-
1
-
-
47849083585
-
Nrf2 signaling: An adaptive response pathway for protection against environmental toxic insults
-
W.O. Osburn, and T.W. Kensler Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults Mutat Res 659 2008 31 39
-
(2008)
Mutat Res
, vol.659
, pp. 31-39
-
-
Osburn, W.O.1
Kensler, T.W.2
-
2
-
-
20144385916
-
Transcriptional regulation of NF-E2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: Direct cross-talk between phase I and II drug-metabolizing enzymes
-
DOI 10.1074/jbc.M412081200
-
W. Miao, L. Hu, P.J. Scrivens, and G. Batist Transcriptional regulation of NF-E2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: direct cross-talk between phase I and II drug-metabolizing enzymes J Biol Chem 280 2005 20340 20348 (Pubitemid 40776732)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.21
, pp. 20340-20348
-
-
Miao, W.1
Hu, L.2
Scrivens, P.J.3
Batist, G.4
-
3
-
-
65549131476
-
Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level
-
X.J. Wang, and D.D. Zhang Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level PLoS One 4 2009 e5492
-
(2009)
PLoS One
, vol.4
, pp. 5492
-
-
Wang, X.J.1
Zhang, D.D.2
-
4
-
-
84864359086
-
Mechanism of chemical activation of Nrf2
-
Y. Li, J.D. Paonessa, and Y. Zhang Mechanism of chemical activation of Nrf2 PLoS One 7 2012 e35122
-
(2012)
PLoS One
, vol.7
, pp. 35122
-
-
Li, Y.1
Paonessa, J.D.2
Zhang, Y.3
-
5
-
-
0030451213
-
NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development
-
DOI 10.1073/pnas.93.24.13943
-
K. Chan, R. Lu, J.C. Chang, and Y.W.N.R.F2 Kan a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development Proc Natl Acad Sci USA 93 1996 13943 13948 (Pubitemid 26424225)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.24
, pp. 13943-13948
-
-
Chan, K.1
Lu, R.2
Chang, J.C.3
Kan, Y.W.4
-
6
-
-
0029043995
-
Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins
-
K. Itoh, K. Igarashi, N. Hayashi, M. Nishizawa, and M. Yamamoto Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins Mol Cell Biol 15 1995 4184 4193
-
(1995)
Mol Cell Biol
, vol.15
, pp. 4184-4193
-
-
Itoh, K.1
Igarashi, K.2
Hayashi, N.3
Nishizawa, M.4
Yamamoto, M.5
-
7
-
-
77649271223
-
The rise of antioxidant signaling - The evolution and hormetic actions of Nrf2
-
J. Maher, and M. Yamamoto The rise of antioxidant signaling - the evolution and hormetic actions of Nrf2 Toxicol Appl Pharmacol 244 2010 4 15
-
(2010)
Toxicol Appl Pharmacol
, vol.244
, pp. 4-15
-
-
Maher, J.1
Yamamoto, M.2
-
8
-
-
77953290236
-
Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver
-
N.R. Kitteringham, A. Abdullah, J. Walsh, L. Randle, R.E. Jenkins, and R. Sison Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver J Proteomics 73 2010 1612 1631
-
(2010)
J Proteomics
, vol.73
, pp. 1612-1631
-
-
Kitteringham, N.R.1
Abdullah, A.2
Walsh, J.3
Randle, L.4
Jenkins, R.E.5
Sison, R.6
-
9
-
-
70349140473
-
Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide
-
S. Shin, J. Wakabayashi, M.S. Yates, N. Wakabayashi, P.M. Dolan, and S. Aja Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide Eur J Pharmacol 620 2009 138 144
-
(2009)
Eur J Pharmacol
, vol.620
, pp. 138-144
-
-
Shin, S.1
Wakabayashi, J.2
Yates, M.S.3
Wakabayashi, N.4
Dolan, P.M.5
Aja, S.6
-
10
-
-
33750613056
-
Two-site substrate recognition model for the Keap1-Nrf2 system: A hinge and latch mechanism
-
DOI 10.1515/BC.2006.164, PII BCHM38710111311
-
K.I. Tong, A. Kobayashi, F. Katsuoka, and M. Yamamoto Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism Biol Chem 387 2006 1311 1320 (Pubitemid 44691409)
-
(2006)
Biological Chemistry
, vol.387
, Issue.10-11
, pp. 1311-1320
-
-
Tong, K.I.1
Kobayashi, A.2
Katsuoka, F.3
Yamamoto, M.4
-
11
-
-
0037763721
-
Regulatory Mechanisms Controlling Gene Expression Mediated by the Antioxidant Response Element
-
DOI 10.1146/annurev.pharmtox.43.100901.140229
-
T. Nguyen, P.J. Sherratt, and C.B. Pickett Regulatory mechanisms controlling gene expression mediated by the antioxidant response element Annu Rev Pharmacol Toxicol 43 2003 233 260 (Pubitemid 37372641)
-
(2003)
Annual Review of Pharmacology and Toxicology
, vol.43
, pp. 233-260
-
-
Nguyen, T.1
Sherratt, P.J.2
Pickett, C.B.3
-
12
-
-
0031577292
-
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
-
DOI 10.1006/bbrc.1997.6943
-
K. Itoh, T. Chiba, S. Takahashi, T. Ishii, K. Igarashi, and Y. Katoh An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements Biochem Biophys Res Commun 236 1997 313 322 (Pubitemid 27373291)
-
(1997)
Biochemical and Biophysical Research Communications
, vol.236
, Issue.2
, pp. 313-322
-
-
Itoh, K.1
Chiba, T.2
Takahashi, S.3
Ishii, T.4
Igarashi, K.5
Katoh, Y.6
Oyake, T.7
Hayashi, N.8
Satoh, K.9
Hatayama, I.10
Yamamoto, M.11
Nabeshima, Y.-I.12
-
13
-
-
0032874845
-
Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress
-
DOI 10.1080/10715769900300851
-
J.D. Hayes, and L.I. McLellan Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress Free Radic Res 31 1999 273 300 (Pubitemid 29452854)
-
(1999)
Free Radical Research
, vol.31
, Issue.4
, pp. 273-300
-
-
Hayes, J.D.1
McLellan, L.I.2
-
14
-
-
33744949194
-
Regulation of Nrf2 transactivation domain activity by p160 RAC3/SRC3 and other nuclear co-regulators
-
W. Lin, G. Shen, X. Yuan, M.R. Jain, S. Yu, and A. Zhang Regulation of Nrf2 transactivation domain activity by p160 RAC3/SRC3 and other nuclear co-regulators J Biochem Mol Biol 39 2006 304 310 (Pubitemid 43854546)
-
(2006)
Journal of Biochemistry and Molecular Biology
, vol.39
, Issue.3
, pp. 304-310
-
-
Lin, W.1
Shen, G.2
Yuan, X.3
Jain, M.R.4
Yu, S.5
Zhang, A.6
Chen, J.D.7
Kong, A.-N.T.8
-
15
-
-
0034522060
-
Chemoprotection by organosulfur inducers of phase 2 enzymes: Dithiolethiones and dithiins
-
T.W. Kensler, T.J. Curphey, Y. Maxiutenko, and B.D. Roebuck Chemoprotection by organosulfur inducers of phase 2 enzymes: dithiolethiones and dithiins Drug Metabol Drug Interact 17 2000 3 22 (Pubitemid 32047530)
-
(2000)
Drug Metabolism and Drug Interactions
, vol.17
, Issue.1-4
, pp. 3-22
-
-
Kensler, T.W.1
Curphey, T.J.2
Maxiutenko, Y.3
Roebuck, B.D.4
-
16
-
-
0037569694
-
Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element
-
DOI 10.1042/BJ20021619
-
E. Balogun, M. Hoque, P. Gong, E. Killeen, C.J. Green, and R. Foresti Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element Biochem J 371 2003 887 895 (Pubitemid 36578887)
-
(2003)
Biochemical Journal
, vol.371
, Issue.3
, pp. 887-895
-
-
