations. Am. J. Respir. Crit. Care Med. 2008, 178:906-912.
47. De Boer W.I. Cytokines and therapy in COPD: a promising combination?. Chest 2002, 121:209S-218S.
48. De Boer W.I., Alagappan V.K., Sharma H.S. Molecular mechanisms in chronic obstructive pulmonary disease: potential targets for therapy. Cell Biochem. Biophys. 2007, 47:131-148.
49. de Boer W.I., Sont J.K., van Schadewijk A., Stolk J., van Krieken J.H., Hiemstra P.S. Monocyte chemoattractant protein 1, interleukin 8, and chronic airways inflammation in COPD. J. Pathol. 2000, 190:619-626.
50. De Boer W.I., Yao H., Rahman I. Future therapeutic treatment of COPD: struggle between oxidants and cytokines. Int. J. Chron. Obstruct. Pulmon. Dis. 2007, 2:205-228.
51. de Ruijter A.J., van Gennip A.H., Caron H.N., Kemp S., van Kuilenburg A.B. Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem. J. 2003, 370:737-749.
52. Decramer M., Rutten-van Molken M., Dekhuijzen P.N., Troosters T., van Herwaarden C., Pellegrino R., van Schayck C.P., Olivieri D., Del Donno M., De Backer W., Lankhorst I., Ardia A. Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial. Lancet 2005, 365:1552-1560.
53. Dekhuijzen P.N. Antioxidant properties of N-acetylcysteine: their relevance in relation to chronic obstructive pulmonary disease. Eur. Respir. J. 2004, 23:629-636.
54. Dentener M.A., Creutzberg E.C., Pennings H.J., Rijkers G.T., Mercken E., Wouters E.F. Effect of infliximab on local and systemic inflammation in chronic obstructive pulmonary disease: a pilot study. Respiration 2008, 76:275-282.
55. Di Stefano A., Caramori G., Oates T., Capelli A., Lusuardi M., Gnemmi I., Ioli F., Chung K.F., Donner C.F., Barnes P.J., Adcock I.M. Increased expression of nuclear factor-kappaB in bronchial biopsies from smokers and patients with COPD. Eur. Respir. J. 2002, 20:556-563.
56. Dinarello C.A. IL-18: a TH1-inducing, proinflammatory cytokine and new member of the IL-1 family. J. Allergy Clin. Immunol. 1999, 103:11-24.
57. Donnelly L.E., Barnes P.J. Chemokine receptors as therapeutic targets in chronic obstructive pulmonary disease. Trends Pharmacol. Sci. 2006, 27:546-553.
58. Duran A., Diaz-Meco M.T., Moscat J. Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation. EMBO J. 2003, 22:3910-3918.
59. Edirisinghe I., Yang S.R., Yao H., Rajendrasozhan S., Caito S., Adenuga D., Wong C., Rahman A., Phipps R.P., Jin Z.G., Rahman I. VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction. FASEB J. 2008, 22:2297-2310.
60. El Moussaoui R., Roede B.M., Speelman P., Bresser P., Prins J.M., Bossuyt P.M. Short-course antibiotic treatment in acute exacerbations of chronic bronchitis and COPD: a meta-analysis of double-blind studies. Thorax 2008, 63:415-422.
61. Facchinetti F., Amadei F., Geppetti P., Tarantini F., Di Serio C., Dragotto A., Gigli P.M., Catinella S., Civelli M., Patacchini R. Alpha, beta-unsaturated aldehydes in cigarette smoke release inflammatory mediators from human macrophages. Am. J. Respir. Cell Mol. Biol. 2007, 37:617-623.
62. Feghali-Bostwick C.A., Gadgil A.S., Otterbein L.E., Pilewski J.M., Stoner M.W., Csizmadia E., Zhang Y., Sciurba F.C., Duncan S.R. Autoantibodies in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2008, 177:156-163.
63. Ferrer E., Peinado V.I., Diez M., Carrasco J.L., Musri M.M., Martinez A., Rodriguez-Roisin R., Barbera J.A. Effects of cigarette smoke on endothelial function of pulmonary arteries in the guinea pig. Respir. Res. 2009, 10:76-87.
64. Foronjy R.F., Mirochnitchenko O., Propokenko O., Lemaitre V., Jia Y., Inouye M., Okada Y., D'Armiento J.M. Superoxide dismutase expression attenuates cigarette smoke- or elastase-generated emphysema in mice. Am. J. Respir. Crit. Care Med. 2006, 173:623-631.
65. Franciosi L.G., Page C.P., Celli B.R., Cazzola M., Walker M.J., Danhof M., Rabe K.F., Della Pasqua O.E. Markers of disease severity in chronic obstructive pulmonary disease. Pulm. Pharmacol. Ther. 2006, 19:189-199.
66. Furukawa A., Tada-Oikawa S., Kawanishi S., Oikawa S. H2O2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of SIRT1 by NAD+depletion. Cell. Physiol. Biochem. 2007, 20:45-54.
67. Galasinski S.C., Resing K.A., Goodrich J.A., Ahn N.G. Phosphatase inhibition leads to histone deacetylases 1 and 2 phosphorylation and disruption of corepressor interactions. J. Biol. Chem. 2002, 277:19618-19626.
68. Ganguly K., Stoeger T., Wesselkamper S.C., Reinhard C., Sartor M.A., Medvedovic M., Tomlinson C.R., Bolle I., Mason J.M., Leikauf G.D., Schulz H. Candidate genes controlling pulmonary function in mice: transcript profiling and predicted protein structure. Physiol. Genomics 2007, 31:410-421.
69. Gargalovic P.S., Gharavi N.M., Clark M.J., Pagnon J., Yang W.P., He A., Truong A., Baruch-Oren T., Berliner J.A., Kirchgessner T.G., Lusis A.J. The unfolded protein response is an important regulator of inflammatory genes in endothelial cells. Arterioscler. Thromb. Vasc. Biol. 2006, 26:2490-2496.
