TRPA1

Handbook of Experimental Pharmacology

Volumn 222, Issue , 2014, Pages 583-630

  Zygmunt, Peter M ^a   Högesättt, Edward D ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Allyl isothiocyanate; Cannabinoid; Chemosensitivity; Hydrogen sulfide; Hyperalgesia; Irritants; Mechanotransduction; Menthol; Mustard oil; Nociceptor; Pain; Sensory transduction; Thermosensitive; TRPA1; TRPV1

Indexed keywords

A 967079; ALLYL ISOTHIOCYANATE; CALCIUM ION; CAPSAICIN; CINNAMALDEHYDE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYSTEINE; HISTIDINE; ION TRANSPORT AFFECTING AGENT; N (4 ISOPROPYLPHENYL) 2 (1,2,3,6 TETRAHYDRO 1,3 DIMETHYL 2,6 DIOXO 7H PURIN 7 YL)ACETAMIDE; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VOLTAGE GATED POTASSIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL; CALCIUM CHANNEL; NERVE PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRPA1 PROTEIN, HUMAN; TRPA1 PROTEIN, MOUSE;

ACTION POTENTIAL; ALLODYNIA; ARTICLE; BINDING SITE; BRAIN LEVEL; CALCIUM TRANSPORT; CHANNEL GATING; CHEMOSENSITIZATION; COLD SENSATION; CYCLOPHOSPHAMIDE-INDUCED CYSTITIS; GAIN OF FUNCTION MUTATION; GENETIC DISORDER; HUMAN; HYPERSENSITIVITY; INFLAMMATORY DISEASE; MECHANICAL HYPERALGESIA; MECHANOSENSATION; NONHUMAN; PERIPHERAL NEUROPATHY; PERMEABILITY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN STRUCTURE; PRURITUS; SENSATION; SENSORY NERVE CELL; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SODIUM TRANSPORT; TRPA1 GENE; UPREGULATION; ANIMAL; CELL MEMBRANE PERMEABILITY; CHEMISTRY; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; KNOCKOUT MOUSE; MEMBRANE POTENTIAL; METABOLISM; MOUSE; PHENOTYPE; REVIEW; STRUCTURE ACTIVITY RELATION;

ANIMALS; CALCIUM CHANNELS; CELL MEMBRANE PERMEABILITY; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; PHENOTYPE; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84904476162     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-642-54215-2_23     Document Type: Article

References (305)

1. Akiyama T, Carstens MI, Carstens E (2010) Facial injections of pruritogens and algogens excite partly overlapping populations of primary and second-order trigeminal neurons in mice. J Neurophysiol 104: 2442-2450.
2. Akopian AN, Ruparel NB, Jeske NA, Hargreaves KM (2007) Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization. J Physiol 583: 175-193.
3. Akopian AN, Ruparel NB, Patwardhan A, Hargreaves KM (2008) Cannabinoids desensitize capsaicin and mustard oil responses in sensory neurons via TRPA1 activation. J Neurosci 28: 1064-1075.
4. Alenmyr L, Högestätt ED, Zygmunt PM, Greiff L (2009) TRPV1-mediated itch in seasonal allergic rhinitis. Allergy 64: 807-810.
5. Alenmyr L, Herrmann A, Högestätt ED, Greiff L, Zygmunt PM (2011) TRPV1 and TRPA1 stimulation induces MUC5B secretion in the human nasal airway in vivo. Clin Physiol Funct Imaging 31: 435-444.
6. Alpizar YA, Gees M, Sanchez A, Apetrei A, Voets T, Nilius B, Talavera K (2013) Bimodal effects of cinnamaldehyde and camphor on mouse TRPA1. Pflugers Arch 465: 853-864.
7. Anand U, Otto WR, Facer P, Zebda N, Selmer I, Gunthorpe MJ, Chessell IP, Sinisi M, Birch R, Anand P (2008) TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons. Neurosci Lett 438: 221-227.
8. Andersson DA, Gentry C, Moss S, Bevan S (2008) Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress. J Neurosci 28: 2485-2494.
9. 2+. Proc Natl Acad Sci USA 106: 8374-8379.
10. Andersson KE, Gratzke C, Hedlund P (2010) The role of the transient receptor potential (TRP) superfamily of cation-selective channels in the management of the overactive bladder. BJU Int 106: 1114-1127.
11. Andersson DA, Gentry C, Alenmyr L, Killander D, Lewis SE, Andersson A, Bucher B, Galzi JL, Sterner O, Bevan S, Högestätt ED, Zygmunt PM (2011) TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Delta(9)-tetrahydrocannabiorcol. Nat Commun 2: 551.
12. Andersson DA, Gentry C, Bevan S (2012) TRPA1 has a key role in the somatic pro-nociceptive actions of hydrogen sulfide. PLoS One 7: e46917.
13. Andersson DA, Gentry C, Light E, Vastani N, Vallortigara J, Bierhaus A, Fleming T, Bevan S (2013) Methylglyoxal evokes pain by stimulating TRPA1. PLoS One 8: e77986.
14. Andrade EL, Forner S, Bento AF, Leite DF, Dias MA, Leal PC, Koepp J, Calixto JB (2011) TRPA1 receptor modulation attenuates bladder overactivity induced by spinal cord injury. Am J Physiol Renal Physiol 300: F1223-F1234.
15. Andrade EL, Meotti FC, Calixto JB (2012) TRPA1 antagonists as potential analgesic drugs. Pharmacol Ther 133: 189-204.
16. Andre E, Campi B, Materazzi S, Trevisani M, Amadesi S, Massi D, Creminon C, Vaksman N, Nassini R, Civelli M, Baraldi PG, Poole DP, Bunnett NW, Geppetti P, Patacchini R (2008) Cigarette smoke-induced neurogenic inflammation is mediated by alpha, beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J Clin Invest 118: 2574-2582.
17. Babes A, Fischer MJ, Filipovic M, Engel MA, Flonta ML, Reeh PW (2013) The anti-diabetic drug glibenclamide is an agonist of the transient receptor potential ankyrin 1 (TRPA1) ion channel. Eur J Pharmacol 704: 15-22.
18. Bandell M, Story GM, Hwang SW, Viswanath V, Eid SR, Petrus MJ, Earley TJ, Patapoutian A (2004) Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 41: 849-857.
19. Bang S, Kim KY, Yoo S, Kim YG, Hwang SW (2007) Transient receptor potential A1 mediates acetaldehyde-evoked pain sensation. Eur J Neurosci 26: 2516-2523.
20. Bang S, Yoo S, Oh U, Hwang SW (2010) Endogenous lipid-derived ligands for sensory TRP ion channels and their pain modulation. Arch Pharm Res 33: 1509-1520.
21. Bang S, Yoo S, Yang TJ, Cho H, Hwang SW (2011) Isopentenyl pyrophosphate is a novel antinociceptive substance that inhibits TRPV3 and TRPA1 ion channels. Pain 152: 1156-1164.
22. Banke TG, Chaplan SR, Wickenden AD (2010) Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilation. Am J Physiol Cell Physiol 298: C1457-C1468.
23. Baraldi PG, Preti D, Materazzi S, Geppetti P (2010) Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents. J Med Chem 53: 5085-5107.
24. Barriere DA, Rieusset J, Chanteranne D, Busserolles J, Chauvin MA, Chapuis L, Salles J, Dubray C, Morio B (2012) Paclitaxel therapy potentiates cold hyperalgesia in streptozotocin-induced diabetic rats through enhanced mitochondrial reactive oxygen species production and TRPA1 sensitization. Pain 153: 553-561.
25. Barrière DA, Mallet C, Blomgren A, Simonsen C, Daulhac L, Libert F, Chapuy E, Etienne M, Högestätt ED, Zygmunt PM, Eschalier A (2013) Fatty acid amide hydrolase-dependent generation of antinociceptive drug metabolites acting on TRPV1 in the brain. PLoS One 8: e70690.
26. Bassoli A, Borgonovo G, Caimi S, Scaglioni L, Morini G, Moriello AS, Di Marzo V, De Petrocellis L (2009) Taste-guided identification of high potency TRPA1 agonists from Perilla frutescens. Bioorg Med Chem 17: 1636-1639.
27. Bautista DM, Movahed P, Hinman A, Axelsson HE, Sterner O, Högestätt ED, Julius D, Jordt S, Zygmunt PM (2005) Pungent products from garlic activate the sensory ion channel TRPA1. Proc Natl Acad Sci USA 102: 12248-12252.
28. Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, Yamoah EN, Basbaum AI, Julius D (2006) TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124: 1269-1282.
