Celastrol: A new therapeutic potential of traditional Chinese medicine

American Journal of Hypertension

Volumn 23, Issue 8, 2010, Pages 821-

  Morita, Toshisuke ^a  

^a TOHO UNIVERSITY OMORI MEDICAL CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELASTROL; HEME OXYGENASE 1; HYDRALAZINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTOPORPHYRIN ZINC; REACTIVE OXYGEN METABOLITE; HEME OXYGENASE; HMOX1 PROTEIN, RAT; TRIPTERINE; TRITERPENE;

ANTIHYPERTENSIVE ACTIVITY; ATHEROSCLEROSIS; AUTOIMMUNE DISEASE; BLOOD PRESSURE REGULATION; CARDIOVASCULAR RISK; CHINESE MEDICINE; CHRONIC INFLAMMATION; COMPETITIVE INHIBITION; DEGENERATIVE DISEASE; DRUG DELIVERY SYSTEM; HEART INFARCTION; HYPERTENSION; INSULIN SENSITIVITY; METABOLIC SYNDROME X; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; THERAPY EFFECT; UPREGULATION; ANIMAL; BIOSYNTHESIS; BLOOD PRESSURE; DRUG EFFECTS; ENZYME INDUCTION; RAT;

ANIMALS; BLOOD PRESSURE; ENZYME INDUCTION; HEME OXYGENASE (DECYCLIZING); HYPERTENSION; MEDICINE, CHINESE TRADITIONAL; RATS; TRITERPENES;

EID: 77955727857     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1038/ajh.2010.87     Document Type: Note

References (6)

1. Morita T. Heme oxygenase and atherosclerosis. Arterioscler Thromb Vasc Biol 2005; 25:1786-1795
2. National Center for Complementary and Alternative Medicine. Herbs at a glance: Thunder God Vine.
3. Lee JH, Koo TH, Yoon H, Jung HS, Jin HZ, Lee K, Hong YS, Lee JJ. Inhibition of NF-kappa B activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid. Biochem Pharmacol 2006; 72:1311-1321.
4. Yu X, Tao W, Jiang F, Li C, Lin J, Liu C. Celastrol attenuates hypertension-induced inflammation and oxidative stress in vascular smooth muscle cells via induction of heme oxygenase-1. Am J Hypertens 2010; 23:895-903.
5. Ogborne RM, Rushworth SA, Charalambos CA, O'Connell MA. Haem oxygenase-1: a target for dietary antioxidants. Biochem Soc Trans 2004; 32(Pt 6):1003-1005.
6. Lamon BD, Zhang FF, Puri N, Brodsky SV, Goligorsky MS, Nasjletti A. Dual pathways of carbon monoxide-mediated vasoregulation: modulation by redox mechanisms. Circ Res 2009; 105:775-783.