70. Georgiou E., Valeri R., Tzimagiorgis G., Anzel J., Krikelis D., Tsilikas C., Sarikos G., Destouni C., Dimitriadou A., Kouidou S. Aberrant p16 promoter methylation among Greek lung cancer patients and smokers: correlation with smoking. Eur. J. Cancer Prev. 2007, 16:396-402.
71. Ghosh S., Karin M. Missing pieces in the NF-kappaB puzzle. Cell 2002, 109(Suppl):S81-S96.
72. Gongora M.C., Lob H.E., Landmesser U., Guzik T.J., Martin W.D., Ozumi K., Wall S.M., Wilson D.S., Murthy N., Gravanis M., Fukai T., Harrison D.G. Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air: a potential mechanism underlying adult respiratory distress syndrome. Am. J. Pathol. 2008, 173:915-926.
73. Goven D., Boutten A., Lecon-Malas V., Marchal-Somme J., Amara N., Crestani B., Fournier M., Leseche G., Soler P., Boczkowski J., Bonay M. Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema. Thorax 2008, 63:916-924.
74. Gracie J.A., Robertson S.E., McInnes I.B. Interleukin-18. J. Leukoc. Biol. 2003, 73:213-224.
75. Grumelli S., Corry D.B., Song L.Z., Song L., Green L., Huh J., Hacken J., Espada R., Bag R., Lewis D.E., Kheradmand F. An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. PLoS Med. 2004, 1:e8-e17.
76. Hardaker E.L., Bacon A.M., Carlson K., Roshak A.K., Foley J.J., Schmidt D.B., Buckley P.T., Comegys M., Panettieri R.A., Sarau H.M., Belmonte K.E. Regulation of TNF-alpha- and IFN-gamma-induced CXCL10 expression: participation of the airway smooth muscle in the pulmonary inflammatory response in chronic obstructive pulmonary disease. FASEB J. 2004, 18:191-193.
77. Harding H.P., Zhang Y., Zeng H., Novoa I., Lu P.D., Calfon M., Sadri N., Yun C., Popko B., Paules R., Stojdl D.F., Bell J.C., Hettmann T., Leiden J.M., Ron D. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol. Cell 2003, 11:619-633.
78. Harju T., Kaarteenaho-Wiik R., Sirvio R., Paakko P., Crapo J.D., Oury T.D., Soini Y., Kinnula V.L. Manganese superoxide dismutase is increased in the airways of smokers' lungs. Eur. Respir. J. 2004, 24:765-771.
79. Harju T., Kaarteenaho-Wiik R., Soini Y., Sormunen R., Kinnula V.L. Diminished immunoreactivity of gamma-glutamylcysteine synthetase in the airways of smokers' lung. Am. J. Respir. Crit. Care Med. 2002, 166:754-759.
80. Harrison D.J., Cantlay A.M., Rae F., Lamb D., Smith C.A. Frequency of glutathione S-transferase M1 deletion in smokers with emphysema and lung cancer. Hum. Exp. Toxicol. 1997, 16:356-360.
81. He J.Q., Ruan J., Connett J.E., Anthonisen N.R., Pare P.D., Sandford A.J. Antioxidant gene polymorphisms and susceptibility to a rapid decline in lung function in smokers. Am. J. Respir. Crit. Care Med. 2002, 166:323-328.
82. Hengstermann A., Muller T. Endoplasmic reticulum stress induced by aqueous extracts of cigarette smoke in 3T3 cells activates the unfolded-protein-response-dependent PERK pathway of cell survival. Free Radic. Biol. Med. 2008, 44:1097-1107.
83. Hogg J.C. Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet 2004, 364:709-721.
84. Hogg J.C., Chu F., Utokaparch S., Woods R., Elliott W.M., Buzatu L., Cherniack R.M., Rogers R.M., Sciurba F.C., Coxson H.O., Pare P.D. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N. Engl. J. Med. 2004, 350:2645-2653.
85. Hoshino T., Kato S., Oka N., Imaoka H., Kinoshita T., Takei S., Kitasato Y., Kawayama T., Imaizumi T., Yamada K., Young H.A., Aizawa H. Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13. Am. J. Respir. Crit. Care Med. 2007, 176:49-62.
86. Hoshino T., Wiltrout R.H., Young H.A. IL-18 is a potent coinducer of IL-13 in NK and T cells: a new potential role for IL-18 in modulating the immune response. J. Immunol. 1999, 162:5070-5077.
87. Hoshino T., Yagita H., Ortaldo J.R., Wiltrout R.H., Young H.A. In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand (CD154) expression on CD4+ T cells. Eur. J. Immunol. 2000, 30:1998-2006.
88. Hung C.C., Ichimura T., Stevens J.L., Bonventre J.V. Protection of renal epithelial cells against oxidative injury by endoplasmic reticulum stress preconditioning is mediated by ERK1/2 activation. J. Biol. Chem. 2003, 278:29317-29326.
89. Hwang J.W., Chung S., Sundar I.K., Yao H., Arunachalam G., McBurney M.W., Rahman I. Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD. Arch. Biochem. Biophys. 2010, 500:203-209.
90. Ichinose M., Sugiura H., Yamagata S., Koarai A., Shirato K. Increase in reactive nitrogen species production in chronic obstructive pulmonary disease airways. Am. J. Respir. Crit. Care Med. 2000, 162:701-706.
91. Igishi T., Hitsuda Y., Kato K., Sako T., Burioka N., Yasuda K., Sano H., Shigeoka Y., Nakanishi H., Shimizu E. Elevated urinary 8-hydroxydeoxyguanosine, a biomarker of oxidative stress, and lack of association with antioxidant vitamins in chronic obstructive pulmonary disease. Respirology 2003, 8:455-460.