29. Bautista DM, Pellegrino M, Tsunozaki M (2013) TRPA1: a gatekeeper for inflammation. Annu Rev Physiol 75: 181-200.
30. Bellono NW, Oancea E (2013) UV light phototransduction depolarizes human melanocytes. Channels (Austin) 7.
31. Bellono NW, Kammel LG, Zimmerman AL, Oancea E (2013) UV light phototransduction activates transient receptor potential A1 ion channels in human melanocytes. Proc Natl Acad Sci USA 110: 2383-2388.
32. Belmonte C, Viana F (2008) Molecular and cellular limits to somatosensory specificity. Mol Pain 4: 14.
33. Belmonte C, Brock JA, Viana F (2009) Converting cold into pain. Exp Brain Res 196: 13-30.
34. Benemei S, Fusi C, Trevisan G, Geppetti P (2013) The TRPA1 Channel in Migraine Mechanism and Treatment. Br J Pharmacol. doi: 10. 1111/bph. 12512.
35. Bessac BF, Jordt SE (2008) Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. Physiology (Bethesda) 23: 360-370.
36. Bessac BF, Sivula M, von Hehn CA, Escalera J, Cohn L, Jordt SE (2008) TRPA1 is a major oxidant sensor in murine airway sensory neurons. J Clin Invest 118: 1899-1910.
37. Bessac BF, Sivula M, von Hehn CA, Caceres AI, Escalera J, Jordt SE (2009) Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. FASEB J 23: 1102-1114.
38. Bianchi BR, Zhang XF, Reilly RM, Kym PR, Yao BB, Chen J (2012) Species comparison and pharmacological characterization of human, monkey, rat, and mouse TRPA1 channels. J Pharmacol Exp Ther 341: 360-368.
39. Binder A, May D, Baron R, Maier C, Tolle TR, Treede RD, Berthele A, Faltraco F, Flor H, Gierthmuhlen J, Haenisch S, Huge V, Magerl W, Maihofner C, Richter H, Rolke R, Scherens A, Uceyler N, Ufer M, Wasner G, Zhu J, Cascorbi I (2011) Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients. PLoS One 6: e17387.
40. Birder LA (2013) Nervous network for lower urinary tract function. Int J Urol 20: 4-12.
41. Bonet IJ, Fischer L, Parada CA, Tambeli CH (2013) The role of transient receptor potential A 1 (TRPA1) in the development and maintenance of carrageenan-induced hyperalgesia. Neuropharmacology 65: 206-212.
42. Brenneis C, Sisignano M, Coste O, Altenrath K, Fischer MJ, Angioni C, Fleming I, Brandes RP, Reeh PW, Woolf CJ, Geisslinger G, Scholich K (2011) Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation. Mol Pain 7: 78.
43. Brenneis C, Kistner K, Puopolo M, Jo S, Roberson D, Sisignano M, Segal D, Cobos EJ, Wainger BJ, Labocha S, Ferreiros N, von Hehn C, Tran J, Geisslinger G, Reeh PW, Bean BP, Woolf CJ (2014) Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block. Br J Pharmacol 171(2): 438-451.
44. Brierley SM, Hughes PA, Page AJ, Kwan KY, Martin CM, O'Donnell TA, Cooper NJ, Harrington AM, Adam B, Liebregts T, Holtmann G, Corey DP, Rychkov GY, Blackshaw LA (2009) The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli. Gastroenterology 137: 2084. e3-2095. e3.
45. Brierley SM, Castro J, Harrington AM, Hughes PA, Page AJ, Rychkov GY, Blackshaw LA (2011) TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity. J Physiol 589: 3575-3593.
46. Brone B, Peeters PJ, Marrannes R, Mercken M, Nuydens R, Meert T, Gijsen HJ (2008) Tear gasses CN, CR, and CS are potent activators of the human TRPA1 receptor. Toxicol Appl Pharmacol 231: 150-156.
47. Buch TR, Schafer EA, Demmel MT, Boekhoff I, Thiermann H, Gudermann T, Steinritz D, Schmidt A (2013) Functional expression of the transient receptor potential channel TRPA1, a sensor for toxic lung inhalants, in pulmonary epithelial cells. Chem Biol Interact 206(3): 462-471.
48. Cao DS, Zhong L, Hsieh TH, Abooj M, Bishnoi M, Hughes L, Premkumar LS (2012) Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells. PLoS One 7: e38005.
49. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389: 816-824.
50. Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288: 306-313.
51. Cattaruzza F, Spreadbury I, Miranda-Morales M, Grady EF, Vanner S, Bunnett NW (2010) Transient receptor potential ankyrin-1 has a major role in mediating visceral pain in mice. Am J Physiol Gastrointest Liver Physiol 298: G81-G91.
52. 2+ reveals different functional channel states. Neuroscience 154: 1467-1476.
53. Cevikbas F, Wang X, Akiyama T, Kempkes C, Savinko T, Antal A, Kukova G, Buhl T, Ikoma A, Buddenkotte J, Soumelis V, Feld M, Alenius H, Dillon SR, Carstens E, Homey B, Basbaum A, Steinhoff M (2014) A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: involvement of TRPV1 and TRPA1. J Allergy Clin Immunol 133: 448-460.
54. Chen J, Kym PR (2009) TRPA1: the species difference. J Gen Physiol 133: 623-625.
55. Chen J, Zhang XF, Kort ME, Huth JR, Sun C, Miesbauer LJ, Cassar SC, Neelands T, Scott VE, Moreland RB, Reilly RM, Hajduk PJ, Kym PR, Hutchins CW, Faltynek CR (2008) Molecular determinants of species-specific activation or blockade of TRPA1 channels. J Neurosci 28: 5063-5071.
56. Chen J, Kim D, Bianchi BR, Cavanaugh EJ, Faltynek CR, Kym PR, Reilly RM (2009) Pore dilation occurs in TRPA1 but not in TRPM8 channels. Mol Pain 5: 3.
57. Chen J, Joshi SK, DiDomenico S, Perner RJ, Mikusa JP, Gauvin DM, Segreti JA, Han P, Zhang XF, Niforatos W, Bianchi BR, Baker SJ, Zhong C, Simler GH, McDonald HA, Schmidt RG, McGaraughty SP, Chu KL, Faltynek CR, Kort ME, Reilly RM, Kym PR (2011a) Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation. Pain 152: 1165-1172.
58. Chen Y, Yang C, Wang ZJ (2011b) Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain. Neuroscience 193: 440-451.
59. Chen J, Kang D, Xu J, Lake M, Hogan JO, Sun C, Walter K, Yao B, Kim D (2013) Species differences and molecular determinant of TRPA1 cold sensitivity. Nat Commun 4: 2501.
60. Cho JH, Jeong MY, Choi IS, Lee HJ, Jang IS (2012) TRPA1-like channels enhance glycinergic transmission in medullary dorsal horn neurons. J Neurochem 122: 691-701.
61. Chung S, Kim YH, Koh JY, Nam TS, Ahn DS (2011) Intracellular acidification evoked by moderate extracellular acidosis attenuates transient receptor potential V1 (TRPV1) channel activity in rat dorsal root ganglion neurons. Exp Physiol 96: 1270-1281.
62. Cordero-Morales JF, Gracheva EO, Julius D (2011) Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli. Proc Natl Acad Sci USA 108: E1184-E1191.
63. Corey D, Garcia-Anoveros J, Holt J, Kwan K, Lin S, Vollrath M, Amalfitano A, Cheung E, Derfler B, Duggan A, Geleoc G, Gray P, Hoffman M, Rehm H, Tamasauskas D, Zhang D (2004) TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature 432: 723-730.
64. Cruz-Orengo L, Dhaka A, Heuermann RJ, Young TJ, Montana MC, Cavanaugh EJ, Kim D, Story GM (2008) Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1. Mol Pain 4: 30.
65. Cvetkov TL, Huynh KW, Cohen MR, Moiseenkova-Bell VY (2011) Molecular architecture and subunit organization of TRPA1 ion channel revealed by electron microscopy. J Biol Chem 286: 38168-38176.
66. da Costa DS, Meotti FC, Andrade EL, Leal PC, Motta EM, Calixto JB (2010) The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation. Pain 148: 431-437.
67. Dai Y, Wang S, Tominaga M, Yamamoto S, Fukuoka T, Higashi T, Kobayashi K, Obata K, Yamanaka H, Noguchi K (2007) Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain. J Clin Invest 117: 1979-1987.
68. Davis JB, Gray J, Gunthorpe MJ, Hatcher JP, Davey PT, Overend P, Harries MH, Latcham J, Clapham C, Atkinson K, Hughes SA, Rance K, Grau E, Harper AJ, Pugh PL, Rogers DC, Bingham S, Randall A, Sheardown SA (2000) Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature 405: 183-187.
