Manganese-exposed developing rats display motor deficits and striatal oxidative stress that are reversed by Trolox

Archives of Toxicology

Volumn 87, Issue 7, 2013, Pages 1231-1244

  Cordova, Fabiano M ^a,c   Aguiar Jr , Aderbal S ^a   Peres, Tanara V ^a   Lopes, Mark W ^a   Gonçalves, Filipe M ^a   Pedro, Daniela Z ^a   Lopes, Samantha C ^a   Pilati, Célso ^b   Prediger, Rui D S ^a   Farina, Marcelo ^a   Erikson, Keith M ^d   Aschner, Michael ^e   Leal, Rodrigo B ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b SANTA CATARINA STATE UNIVERSITY   (Brazil)

^c UNIVERSIDADE FEDERAL DO TOCANTINS   (Brazil)

^d UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

^e VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Behavior; DARPP 32; Developing brain; Manganese; MAPK; Oxidative stress

Indexed keywords

CASPASE; ISOPROSTANE DERIVATIVE; MANGANESE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOPROTEIN DARPP 32; PROTEIN KINASE B; TROLOX C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRESS; CHEMICAL PARAMETERS; CONTROLLED STUDY; CORPUS STRIATUM; DEVELOPMENTAL TOXICITY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FATTY ACID SYNTHESIS; FEMALE; LATENT PERIOD; LIPID PEROXIDATION; MALE; MOTOR COORDINATION; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; NERVE CELL NECROSIS; NEUROCHEMISTRY; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PERINATAL PERIOD; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; ANTIOXIDANTS; BASAL GANGLIA; BEHAVIOR, ANIMAL; CASPASES; CHROMANS; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; FEMALE; MALE; MANGANESE POISONING; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RATS; RATS, WISTAR; ROTAROD PERFORMANCE TEST; SIGNAL TRANSDUCTION;

RATTUS;

EID: 84879159921     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-013-1017-5     Document Type: Article

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