92. Iizuka T., Ishii Y., Itoh K., Kiwamoto T., Kimura T., Matsuno Y., Morishima Y., Hegab A.E., Homma S., Nomura A., Sakamoto T., Shimura M., Yoshida A., Yamamoto M., Sekizawa K. Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema. Genes Cells 2005, 10:1113-1125.
93. Imaoka H., Hoshino T., Takei S., Kinoshita T., Okamoto M., Kawayama T., Kato S., Iwasaki H., Watanabe K., Aizawa H. Interleukin-18 production and pulmonary function in COPD. Eur. Respir. J. 2008, 31:287-297.
94. Imhof A., Wolffe A.P. Transcription: gene control by targeted histone acetylation. Curr. Biol. 1998, 8:R422-R424.
95. Ishii Y., Itoh K., Morishima Y., Kimura T., Kiwamoto T., Iizuka T., Hegab A.E., Hosoya T., Nomura A., Sakamoto T., Yamamoto M., Sekizawa K. Transcription factor Nrf2 plays a pivotal role in protection against elastase-induced pulmonary inflammation and emphysema. J. Immunol. 2005, 175:6968-6975.
96. Ito K., Barnes P.J., Adcock I.M. Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12. Mol. Cell. Biol. 2000, 20:6891-6903.
97. Ito K., Charron C.E., Adcock I.M. Impact of protein acetylation in inflammatory lung diseases. Pharmacol. Ther. 2007, 116:249-265.
98. Ito K., Ito M., Elliott W.M., Cosio B., Caramori G., Kon O.M., Barczyk A., Hayashi S., Adcock I.M., Hogg J.C., Barnes P.J. Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N. Engl. J. Med. 2005, 352:1967-1976.
99. Ito K., Yamamura S., Essilfie-Quaye S., Cosio B., Ito M., Barnes P.J., Adcock I.M. Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression. J. Exp. Med. 2006, 203:7-13.
100. Jorgensen E.D., Stinson A., Shan L., Yang J., Gietl D., Albino A.P. Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells. BMC Cancer 2008, 8:229.
101. Juul K., Tybjaerg-Hansen A., Marklund S., Lange P., Nordestgaard B.G. Genetically increased antioxidative protection and decreased chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2006, 173:858-864.
102. Kamei Y., Xu L., Heinzel T., Torchia J., Kurokawa R., Gloss B., Lin S.C., Heyman R.A., Rose D.W., Glass C.K., Rosenfeld M.G. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 1996, 85:403-414.
103. Kang M.J., Homer R.J., Gallo A., Lee C.G., Crothers K.A., Cho S.J., Rochester C., Cain H., Chupp G., Yoon H.J., Elias J.A. IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation. J. Immunol. 2007, 178:1948-1959.
104. Kang M.J., Lee C.G., Lee J.Y., Dela Cruz C.S., Chen Z.J., Enelow R., Elias J.A. Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice. J. Clin. Invest. 2008, 118:2771-2784.
105. Kasahara Y., Tuder R.M., Cool C.D., Lynch D.A., Flores S.C., Voelkel N.F. Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. Am. J. Respir. Crit. Care Med. 2001, 163:737-744.
106. Kassim S.Y., Fu X., Liles W.C., Shapiro S.D., Parks W.C., Heinecke J.W. NADPH oxidase restrains the matrix metalloproteinase activity of macrophages. J. Biol. Chem. 2005, 280:30201-30205.
107. Kawahara T.L., Michishita E., Adler A.S., Damian M., Berber E., Lin M., McCord R.A., Ongaigui K.C., Boxer L.D., Chang H.Y., Chua K.F. SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell 2009, 136:62-74.
108. Keatings V.M., Cave S.J., Henry M.J., Morgan K., O'Connor C.M., FitzGerald M.X., Kalsheker N. A polymorphism in the tumor necrosis factor-alpha gene promoter region may predispose to a poor prognosis in COPD. Chest 2000, 118:971-975.
109. Keatings V.M., Collins P.D., Scott D.M., Barnes P.J. Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am. J. Respir. Crit. Care Med. 1996, 153:530-534.
110. Kelsen S.G., Duan X., Ji R., Perez O., Liu C., Merali S. Cigarette smoke induces an unfolded protein response in the human lung: a proteomic approach. Am. J. Respir. Cell Mol. Biol. 2008, 38:541-550.
111. Kim S.H., Han S.Y., Azam T., Yoon D.Y., Dinarello C.A. Interleukin-32: a cytokine and inducer of TNFalpha. Immunity 2005, 22:131-142.
112. Kinnula V.L. Focus on antioxidant enzymes and antioxidant strategies in smoking related airway diseases. Thorax 2005, 60:693-700.
113. Kode A., Rajendrasozhan S., Caito S., Yang S.R., Megson I.L., Rahman I. Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 2008, 294:L478-L488.
114. Kucukaycan M., Van Krugten M., Pennings H.J., Huizinga T.W., Buurman W.A., Dentener M.A., Wouters E.F. Tumor necrosis factor-alpha +489G/A gene polymorphism is associated with chronic obstructive pulmonary disease. Respir. Res. 2002, 3:29-35.
115. Lee I.H., Cao L., Mostoslavsky R., Lombard D.B., Liu J., Bruns N.E., Tsokos M., Alt F.W., Finkel T. A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc. Natl Acad. Sci. USA 2008, 105:3374-3379.
116. Lee K.Y., Ito K., Hayashi R., Jazrawi E.P., Barnes P.J., Adcock I.M. NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription. J. Immunol. 2006, 176:603-615.