69. de la Roche J, Eberhardt MJ, Klinger AB, Stanslowsky N, Wegner F, Koppert W, Reeh PW, Lampert A, Fischer MJ, Leffler A (2013) The molecular basis for species-specific activation of human TRPA1 protein by protons involves poorly conserved residues within transmembrane domains 5 and 6. J Biol Chem 288: 20280-20292.
70. De Petrocellis L, Vellani V, Schiano-Moriello A, Marini P, Magherini PC, Orlando P, Di Marzo V (2008) Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8. J Pharmacol Exp Ther 325: 1007-1015.
71. Deanfield JE, Halcox JP, Rabelink TJ (2007) Endothelial function and dysfunction: testing and clinical relevance. Circulation 115: 1285-1295.
72. del Camino D, Murphy S, Heiry M, Barrett LB, Earley TJ, Cook CA, Petrus MJ, Zhao M, D'Amours M, Deering N, Brenner GJ, Costigan M, Hayward NJ, Chong JA, Fanger CM, Woolf CJ, Patapoutian A, Moran MM (2010) TRPA1 contributes to cold hypersensitivity. J Neurosci 30: 15165-15174.
73. Descoeur J, Pereira V, Pizzoccaro A, Francois A, Ling B, Maffre V, Couette B, Busserolles J, Courteix C, Noel J, Lazdunski M, Eschalier A, Authier N, Bourinet E (2011) Oxaliplatininduced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors. EMBO Mol Med 3: 266-278.
74. Dhaka A, Uzzell V, Dubin AE, Mathur J, Petrus M, Bandell M, Patapoutian A (2009) TRPV1 is activated by both acidic and basic pH. J Neurosci 29: 153-158.
75. Diogenes A, Akopian AN, Hargreaves KM (2007) NGF up-regulates TRPA1: implications for orofacial pain. J Dent Res 86: 550-555.
76. Doerner JF, Gisselmann G, Hatt H, Wetzel CH (2007) Transient receptor potential channel A1 is directly gated by calcium ions. J Biol Chem 282: 13180-13189.
77. Du S, Araki I, Yoshiyama M, Nomura T, Takeda M (2007) Transient receptor potential channel A1 involved in sensory transduction of rat urinary bladder through C-fiber pathway. Urology 70: 826-831.
78. Due MR, Park J, Zheng L, Walls M, Allette YM, White FA, Shi R (2013) Acrolein involvement in sensory and behavioral hypersensitivity following spinal cord injury in the rat. J Neurochem. doi: 10. 1111/jnc. 12500.
79. Earley S (2012) TRPA1 channels in the vasculature. Br J Pharmacol 167: 13-22.
80. Eberhardt MJ, Filipovic MR, Leffler A, de la Roche J, Kistner K, Fischer MJ, Fleming T, Zimmermann K, Ivanovic-Burmazovic I, Nawroth PP, Bierhaus A, Reeh PW, Sauer SK (2012) Methylglyoxal activates nociceptors through transient receptor potential channel A1 (TRPA1): a possible mechanism of metabolic neuropathies. J Biol Chem 287: 28291-28306.
81. Eid SR, Crown ED, Moore EL, Liang HA, Choong KC, Dima S, Henze DA, Kane SA, Urban MO (2008) HC-030031, a TRPA1 selective antagonist, attenuates inflammatory-and neuropathyinduced mechanical hypersensitivity. Mol Pain 4: 48.
82. Eilers H, Cattaruzza F, Nassini R, Materazzi S, Andre E, Chu C, Cottrell GS, Schumacher M, Geppetti P, Bunnett NW (2010) Pungent general anesthetics activate transient receptor potential-A1 to produce hyperalgesia and neurogenic bronchoconstriction. Anesthesiology 112: 1452-1463.
83. Escalera J, von Hehn CA, Bessac BF, Sivula M, Jordt SE (2008) TRPA1 mediates the noxious effects of natural sesquiterpene deterrents. J Biol Chem 283: 24136-24144.
84. Fajardo O, Meseguer V, Belmonte C, Viana F (2008a) TRPA1 channels mediate cold temperature sensing in mammalian vagal sensory neurons: pharmacological and genetic evidence. J Neurosci 28: 7863-7875.
85. Fajardo O, Meseguer V, Belmonte C, Viana F (2008b) TRPA1 channels: novel targets of 1, 4-dihydropyridines. Channels (Austin) 2: 429-438.
86. Fernandes ES, Russell FA, Spina D, McDougall JJ, Graepel R, Gentry C, Staniland AA, Mountford DM, Keeble JE, Malcangio M, Bevan S, Brain SD (2011) A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor alpha-induced inflammatory hyperalgesia and Freund's complete adjuvant-induced monarthritis. Arthritis Rheum 63: 819-829.
87. Fernandes ES, Vong CT, Quek S, Cheong J, Awal S, Gentry C, Aubdool AA, Liang L, Bodkin JV, Bevan S, Heads R, Brain SD (2013) Superoxide generation and leukocyte accumulation: key elements in the mediation of leukotriene B(4)-induced itch by transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1. FASEB J 27: 1664-1673.
88. Fischer MJ, Leffler A, Niedermirtl F, Kistner K, Eberhardt M, Reeh PW, Nau C (2010) The general anesthetic propofol excites nociceptors by activating TRPV1 and TRPA1 rather than GABAA receptors. J Biol Chem 285: 34781-34792.
89. Forster AB, Reeh PW, Messlinger K, Fischer MJ (2009) High concentrations of morphine sensitize and activate mouse dorsal root ganglia via TRPV1 and TRPA1 receptors. Mol Pain 5: 17.
90. Fujita F, Moriyama T, Higashi T, Shima A, Tominaga M (2007) Methyl p-hydroxybenzoate causes pain sensation through activation of TRPA1 channels. Br J Pharmacol 151: 153-160.
91. Fujita F, Uchida K, Moriyama T, Shima A, Shibasaki K, Inada H, Sokabe T, Tominaga M (2008) Intracellular alkalization causes pain sensation through activation of TRPA1 in mice. J Clin Invest 118: 4049-4057.
92. Furchgott RF, Zawadzki JV (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288: 373-376.
93. Gaudet R (2008) A primer on ankyrin repeat function in TRP channels and beyond. Mol Biosyst 4: 372-379.
94. Gentry C, Stoakley N, Andersson DA, Bevan S (2010) The roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity. Mol Pain 6: 4.
95. Gijsen HJ, Berthelot D, Zaja M, Brone B, Geuens I, Mercken M (2010) Analogues of morphanthridine and the tear gas dibenz[b, f][1, 4]oxazepine (CR) as extremely potent activators of the human transient receptor potential ankyrin 1 (TRPA1) channel. J Med Chem 53: 7011-7020.
96. Graepel R, Fernandes ES, Aubdool AA, Andersson DA, Bevan S, Brain SD (2011) 4-oxo-2-nonenal (4-ONE): evidence of transient receptor potential ankyrin 1-dependent and-independent nociceptive and vasoactive responses in vivo. J Pharmacol Exp Ther 337: 117-124.
97. Gregus AM, Doolen S, Dumlao DS, Buczynski MW, Takasusuki T, Fitzsimmons BL, Hua XY, Taylor BK, Dennis EA, Yaksh TL (2012) Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors. Proc Natl Acad Sci USA 109: 6721-6726.
98. Hill K, Schaefer M (2007) TRPA1 is differentially modulated by the amphipathic molecules trinitrophenol and chlorpromazine. J Biol Chem 282: 7145-7153.
99. Hinman A, Chuang HH, Bautista DM, Julius D (2006) TRP channel activation by reversible covalent modification. Proc Natl Acad Sci USA 103: 19564-19568.
100. Hjerling-Leffler J, Alqatari M, Ernfors P, Koltzenburg M (2007) Emergence of functional sensory subtypes as defined by transient receptor potential channel expression. J Neurosci 27: 2435-2443.
101. Hoffmann T, Kistner K, Miermeister F, Winkelmann R, Wittmann J, Fischer MJ, Weidner C, Reeh PW (2013) TRPA1 and TRPV1 are differentially involved in heat nociception of mice. Eur J Pain 17: 1472-1482.
102. Högestätt ED, Johansson R, Andersson DA, Zygmunt PM (2000) Involvement of sensory nerves in vasodilator responses to acetylcholine and potassium ions in rat hepatic artery. Br J Pharmacol 130: 27-32.
103. Holzer P (2011) Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system. Pharmacol Ther 131: 142-170.
104. Howard J, Bechstedt S (2004) Hypothesis: a helix of ankyrin repeats of the NOMPC-TRP ion channel is the gating spring of mechanoreceptors. Curr Biol 14: R224-R226.
105. Hsu CC, Lin RL, Lee LY, Lin YS (2013) Hydrogen sulfide induces hypersensitivity of rat capsaicin-sensitive lung vagal neurons: role of TRPA1 receptors. Am J Physiol Regul Integr Comp Physiol 305: R769-R779.
