TRPA1 agonist activity of probenecid desensitizes channel responses: Consequences for screening

Assay and Drug Development Technologies

Volumn 10, Issue 6, 2012, Pages 533-541

  McClenaghan, Conor ^a,b   Zeng, Fanning ^a   Verkuyl, Jan Martin ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; CALCIUM SENSITIZER; FLUO 4 DYE; FLUORESCENT DYE; FURA 2 DYE; N (4 ISOPROPYLPHENYL) 2 (1,2,3,6 TETRAHYDRO 1,3 DIMETHYL 2,6 DIOXO 7H PURIN 7 YL)ACETAMIDE; PROBENECID; SULFINPYRAZONE; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TRANSIENT RECEPTOR POTENTIAL CHANNEL AFFECTING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ASSAY; CHO CELL; CONTROLLED STUDY; DESENSITIZATION; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; HUMAN; HUMAN CELL; IMAGING; MOUSE; NONHUMAN;

ANIMALS; CALCIUM CHANNELS; CHO CELLS; COLORING AGENTS; CRICETINAE; CRICETULUS; DRUG EVALUATION, PRECLINICAL; HEK293 CELLS; HUMANS; INDICATOR DILUTION TECHNIQUES; ION CHANNELS; NERVE TISSUE PROTEINS; PATCH-CLAMP TECHNIQUES; PROBENECID; RENAL AGENTS; SULFINPYRAZONE; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84870953045     PISSN: 1540658X     EISSN: 15578127     Source Type: Journal    
DOI: 10.1089/adt.2012.447     Document Type: Article

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