Balogun, E.1
Hoque, M.2
Gong, P.3
Killeen, E.4
Green, C.J.5
Foresti, R.6
Alam, J.7
Motterlini, R.8
-
17
-
-
46949104416
-
Dietary curcumin modulates transcriptional regulators of phase I and phase II enzymes in benzo[a]pyrene-treated mice: Mechanism of its anti-initiating action
-
DOI 10.1093/carcin/bgn064
-
R. Garg, S. Gupta, and G.B. Maru Dietary curcumin modulates transcriptional regulators of phase I and phase II enzymes in benzo[a]pyrene-treated mice: mechanism of its anti-initiating action Carcinogenesis 29 2008 1022 1032 (Pubitemid 351982248)
-
(2008)
Carcinogenesis
, vol.29
, Issue.5
, pp. 1022-1032
-
-
Garg, R.1
Gupta, S.2
Maru, G.B.3
-
18
-
-
41549108838
-
Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells
-
A. Kode, S. Rajendrasozhan, S. Caito, S.R. Yang, I.L. Megson, and I. Rahman Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells Am J Physiol Lung Cell Mol Physiol 294 2008 L478 L488
-
(2008)
Am J Physiol Lung Cell Mol Physiol
, vol.294
-
-
Kode, A.1
Rajendrasozhan, S.2
Caito, S.3
Yang, S.R.4
Megson, I.L.5
Rahman, I.6
-
19
-
-
18844402874
-
Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells
-
C.Y. Chen, J.H. Jang, M.H. Li, and Y.J. Surh Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells Biochem Biophys Res Commun 331 2005 993 1000
-
(2005)
Biochem Biophys Res Commun
, vol.331
, pp. 993-1000
-
-
Chen, C.Y.1
Jang, J.H.2
Li, M.H.3
Surh, Y.J.4
-
20
-
-
33750885385
-
Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer
-
A. Singh, V. Misra, R.K. Thimmulappa, H. Lee, S. Ames, and M.O. Hoque Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer PLoS Med 3 2006 e420
-
(2006)
PLoS Med
, vol.3
, pp. 420
-
-
Singh, A.1
Misra, V.2
Thimmulappa, R.K.3
Lee, H.4
Ames, S.5
Hoque, M.O.6
-
21
-
-
40449107193
-
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
-
DOI 10.1158/0008-5472.CAN-07-5003
-
T. Ohta, K. Iijima, M. Miyamoto, I. Nakahara, H. Tanaka, and M. Ohtsuji Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth Cancer Res 68 2008 1303 1309 (Pubitemid 351346836)
-
(2008)
Cancer Research
, vol.68
, Issue.5
, pp. 1303-1309
-
-
Ohta, T.1
Iijima, K.2
Miyamoto, M.3
Nakahara, I.4
Tanaka, H.5
Ohtsuji, M.6
Suzuki, T.7
Kobayashi, A.8
Yokota, J.9
Sakiyama, T.10
Shibata, T.11
Yamamoto, M.12
Hirohashi, S.13
-
22
-
-
79953889329
-
Nrf2 is overexpressed in pancreatic cancer: Implications for cell proliferation and therapy
-
A. Lister, T. Nedjadi, N.R. Kitteringham, F. Campbell, E. Costello, and B. Lloyd Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy Mol Cancer 10 2011 37
-
(2011)
Mol Cancer
, vol.10
, pp. 37
-
-
Lister, A.1
Nedjadi, T.2
Kitteringham, N.R.3
Campbell, F.4
Costello, E.5
Lloyd, B.6
-
23
-
-
79960060305
-
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
-
G.M. DeNicola, F.A. Karreth, T.J. Humpton, A. Gopinathan, C. Wei, and K. Frese Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis Nature 475 2011 106 109
-
(2011)
Nature
, vol.475
, pp. 106-109
-
-
Denicola, G.M.1
Karreth, F.A.2
Humpton, T.J.3
Gopinathan, A.4
Wei, C.5
Frese, K.6
-
24
-
-
33847050801
-
Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
-
T.W. Kensler, N. Wakabayashi, and S. Biswal Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway Annu Rev Pharmacol Toxicol 47 2007 89 116
-
(2007)
Annu Rev Pharmacol Toxicol
, vol.47
, pp. 89-116
-
-
Kensler, T.W.1
Wakabayashi, N.2
Biswal, S.3
-
25
-
-
84863769005
-
The Keap1-Nrf2 cell defense pathway - A promising therapeutic target
-
I.M. Copple The Keap1-Nrf2 cell defense pathway - a promising therapeutic target Adv Pharmacol 63 2012 43 79
-
(2012)
Adv Pharmacol
, vol.63
, pp. 43-79
-
-
Copple, I.M.1
-
26
-
-
1242274394
-
Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes
-
DOI 10.1073/pnas.0308347100
-
M.I. Kang, A. Kobayashi, N. Wakabayashi, S.G. Kim, and M. Yamamoto Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes Proc Natl Acad Sci USA 101 2004 2046 2051 (Pubitemid 38229012)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.7
, pp. 2046-2051
-
-
Kang, M.-I.1
Kobayashi, A.2
Wakabayashi, N.3
Kim, S.-G.4
Yamamoto, M.5
-
27
-
-
0032953192
-
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
-
K. Itoh, N. Wakabayashi, Y. Katoh, T. Ishii, K. Igarashi, and J.D. Engel Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain Genes Dev 13 1999 76 86 (Pubitemid 29045117)
-
(1999)
Genes and Development
, vol.13
, Issue.1
, pp. 76-86
-
-
Itoh, K.1
Wakabayashi, N.2
Katoh, Y.3
Ishii, T.4
Igarashi, K.5
Engel, J.D.6
Yamamoto, M.7
-
28
-
-
0035963293
-
Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene
-
DOI 10.1038/sj.onc.1204506
-
S. Dhakshinamoorthy, and A.K. Jaiswal Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene Oncogene 20 2001 3906 3917 (Pubitemid 32646201)
-
(2001)
Oncogene
, vol.20
, Issue.29
, pp. 3906-3917
-
-
Dhakshinamoorthy, S.1
Jaiswal, A.K.2
-
29
-
-
0037183998
-
The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm
-
L.M. Zipper, and R.T. Mulcahy The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm J Biol Chem 277 2002 36544 36552
-
(2002)
J Biol Chem
, vol.277
, pp. 36544-36552
-
-
Zipper, L.M.1
Mulcahy, R.T.2
-
30
-
-
77958125017
-
Discovery of the negative regulator of Nrf2, Keap1: A historical overview
-
K. Itoh, J. Mimura, and M. Yamamoto Discovery of the negative regulator of Nrf2, Keap1: a historical overview Antioxid Redox Signal 13 2010 1665 1678
-
(2010)
Antioxid Redox Signal
, vol.13
, pp. 1665-1678
-
-
Itoh, K.1
Mimura, J.2
Yamamoto, M.3
-
31
-
-
0242329881
-
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
-
DOI 10.1038/ng1248
-
N. Wakabayashi, K. Itoh, J. Wakabayashi, H. Motohashi, S. Noda, and S. Takahashi Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation Nat Genet 35 2003 238 245 (Pubitemid 37363177)
-
(2003)
Nature Genetics
, vol.35
, Issue.3
, pp. 238-245
-
-
Wakabayashi, N.1
Itoh, K.2
Wakabayashi, J.3
Motohashi, H.4
Noda, S.5
Takahashi, S.6
Imakado, S.7
Kotsuji, T.8
Otsuka, F.9
Roop, D.R.10
Harada, T.11
Engel, J.D.12
Yamamoto, M.13
-
32
-
-
12444257799
-
Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles
-
DOI 10.1046/j.1365-2443.2003.00640.x
-
K. Itoh, N. Wakabayashi, Y. Katoh, T. Ishii, T. O'Connor, and M. Yamamoto Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles Genes Cells 8 2003 379 391 (Pubitemid 36504013)
-
(2003)
Genes to Cells
, vol.8
, Issue.4
, pp. 379-391
-
-
Itoh, K.1
Wakabayashi, N.2
Katoh, Y.3
Ishii, T.4
O'Connor, T.5
Yamamoto, M.6
-
33
-
-
0037377144
-