106. Hu H, Tian J, Zhu Y, Wang C, Xiao R, Herz JM, Wood JD, Zhu MX (2010) Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs. Pflugers Arch 459: 579-592.
107. Hu H, Bandell M, Petrus MJ, Zhu MX, Patapoutian A (2009) Zinc activates damage-sensing TRPA1 ion channels. Nat Chem Biol 5: 183-190.
108. Huang J, Liu CH, Hughes SA, Postma M, Schwiening CJ, Hardie RC (2010) Activation of TRP channels by protons and phosphoinositide depletion in Drosophila photoreceptors. Curr Biol 20: 189-197.
109. Hughes PA, Harrington AM, Castro J, Liebregts T, Adam B, Grasby DJ, Isaacs NJ, Maldeniya L, Martin CM, Persson J, Andrews JM, Holtmann G, Blackshaw LA, Brierley SM(2013) Sensory neuro-immune interactions differ between irritable bowel syndrome subtypes. Gut 62: 1456-1465.
110. Ibarra Y, Blair NT (2013) Benzoquinone reveals a cysteine-dependent desensitization mechanism of TRPA1. Mol Pharmacol 83: 1120-1132.
111. Jaquemar D, Schenker T, Trueb B (1999) An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts. J Biol Chem 274: 7325-7333.
112. Jeffry JA, Yu SQ, Sikand P, Parihar A, Evans MS, Premkumar LS (2009) Selective targeting of TRPV1 expressing sensory nerve terminals in the spinal cord for long lasting analgesia. PLoS One 4: e7021.
113. Ji G, Zhou S, Carlton SM (2008) Intact Adelta-fibers up-regulate transient receptor potential A1 and contribute to cold hypersensitivity in neuropathic rats. Neuroscience 154: 1054-1066.
114. Jordt SE, Bautista DM, Chuang HH, McKemy DD, Zygmunt PM, Högestätt ED, Meng ID, Julius D (2004) Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427: 260-265.
115. Kanai AJ (2011) Afferent mechanism in the urinary tract. Handb Exp Pharmacol 202: 171-205.
116. Kaneko Y, Szallasi A (2013) Transient receptor potential (TRP) channels: a clinical perspective. Br J Pharmacol. doi: 10. 1111/bph. 12414.
117. Kang K, Pulver S, Panzano V, Chang E, Griffith L, Theobald D, Garrity P (2010) Analysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception. Nature 464: 597-600.
118. Karashima Y, Damann N, Prenen J, Talavera K, Segal A, Voets T, Nilius B (2007) Bimodal action of menthol on the transient receptor potential channel TRPA1. J Neurosci 27: 9874-9884.
119. Karashima Y, Prenen J, Meseguer V, Owsianik G, Voets T, Nilius B (2008) Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4, 5-biphosphate manipulators. Pflugers Arch 457: 77-89.
120. Karashima Y, Talavera K, Everaerts W, Janssens A, Kwan KY, Vennekens R, Nilius B, Voets T (2009) TRPA1 acts as a cold sensor in vitro and in vivo. Proc Natl Acad Sci USA 106: 1273-1278.
121. Karashima Y, Prenen J, Talavera K, Janssens A, Voets T, Nilius B (2010) Agonist-induced changes in Ca(2+) permeation through the nociceptor cation channel TRPA1. Biophys J 98: 773-783.
122. Katsura H, Obata K, Mizushima T, Yamanaka H, Kobayashi K, Dai Y, Fukuoka T, Tokunaga A, Sakagami M, Noguchi K (2006) Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats. Exp Neurol 200: 112-123.
123. Kerstein PC, del Camino D, Moran MM, Stucky CL (2009) Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors. Mol Pain 5: 19.
124. Kichko TI, Lennerz J, Eberhardt M, Babes RM, Neuhuber W, Kobal G, Reeh PW (2013) Bimodal concentration-response of nicotine involves the nicotinic acetylcholine receptor, transient receptor potential vanilloid type 1, and transient receptor potential ankyrin 1 channels in mouse trachea and sensory neurons. J Pharmacol Exp Ther 347: 529-539.
125. Kim D, Cavanaugh EJ (2007) Requirement of a soluble intracellular factor for activation of transient receptor potential A1 by pungent chemicals: role of inorganic polyphosphates. J Neurosci 27: 6500-6509.
126. Kim D, Cavanaugh EJ, Simkin D (2008) Inhibition of transient receptor potential A1 channel by phosphatidylinositol-4, 5-bisphosphate. Am J Physiol Cell Physiol 295: C92-C99.
127. Kim YS, Son JY, Kim TH, Paik SK, Dai Y, Noguchi K, Ahn DK, Bae YC (2010) Expression of transient receptor potential ankyrin 1 (TRPA1) in the rat trigeminal sensory afferents and spinal dorsal horn. J Comp Neurol 518: 687-698.
128. Kindt KS, Viswanath V, Macpherson L, Quast K, Hu H, Patapoutian A, Schafer WR (2007) Caenorhabditis elegans TRPA-1 functions in mechanosensation. Nat Neurosci 10: 568-577.
129. Klement G, Eisele L, Malinowsky D, Nolting A, Svensson M, Terp G, Weigelt D, Dabrowski M (2013) Characterization of a ligand binding site in the human transient receptor potential ankyrin 1 pore. Biophys J 104: 798-806.
130. Klionsky L, Tamir R, Gao B, Wang W, Immke DC, Nishimura N, Gavva NR (2007) Speciesspecific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists. Mol Pain 3: 39.
131. Koch M, Kreutz S, Bottger C, Grabiec U, Ghadban C, Korf HW, Dehghani F (2011) The cannabinoid WIN 55, 212-2-mediated protection of dentate gyrus granule cells is driven by CB1 receptors and modulated by TRPA1 and Cav 2. 2 channels. Hippocampus 21: 554-564.
132. Koivisto A, Hukkanen M, Saarnilehto M, Chapman H, Kuokkanen K, Wei H, Viisanen H, Akerman KE, Lindstedt K, Pertovaara A (2012) Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy. Pharmacol Res 65: 149-158.
133. Koltzenburg M, Lundberg LE, Torebjörk HE (1992) Dynamic and static components of mechanical hyperalgesia in human hairy skin. Pain 51: 207-219.
134. Kondo T, Obata K, Miyoshi K, Sakurai J, Tanaka J, Miwa H, Noguchi K (2009) Transient receptor potential A1 mediates gastric distention-induced visceral pain in rats. Gut 58: 1342-1352.
135. Kosugi M, Nakatsuka T, Fujita T, Kuroda Y, Kumamoto E (2007) Activation of TRPA1 channel facilitates excitatory synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord. J Neurosci 27: 4443-4451.
136. Kremeyer B, Lopera F, Cox JJ, Momin A, Rugiero F, Marsh S, Woods CG, Jones NG, Paterson KJ, Fricker FR, Villegas A, Acosta N, Pineda-Trujillo NG, Ramirez JD, Zea J, Burley MW, Bedoya G, Bennett DL, Wood JN, Ruiz-Linares A (2010) A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome. Neuron 66: 671-680.
137. Kwan KY, Allchorne AJ, Vollrath MA, Christensen AP, Zhang D-S, Woolf CJ, Corey DP (2006) TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for haircell transduction. Neuron 50: 277-289.
138. Kwan KY, Glazer JM, Corey DP, Rice FL, Stucky CL (2009) TRPA1 modulates mechanotransduction in cutaneous sensory neurons. J Neurosci 29: 4808-4819.
139. + channels between the lumbar splanchnic and pelvic nerve innervations of mouse urinary bladder and colon. Neuroscience 186: 179-187.
140. Lanosa MJ, Willis DN, Jordt S, Morris JB (2010) Role of metabolic activation and the TRPA1 receptor in the sensory irritation response to styrene and naphthalene. Toxicol Sci 115: 589-595.
141. Lee I, Kim HK, Kim JH, Chung K, Chung JM (2007) The role of reactive oxygen species in capsaicin-induced mechanical hyperalgesia and in the activities of dorsal horn neurons. Pain 133: 9-17.
142. Lee SP, Buber MT, Yang Q, Cerne R, Cortes RY, Sprous DG, Bryant RW (2008) Thymol and related alkyl phenols activate the hTRPA1 channel. Br J Pharmacol 153: 1739-1749.
143. Lee SM, Cho YS, Kim TH, Jin MU, Ahn DK, Noguchi K, Bae YC (2012) An ultrastructural evidence for the expression of transient receptor potential ankyrin 1 (TRPA1) in astrocytes in the rat trigeminal caudal nucleus. J Chem Neuroanat 45: 45-49.
144. Leffler A, Fischer MJ, Rehner D, Kienel S, Kistner K, Sauer SK, Gavva NR, Reeh PW, Nau C (2008) The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons. J Clin Invest 118: 763-776.