117. Lee S.H., Goswami S., Grudo A., Song L.Z., Bandi V., Goodnight-White S., Green L., Hacken-Bitar J., Huh J., Bakaeen F., Coxson H.O., Cogswell S., Storness-Bliss C., Corry D.B., Kheradmand F. Antielastin autoimmunity in tobacco smoking-induced emphysema. Nat. Med. 2007, 13:567-569.
118. Leitges M., Sanz L., Martin P., Duran A., Braun U., Garcia J.F., Camacho F., Diaz-Meco M.T., Rennert P.D., Moscat J. Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway. Mol. Cell 2001, 8:771-780.
119. Liu H., Miller E., van de Water B., Stevens J.L. Endoplasmic reticulum stress proteins block oxidant-induced Ca2+ increases and cell death. J. Biol. Chem. 1998, 273:12858-12862.
120. Lukacs N.W., Hogaboam C.M., Kunkel S.L. Chemokines and their receptors in chronic pulmonary disease. Curr. Drug Targets Inflamm. Allergy 2005, 4:313-317.
121. Luo J., Li M., Tang Y., Laszkowska M., Roeder R.G., Gu W. Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc. Natl Acad. Sci. USA 2004, 101:2259-2264.
122. Macnee W., Rahman I. Oxidants and antioxidants as therapeutic targets in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1999, 160:S58-S65.
123. MacNee W., Tuder R.M. New paradigms in the pathogenesis of chronic obstructive pulmonary disease I. Proc. Am. Thorac. Soc. 2009, 6:527-531.
124. Mahler D.A., Huang S., Tabrizi M., Bell G.M. Efficacy and safety of a monoclonal antibody recognizing interleukin-8 in COPD: a pilot study. Chest 2004, 126:926-934.
125. Mak J.C., Ho S.P., Yu W.C., Choo K.L., Chu C.M., Yew W.W., Lam W.K., Chan-Yeung M. Polymorphisms and functional activity in superoxide dismutase and catalase genes in smokers with COPD. Eur. Respir. J. 2007, 30:684-690.
126. Malhotra D., Thimmulappa R., Navas-Acien A., Sandford A., Elliott M., Singh A., Chen L., Zhuang X., Hogg J., Pare P., Tuder R.M., Biswal S. Decline in NRF2 regulated antioxidants in COPD lungs due to loss of its positive regulator DJ-1. Am. J. Respir. Crit. Care Med. 2008, 178:592-604.
127. Mattagajasingh I., Kim C.S., Naqvi A., Yamamori T., Hoffman T.A., Jung S.B., DeRicco J., Kasuno K., Irani K. SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proc. Natl Acad. Sci. USA 2007, 104:14855-14860.
128. McComb J.G., Ranganathan M., Liu X.H., Pilewski J.M., Ray P., Watkins S.C., Choi A.M., Lee J.S. CX3CL1 up-regulation is associated with recruitment of CX3CR1+ mononuclear phagocytes and T lymphocytes in the lungs during cigarette smoke-induced emphysema. Am. J. Pathol. 2008, 173:949-961.
129. Meja K.K., Rajendrasozhan S., Adenuga D., Biswas S.K., Sundar I.K., Spooner G., Marwick J.A., Chakravarty P., Fletcher D., Whittaker P., Megson I.L., Kirkham P.A., Rahman I. Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. Am. J. Respir. Cell Mol. Biol. 2008, 39:312-323.
130. Michaud S.E., Dussault S., Groleau J., Haddad P., Rivard A. Cigarette smoke exposure impairs VEGF-induced endothelial cell migration: role of NO and reactive oxygen species. J. Mol. Cell. Cardiol. 2006, 41:275-284.
131. Michishita E., McCord R.A., Berber E., Kioi M., Padilla-Nash H., Damian M., Cheung P., Kusumoto R., Kawahara T.L., Barrett J.C., Chang H.Y., Bohr V.A., Ried T., Gozani O., Chua K.F. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature 2008, 452:492-496.
132. Milne J.C., Denu J.M. The Sirtuin family: therapeutic targets to treat diseases of aging. Curr. Opin. Chem. Biol. 2008, 12:11-17.
133. Milne J.C., Lambert P.D., Schenk S., Carney D.P., Smith J.J., Gagne D.J., Jin L., Boss O., Perni R.B., Vu C.B., Bemis J.E., Xie R., Disch J.S., Ng P.Y., Nunes J.J., Lynch A.V., Yang H., Galonek H., Israelian K., Choy W., Iffland A., Lavu S., Medvedik O., Sinclair D.A., Olefsky J.M., Jirousek M.R., Elliott P.J., Westphal C.H. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 2007, 450:712-716.
134. Miotto D., Ruggieri M.P., Boschetto P., Cavallesco G., Papi A., Bononi I., Piola C., Murer B., Fabbri L.M., Mapp C.E. Interleukin-13 and -4 expression in the central airways of smokers with chronic bronchitis. Eur. Respir. J. 2003, 22:602-608.
135. Mojtahedi Z. An assumption on possible long-term side effects of CCR5 antagonists. HIV Clin. Trials 2006, 7:215-217.
136. Moretti M., Bottrighi P., Dallari R., Da Porto R., Dolcetti A., Grandi P., Garuti G., Guffanti E., Roversi P., De Gugliemo M., Potena A. The effect of long-term treatment with erdosteine on chronic obstructive pulmonary disease: the EQUALIFE Study. Drugs Exp. Clin. Res. 2004, 30:143-152.
137. Morrison D., Strieter R.M., Donnelly S.C., Burdick M.D., Kunkel S.L., MacNee W. Neutrophil chemokines in bronchoalveolar lavage fluid and leukocyte-conditioned medium from nonsmokers and smokers. Eur. Respir. J. 1998, 12:1067-1072.