Heme activates the heme oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2
-
J. Alam, E. Killeen, P. Gong, R. Naquin, B. Hu, and D. Stewart Heme activates the heme oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2 Am J Physiol Renal Physiol 284 2003 F743 F752
-
(2003)
Am J Physiol Renal Physiol
, vol.284
-
-
Alam, J.1
Killeen, E.2
Gong, P.3
Naquin, R.4
Hu, B.5
Stewart, D.6
-
34
-
-
3543008924
-
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
-
DOI 10.1128/MCB.24.16.7130-7139.2004
-
A. Kobayashi, M.I. Kang, H. Okawa, M. Ohtsuji, Y. Zenke, and T. Chiba Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 Mol Cell Biol 24 2004 7130 7139 (Pubitemid 39014439)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.16
, pp. 7130-7139
-
-
Kobayashi, A.1
Kang, M.-I.2
Okawa, H.3
Ohtsuji, M.4
Zenke, Y.5
Chiba, T.6
Igarashi, K.7
Yamamoto, M.8
-
35
-
-
0037821802
-
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
-
DOI 10.1074/jbc.M300931200
-
M. McMahon, K. Itoh, M. Yamamoto, and J.D. Hayes Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression J Biol Chem 278 2003 21592 21600 (Pubitemid 36792558)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.24
, pp. 21592-21600
-
-
McMahon, M.1
Itoh, K.2
Yamamoto, M.3
Hayes, J.D.4
-
36
-
-
0035260034
-
Role of Transcription Factor Nrf2 in the Induction of Hepatic Phase 2 and Antioxidative Enzymes in vivo by the Cancer Chemoprotective Agent, 3H-1, 2-Dithiole-3-thione
-
M.K. Kwak, K. Itoh, M. Yamamoto, T.R. Sutter, and T.W. Kensler Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione Mol Med 7 2001 135 145 (Pubitemid 33702029)
-
(2001)
Molecular Medicine
, vol.7
, Issue.2
, pp. 135-145
-
-
Kwak, M.-K.1
Itoh, K.2
Yamamoto, M.3
Sutter, T.R.4
Kensler, T.W.5
-
37
-
-
0013282861
-
Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element: Degradation of Nrf2 by the 26 S proteasome
-
DOI 10.1074/jbc.M207293200
-
T. Nguyen, P.J. Sherratt, H.C. Huang, C.S. Yang, and C.B. Pickett Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome J Biol Chem 278 2003 4536 4541 (Pubitemid 36800950)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.7
, pp. 4536-4541
-
-
Nguyen, T.1
Sherratt, P.J.2
Huang, H.-C.3
Yang, C.S.4
Pickett, C.B.5
-
38
-
-
0036240610
-
Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: Role of antioxidant response element-like sequences in the nrf2 promoter
-
DOI 10.1128/MCB.22.9.2883-2892.2002
-
M.K. Kwak, K. Itoh, M. Yamamoto, and T.W. Kensler Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter Mol Cell Biol 22 2002 2883 2892 (Pubitemid 34437448)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.9
, pp. 2883-2892
-
-
Kwak, M.-K.1
Itoh, K.2
Yamamoto, M.3
Kensler, T.W.4
-
39
-
-
1642282736
-
Cellular mechanisms of redox cell signalling: Role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products
-
DOI 10.1042/BJ20031049
-
A.L. Levonen, A. Landar, A. Ramachandran, E.K. Ceaser, D.A. Dickinson, and G. Zanoni Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products Biochem J 378 2004 373 382 (Pubitemid 38367228)
-
(2004)
Biochemical Journal
, vol.378
, Issue.2
, pp. 373-382
-
-
Levonen, A.-L.1
Landar, A.2
Ramachandran, A.3
Ceaser, E.K.4
Dickinson, D.A.5
Zanoni, G.6
Morrow, J.D.7
Darley-Usmar, V.M.8
-
40
-
-
71449099635
-
Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance
-
S.K. Niture, A.K. Jain, and A.K. Jaiswal Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance J Cell Sci 122 2009 4452 4464
-
(2009)
J Cell Sci
, vol.122
, pp. 4452-4464
-
-
Niture, S.K.1
Jain, A.K.2
Jaiswal, A.K.3
-
41
-
-
68749091158
-
Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1
-
A.L. Eggler, E. Small, M. Hannink, and A.D. Mesecar Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1 Biochem J 422 2009 171 180
-
(2009)
Biochem J
, vol.422
, pp. 171-180
-
-
Eggler, A.L.1
Small, E.2
Hannink, M.3
Mesecar, A.D.4
-
42
-
-
34047273206
-
Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3
-
DOI 10.1074/jbc.M607622200
-
L. Gao, J. Wang, K.R. Sekhar, H. Yin, N.F. Yared, and S.N. Schneider Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3 J Biol Chem 282 2007 2529 2537 (Pubitemid 47076775)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.4
, pp. 2529-2537
-
-
Gao, L.1
Wang, J.2
Sekhar, K.R.3
Yin, H.4
Yared, N.F.5
Schneider, S.N.6
Sasi, S.7
Dalton, T.P.8
Anderson, M.E.9
Chan, J.Y.10
Morrow, J.D.11
Freeman, M.L.12
-
43
-
-
41849146057
-
Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3
-
DOI 10.1021/tx700302s
-
G. Rachakonda, Y. Xiong, K.R. Sekhar, S.L. Stamer, D.C. Liebler, and M.L. Freeman Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3 Chem Res Toxicol 21 2008 705 710 (Pubitemid 351498046)
-
(2008)
Chemical Research in Toxicology
, vol.21
, Issue.3
, pp. 705-710
-
-
Rachakonda, G.1
Xiong, Y.2
Sekhar, K.R.3
Stamer, S.L.4
Liebler, D.C.5
Freeman, M.L.6
-
44
-
-
24044466764
-
Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway
-
DOI 10.1074/jbc.M501279200
-
D.D. Zhang, S.C. Lo, Z. Sun, G.M. Habib, M.W. Lieberman, and M. Hannink Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway J Biol Chem 280 2005 30091 30099 (Pubitemid 41216185)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.34
, pp. 30091-30099
-
-
Zhang, D.D.1
Lo, S.-C.2
Sun, Z.3
Habib, G.M.4
Lieberman, M.W.5
Hannink, M.6
-
45
-
-
25444449520
-
Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1
-
DOI 10.1074/jbc.M503074200
-
T. Nguyen, P.J. Sherratt, P. Nioi, C.S. Yang, and C.B. Pickett Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1 J Biol Chem 280 2005 32485 32492 (Pubitemid 41361861)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.37
, pp. 32485-32492
-
-
Nguyen, T.1
Sherratt, P.J.2
Nioi, P.3
Yang, C.S.4
Pickett, C.B.5
-
46
-
-
34548772935
-
Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2
-
DOI 10.1128/MCB.00630-07
-
Z. Sun, S. Zhang, J.Y. Chan, and D.D. Zhang Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2 Mol Cell Biol 27 2007 6334 6349 (Pubitemid 47435741)
-
(2007)
Molecular and Cellular Biology
, vol.27
, Issue.18
, pp. 6334-6349
-
-
Sun, Z.1
Zhang, S.2
Chan, J.Y.3
Zhang, D.D.4
-
47
-
-
34848827480
-
Subcellular localization and cytoplasmic complex status of endogenous Keap1
-
DOI 10.1111/j.1365-2443.2007.01118.x
-
Y. Watai, A. Kobayashi, H. Nagase, M. Mizukami, J. McEvoy, and J.D. Singer Subcellular localization and cytoplasmic complex status of endogenous Keap1 Genes Cells 12 2007 1163 1178 (Pubitemid 47500530)
-
(2007)
Genes to Cells
, vol.12
, Issue.10