145. Lennertz RC, Kossyreva EA, Smith AK, Stucky CL (2012) TRPA1 mediates mechanical sensitization in nociceptors during inflammation. PLoS One 7: e43597.
146. Li L, Rose P, Moore PK (2011) Hydrogen sulfide and cell signaling. Annu Rev Pharmacol Toxicol 51: 169-187.
147. Liu T, Ji RR (2012) Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice. Neurosci Bull 28: 145-154.
148. Liu K, Samuel M, Ho M, Harrison RK, Paslay JW (2010) NPPB structure-specifically activates TRPA1 channels. Biochem Pharmacol 80: 113-121.
149. Liu B, Escalera J, Balakrishna S, Fan L, Caceres AI, Robinson E, Sui A, McKay MC, McAlexander MA, Herrick CA, Jordt SE (2013) TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis. FASEB J 27: 3549-3563.
150. Lozano-Ondoua AN, Symons-Liguori AM, Vanderah TW (2013) Cancer-induced bone pain: mechanisms and models. Neurosci Lett 557 Pt A: 52-59.
151. Lumpkin EA, Caterina MJ (2007) Mechanisms of sensory transduction in the skin. Nature 445: 858-865.
152. Macpherson LJ, Geierstanger BH, Viswanath V, Bandell M, Eid SR, Hwang S, Patapoutian A (2005) The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin. Curr Biol 15: 929-934.
153. Macpherson LJ, Dubin AE, Evans MJ, Marr F, Schultz PG, Cravatt BF, Patapoutian A (2007a) Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 445: 541-545.
154. Macpherson LJ, Xiao B, Kwan KY, Petrus MJ, Dubin AE, Hwang S, Cravatt B, Corey DP, Patapoutian A (2007b) An ion channel essential for sensing chemical damage. J Neurosci 27: 11412-11415.
155. Maggi CA (1995) Tachykinins and calcitonin gene-related peptide (CGRP) as co-transmitters released from peripheral endings of sensory nerves. Prog Neurobiol 45: 1-98.
156. Maher M, Ao H, Banke T, Nasser N, Wu NT, Breitenbucher JG, Chaplan SR, Wickenden AD (2008) Activation of TRPA1 by farnesyl thiosalicylic acid. Mol Pharmacol 73: 1225-1234.
157. Malin S, Molliver D, Christianson JA, Schwartz ES, Cornuet P, Albers KM, Davis BM (2011) TRPV1 and TRPA1 function and modulation are target tissue dependent. J Neurosci 31: 10516-10528.
158. Mallet C, Barriere DA, Ermund A, Jönsson BA, Eschalier A, Zygmunt PM, Högestätt ED (2010) TRPV(1) in brain is involved in acetaminophen-induced antinociception. PLoS One 5: e12748.
159. Masamoto Y, Kawabata F, Fushiki T (2009) Intragastric administration of TRPV1, TRPV3, TRPM8, and TRPA1 agonists modulates autonomic thermoregulation in different manners in mice. Biosci Biotechnol Biochem 73: 1021-1027.
160. Materazzi S, Nassini R, Andre E, Campi B, Amadesi S, Trevisani M, Bunnett NW, Patacchini R, Geppetti P (2008) Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1. Proc Natl Acad Sci USA 105: 12045-12050.
161. Materazzi S, Fusi C, Benemei S, Pedretti P, Patacchini R, Nilius B, Prenen J, Creminon C, Geppetti P, Nassini R (2012) TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism. Pflugers Arch 463: 561-569.
162. Materazzi S, Benemei S, Fusi C, Gualdani R, De Siena G, Vastani N, Andersson DA, Trevisan G, Moncelli MR, Wei X, Dussor G, Pollastro F, Patacchini R, Appendino G, Geppetti P, Nassini R (2013) Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel. Pain 154: 2750-2758.
163. Matta JA, Cornett PM, Miyares RL, Abe K, Sahibzada N, Ahern GP (2008) General anesthetics activate a nociceptive ion channel to enhance pain and inflammation. Proc Natl Acad Sci USA 105: 8784-8789.
164. May D, Baastrup J, Nientit MR, Binder A, Schunke M, Baron R, Cascorbi I (2012) Differential expression and functionality of TRPA1 protein genetic variants in conditions of thermal stimulation. J Biol Chem 287: 27087-27094.
165. McClenaghan C, Zeng F, Verkuyl JM (2012) TRPA1 agonist activity of probenecid desensitizes channel responses: consequences for screening. Assay Drug Dev Technol 10: 533-541.
166. McGaraughty S, Chu KL, Perner RJ, Didomenico S, Kort ME, Kym PR (2010) TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats. Mol Pain 6: 14.
167. McNamara CR, Mandel-Brehm J, Bautista DM, Siemens J, Deranian KL, Zhao M, Hayward NJ, Chong JA, Julius D, Moran MM, Fanger CM (2007) TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci USA 104: 13525-13530.
168. Meotti FC, Forner S, Lima-Garcia JF, Viana AF, Calixto JB (2013) Antagonism of the transient receptor potential ankyrin 1 (TRPA1) attenuates hyperalgesia and urinary bladder overactivity in cyclophosphamide-induced haemorrhagic cystitis. Chem Biol Interact 203: 440-447.
169. Meseguer V, Karashima Y, Talavera K, D'Hoedt D, Donovan-Rodriguez T, Viana F, Nilius B, Voets T (2008) Transient receptor potential channels in sensory neurons are targets of the antimycotic agent clotrimazole. J Neurosci 28: 576-586.
170. Messlinger K, Lennerz JK, Eberhardt M, Fischer MJ (2012) CGRP and NO in the trigeminal system: mechanisms and role in headache generation. Headache 52: 1411-1427.
171. Miyamoto T, Dubin AE, Petrus MJ, Patapoutian A (2009) TRPV1 and TRPA1 mediate peripheral nitric oxide-induced nociception in mice. PLoS One 4: e7596.
172. Mogil JS (2009) Animal models of pain: progress and challenges. Nat Rev Neurosci 10: 283-294.
173. Moilanen LJ, Laavola M, Kukkonen M, Korhonen R, Leppanen T, Högestätt ED, Zygmunt PM, Nieminen RM, Moilanen E (2012) TRPA1 contributes to the acute inflammatory response and mediates carrageenan-induced paw edema in the mouse. Sci Rep 2: 380.
174. Momin A, Wood JN (2008) Sensory neuron voltage-gated sodium channels as analgesic drug targets. Curr Opin Neurobiol 18: 383-388.
175. Moran MM, McAlexander MA, Biro T, Szallasi A (2011) Transient receptor potential channels as therapeutic targets. Nat Rev Drug Discov 10: 601-620.
176. Motter AL, Ahern GP (2012) TRPA1 is a polyunsaturated fatty acid sensor in mammals. PLoS One 7: e38439.
177. Movahed P, Jönsson BA, Birnir B, Wingstrand JA, Jørgensen TD, Ermund A, Sterner O, Zygmunt PM, Högestätt ED (2005) Endogenous unsaturated C18 N-acylethanolamines are vanilloid receptor (TRPV1) agonists. J Biol Chem 280: 38496-38504.
178. Nagata K, Duggan A, Kumar G, Garcia-Anoveros J (2005) Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing. J Neurosci 25: 4052-4061.
179. Nagatomo K, Kubo Y (2008) Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels. Proc Natl Acad Sci USA 105: 17373-17378.
180. Namer B, Seifert F, Handwerker HO, Maihofner C (2005) TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol. Neuroreport 16: 955-959.
181. Namer B, Carr R, Johanek LM, Schmelz M, Handwerker HO, Ringkamp M (2008) Separate peripheral pathways for pruritus in man. J Neurophysiol 100: 2062-2069.
182. Narukawa M, Koizumi K, Iwasaki Y, Kubota K, Watanabe T (2010) Galangal pungent component, 10-acetoxychavicol acetate, activates TRPA1. Biosci Biotechnol Biochem 74: 1694-1696.
183. Nassini R (2010) Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents. FASEB J 24: 4904-4916.
184. Nassini R, Gees M, Harrison S, De Siena G, Materazzi S, Moretto N, Failli P, Preti D, Marchetti N, Cavazzini A, Mancini F, Pedretti P, Nilius B, Patacchini R, Geppetti P (2011) Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation. Pain 152: 1621-1631.
185. Nassini R, Materazzi S, Vriens J, Prenen J, Benemei S, De Siena G, la Marca G, Andre E, Preti D, Avonto C, Sadofsky L, Di Marzo V, De Petrocellis L, Dussor G, Porreca F, Taglialatela-Scafati O, Appendino G, Nilius B, Geppetti P (2012) The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Brain 135: 376-390.