138. Motz G.T., Eppert B.L., Sun G., Wesselkamper S.C., Linke M.J., Deka R., Borchers M.T. Persistence of lung CD8 T cell oligoclonal expansions upon smoking cessation in a mouse model of cigarette smoke-induced emphysema. J. Immunol. 2008, 181:8036-8043.
139. Murooka T.T., Wong M.M., Rahbar R., Majchrzak-Kita B., Proudfoot A.E., Fish E.N. CCL5-CCR5-mediated apoptosis in T cells: requirement for glycosaminoglycan binding and CCL5 aggregation. J. Biol. Chem. 2006, 281:25184-25194.
140. Nakamaru Y., Vuppusetty C., Wada H., Milne J.C., Ito M., Rossios C., Elliot M., Hogg J., Kharitonov S., Goto H., Bemis J.E., Elliott P., Barnes P.J., Ito K. A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9. FASEB J. 2009, 23:2810-2819.
141. Nan X., Ng H.H., Johnson C.A., Laherty C.D., Turner B.M., Eisenman R.N., Bird A. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 1998, 393:386-389.
142. Netea M.G., Azam T., Ferwerda G., Girardin S.E., Walsh M., Park J.S., Abraham E., Kim J.M., Yoon D.Y., Dinarello C.A., Kim S.H. IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism. Proc. Natl Acad. Sci. USA 2005, 102:16309-16314.
143. Niess J.H., Brand S., Gu X., Landsman L., Jung S., McCormick B.A., Vyas J.M., Boes M., Ploegh H.L., Fox J.G., Littman D.R., Reinecker H.C. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 2005, 307:254-258.
144. Ning W., Li C.J., Kaminski N., Feghali-Bostwick C.A., Alber S.M., Di Y.P., Otterbein S.L., Song R., Hayashi S., Zhou Z., Pinsky D.J., Watkins S.C., Pilewski J.M., Sciurba F.C., Peters D.G., Hogg J.C., Choi A.M. Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease. Proc. Natl Acad. Sci. USA 2004, 101:14895-14900.
145. Nisoli E., Tonello C., Cardile A., Cozzi V., Bracale R., Tedesco L., Falcone S., Valerio A., Cantoni O., Clementi E., Moncada S., Carruba M.O. Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 2005, 310:314-317.
146. Nozik-Grayck E., Suliman H.B., Majka S., Albietz J., Van Rheen Z., Roush K., Stenmark K.R. Lung EC-SOD overexpression attenuates hypoxic induction of Egr-1 and chronic hypoxic pulmonary vascular remodeling. Am. J. Physiol. Lung Cell. Mol. Physiol. 2008, 295:L422-L430.
147. Ota H., Akishita M., Eto M., Iijima K., Kaneki M., Ouchi Y. Sirt1 modulates premature senescence-like phenotype in human endothelial cells. J. Mol. Cell. Cardiol. 2007, 43:571-579.
148. Ota H., Eto M., Kano M.R., Ogawa S., Iijima K., Akishita M., Ouchi Y. Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells. Arterioscler. Thromb. Vasc. Biol. 2008, 28:1634-1639.
149. Pantano C., Reynaert N.L., van der Vliet A., Janssen-Heininger Y.M. Redox-sensitive kinases of the nuclear factor-kappaB signaling pathway. Antioxid. Redox Signal. 2006, 8:1791-1806.
150. Park J.W., Kim H.P., Lee S.J., Wang X., Wang Y., Ifedigbo E., Watkins S.C., Ohba M., Ryter S.W., Vyas Y.M., Choi A.M. Protein kinase C alpha and zeta differentially regulate death-inducing signaling complex formation in cigarette smoke extract-induced apoptosis. J. Immunol. 2008, 180:4668-4678.
151. Pesci A., Balbi B., Majori M., Cacciani G., Bertacco S., Alciato P., Donner C.F. Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease. Eur. Respir. J. 1998, 12:380-386.
152. Petersen A.M., Penkowa M., Iversen M., Frydelund-Larsen L., Andersen J.L., Mortensen J., Lange P., Pedersen B.K. Elevated levels of IL-18 in plasma and skeletal muscle in chronic obstructive pulmonary disease. Lung 2007, 185:161-171.
153. Petrache I., Medler T.R., Richter A.T., Kamocki K., Chukwueke U., Zhen L., Gu Y., Adamowicz J., Schweitzer K.S., Hubbard W.C., Berdyshev E.V., Lungarella G., Tuder R.M. Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramide. Am. J. Physiol. Lung Cell. Mol. Physiol. 2008, 295:L44-L53.
154. Pinamonti S., Leis M., Barbieri A., Leoni D., Muzzoli M., Sostero S., Chicca M.C., Carrieri A., Ravenna F., Fabbri L.M., Ciaccia A. Detection of xanthine oxidase activity products by EPR and HPLC in bronchoalveolar lavage fluid from patients with chronic obstructive pulmonary disease. Free Radic. Biol. Med. 1998, 25:771-779.
155. Porter J.C., Falzon M., Hall A. Polarized localization of epithelial CXCL11 in chronic obstructive pulmonary disease and mechanisms of T cell egression. J. Immunol. 2008, 180:1866-1877.
156. Potente M., Dimmeler S. Emerging roles of SIRT1 in vascular endothelial homeostasis. Cell Cycle 2008, 7:2117-2122.
157. Potente M., Dimmeler S. NO targets SIRT1: a novel signaling network in endothelial senescence. Arterioscler. Thromb. Vasc. Biol. 2008, 28:1577-1579.
158. Rabe K.F., Hurd S., Anzueto A., Barnes P.J., Buist S.A., Calverley P., Fukuchi Y., Jenkins C., Rodriguez-Roisin R., van Weel C., Zielinski J. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am. J. Respir. Crit. Care Med. 2007, 176:532-555.