, pp. 1163-1178
-
-
Watai, Y.1
Kobayashi, A.2
Nagase, H.3
Mizukami, M.4
Mcevoy, J.5
Singer, J.D.6
Itoh, K.7
Yamamoto, M.8
-
48
-
-
34249934085
-
Selective degradation of mitochondria by mitophagy
-
DOI 10.1016/j.abb.2007.03.034, PII S0003986107001622, Highlight Issue: Pro- and antiapoptotic Signalling
-
I. Kim, S. Rodriguez-Enriquez, and J.J. Lemasters Selective degradation of mitochondria by mitophagy Arch Biochem Biophys 462 2007 245 253 (Pubitemid 46876640)
-
(2007)
Archives of Biochemistry and Biophysics
, vol.462
, Issue.2
, pp. 245-253
-
-
Kim, I.1
Rodriguez-Enriquez, S.2
Lemasters, J.J.3
-
49
-
-
33845298622
-
Pexophagy: Autophagic degradation of peroxisomes
-
DOI 10.1016/j.bbamcr.2006.08.023, PII S0167488906002278, Peroxisomes: Morphology, Function, Biogenesis and Disorders
-
Y. Sakai, M. Oku, I.J. van der Klei, and J.A. Kiel Pexophagy: autophagic degradation of peroxisomes Biochim Biophys Acta 1763 2006 1767 1775 (Pubitemid 44880462)
-
(2006)
Biochimica et Biophysica Acta - Molecular Cell Research
, vol.1763
, Issue.12
, pp. 1767-1775
-
-
Sakai, Y.1
Oku, M.2
Van Der Klei, I.J.3
Kiel, J.A.K.W.4
-
50
-
-
33745357459
-
Autophagy as an immune defense mechanism
-
DOI 10.1016/j.coi.2006.05.019, PII S095279150600094X
-
V. Deretic Autophagy as an immune defense mechanism Curr Opin Immunol 18 2006 375 382 (Pubitemid 43947574)
-
(2006)
Current Opinion in Immunology
, vol.18
, Issue.4
, pp. 375-382
-
-
Deretic, V.1
-
51
-
-
34047179973
-
Ubiquitinated-protein aggregates form in pancreatic β-cells during diabetes-induced oxidative stress and are regulated by autophagy
-
DOI 10.2337/db06-1160
-
N.A. Kaniuk, M. Kiraly, H. Bates, M. Vranic, A. Volchuk, and J.H. Brumell Ubiquitinated-protein aggregates form in pancreatic beta-cells during diabetes-induced oxidative stress and are regulated by autophagy Diabetes 56 2007 930 939 (Pubitemid 46525060)
-
(2007)
Diabetes
, vol.56
, Issue.4
, pp. 930-939
-
-
Kaniuk, N.A.1
Kiraly, M.2
Bates, H.3
Vranic, M.4
Volchuk, A.5
Brumell, J.H.6
-
53
-
-
34548259958
-
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy*[S]
-
DOI 10.1074/jbc.M702824200
-
S. Pankiv, T.H. Clausen, T. Lamark, A. Brech, J.A. Bruun, and H. Outzen p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy J Biol Chem 282 2007 24131 24145 (Pubitemid 47328003)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.33
, pp. 24131-24145
-
-
Pankiv, S.1
Clausen, T.H.2
Lamark, T.3
Brech, A.4
Bruun, J.-A.5
Outzen, H.6
Overvatn, A.7
Bjorkoy, G.8
Johansen, T.9
-
54
-
-
77649265091
-
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
-
M. Komatsu, H. Kurokawa, S. Waguri, K. Taguchi, A. Kobayashi, and Y. Ichimura The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 Nat Cell Biol 12 2010 213 223
-
(2010)
Nat Cell Biol
, vol.12
, pp. 213-223
-
-
Komatsu, M.1
Kurokawa, H.2
Waguri, S.3
Taguchi, K.4
Kobayashi, A.5
Ichimura, Y.6
-
55
-
-
77953366801
-
A noncanonical mechanism of Nrf2 activation by autophagy deficiency: Direct interaction between keap1 and p62
-
A. Lau, X.J. Wang, F. Zhao, N.F. Villeneuve, T. Wu, and T. Jiang A noncanonical mechanism of Nrf2 activation by autophagy deficiency: Direct interaction between keap1 and p62 Mol Cell Biol 30 2010 3275 3285
-
(2010)
Mol Cell Biol
, vol.30
, pp. 3275-3285
-
-
Lau, A.1
Wang, X.J.2
Zhao, F.3
Villeneuve, N.F.4
Wu, T.5
Jiang, T.6
-
56
-
-
77954599053
-
P62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
-
A. Jain, T. Lamark, E. Sjøttem, K.B. Larsen, J.A. Awuh, and A. Øvervatn p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription J Biol Chem 285 2010 22576 22591
-
(2010)
J Biol Chem
, vol.285
, pp. 22576-22591
-
-
Jain, A.1
Lamark, T.2
Sjøttem, E.3
Larsen, K.B.4
Awuh, J.A.5
Øvervatn, A.6
-
57
-
-
77955352128
-
Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy
-
W. Fan, Z. Tang, D. Chen, D. Moughon, X. Ding, and S. Chen Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy Autophagy 6 2010 614 621
-
(2010)
Autophagy
, vol.6
, pp. 614-621
-
-
Fan, W.1
Tang, Z.2
Chen, D.3
Moughon, D.4
Ding, X.5
Chen, S.6
-
58
-
-
77952781968
-
Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway
-
I.M. Copple, A. Lister, A.D. Obeng, N.R. Kitteringham, R.E. Jenkins, and R. Layfield Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway J Biol Chem 285 2010 16782 16788
-
(2010)
J Biol Chem
, vol.285
, pp. 16782-16788
-
-
Copple, I.M.1
Lister, A.2
Obeng, A.D.3
Kitteringham, N.R.4
Jenkins, R.E.5
Layfield, R.6
-
59
-
-
79955492012
-
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells
-
Y. Inami, S. Waguri, A. Sakamoto, T. Kouno, K. Nakada, and O. Hino Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells J Cell Biol 193 2011 275 284
-
(2011)
J Cell Biol
, vol.193
, pp. 275-284
-
-
Inami, Y.1
Waguri, S.2
Sakamoto, A.3
Kouno, T.4
Nakada, K.5
Hino, O.6
-
60
-
-
0033861403
-
Relationship between the occurrence of cysteine in proteins and the complexity of organisms
-
A. Miseta, and P. Csutora Relationship between the occurrence of cysteine in proteins and the complexity of organisms Mol Biol Evol 17 2000 1232 1239 (Pubitemid 30617150)
-
(2000)
Molecular Biology and Evolution
, vol.17
, Issue.8
, pp. 1232-1239
-
-
Miseta, A.1
Csutora, P.2
-
61
-
-
84856834259
-
Analysis and functional prediction of reactive cysteine residues
-
S.M. Marino, and V.N. Gladyshev Analysis and functional prediction of reactive cysteine residues J Biol Chem 287 2012 4419 4425
-
(2012)
J Biol Chem
, vol.287
, pp. 4419-4425
-
-
Marino, S.M.1
Gladyshev, V.N.2
-
62
-
-
77958122499
-
Chemistry of the cysteine sensors in Kelch-like ECH-associated protein 1
-
R. Holland, and J.C. Fishbein Chemistry of the cysteine sensors in Kelch-like ECH-associated protein 1 Antioxid Redox Signal 13 2010 1749 1761
-
(2010)
Antioxid Redox Signal
, vol.13
, pp. 1749-1761
-
-
Holland, R.1
Fishbein, J.C.2
-
63
-
-
0019877708
-
Electrostatic influence of local cysteine environments on disulfide exchange kinetics
-
G.H. Snyder, M.J. Cennerazzo, A.J. Karalis, and D. Field Electrostatic influence of local cysteine environments on disulfide exchange kinetics Biochemistry 20 1981 6509 6519
-
(1981)
Biochemistry
, vol.20
, pp. 6509-6519
-
-
Snyder, G.H.1
Cennerazzo, M.J.2
Karalis, A.J.3
Field, D.4
-
64
-
-
22544464124
-
Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2
-
DOI 10.1073/pnas.0502402102
-
A.L. Eggler, G. Liu, J.M. Pezzuto, R.B. van Breemen, and A.D. Mesecar Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2 Proc Natl Acad Sci USA 102 2005 10070 10075 (Pubitemid 41023327)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.29