186. Nativi C, Gualdani R, Dragoni E, Di Cesare Mannelli L, Sostegni S, Norcini M, Gabrielli G, la Marca G, Richichi B, Francesconi O, Moncelli MR, Ghelardini C, Roelens S (2013) A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain. Sci Rep 3: 2005.
187. Niforatos W, Zhang XF, Lake MR, Walter KA, Neelands T, Holzman TF, Scott VE, Faltynek CR, Moreland RB, Chen J (2007) Activation of TRPA1 channels by the fatty acid amide hydrolase inhibitor 30-carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597). Mol Pharmacol 71: 1209-1216.
188. Nilius B, Appendino G (2013) Spices: the savory and beneficial science of pungency. Rev Physiol Biochem Pharmacol 164: 1-76.
189. Nilius B, Owsianik G (2011) The transient receptor potential family of ion channels. Genome Biol 12: 218.
190. Nilius B, Prenen J, Owsianik G (2011) Irritating channels: the case of TRPA1. J Physiol 589: 1543-1549.
191. Nilius B, Appendino G, Owsianik G (2012) The transient receptor potential channel TRPA1: from gene to pathophysiology. Pflugers Arch 464: 425-458.
192. Noel J, Sandoz G, Lesage F (2011) Molecular regulations governing TREK and TRAAK channel functions. Channels (Austin) 5: 402-409.
193. Nyman E, Franzen B, Nolting A, Klement G, Liu G, Nilsson M, Rosen A, Bjork C, Weigelt D, Wollberg P, Karila P, Raboisson P (2013) In vitro pharmacological characterization of a novel TRPA1 antagonist and proof of mechanism in a human dental pulp model. J Pain Res 6: 59-70.
194. Obata K, Katsura H, Mizushima T, Yamanaka H, Kobayashi K, Dai Y, Fukuoka T, Tokunaga A, Tominaga M, Noguchi K (2005) TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. J Clin Invest 115: 2393-2401.
195. Ogawa H, Takahashi K, Miura S, Imagawa T, Saito S, Tominaga M, Ohta T (2012) H(2)S functions as a nociceptive messenger through transient receptor potential ankyrin 1 (TRPA1) activation. Neuroscience 218: 335-343.
196. Oh MH, Oh SY, Lu J, Lou H, Myers AC, Zhu Z, Zheng T (2013) TRPA1-dependent pruritus in IL-13-induced chronic atopic dermatitis. J Immunol 191(11): 5371-5382.
197. Ohkawara S, Tanaka-Kagawa T, Furukawa Y, Jinno H (2012) Methylglyoxal activates the human transient receptor potential ankyrin 1 channel. J Toxicol Sci 37: 831-835.
198. Okubo K, Matsumura M, Kawaishi Y, Aoki Y, Matsunami M, Okawa Y, Sekiguchi F, Kawabata A (2012) Hydrogen sulfide-induced mechanical hyperalgesia and allodynia require activation of both Cav3. 2 and TRPA1 channels in mice. Br J Pharmacol 166: 1738-1743.
199. Okumura Y, Narukawa M, Iwasaki Y, Ishikawa A, Matsuda H, Yoshikawa M, Watanabe T (2010) Activation of TRPV1 and TRPA1 by black pepper components. Biosci Biotechnol Biochem 74: 1068-1072.
200. Olausson B (1998) Recordings of human polymodal single C-fiber afferents following mechanical and argon-laser heat stimulation of inflamed skin. Exp Brain Res 122: 55-61.
201. Panzano VC, Kang K, Garrity PA (2010) Infrared snake eyes: TRPA1 and the thermal sensitivity of the snake pit organ. Sci Signal 3: pe22.
202. Park CK, Xu ZZ, Liu T, Lu N, Serhan CN, Ji RR (2011) Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1. J Neurosci 31: 18433-18438.
203. Patapoutian A, Tate S, Woolf CJ (2009) Transient receptor potential channels: targeting pain at the source. Nat Rev Drug Discov 8: 55-68.
204. Pereira LM, Lima-Junior RC, Bem AX, Teixeira CG, Grassi LS, Medeiros RP, Marques-Neto RD, Callado RB, Aragao KS, Wong DV, Vale ML, Brito GA, Ribeiro RA (2013) Blockade of TRPA1 with HC-030031 attenuates visceral nociception by a mechanism independent of inflammatory resident cells, nitric oxide and the opioid system. Eur J Pain 17: 223-233.
205. Petersson J, Zygmunt PM, Brandt L, Högestätt ED (1995) Substance P-induced relaxation and hyperpolarization in human cerebral arteries. Br J Pharmacol 115: 889-894.
206. Petersson J, Zygmunt PM, Högestätt ED (1997) Characterization of the potassium channels involved in EDHF-mediated relaxation in cerebral arteries. Br J Pharmacol 120: 1344-1350.
207. Petersson J, Zygmunt PM, Jönsson P, Högestätt ED (1998) Characterization of endotheliumdependent relaxation in guinea pig basilar artery-effect of hypoxia and role of cytochrome P450 monooxygenase. J Vasc Res 35: 285-294.
208. Petrus M, Peier AM, Bandell M, Hwang SW, Huynh T, Olney N, Jegla T, Patapoutian A (2007) A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol Pain 3: 40.
209. Peyrot des Gachons C, Uchida K, Bryant B, Shima A, Sperry JB, Dankulich-Nagrudny L, Tominaga M, Smith AB 3rd, Beauchamp GK, Breslin PA (2011) Unusual pungency from extra-virgin olive oil is attributable to restricted spatial expression of the receptor of oleocanthal. J Neurosci 31: 999-1009.
210. Pozsgai G, Hajna Z, Bagoly T, Boros M, Kemeny A, Materazzi S, Nassini R, Helyes Z, Szolcsanyi J, Pinter E (2012) The role of transient receptor potential ankyrin 1 (TRPA1) receptor activation in hydrogen-sulphide-induced CGRP-release and vasodilation. Eur J Pharmacol 689: 56-64.
211. Prasad P, Yanagihara AA, Small-Howard AL, Turner H, Stokes AJ (2008) Secretogranin III directs secretory vesicle biogenesis in mast cells in a manner dependent upon interaction with chromogranin A. J Immunol 181: 5024-5034.
212. Proudfoot CJ, Garry EM, Cottrell DF, Rosie R, Anderson H, Robertson DC, Fleetwood-Walker SM, Mitchell R (2006) Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain. Curr Biol 16: 1591-1605.
213. Raisinghani M, Zhong L, Jeffry JA, Bishnoi M, Pabbidi RM, Pimentel F, Cao DS, Evans MS, Premkumar LS (2011) Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception. Am J Physiol Cell Physiol 301: C587-C600.
214. Riera CE, Menozzi-Smarrito C, Affolter M, Michlig S, Munari C, Robert F, Vogel H, Simon SA, le Coutre J (2009) Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. Br J Pharmacol 157: 1398-1409.
215. Roberson DP, Gudes S, Sprague JM, Patoski HA, Robson VK, Blasl F, Duan B, Oh SB, Bean BP, Ma Q, Binshtok AM, Woolf CJ (2013) Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons. Nat Neurosci 16: 910-918.
216. Ross SE (2011) Pain and itch: insights into the neural circuits of aversive somatosensation in health and disease. Curr Opin Neurobiol 21: 880-887.
217. Ryosuke K, Katsura N, Hitoshi D, Yoshihiro K, Hidetaka K, Toshihide Y, Hiroyuki I (2014) Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain. Eur J Pharmacol 723: 288-293.
218. Sadofsky LR, Boa AN, Maher SA, Birrell MA, Belvisi MG, Morice AH (2011) TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids. Pharmacol Res 63: 30-36.
219. Salas MM, Hargreaves KM, Akopian AN (2009) TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1. Eur J Neurosci 29: 1568-1578.
220. Samad A, Sura L, Benedikt J, Ettrich R, Minofar B, Teisinger J, Vlachova V (2011) The C-terminal basic residues contribute to the chemical-and voltage-dependent activation of TRPA1. Biochem J 433: 197-204.
221. Sawada Y, Hosokawa H, Hori A, Matsumura K, Kobayashi S (2007) Cold sensitivity of recombinant TRPA1 channels. Brain Res 1160: 39-46.
222. Sawada Y, Hosokawa H, Matsumura K, Kobayashi S (2008) Activation of transient receptor potential ankyrin 1 by hydrogen peroxide. Eur J Neurosci 27: 1131-1142.
223. Schmelz M, Schmidt R, Bickel A, Handwerker HO, Torebjörk HE (1997) Specific C-receptors for itch in human skin. J Neurosci 17: 8003-8008.
224. Schmidt M, Dubin AE, Petrus MJ, Earley TJ, Patapoutian A (2009) Nociceptive signals induce trafficking of TRPA1 to the plasma membrane. Neuron 64: 498-509.