159. Rahman I., MacNee W. Oxidative stress and regulation of glutathione in lung inflammation. Eur. Respir. J. 2000, 16:534-554.
160. Rahman I., Marwick J., Kirkham P. Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-kappaB and proinflammatory gene expression. Biochem. Pharmacol. 2004, 68:1255-1267.
161. Rahman I., Morrison D., Donaldson K., MacNee W. Systemic oxidative stress in asthma, COPD, and smokers. Am. J. Respir. Crit. Care Med. 1996, 154:1055-1060.
162. Rahman I., van Schadewijk A.A., Crowther A.J., Hiemstra P.S., Stolk J., MacNee W., De Boer W.I. 4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2002, 166:490-495.
163. Rajendrasozhan S., Yang S.R., Caito S., Rahman I. Nucleocytoplasmic shuttling and post-translational modifications of sirtuin in response to cigarette smoke lead to increased acetylation of NF-kappaB and FOXO3. Am. J. Respir. Crit. Care Med. 2008, 177:A266.
164. Rajendrasozhan S., Yang S.R., Kinnula V.L., Rahman I. SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2008, 177:861-870.
165. Rangasamy T., Cho C.Y., Thimmulappa R.K., Zhen L., Srisuma S.S., Kensler T.W., Yamamoto M., Petrache I., Tuder R.M., Biswal S. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J. Clin. Invest. 2004, 114:1248-1259.
166. Rennard S.I., Fogarty C., Kelsen S., Long W., Ramsdell J., Allison J., Mahler D., Saadeh C., Siler T., Snell P., Korenblat P., Smith W., Kaye M., Mandel M., Andrews C., Prabhu R., Donohue J.F., Watt R., Lo K.H., Schlenker-Herceg R., Barnathan E.S., Murray J. The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2007, 175:926-934.
167. Repine J.E., Bast A., Lankhorst I. Oxidative stress in chronic obstructive pulmonary disease. Oxidative Stress Study Group. Am. J. Respir. Crit. Care Med. 1997, 156:341-357.
168. Ryter S.W., Chen Z.H., Kim H.P., Choi A.M. Autophagy in chronic obstructive pulmonary disease: homeostatic or pathogenic mechanism?. Autophagy 2009, 5:235-237.
169. Rytila P., Rehn T., Ilumets H., Rouhos A., Sovijarvi A., Myllarniemi M., Kinnula V.L. Increased oxidative stress in asymptomatic current chronic smokers and GOLD stage 0 COPD. Respir. Res. 2006, 7:69-79.
170. Saetta M., Mariani M., Panina-Bordignon P., Turato G., Buonsanti C., Baraldo S., Bellettato C.M., Papi A., Corbetta L., Zuin R., Sinigaglia F., Fabbri L.M. Increased expression of the chemokine receptor CXCR3 and its ligand CXCL10 in peripheral airways of smokers with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2002, 165:1404-1409.
171. Saha S., Brightling C.E. Eosinophilic airway inflammation in COPD. Int. J. Chron. Obstruct. Pulmon. Dis. 2006, 1:39-47.
172. Saha S., Doe C., Mistry V., Siddiqui S., Parker D., Sleeman M., Cohen E.S., Brightling C.E. Granulocyte-macrophage colony-stimulating factor expression in induced sputum and bronchial mucosa in asthma and COPD. Thorax 2009, 64:671-676.
173. Sandford A.J., Chagani T., Weir T.D., Connett J.E., Anthonisen N.R., Pare P.D. Susceptibility genes for rapid decline of lung function in the lung health study. Am. J. Respir. Crit. Care Med. 2001, 163:469-473.
174. Scherz-Shouval R., Shvets E., Elazar Z. Oxidation as a post-translational modification that regulates autophagy. Autophagy 2007, 3:371-373.
175. Scherz-Shouval R., Shvets E., Fass E., Shorer H., Gil L., Elazar Z. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J. 2007, 26:1749-1760.
176. Senftleben U., Cao Y., Xiao G., Greten F.R., Krahn G., Bonizzi G., Chen Y., Hu Y., Fong A., Sun S.C., Karin M. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 2001, 293:1495-1499.
177. Sengupta N., Seto E. Regulation of histone deacetylase activities. J. Cell. Biochem. 2004, 93:57-67.
178. Sethi J.M., Rochester C.L. Smoking and chronic obstructive pulmonary disease. Clin. Chest Med. 2000, 21:67-86. viii.
179. Sethi S., Mallia P., Johnston S.L. New paradigms in the pathogenesis of chronic obstructive pulmonary disease II. Proc. Am. Thorac. Soc. 2009, 6:532-534.
180. Shapiro S.D., Ingenito E.P. The pathogenesis of chronic obstructive pulmonary disease: advances in the past 100years. Am. J. Respir. Cell Mol. Biol. 2005, 32:367-372.
181. Siedlinski M., Postma D.S., van Diemen C.C., Blokstra A., Smit H.A., Boezen H.M. Lung function loss, smoking, vitamin C intake, and polymorphisms of the glutamate-cysteine ligase genes. Am. J. Respir. Crit. Care Med. 2008, 178:13-19.
182. Simon S.A., Liedtke W. How irritating: the role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airways. J. Clin. Invest. 2008, 118:2383-2386.
183. Singh A., Ling G., Suhasini A.N., Zhang P., Yamamoto M., Navas-Acien A., Cosgrove G., Tuder R.M., Kensler T.W., Watson W.H., Biswal S. Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs. Free Radic. Biol. Med. 2009, 46:376-386.
184. Siva R., Green R.H., Brightling C.E., Shelley M., Hargadon B., McKenna S., Monteiro W., Berry M., Parker D., Wardlaw A.J., Pavord I.D. Eosinophilic airway inflammation and exacerbations of COPD: a randomised controlled trial. Eur. Respir. J. 2007, 29:906-913.