, pp. 10070-10075
-
-
Eggler, A.L.1
Liu, G.2
Pezzuto, J.M.3
Van Breemen, R.B.4
Mesecar, A.D.5
-
65
-
-
0037015035
-
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
-
DOI 10.1073/pnas.172398899
-
A.T. Dinkova-Kostova, W.D. Holtzclaw, R.N. Cole, K. Itoh, N. Wakabayashi, and Y. Katoh Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants Proc Natl Acad Sci USA 99 2002 11908 11913 (Pubitemid 34994497)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.18
, pp. 11908-11913
-
-
Dinkova-Kostova, A.T.1
Holtzclaw, W.D.2
Cole, R.N.3
Itoh, K.4
Wakabayashi, N.5
Katoh, Y.6
Yamamoto, M.7
Talalay, P.8
-
66
-
-
55949088750
-
Prospective type 1 and type 2 disulfides of Keap1 protein
-
R. Holland, A.E. Hawkins, A.L. Eggler, A.D. Mesecar, D. Fabris, and J.C. Fishbein Prospective type 1 and type 2 disulfides of Keap1 protein Chem Res Toxicol 21 2008 2051 2060
-
(2008)
Chem Res Toxicol
, vol.21
, pp. 2051-2060
-
-
Holland, R.1
Hawkins, A.E.2
Eggler, A.L.3
Mesecar, A.D.4
Fabris, D.5
Fishbein, J.C.6
-
67
-
-
58249117780
-
The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds
-
M. Kobayashi, L. Li, N. Iwamoto, Y. Nakajima-Takagi, H. Kaneko, and Y. Nakayama The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds Mol Cell Biol 29 2009 493 502
-
(2009)
Mol Cell Biol
, vol.29
, pp. 493-502
-
-
Kobayashi, M.1
Li, L.2
Iwamoto, N.3
Nakajima-Takagi, Y.4
Kaneko, H.5
Nakayama, Y.6
-
68
-
-
84864461148
-
Validation of the multiple sensor mechanism of the Keap1-Nrf2 system
-
K. Takaya, T. Suzuki, H. Motohashi, K. Onodera, S. Satomi, and T.W. Kensler Validation of the multiple sensor mechanism of the Keap1-Nrf2 system Free Radic Biol Med 53 2012 817 827
-
(2012)
Free Radic Biol Med
, vol.53
, pp. 817-827
-
-
Takaya, K.1
Suzuki, T.2
Motohashi, H.3
Onodera, K.4
Satomi, S.5
Kensler, T.W.6
-
69
-
-
42149196050
-
Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity
-
DOI 10.1128/MCB.01704-07
-
T. Yamamoto, T. Suzuki, A. Kobayashi, J. Wakabayashi, J. Maher, and H. Motohashi Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity Mol Cell Biol 28 2008 2758 2770 (Pubitemid 351542373)
-
(2008)
Molecular and Cellular Biology
, vol.28
, Issue.8
, pp. 2758-2770
-
-
Yamamoto, T.1
Suzuki, T.2
Kobayashi, A.3
Wakabayashi, J.4
Maher, J.5
Motohashi, H.6
Yamamoto, M.7
-
70
-
-
78650509515
-
Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals
-
M. McMahon, D.J. Lamont, K.A. Beattie, and J.D. Hayes Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals Proc Natl Acad Sci USA 107 2010 18838 18843
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 18838-18843
-
-
McMahon, M.1
Lamont, D.J.2
Beattie, K.A.3
Hayes, J.D.4
-
71
-
-
77954947797
-
The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response
-
S. Fujii, T. Sawa, H. Ihara, K.I. Tong, T. Ida, and T. Okamoto The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response J Biol Chem 285 2010 23970 23984
-
(2010)
J Biol Chem
, vol.285
, pp. 23970-23984
-
-
Fujii, S.1
Sawa, T.2
Ihara, H.3
Tong, K.I.4
Ida, T.5
Okamoto, T.6
-
72
-
-
80051548161
-
Nitric oxide activates Nrf2 through S-nitrosylation of Keap1 in PC12 cells
-
H.C. Um, J.H. Jang, D.H. Kim, C. Lee, and Y.J. Surh Nitric oxide activates Nrf2 through S-nitrosylation of Keap1 in PC12 cells Nitric Oxide 25 2011 161 168
-
(2011)
Nitric Oxide
, vol.25
, pp. 161-168
-
-
Um, H.C.1
Jang, J.H.2
Kim, D.H.3
Lee, C.4
Surh, Y.J.5
-
73
-
-
77953357236
-
Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-kappaB
-
A.J. Chia, C.E. Goldring, N.R. Kitteringham, S.Q. Wong, P. Morgan, and B.K. Park Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-kappaB Biochem Pharmacol 80 2010 410 421
-
(2010)
Biochem Pharmacol
, vol.80
, pp. 410-421
-
-
Chia, A.J.1
Goldring, C.E.2
Kitteringham, N.R.3
Wong, S.Q.4
Morgan, P.5
Park, B.K.6
-
74
-
-
54449093352
-
The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system
-
I.M. Copple, C.E. Goldring, R.E. Jenkins, A.J. Chia, L.E. Randle, and J.D. Hayes The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system Hepatology 48 2008 1292 1301
-
(2008)
Hepatology
, vol.48
, pp. 1292-1301
-
-
Copple, I.M.1
Goldring, C.E.2
Jenkins, R.E.3
Chia, A.J.4
Randle, L.E.5
Hayes, J.D.6
-
75
-
-
0036783335
-
Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes
-
DOI 10.2174/1389200023337171
-
T.H. Rushmore, and A.N. Kong Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes Curr Drug Metab 3 2002 481 490 (Pubitemid 34987481)
-
(2002)
Current Drug Metabolism
, vol.3
, Issue.5
, pp. 481-490
-
-
Rushmore, T.H.1
Kong, A.-N.T.2
-
76
-
-
0025368036
-
Regulation of glutathione S-transferase Ya subunit gene expression: Identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds
-
T.H. Rushmore, R.G. King, K.E. Paulson, and C.B. Pickett Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds Proc Natl Acad Sci USA 87 1990 3826 3830
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 3826-3830
-
-
Rushmore, T.H.1
King, R.G.2
Paulson, K.E.3
Pickett, C.B.4
-
77
-
-
7444251509
-
Identification of polymorphisms in the promoter region of the human NRF2 gene
-
DOI 10.1016/j.bbrc.2004.06.112, PII S0006291X04013695
-
T. Yamamoto, K. Yoh, A. Kobayashi, Y. Ishii, S. Kure, and A. Koyama Identification of polymorphisms in the promoter region of the human NRF2 gene Biochem Biophys Res Commun 321 2004 72 79 (Pubitemid 39055607)
-
(2004)
Biochemical and Biophysical Research Communications
, vol.321
, Issue.1
, pp. 72-79
-
-
Yamamoto, T.1
Yoh, K.2
Kobayashi, A.3
Ishii, Y.4
Kure, S.5
Koyama, A.6
Sakamoto, T.7
Sekizawa, K.8
Motohashi, H.9
Yamamoto, M.10
-
78
-
-
34347392512
-
Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury
-
DOI 10.1096/fj.06-7759com
-
J.M. Marzec, J.D. Christie, S.P. Reddy, A.E. Jedlicka, H. Vuong, and P.N. Lanken Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury FASEB J 21 2007 2237 2246 (Pubitemid 47026458)
-
(2007)
FASEB Journal
, vol.21
, Issue.9
, pp. 2237-2246
-
-
Marzec, J.M.1
Christie, J.D.2
Reddy, S.P.3
Jedlicka, A.E.4
Vuong, H.5
Lanken, P.N.6
Aplenc, R.7
Yamamoto, T.8
Yamamoto, M.9
Cho, H.-Y.10
Kleeberger, S.R.11
-
79
-
-
56349163056
-
The susceptibility to vitiligo is associated with NF-E2-related factor2 (Nrf2) gene polymorphisms: A study on Chinese Han population
-
C.P. Guan, M.N. Zhou, A.E. Xu, K.F. Kang, J.F. Liu, and X.D. Wei The susceptibility to vitiligo is associated with NF-E2-related factor2 (Nrf2) gene polymorphisms: a study on Chinese Han population Exp Dermatol 17 2008 1059 1062