225. Schulze A, Oehler B, Urban N, Schaefer M, Hill K (2013) Apomorphine is a bimodal modulator of TRPA1 channels. Mol Pharmacol 83: 542-551.
226. Schwartz ES, Christianson JA, Chen X, La JH, Davis BM, Albers KM, Gebhart GF (2011) Synergistic role of TRPV1 and TRPA1 in pancreatic pain and inflammation. Gastroenterology 140: 1283-1291.
227. Sculptoreanu A, Kullmann FA, Artim DE, Bazley FA, Schopfer F, Woodcock S, Freeman BA, de Groat WC (2010) Nitro-oleic acid inhibits firing and activates TRPV1-and TRPA1-mediated inward currents in dorsal root ganglion neurons from adult male rats. J Pharmacol Exp Ther 333: 883-895.
228. Shigetomi E, Tong X, Kwan KY, Corey DP, Khakh BS (2012) TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3. Nat Neurosci 15: 70-80.
229. Shigetomi E, Jackson-Weaver O, Huckstepp RT, O'Dell TJ, Khakh BS (2013) TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-serine release. J Neurosci 33: 10143-10153.
230. Shintaku K, Uchida K, Suzuki Y, Zhou Y, Fushiki T, Watanabe T, Yazawa S, Tominaga M (2012) Activation of transient receptor potential A1 by a non-pungent capsaicin-like compound, capsiate. Br J Pharmacol 165: 1476-1486.
231. Sidi S, Friedrich RW, Nicolson T (2003) NompC TRP channel required for vertebrate sensory hair cell mechanotransduction. Science 301: 96-99.
232. Sisignano M, Park CK, Angioni C, Zhang DD, von Hehn C, Cobos EJ, Ghasemlou N, Xu ZZ, Kumaran V, Lu R, Grant A, Fischer MJ, Schmidtko A, Reeh P, Ji RR, Woolf CJ, Geisslinger G, Scholich K, Brenneis C (2012) 5, 6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals. J Neurosci 32: 6364-6372.
233. Spahn V, Stein C, Zollner C (2013) Modulation of transient receptor vanilloid 1 activity by transient receptor potential ankyrin 1. Mol Pharmacol 85(2): 335-344.
234. Staruschenko A, Jeske NA, Akopian AN (2010) Contribution of TRPV1-TRPA1 interaction to the single channel properties of the TRPA1 channel. J Biol Chem 285: 15167-15177.
235. Stokes A, Wakano C, Koblan-Huberson M, Adra CN, Fleig A, Turner H (2006) TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD. Cell Signal 18(10): 1584-1594.
236. Story GM, Peier AM, Reeve AJ, Eid SR, Mosbacher J, Hricik TR, Earley TJ, Hergarden AC, Andersson DA, Hwang SW, McIntyre P, Jegla T, Bevan S, Patapoutian A (2003) ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112: 819-829.
237. Stotz SC, Vriens J, Martyn D, Clardy J, Clapham DE (2008) Citral sensing by transient [corrected] receptor potential channels in dorsal root ganglion neurons. PLoS One 3: e2082.
238. Streng T, Axelsson HE, Hedlund P, Andersson DA, Jordt SE, Bevan S, Andersson KE, Högestätt ED, Zygmunt PM (2008) Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder. Eur Urol 53: 391-399.
239. 2+-induced regulation of human transient receptor potential ankyrin 1 channel. J Biol Chem 287: 18067-18077.
240. Takahashi N, Mori Y (2011) TRP channels as sensors and signal integrators of redox status changes. Front Pharmacol 2: 58.
241. Takahashi N, Mizuno Y, Kozai D, Yamamoto S, Kiyonaka S, Shibata T, Uchida K, Mori Y (2008) Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators. Channels (Austin) 2: 287-298.
242. Takahashi N, Kuwaki T, Kiyonaka S, Numata T, Kozai D, Mizuno Y, Yamamoto S, Naito S, Knevels E, Carmeliet P, Oga T, Kaneko S, Suga S, Nokami T, Yoshida J, Mori Y (2011) TRPA1 underlies a sensing mechanism for O2. Nat Chem Biol 7: 701-711.
243. Takahashi N, Kozai D, Mori Y (2012) TRP channels: sensors and transducers of gasotransmitter signals. Front Physiol 3: 324.
244. Takaishi M, Uchida K, Fujita F, Tominaga M(2013) Inhibitory effects of monoterpenes on human TRPA1 and the structural basis of their activity. J Physiol Sci 64(1): 47-57.
245. Talavera K, Gees M, Karashima Y, Meseguer VM, Vanoirbeek JA, Damann N, Everaerts W, Benoit M, Janssens A, Vennekens R, Viana F, Nemery B, Nilius B, Voets T (2009) Nicotine activates the chemosensory cation channel TRPA1. Nat Neurosci 12: 1293-1299.
246. Tang G, Yang G, Jiang B, Ju Y, Wu L, Wang R (2013) H2S Is an endothelium-derived hyperpolarizing factor. Antioxid Redox Signal 19: 1634-1646.
247. Taylor-Clark TE, Undem BJ (2010) Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels. J Physiol 588: 423-433.
248. Taylor-Clark TE, Undem BJ (2011) Sensing pulmonary oxidative stress by lung vagal afferents. Respir Physiol Neurobiol 178: 406-413.
249. Taylor-Clark TE, McAlexander MA, Nassenstein C, Sheardown SA, Wilson S, Thornton J, Carr MJ, Undem BJ (2008a) Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal. J Physiol 586: 3447-3459.
250. Taylor-Clark TE, Undem BJ, Macglashan DW Jr, Ghatta S, Carr MJ, McAlexander MA (2008b) Prostaglandin-induced activation of nociceptive neurons via direct interaction with transient receptor potential A1 (TRPA1). Mol Pharmacol 73: 274-281.
251. Taylor-Clark TE, Ghatta S, Bettner W, Undem BJ (2009a) Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1. Mol Pharmacol 75: 820-829.
252. Taylor-Clark TE, Kiros F, Carr MJ, McAlexander MA (2009b) Transient receptor potential ankyrin 1 mediates toluene diisocyanate-evoked respiratory irritation. Am J Respir Cell Mol Biol 40: 756-762.
253. Trevisan G, Materazzi S, Fusi C, Altomare A, Aldini G, Lodovici M, Patacchini R, Geppetti P, Nassini R (2013) Novel therapeutic strategy to prevent chemotherapy-induced persistent sensory neuropathy by TRPA1 blockade. Cancer Res 73: 3120-3131.
254. Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andre E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P (2007) 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci USA 104: 13519-13524.
255. Tsubota-Matsunami M, Noguchi Y, Okawa Y, Sekiguchi F, Kawabata A (2012) Colonic hydrogen sulfide-induced visceral pain and referred hyperalgesia involve activation of both Ca(v)3. 2 and TRPA1 channels in mice. J Pharmacol Sci 119: 293-296.
256. Uta D, Furue H, Pickering AE, Rashid MH, Mizuguchi-Takase H, Katafuchi T, Imoto K, Yoshimura M (2010) TRPA1-expressing primary afferents synapse with a morphologically identified subclass of substantia gelatinosa neurons in the adult rat spinal cord. Eur J Neurosci 31: 1960-1973.
257. Venkatachalam K, Montell C (2007) TRP channels. Annu Rev Biochem 76: 387-417.
258. Vennekens R, Menigoz A, Nilius B (2012) TRPs in the brain. Rev Physiol Biochem Pharmacol 163: 27-64.
259. Vetter I, Touska F, Hess A, Hinsbey R, Sattler S, Lampert A, Sergejeva M, Sharov A, Collins LS, Eberhardt M, Engel M, Cabot PJ, Wood JN, Vlachova V, Reeh PW, Lewis RJ, Zimmermann K (2012) Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling. EMBO J 31: 3795-3808.
260. Viana F, Ferrer-Montiel A (2009) TRPA1 modulators in preclinical development. Expert Opin Ther Pat 19: 1787-1799.
261. Vilceanu D, Stucky CL (2010) TRPA1 mediates mechanical currents in the plasma membrane of mouse sensory neurons. PLoS One 5: e12177.
262. Voets T, Droogmans G, Wissenbach U, Janssens A, Flockerzi V, Nilius B (2004) The principle of temperature-dependent gating in cold-and heat-sensitive TRP channels. Nature 430: 748-754.
263. Walker RG, Willingham AT, Zuker CS (2000) A Drosophila mechanosensory transduction channel. Science 287: 2229-2234.
264. Wang R (2012) Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. Physiol Rev 92: 791-896.
265. Wang S, Dai Y, Fukuoka T, Yamanaka H, Kobayashi K, Obata K, Cui X, Tominaga M, Noguchi K (2008a) Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain. Brain 131: 1241-1251.