185. Sizemore N., Lerner N., Dombrowski N., Sakurai H., Stark G.R. Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B. J. Biol. Chem. 2002, 277:3863-3869.
186. Soler N., Ewig S., Torres A., Filella X., Gonzalez J., Zaubet A. Airway inflammation and bronchial microbial patterns in patients with stable chronic obstructive pulmonary disease. Eur. Respir. J. 1999, 14:1015-1022.
187. Sullivan A.K., Simonian P.L., Falta M.T., Mitchell J.D., Cosgrove G.P., Brown K.K., Kotzin B.L., Voelkel N.F., Fontenot A.P. Oligoclonal CD4+ T cells in the lungs of patients with severe emphysema. Am. J. Respir. Crit. Care Med. 2005, 172:590-596.
188. Sussan T.E., Rangasamy T., Blake D.J., Malhotra D., El-Haddad H., Bedja D., Yates M.S., Kombairaju P., Yamamoto M., Liby K.T., Sporn M.B., Gabrielson K.L., Champion H.C., Tuder R.M., Kensler T.W., Biswal S. Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proc. Natl Acad. Sci. USA 2009, 106:250-255.
189. Suzuki M., Betsuyaku T., Ito Y., Nagai K., Nasuhara Y., Kaga K., Kondo S., Nishimura M. Down-regulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease. Am. J. Respir. Cell Mol. Biol. 2008, 39:673-682.
190. Thatcher T.H., McHugh N.A., Egan R.W., Chapman R.W., Hey J.A., Turner C.K., Redonnet M.R., Seweryniak K.E., Sime P.J., Phipps R.P. Role of CXCR2 in cigarette smoke-induced lung inflammation. Am. J. Physiol. Lung Cell. Mol. Physiol. 2005, 289:L322-L328.
191. Thomson S., Mahadevan L.C., Clayton A.L. MAP kinase-mediated signalling to nucleosomes and immediate-early gene induction. Semin. Cell Dev. Biol. 1999, 10:205-214.
192. Tomaki M., Sugiura H., Koarai A., Komaki Y., Akita T., Matsumoto T., Nakanishi A., Ogawa H., Hattori T., Ichinose M. Decreased expression of antioxidant enzymes and increased expression of chemokines in COPD lung. Pulm. Pharmacol. Ther. 2007, 20:596-605.
193. Traves S.L., Culpitt S.V., Russell R.E., Barnes P.J., Donnelly L.E. Increased levels of the chemokines GROalpha and MCP-1 in sputum samples from patients with COPD. Thorax 2002, 57:590-595.
194. Trevisani M., Siemens J., Materazzi S., Bautista D.M., Nassini R., Campi B., Imamachi N., Andre E., Patacchini R., Cottrell G.S., Gatti R., Basbaum A.I., Bunnett N.W., Julius D., Geppetti P. 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc. Natl Acad. Sci. USA 2007, 104:13519-13524.
195. Tsoumakidou M., Demedts I.K., Brusselle G.G., Jeffery P.K. Dendritic cells in chronic obstructive pulmonary disease: new players in an old game. Am. J. Respir. Crit. Care Med. 2008, 177:1180-1186.
196. Tuder R.M., Yun Y.H. It takes two to tango: cigarette smoke partners with viruses to promote emphysema. J. Clin. Invest. 2008, 118:15-19.
197. Turato G., Zuin R., Miniati M., Baraldo S., Rea F., Beghe B., Monti S., Formichi B., Boschetto P., Harari S., Papi A., Maestrelli P., Fabbri L.M., Saetta M. Airway inflammation in severe chronic obstructive pulmonary disease: relationship with lung function and radiologic emphysema. Am. J. Respir. Crit. Care Med. 2002, 166:105-110.
198. van der Pouw Kraan T.C., Kucukaycan M., Bakker A.M., Baggen J.M., van der Zee J.S., Dentener M.A., Wouters E.F., Verweij C.L. Chronic obstructive pulmonary disease is associated with the -1055 IL-13 promoter polymorphism. Genes Immun. 2002, 3:436-439.
199. van der Strate B.W., Postma D.S., Brandsma C.A., Melgert B.N., Luinge M.A., Geerlings M., Hylkema M.N., van den Berg A., Timens W., Kerstjens H.A. Cigarette smoke-induced emphysema: a role for the B cell?. Am. J. Respir. Crit. Care Med. 2006, 173:751-758.
200. van der Vlies D., Pap E.H., Post J.A., Celis J.E., Wirtz K.W. Endoplasmic reticulum resident proteins of normal human dermal fibroblasts are the major targets for oxidative stress induced by hydrogen peroxide. Biochem. J. 2002, 366:825-830.
201. Van Gool F., Galli M., Gueydan C., Kruys V., Prevot P.P., Bedalov A., Mostoslavsky R., Alt F.W., De Smedt T., Leo O. Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner. Nat. Med. 2009, 15:206-210.
202. van Overveld F.J., Demkow U., Gorecka D., de Backer W.A., Zielinski J. New developments in the treatment of COPD: comparing the effects of inhaled corticosteroids and N-acetylcysteine. J. Physiol. Pharmacol. 2005, 56(Suppl 4):135-142.
203. Vaziri H., Dessain S.K., Ng Eaton E., Imai S.I., Frye R.A., Pandita T.K., Guarente L., Weinberg R.A. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 2001, 107:149-159.
204. Vermeulen L., De Wilde G., Van Damme P., Vanden Berghe W., Haegeman G. Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). EMBO J. 2003, 22:1313-1324.
205. Vlahos R., Bozinovski S., Hamilton J.A., Anderson G.P. Therapeutic potential of treating chronic obstructive pulmonary disease (COPD) by neutralising granulocyte macrophage-colony stimulating factor (GM-CSF). Pharmacol. Ther. 2006, 112:106-115.