-
(2008)
Exp Dermatol
, vol.17
, pp. 1059-1062
-
-
Guan, C.P.1
Zhou, M.N.2
Xu, A.E.3
Kang, K.F.4
Liu, J.F.5
Wei, X.D.6
-
80
-
-
57449111441
-
Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis
-
S. Nair, S.T. Doh, J.Y. Chan, A.N. Kong, and L. Cai Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis Br J Cancer 99 2008 2070 2082
-
(2008)
Br J Cancer
, vol.99
, pp. 2070-2082
-
-
Nair, S.1
Doh, S.T.2
Chan, J.Y.3
Kong, A.N.4
Cai, L.5
-
81
-
-
77955653742
-
Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation
-
J.E. Kim, D.J. You, C. Lee, C. Ahn, J.Y. Seong, and J.I. Hwang Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation Cell Signal 22 2010 1645 1654
-
(2010)
Cell Signal
, vol.22
, pp. 1645-1654
-
-
Kim, J.E.1
You, D.J.2
Lee, C.3
Ahn, C.4
Seong, J.Y.5
Hwang, J.I.6
-
82
-
-
70349970493
-
KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta
-
D.F. Lee, H.P. Kuo, M. Liu, C.K. Chou, W. Xia, and Y. Du KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta Mol Cell 36 2009 131 140
-
(2009)
Mol Cell
, vol.36
, pp. 131-140
-
-
Lee, D.F.1
Kuo, H.P.2
Liu, M.3
Chou, C.K.4
Xia, W.5
Du, Y.6
-
83
-
-
80052570740
-
MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism
-
M. Yang, Y. Yao, G. Eades, Y. Zhang, and Q. Zhou MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism Breast Cancer Res Treat 129 2011 983 991
-
(2011)
Breast Cancer Res Treat
, vol.129
, pp. 983-991
-
-
Yang, M.1
Yao, Y.2
Eades, G.3
Zhang, Y.4
Zhou, Q.5
-
84
-
-
78549277802
-
Chi JT. microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease
-
C. Sangokoya, and M.J. Telen Chi JT. microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease Blood 116 2010 4338 4348
-
(2010)
Blood
, vol.116
, pp. 4338-4348
-
-
Sangokoya, C.1
Telen, M.J.2
-
85
-
-
81755171451
-
MiR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells
-
G. Eades, M. Yang, Y. Yao, Y. Zhang, and Q. Zhou miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells J Biol Chem 286 2011 40725 40733
-
(2011)
J Biol Chem
, vol.286
, pp. 40725-40733
-
-
Eades, G.1
Yang, M.2
Yao, Y.3
Zhang, Y.4
Zhou, Q.5
-
86
-
-
79952742806
-
Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1
-
N. Li, S. Muthusamy, R. Liang, H. Sarojini, and E. Wang Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1 Mech Ageing Dev 132 2011 75 85
-
(2011)
Mech Ageing Dev
, vol.132
, pp. 75-85
-
-
Li, N.1
Muthusamy, S.2
Liang, R.3
Sarojini, H.4
Wang, E.5
-
87
-
-
38349169664
-
Mechanisms of post-transcriptional regulation by microRNAs: Are the answers in sight
-
W. Filipowicz, S.N. Bhattacharyya, and N. Sonenberg Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight Nat Rev Genet 9 2008 102 114
-
(2008)
Nat Rev Genet
, vol.9
, pp. 102-114
-
-
Filipowicz, W.1
Bhattacharyya, S.N.2
Sonenberg, N.3
-
88
-
-
84855458875
-
Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3
-
A.I. Rojo, O.N. Medina-Campos, P. Rada, A. Zuniga-Toala, A. Lopez-Gazcon, and S. Espada Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: role of glycogen synthase kinase-3 Free Radic Biol Med 52 2012 473 487
-
(2012)
Free Radic Biol Med
, vol.52
, pp. 473-487
-
-
Rojo, A.I.1
Medina-Campos, O.N.2
Rada, P.3
Zuniga-Toala, A.4
Lopez-Gazcon, A.5
Espada, S.6
-
89
-
-
0037044791
-
Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription
-
DOI 10.1074/jbc.M206911200
-
H.C. Huang, T. Nguyen, and C.B. Pickett Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription J Biol Chem 277 2002 42769 42774 (Pubitemid 35285650)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.45
, pp. 42769-42774
-
-
Huang, H.-C.1
Nguyen, T.2
Pickett, C.B.3
-
90
-
-
0041742490
-
Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress
-
S. Numazawa, M. Ishikawa, A. Yoshida, S. Tanaka, and T. Yoshida Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress Am J Physiol Cell Physiol 285 2003 C334 C342
-
(2003)
Am J Physiol Cell Physiol
, vol.285
-
-
Numazawa, S.1
Ishikawa, M.2
Yoshida, A.3
Tanaka, S.4
Yoshida, T.5
-
91
-
-
0242666198
-
40 by Protein Kinase C in Response to Antioxidants Leads to the Release of Nrf2 from INrf2, but Is Not Required for Nrf2 Stabilization/Accumulation in the Nucleus and Transcriptional Activation of Antioxidant Response Element-mediated NAD(P)H:Quinone Oxidoreductase-1 Gene Expression
-
DOI 10.1074/jbc.M307633200
-
D.A. Bloom, and A.K. Jaiswal Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression J Biol Chem 278 2003 44675 44682 (Pubitemid 37377224)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.45
, pp. 44675-44682
-
-
Bloom, D.A.1
Jaiswal, A.K.2
-
92
-
-
44049093741
-
Multiple nuclear localization signals function in the nuclear import of the transcription factor Nrf2
-
M. Theodore, Y. Kawai, J. Yang, Y. Kleshchenko, S.P. Reddy, and F. Villalta Multiple nuclear localization signals function in the nuclear import of the transcription factor Nrf2 J Biol Chem 283 2008 8984 8994
-
(2008)
J Biol Chem
, vol.283
, pp. 8984-8994
-
-
Theodore, M.1
Kawai, Y.2
Yang, J.3
Kleshchenko, Y.4
Reddy, S.P.5
Villalta, F.6
-
93
-
-
34248593492
-
Molecular mechanism of human Nrf2 activation and degradation: Role of sequential phosphorylation by protein kinase CK2
-
DOI 10.1016/j.freeradbiomed.2007.03.001, PII S0891584907001761
-
J. Pi, Y. Bai, J.M. Reece, J. Williams, D. Liu, and M.L. Freeman Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2 Free Radic Biol Med 42 2007 1797 1806 (Pubitemid 46754754)
-
(2007)
Free Radical Biology and Medicine
, vol.42
, Issue.12
, pp. 1797-1806
-
-
Pi, J.1
Bai, Y.2
Reece, J.M.3
Williams, J.4
Liu, D.5
Freeman, M.L.6
Fahl, W.E.7
Shugar, D.8
Liu, J.9
Qu, W.10
Collins, S.11
Waalkes, M.P.12
-
94
-
-
40549121572
-
Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells
-
DOI 10.1002/jbt.20212
-
P.L. Apopa, X. He, and Q. Ma Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells J Biochem Mol Toxicol 22 2008 63 76 (Pubitemid 351360163)
-
(2008)
Journal of Biochemical and Molecular Toxicology
, vol.22
, Issue.1
, pp. 63-76
-
-
Apopa, P.L.1
He, X.2
Ma, Q.3
-
95
-
-
33744953050
-
Phosphorylation of tyrosine 568 controls nuclear export of Nrf2
-
DOI 10.1074/jbc.M511198200
-
A.K. Jain, and A.K. Jaiswal Phosphorylation of tyrosine 568 controls nuclear export of Nrf2 J Biol Chem 281 2006 12132 12142 (Pubitemid 43855477)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.17
, pp. 12132-12142
-
-
Jain, A.K.1
Jaiswal, A.K.2
