Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling

EMBO Journal

Volumn 31, Issue 19, 2012, Pages 3795-3808

  Vetter, Irina ^a   Touska, Filip ^b,c   Hess, Andreas ^b   Hinsbey, Rachel ^d   Sattler, Simon ^b   Lampert, Angelika ^b   Sergejeva, Marina ^b   Sharov, Anastasia ^a   Collins, Lindon S ^a   Eberhardt, Mirjam ^b   Engel, Matthias ^b   Cabot, Peter J ^a   Wood, John N ^d   Vlachová, Viktorie ^c   Reeh, Peter W ^b   Lewis, Richard J ^a   Zimmermann, Katharina ^b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

ciguatoxin; cold allodynia; Nav; nociceptor; TRPA1

Indexed keywords

CALCIUM; CIGUATOXIN; SODIUM CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1;

AFFERENT NERVE GROUP 1; ALLODYNIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BOLD SIGNAL; BURNING SENSATION; CALCIUM TRANSPORT; COLD ALLODYNIA; CONTROLLED STUDY; COOLING; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; HUMAN CELL; MALE; MOUSE; MYELINATED NERVE; NERVE CELL STIMULATION; NERVE FIBER C; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENSORY NERVE CELL;

ANIMALS; CIGUATOXINS; COLD TEMPERATURE; HYPERALGESIA; MAGNETIC RESONANCE IMAGING; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PAIN; RATS; RATS, WISTAR; SENSORY RECEPTOR CELLS; SIGNAL TRANSDUCTION; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

CIGUATERA; MUS;

EID: 84867100648     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2012.207     Document Type: Article

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