206. Wang Z., Zang C., Rosenfeld J.A., Schones D.E., Barski A., Cuddapah S., Cui K., Roh T.Y., Peng W., Zhang M.Q., Zhao K. Combinatorial patterns of histone acetylations and methylations in the human genome. Nat. Genet. 2008, 40:897-903.
207. Widdowson K.L., Elliott J.D., Veber D.F., Nie H., Rutledge M.C., McCleland B.W., Xiang J.N., Jurewicz A.J., Hertzberg R.P., Foley J.J., Griswold D.E., Martin L., Lee J.M., White J.R., Sarau H.M. Evaluation of potent and selective small-molecule antagonists for the CXCR2 chemokine receptor. J. Med. Chem. 2004, 47:1319-1321.
208. Wright J.L., Churg A. Advances in the pathology of COPD. Histopathology 2006, 49:1-9.
209. Wright J.L., Churg A. Short-term exposure to cigarette smoke induces endothelial dysfunction in small intrapulmonary arteries: analysis using guinea pig precision cut lung slices. J. Appl. Physiol. 2008, 104:1462-1469.
210. Xiao G., Fong A., Sun S.C. Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation. J. Biol. Chem. 2004, 279:30099-30105.
211. Yagi O., Aoshiba K., Nagai A. Activation of nuclear factor-kappaB in airway epithelial cells in patients with chronic obstructive pulmonary disease. Respiration 2006, 73:610-616.
212. Yamamoto Y., Verma U.N., Prajapati S., Kwak Y.T., Gaynor R.B. Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression. Nature 2003, 423:655-659.
213. Yamato H., Sun J.P., Churg A., Wright J.L. Cigarette smoke-induced emphysema in guinea pigs is associated with diffusely decreased capillary density and capillary narrowing. Lab. Invest. 1996, 75:211-219.
214. Yang F., Tang E., Guan K., Wang C.Y. IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide. J. Immunol. 2003, 170:5630-5635.
215. Yang S.R., Chida A.S., Bauter M.R., Shafiq N., Seweryniak K., Maggirwar S.B., Kilty I., Rahman I. Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages. Am. J. Physiol. Lung Cell. Mol. Physiol. 2006, 291:L46-L57.
216. Yang S.R., Valvo S., Yao H., Kode A., Rajendrasozhan S., Edirisinghe I., Caito S., Adenuga D., Henry R., Fromm G., Maggirwar S., Li J.D., Bulger M., Rahman I. IKK alpha causes chromatin modification on proinflammatory genes by cigarette smoke in mouse lung. Am. J. Respir. Cell Mol. Biol. 2008, 38:689-698.
217. Yang S.R., Wright J., Bauter M., Seweryniak K., Kode A., Rahman I. Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging. Am. J. Physiol. Lung Cell. Mol. Physiol. 2007, 292:L567-L576.
218. Yang S.R., Yao H., Rajendrasozhan S., Chung S., Edirisinghe I., Valvo S., Fromm G., McCabe M.J., Sime P.J., Phipps R.P., Li J.D., Bulger M., Rahman I. RelB is differentially regulated by IkappaB kinase-alpha in B cells and mouse lung by cigarette smoke. Am. J. Respir. Cell Mol. Biol. 2009, 40:147-158.
219. Yang T., Sauve A.A. NAD metabolism and sirtuins: metabolic regulation of protein deacetylation in stress and toxicity. AAPS J. 2006, 8:E632-E643.
220. Yao H., Edirisinghe I., Yang S.R., Rajendrasozhan S., Kode A., Caito S., Adenuga D., Rahman I. Genetic ablation of NADPH oxidase enhances susceptibility to cigarette smoke-induced lung inflammation and emphysema in mice. Am. J. Pathol. 2008, 172:1222-1237.
221. Yao H., Edirisinghe I., Rajendrasozhan S., Yang S.R., Caito S., Adenuga D., Rahman I. Cigarette smoke-mediated inflammatory and oxidative responses are strain dependent in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 2008, 294:L1174-L1186.
222. Yao H., Arunachalam G., Hwang J.W., Chung S., Sundar I.K., Kinnula V.L., Crapo J.D., Rahman I. Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM. Proc. Natl. Acad. Sci. U S A. 2010, 107:15571-15576.
223. Yao H., Hwang J.W., Moscat J., Diaz-Meco M.T., Leitges M., Kishore N., Li X., Rahman I. Protein kinase C zeta mediates cigarette smoke/aldehyde- and lipopolysaccharide-induced lung inflammation and histone modifications. J. Biol. Chem. 2010, 285:5405-5416.
224. Yin L., Wu L., Wesche H., Arthur C.D., White J.M., Goeddel D.V., Schreiber R.D. Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice. Science 2001, 291:2162-2165.
225. Young R.P., Hopkins R., Black P.N., Eddy C., Wu L., Gamble G.D., Mills G.D., Garrett J.E., Eaton T.E., Rees M.I. Functional variants of antioxidant genes in smokers with COPD and in those with normal lung function. Thorax 2006, 61:394-399.
226. Zhang K., Kaufman R.J. From endoplasmic-reticulum stress to the inflammatory response. Nature 2008, 454:455-462.
227. Zhang Y., Reinberg D. Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails. Genes Dev. 2001, 15:2343-2360.
228. Zheng T., Zhu Z., Wang Z., Homer R.J., Ma B., Riese R.J., Chapman H.A., Shapiro S.D., Elias J.A. Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. J. Clin. Invest. 2000, 106:1081-1093.
229. Zochbauer-Muller S., Fong K.M., Virmani A.K., Geradts J., Gazdar A.F., Minna J.D. Aberrant promoter methylation of multiple genes in non-small cell lung cancers. Cancer Res. 2001, 61:249-255.