-
96
-
-
34447526197
-
GSK-3β acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2
-
DOI 10.1074/jbc.M611336200
-
A.K. Jain, and A.K. Jaiswal GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2 J Biol Chem 282 2007 16502 16510 (Pubitemid 47100395)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.22
, pp. 16502-16510
-
-
Jain, A.K.1
Jaiswal, A.K.2
-
97
-
-
33749019130
-
Mechanism of action of sulforaphane: Inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells
-
DOI 10.1158/0008-5472.CAN-05-3513
-
Y.S. Keum, S. Yu, P.P. Chang, X. Yuan, J.H. Kim, and C. Xu Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells Cancer Res 66 2006 8804 8813 (Pubitemid 44449198)
-
(2006)
Cancer Research
, vol.66
, Issue.17
, pp. 8804-8813
-
-
Keum, Y.-S.1
Yu, S.2
Chang, P.P.-J.3
Yuan, X.4
Kim, J.-H.5
Xu, C.6
Han, J.7
Agarwal, A.8
Kong, A.-N.T.9
-
98
-
-
33750430654
-
Butylated hydroxyanisole regulates ARE-mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells
-
DOI 10.1002/mc.20234
-
X. Yuan, C. Xu, Z. Pan, Y.S. Keum, J.H. Kim, and G. Shen Butylated hydroxyanisole regulates ARE-mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells Mol Carcinog 45 2006 841 850 (Pubitemid 44646336)
-
(2006)
Molecular Carcinogenesis
, vol.45
, Issue.11
, pp. 841-850
-
-
Yuan, X.1
Xu, C.2
Pan, Z.3
Keum, Y.-S.4
Kim, J.-H.5
Shen, G.6
Yu, S.7
Oo, K.T.8
Ma, J.9
Kong, A.-N.T.10
-
99
-
-
0141752795
-
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival
-
DOI 10.1128/MCB.23.20.7198-7209.2003
-
S.B. Cullinan, D. Zhang, M. Hannink, E. Arvisais, R.J. Kaufman, and J.A. Diehl Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival Mol Cell Biol 23 2003 7198 7209 (Pubitemid 37211002)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.20
, pp. 7198-7209
-
-
Cullinan, S.B.1
Zhang, D.2
Hannink, M.3
Arvisais, E.4
Kaufman, R.J.5
Diehl, J.A.6
-
100
-
-
33744950387
-
Glycogen synthase kinase-3β inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2
-
DOI 10.1074/jbc.M513737200
-
M. Salazar, A.I. Rojo, D. Velasco, R.M. de Sagarra, and A. Cuadrado Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2 J Biol Chem 281 2006 14841 14851 (Pubitemid 43855189)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.21
, pp. 14841-14851
-
-
Salazar, M.1
Rojo, A.I.2
Velasco, D.3
De Sagarra, R.M.4
Cuadrado, A.5
-
101
-
-
79952256187
-
SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner
-
P. Rada, A.I. Rojo, S. Chowdhry, M. McMahon, J.D. Hayes, and A. Cuadrado SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner Mol Cell Biol 31 2011 1121 1133
-
(2011)
Mol Cell Biol
, vol.31
, pp. 1121-1133
-
-
Rada, P.1
Rojo, A.I.2
Chowdhry, S.3
McMahon, M.4
Hayes, J.D.5
Cuadrado, A.6
-
102
-
-
0030890234
-
Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3
-
C.R. Beals, C.M. Sheridan, C.W. Turck, P. Gardner, and G.R. Crabtree Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3 Science 275 1997 1930 1934
-
(1997)
Science
, vol.275
, pp. 1930-1934
-
-
Beals, C.R.1
Sheridan, C.M.2
Turck, C.W.3
Gardner, P.4
Crabtree, G.R.5
-
103
-
-
0034671768
-
Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation
-
DOI 10.1101/gad.854900
-
J.R. Alt, J.L. Cleveland, M. Hannink, and J.A. Diehl Phosphorylation- dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation Genes Dev 14 2000 3102 3114 (Pubitemid 32015129)
-
(2000)
Genes and Development
, vol.14
, Issue.24
, pp. 3102-3114
-
-
Alt, J.R.1
Cleveland, J.L.2
Hannink, M.3
Diehl, J.A.4
-
104
-
-
0030606239
-
The transcriptional coactivators p300 and CBP are histone acetyltransferases
-
DOI 10.1016/S0092-8674(00)82001-2
-
V.V. Ogryzko, R.L. Schiltz, V. Russanova, B.H. Howard, and Y. Nakatani The transcriptional coactivators p300 and CBP are histone acetyltransferases Cell 87 1996 953 959 (Pubitemid 26404293)
-
(1996)
Cell
, vol.87
, Issue.5
, pp. 953-959
-
-
Ogryzko, V.V.1
Schiltz, R.L.2
Russanova, V.3
Howard, B.H.4
Nakatani, Y.5
-
106
-
-
66349129338
-
Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response
-
Z. Sun, Y.E. Chin, and D.D. Zhang Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response Mol Cell Biol 29 2009 2658 2672
-
(2009)
Mol Cell Biol
, vol.29
, pp. 2658-2672
-
-
Sun, Z.1
Chin, Y.E.2
Zhang, D.D.3
-
107
-
-
0034752461
-
Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription
-
DOI 10.1046/j.1365-2443.2001.00469.x
-
Y. Katoh, K. Itoh, E. Yoshida, M. Miyagishi, A. Fukamizu, and M. Yamamoto Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription Genes Cells 6 2001 857 868 (Pubitemid 33019739)
-
(2001)
Genes to Cells
, vol.6
, Issue.10
, pp. 857-868
-
-
Katoh, Y.1
Itoh, K.2
Yoshida, E.3
Miyagishi, M.4
Fukamizu, A.5
Yamamoto, M.6
-
108
-
-
84861911235
-
Interaction with CREB binding protein modulates the activities of Nrf2 and NF-kappaB in cystic fibrosis airway epithelial cells
-
A.G. Ziady, A. Sokolow, S. Shank, D. Corey, R. Myers, and S. Plafker Interaction with CREB binding protein modulates the activities of Nrf2 and NF-kappaB in cystic fibrosis airway epithelial cells Am J Physiol Lung Cell Mol Physiol 302 2012 L1221 L1231
-
(2012)
Am J Physiol Lung Cell Mol Physiol
, vol.302
-
-
Ziady, A.G.1
Sokolow, A.2
Shank, S.3
Corey, D.4
Myers, R.5
Plafker, S.6
-
109
-
-
45549091466
-
BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase
-
P. Rondou, G. Haegeman, P. Vanhoenacker, and K. Van Craenenbroeck BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase J Biol Chem 283 2008 11083 11096
-
(2008)
J Biol Chem
, vol.283
, pp. 11083-11096
-
-
Rondou, P.1
Haegeman, G.2
Vanhoenacker, P.3
Van Craenenbroeck, K.4
-
110
-
-
33750052885
-
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2
-
DOI 10.1073/pnas.0607260103
-
C.M. Clements, R.S. McNally, B.J. Conti, T.W. Mak, and J.P. Ting DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2 Proc Natl Acad Sci USA 103 2006 15091 15096 (Pubitemid 44583169)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.41
, pp. 15091-15096
-
-
Clements, C.M.1
McNally, R.S.2
Conti, B.J.3
Mak, T.W.4
Ting, J.P.-Y.5
-
111
-
-
77949550917
-
Keap1-Nrf2 activation in the presence and absence of DJ-1
-
L. Gan, D.A. Johnson, and J.A. Johnson Keap1-Nrf2 activation in the presence and absence of DJ-1 Eur J Neurosci 31 2010 967 977
-
(2010)
Eur J Neurosci
, vol.31
, pp. 967-977
-
-
Gan, L.1
Johnson, D.A.2
Johnson, J.A.3
-
112
-
-
67449128222
-
Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response
-
