Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels

British Journal of Pharmacology

Volumn 157, Issue 8, 2009, Pages 1398-1409

  Riera, C E ^a   Menozzi Smarrito, C ^a   Affolter, M ^a   Michlig, S ^a   Munari, C ^a   Robert, F ^a   Vogel, H ^b   Simon, S A ^c   Le Coutre, J ^a  

^a NESTLÉ RESEARCH CENTER   (Switzerland)

^b EPFL   (Switzerland)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Calcium imaging; Chemosensation; Covalent binding; Structure activity; Taste preference; TRP channel; TRPV1 knockout

Indexed keywords

6 PARADOL; 6 SHOGAOL; ALPHA SANSHOOL; LINALOOL; PEPPER EXTRACT; TRANSIENT RECEPTOR POTENTIAL ANKYRIN 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHANNEL GATING; CHEMICAL STRUCTURE; CONTROLLED STUDY; COVALENT BOND; DORSAL ROOT; FEMALE; GENE MUTATION; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; RAT; SPINAL NERVE; STRUCTURE ACTIVITY RELATION; TASTE; WILD TYPE;

AMIDES; ANIMALS; ANIMALS, NEWBORN; CATECHOLS; CELLS, CULTURED; FEMALE; GUAIACOL; HUMANS; KETONES; MALE; MICE; MICE, KNOCKOUT; PLANT OILS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TRPV CATION CHANNELS; ZANTHOXYLUM; ZINGIBERACEAE;

EID: 70350338210     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00307.x     Document Type: Article

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