266. Wang YY, Chang RB, Waters HN, McKemy DD, Liman ER (2008b) The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions. J Biol Chem 283: 32691-32703.
267. 2. J Neurosci 30: 12958-12963.
268. Wang YY, Chang RB, Allgood SD, Silver WL, Liman ER (2011) A TRPA1-dependent mechanism for the pungent sensation of weak acids. J Gen Physiol 137: 493-505.
269. Wang L, Cvetkov TL, Chance MR, Moiseenkova-Bell VY (2012) Identification of in vivo disulfide conformation of TRPA1 ion channel. J Biol Chem 287: 6169-6176.
270. Wang H, Schupp M, Zurborg S, Heppenstall PA (2013) Residues in the pore region of Drosophila transient receptor potential A1 dictate sensitivity to thermal stimuli. J Physiol 591: 185-201.
271. Wei H, Hamalainen MM, Saarnilehto M, Koivisto A, Pertovaara A (2009) Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals. Anesthesiology 111: 147-154.
272. Wei H, Chapman H, Saarnilehto M, Kuokkanen K, Koivisto A, Pertovaara A (2010a) Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat. Neuropharmacology 58: 578-584.
273. Wei H, Koivisto A, Pertovaara A (2010b) Spinal TRPA1 ion channels contribute to cutaneous neurogenic inflammation in the rat. Neurosci Lett 479: 253-256.
274. Wei H, Koivisto A, Saarnilehto M, Chapman H, Kuokkanen K, Hao B, Huang JL, Wang YX, Pertovaara A (2011) Spinal transient receptor potential ankyrin 1 channel contributes to central pain hypersensitivity in various pathophysiological conditions in the rat. Pain 152: 582-591.
275. Wei H, Karimaa M, Korjamo T, Koivisto A, Pertovaara A (2012) Transient receptor potential ankyrin 1 ion channel contributes to guarding pain and mechanical hypersensitivity in a rat model of postoperative pain. Anesthesiology 117: 137-148.
276. Wei H, Saarnilehto M, Falck L, Viisanen H, Lasierra M, Koivisto A, Pertovaara A (2013a) Spinal transient receptor potential ankyrin 1 channel induces mechanical hypersensitivity, increases cutaneous blood flow, and mediates the pronociceptive action of dynorphin A. J Physiol Pharmacol 64: 331-340.
277. Wei H, Viisanen H, Amorim D, Koivisto A, Pertovaara A (2013b) Dissociated modulation of conditioned place-preference and mechanical hypersensitivity by a TRPA1 channel antagonist in peripheral neuropathy. Pharmacol Biochem Behav 104: 90-96.
278. Weller K, Reeh PW, Sauer SK (2011) TRPV1, TRPA1, and CB1 in the isolated vagus nerve-axonal chemosensitivity and control of neuropeptide release. Neuropeptides 45: 391-400.
279. Weng Y, Batista PA, Barabas ME, Harris EQ, Dinsmore TB, Kossyreva EA, Foshage AM, Wang MH, Schwab MJ, Wang VM, Stucky CL, Story GM (2012) Prostaglandin metabolite induces inhibition of TRPA1 and channel-dependent nociception. Mol Pain 8: 75.
280. Wilson SR, Gerhold KA, Bifolck-Fisher A, Liu Q, Patel KN, Dong X, Bautista DM (2011) TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch. Nat Neurosci 14: 595-602.
281. Wilson SR, Nelson AM, Batia L, Morita T, Estandian D, Owens DM, Lumpkin EA, Bautista DM (2013) The ion channel TRPA1 is required for chronic itch. J Neurosci 33: 9283-9294.
282. Wrigley PJ, Jeong HJ, Vaughan CW (2009) Primary afferents with TRPM8 and TRPA1 profiles target distinct subpopulations of rat superficial dorsal horn neurones. Br J Pharmacol 157: 371-380.
283. Xiao B, Dubin AE, Bursulaya B, Viswanath V, Jegla TJ, Patapoutian A (2008) Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels. J Neurosci 28: 9640-9651.
284. Xu H, Delling M, Jun JC, Clapham DE (2006) Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci 9: 628-635.
285. Yang J, Li Y, Zuo X, Zhen Y, Yu Y, Gao L (2008) Transient receptor potential ankyrin-1 participates in visceral hyperalgesia following experimental colitis. Neurosci Lett 440: 237-241.
286. Ye Y, Dang D, Zhang J, Viet CT, Lam DK, Dolan JC, Gibbs JL, Schmidt BL (2011) Nerve growth factor links oral cancer progression, pain, and cachexia. Mol Cancer Ther 10: 1667-1676.
287. Yokoyama T, Ohbuchi T, Saito T, Sudo Y, Fujihara H, Minami K, Nagatomo T, Uezono Y, Ueta Y (2011) Allyl isothiocyanates and cinnamaldehyde potentiate miniature excitatory postsynaptic inputs in the supraoptic nucleus in rats. Eur J Pharmacol 655: 31-37.
288. Yu YB, Yang J, Zuo XL, Gao LJ, Wang P, Li YQ (2010) Transient receptor potential vanilloid-1 (TRPV1) and ankyrin-1 (TRPA1) participate in visceral hyperalgesia in chronic water avoidance stress rat model. Neurochem Res 35: 797-803.
289. Yue HY, Jiang CY, Fujita T, Kumamoto E (2013) Zingerone enhances glutamatergic spontaneous excitatory transmission by activating TRPA1 but not TRPV1 channels in the adult rat substantia gelatinosa. J Neurophysiol 110: 658-671.
290. Zhang X, Li L, McNaughton PA (2008a) Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150. Neuron 59: 450-461.
291. Zhang XF, Chen J, Faltynek CR, Moreland RB, Neelands TR (2008b) Transient receptor potential A1 mediates an osmotically activated ion channel. Eur J Neurosci 27: 605-611.
292. Zhang D, Macinkovic I, Devarie-Baez NO, Pan J, Park CM, Carroll KS, Filipovic MR, Xian M (2014) Detection of protein S-sulfhydration by a tag-switch technique. Angew Chem Int Ed Engl 53: 575-581.
293. Zhao M, Isami K, Nakamura S, Shirakawa H, Nakagawa T, Kaneko S (2012) Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by the enhanced responsiveness of TRPA1 in mice. Mol Pain 8: 55.
294. Zhong J, Minassi A, Prenen J, Taglialatela-Scafati O, Appendino G, Nilius B (2011a) Umbellulone modulates TRP channels. Pflugers Arch 462: 861-870.
295. Zhong J, Pollastro F, Prenen J, Zhu Z, Appendino G, Nilius B (2011b) Ligustilide: a novel TRPA1 modulator. Pflugers Arch 462: 841-849.
296. 2+. Nat Neurosci 10: 277-279.
297. Zygmunt PM (2011) Channels: a TR(i)P in the air. Nat Chem Biol 7: 661-663.
298. Zygmunt PM, Högestätt ED (1996) Role of potassium channels in endothelium-dependent relaxation resistant to nitroarginine in the rat hepatic artery. Br J Pharmacol 117: 1600-1606.
299. Zygmunt PM, Grundemar L, Högestätt ED (1994a) Endothelium-dependent relaxation resistant to N omega-nitro-L-arginine in the rat hepatic artery and aorta. Acta Physiol Scand 152: 107-114.
300. Zygmunt PM, Waldeck K, Högestätt ED (1994b) The endothelium mediates a nitric oxideindependent hyperpolarization and relaxation in the rat hepatic artery. Acta Physiol Scand 152: 375-384.
301. Zygmunt PM, Plane F, Paulsson M, Garland CJ, Högestätt ED (1998) Interactions between endothelium-derived relaxing factors in the rat hepatic artery: focus on regulation of EDHF. Br J Pharmacol 124: 992-1000.
302. Zygmunt PM, Petersson J, Andersson DA, Chuang H, Sørgard M, Di Marzo V, Julius D, Högestätt ED (1999) Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 400: 452-457.
303. Zygmunt PM, Chuang H, Movahed P, Julius D, Högestätt ED (2000) The anandamide transport inhibitor AM404 activates vanilloid receptors. Eur J Pharmacol 396: 39-42.
304. 9-Tetrahydrocannabinol and cannabinol activate capsaicin-sensitive sensory nerves via a CB1 and CB2 cannabinoid receptorindependent mechanism. J Neurosci 22: 4720-4727.
305. Zygmunt PM, Ermund A, Movahed P, Andersson DA, Simonsen C, Jönsson BAG, Blomgren A, Birnir B, Bevan S, Eschlier A, Mallet C, Gomis A, Högestätt ED (2013) Monoacylglycerols activate TRPV1-a link between phospholipase C and TRPV1. PLoS One 8: e81618.