W. Chen, Z. Sun, X.J. Wang, T. Jiang, Z. Huang, and D. Fang Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response Mol Cell 34 2009 663 673
-
(2009)
Mol Cell
, vol.34
, pp. 663-673
-
-
Chen, W.1
Sun, Z.2
Wang, X.J.3
Jiang, T.4
Huang, Z.5
Fang, D.6
-
113
-
-
84862280943
-
Caveolin-1 inhibits expression of antioxidant enzymes through direct interaction with nuclear erythroid 2 p45-related factor-2 (Nrf2)
-
W. Li, H. Liu, J.S. Zhou, J.F. Cao, X.B. Zhou, and A.M. Choi Caveolin-1 inhibits expression of antioxidant enzymes through direct interaction with nuclear erythroid 2 p45-related factor-2 (Nrf2) J Biol Chem 287 2012 20922 20930
-
(2012)
J Biol Chem
, vol.287
, pp. 20922-20930
-
-
Li, W.1
Liu, H.2
Zhou, J.S.3
Cao, J.F.4
Zhou, X.B.5
Choi, A.M.6
-
114
-
-
84855478994
-
Epigallocatechin-gallate stimulates NF-E2-related factor and heme oxygenase-1 via caveolin-1 displacement
-
Y. Zheng, A. Morris, M. Sunkara, J. Layne, M. Toborek, and B. Hennig Epigallocatechin-gallate stimulates NF-E2-related factor and heme oxygenase-1 via caveolin-1 displacement J Nutr Biochem 23 2012 163 168
-
(2012)
J Nutr Biochem
, vol.23
, pp. 163-168
-
-
Zheng, Y.1
Morris, A.2
Sunkara, M.3
Layne, J.4
Toborek, M.5
Hennig, B.6
-
115
-
-
33748752586
-
Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain
-
DOI 10.1074/jbc.M602746200
-
W. Li, S.W. Yu, and A.N. Kong Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain J Biol Chem 281 2006 27251 27263 (Pubitemid 44401754)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.37
, pp. 27251-27263
-
-
Li, W.1
Yu, S.-W.2
Kong, A.-N.T.3
-
116
-
-
79953314978
-
Managing the challenge of chemically reactive metabolites in drug development
-
B.K. Park, A. Boobis, S. Clarke, C.E. Goldring, D. Jones, and J.G. Kenna Managing the challenge of chemically reactive metabolites in drug development Nat Rev Drug Discov 10 2011 292 306
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 292-306
-
-
Park, B.K.1
Boobis, A.2
Clarke, S.3
Goldring, C.E.4
Jones, D.5
Kenna, J.G.6
-
117
-
-
84862494503
-
The NRF2-related interactome and regulome contain multifunctional proteins and fine-tuned autoregulatory loops
-
D. Papp, K. Lenti, D. Modos, D. Fazekas, Z. Dul, and D. Turei The NRF2-related interactome and regulome contain multifunctional proteins and fine-tuned autoregulatory loops FEBS Lett 586 2012 1795 1802
-
(2012)
FEBS Lett
, vol.586
, pp. 1795-1802
-
-
Papp, D.1
Lenti, K.2
Modos, D.3
Fazekas, D.4
Dul, Z.5
Turei, D.6
-
118
-
-
66449114033
-
P62 at the crossroads of autophagy, apoptosis, and cancer
-
J. Moscat, and M.T. Diaz-Meco p62 at the crossroads of autophagy, apoptosis, and cancer Cell 137 2009 1001 1004
-
(2009)
Cell
, vol.137
, pp. 1001-1004
-
-
Moscat, J.1
Diaz-Meco, M.T.2
-
119
-
-
2342613543
-
Activation of Hepatic Nrf2 in Vivo by Acetaminophen in CD-1 Mice
-
DOI 10.1002/hep.20183
-
C.E. Goldring, N.R. Kitteringham, R. Elsby, L.E. Randle, Y.N. Clement, and D.P. Williams Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice Hepatology 39 2004 1267 1276 (Pubitemid 38569048)
-
(2004)
Hepatology
, vol.39
, Issue.5
, pp. 1267-1276
-
-
Goldring, C.E.P.1
Kitteringham, N.R.2
Elsby, R.3
Randle, L.E.4
Clement, Y.N.5
Williams, D.P.6
McMahon, M.7
Hayes, J.D.8
Itoh, K.9
Yamamoto, M.10
Park, B.K.11
-
120
-
-
13844314221
-
The role of metabolic activation in drug-induced hepatotoxicity
-
DOI 10.1146/annurev.pharmtox.45.120403.100058
-
B.K. Park, N.R. Kitteringham, J.L. Maggs, M. Pirmohamed, and D.P. Williams The role of metabolic activation in drug-induced hepatotoxicity Annu Rev Pharmacol Toxicol 45 2005 177 202 (Pubitemid 40261802)
-
(2005)
Annual Review of Pharmacology and Toxicology
, vol.45
, pp. 177-202
-
-
Park, B.K.1
Kitteringham, N.R.2
Maggs, J.L.3
Pirmohamed, M.4
Williams, D.P.5
-
121
-
-
24744453945
-
Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation
-
DOI 10.1074/jbc.M503346200
-
F. Hong, K.R. Sekhar, M.L. Freeman, and D.C. Liebler Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation J Biol Chem 280 2005 31768 31775 (Pubitemid 41291926)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.36
, pp. 31768-31775
-
-
Hong, F.1
Sekhar, K.E.2
Freeman, M.L.3
Liebler, D.C.4
-
122
-
-
36349020163
-
Sites of Alkylation of Human Keap1 by Natural Chemoprevention Agents
-
DOI 10.1016/j.jasms.2007.09.015, PII S1044030507008483
-
Y. Luo, A.L. Eggler, D. Liu, G. Liu, A.D. Mesecar, and R.B. van Breemen Sites of alkylation of human Keap1 by natural chemoprevention agents J Am Soc Mass Spectrom 18 2007 2226 2232 (Pubitemid 350161332)
-
(2007)
Journal of the American Society for Mass Spectrometry
, vol.18
, Issue.12
, pp. 2226-2232
-
-
Luo, Y.1
Eggler, A.L.2
Liu, D.3
Liu, G.4
Mesecar, A.D.5
Van Breemen, R.B.6
-
123
-
-
36349019109
-
Identification of the highly reactive cysteine 151 in the chemopreventive agent-sensor Keap1 protein is method-dependent
-
A.L. Eggler, Y. Luo, R.B. van Breemen, and A.D. Mesecar Identification of the highly reactive cysteine 151 in the chemopreventive agent-sensor Keap1 protein is method-dependent Chem Res Toxicol 20 2007 1878 1884
-
(2007)
Chem Res Toxicol
, vol.20
, pp. 1878-1884
-
-
Eggler, A.L.1
Luo, Y.2
Van Breemen, R.B.3
Mesecar, A.D.4
-
124
-
-
29644443964
-
Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane
-
DOI 10.1021/tx0502138
-
F. Hong, M.L. Freeman, and D.C. Liebler Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane Chem Res Toxicol 18 2005 1917 1926 (Pubitemid 43023050)
-
(2005)
Chemical Research in Toxicology
, vol.18
, Issue.12
, pp. 1917-1926
-
-
Hong, F.1
Freeman, M.L.2
Liebler, D.C.3
-
125
-
-
76449118748
-
Chapter 3: Site-specific modification of the electrophile sensor protein Keap1 and activation of Nrf2-dependent gene expression
-
D.C. Liebler, F. Hong, K.R. Sekhar, M.L. Freeman, and C.F. James Chapter 3: Site-specific modification of the electrophile sensor protein Keap1 and activation of Nrf2-dependent gene expression Adv Mol Toxicol 1 2006 65 83
-
(2006)
Adv Mol Toxicol
, vol.1
, pp. 65-83
-
-
Liebler, D.C.1
Hong, F.2
Sekhar, K.R.3
Freeman, M.L.4
James, C.F.5
-
126
-
-
55949128500
-
Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: Quinone oxidoreductase 1 by alkylating Keap1
-
B.M. Dietz, D. Liu, G.K. Hagos, P. Yao, A. Schinkovitz, and S.M. Pro Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: quinone oxidoreductase 1 by alkylating Keap1 Chem Res Toxicol 21 2008 1939 1948
-
(2008)
Chem Res Toxicol
, vol.21
, pp. 1939-1948
-
-
Dietz, B.M.1
Liu, D.2
Hagos, G.K.3
Yao, P.4
Schinkovitz, A.5
Pro, S.M.6
|