Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain

European Journal of Pharmacology

Volumn 723, Issue 1, 2014, Pages 288-293

  Kojima, Ryosuke ^a   Nozawa, Katsura ^a   Doihara, Hitoshi ^a   Keto, Yoshihiro ^a   Kaku, Hidetaka ^a   Yokoyama, Toshihide ^a   Itou, Hiroyuki ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Abdominal pain; Constipation model; IBS; TRPA1

Indexed keywords

ABDOMINAL PAIN; CONSTIPATION MODEL; IBS; TRPA1;

ABDOMINAL PAIN; ANALGESICS; ANIMALS; CALCIUM; CALCIUM CHANNELS; CLONIDINE; COLON; CONSTIPATION; GASTROINTESTINAL TRANSIT; HEK293 CELLS; HUMANS; INDOLEACETIC ACIDS; LOPERAMIDE; MALE; MICE; NERVE TISSUE PROTEINS; RATS; RATS, WISTAR; SEROTONIN; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TRPC CATION CHANNELS; VISCERAL PAIN;

EID: 84893739125     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.11.020     Document Type: Article

References (37)

1. M. Bandell, G.M. Story, S.W. Hwang, V. Viswanath, S.R. Eid, M.J. Petrus, T.J. Earley, and A. Patapoutian Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin Neuron 41 2004 849 857 (Pubitemid 38429729)
2. D.M. Bautista, P. Movahed, A. Hinman, H.E. Axelsson, O. Sterner, E.D. Hogestatt, D. Julius, S.E. Jordt, and P.M. Zygmunt Pungent products from garlic activate the sensory ion channel TRPA1 Proc. Natl. Acad. Sci. USA 102 2005 12248 12252 (Pubitemid 41291160)
3. D.M. Bautista, S.E. Jordt, T. Nikai, P.R. Tsuruda, A.J. Read, J. Poblete, E.N. Yamoah, A.I. Basbaum, and D. Julius TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents Cell 124 2006 1269 1282
4. M. Bengtsson, and B. Ohlsson Psychological well-being and symptoms in women with chronic constipation treated with sodium picosulphate Gastroenterol. Nurs. 28 2005 3 12
5. G. Bhave, W. Zhu, H. Wang, D.J. Brasier, G.S. Oxford, and R.Wt. Gereau cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation Neuron 35 2002 721 731 (Pubitemid 35223031)
6. S.M. Brierley et al. The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli Gastroenterology 137 2084-2095 2009 e2083
7. B.D. Cash, E. Chang, N.J. Talley, and A. Wald Fresh perspectives in chronic constipation and other functional bowel disorders Rev. Gastroenterol. Disord. 7 2007 116 133 (Pubitemid 47512091)
8. F. Cattaruzza, I. Spreadbury, M. Miranda-Morales, E.F. Grady, S. Vanner, and N.W. Bunnett Transient receptor potential ankyrin-1 has a major role in mediating visceral pain in mice Am. J. Physiol. Gastrointestinal Liver Physiol. 298 2010 G81 G91
9. H. Doihara, K. Nozawa, E. Kawabata-Shoda, R. Kojima, T. Yokoyama, and H. Ito TRPA1 agonists delay gastric emptying in rats through serotonergic pathways Naunyn Schmiedebergs Arch. Pharmacol. 380 2009 353 357
10. H. Doihara, K. Nozawa, R. Kojima, E. Kawabata-Shoda, T. Yokoyama, and H. Ito QGP-1 cells release 5-HT via TRPA1 activation; a model of human enterochromaffin cells Mol. Cell. Biochem. 331 2009 239 245
11. D.A. Drossman et al. U.S. householder survey of functional gastrointestinal disorders. Prevalence, sociodemography, and health impact Dig. Dis. Sci. 38 1993 1569 1580 (Pubitemid 23271409)
12. J.E. Everhart, V.L. Go, R.S. Johannes, S.C. Fitzsimmons, H.P. Roth, and L.R. White A longitudinal survey of self-reported bowel habits in the United States Dig. Dis. Sci. 34 1989 1153 1162 (Pubitemid 19202107)
13. J. Fioramonti, E. Gaultier, M. Toulouse, G.J. Sanger, and L. Bueno Intestinal anti-nociceptive behaviour of NK3 receptor antagonism in conscious rats: evidence to support a peripheral mechanism of action Neurogastroenterol Motility 15 2003 363 369 (Pubitemid 36876251)
14. M.D. Gershon Plasticity in serotonin control mechanisms in the gut Curr. Opin. Pharmacol. 3 2003 600 607 (Pubitemid 37451867)
15. M.D. Gershon, and J. Tack The serotonin signaling system: from basic understanding to drug development for functional GI disorders Gastroenterology 132 2007 397 414 (Pubitemid 46127672)
16. J.E. Ghia, P. Blennerhassett, H. Kumar-Ondiveeran, E.F. Verdu, and S.M. Collins The vagus nerve: a tonic inhibitory influence associated with inflammatory bowel disease in a murine model Gastroenterology 131 2006 1122 1130 (Pubitemid 44498700)
17. D.A. Johnson Treating chronic constipation: how should we interpret the recommendations? Clin. Drug Investig. 26 2006 547 557 (Pubitemid 44411330)
18. M.P. Jones, N.J. Talley, G. Nuyts, and D. Dubois Lack of objective evidence of efficacy of laxatives in chronic constipation Dig. Dis. Sci. 47 2002 2222 2230 (Pubitemid 35205297)
19. S.E. Jordt, D.M. Bautista, H.H. Chuang, D.D. McKemy, P.M. Zygmunt, E.D. Hogestatt, I.D. Meng, and D. Julius Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1 Nature 427 2004 260 265 (Pubitemid 38112043)
20. T. Kiso, H. Ito, K. Miyata, T. Kamato, Y. Naitoh, K. Iwaoka, and T. Yamaguchi A novel 5-HT3 receptor agonist, YM-31636, increases gastrointestinal motility without increasing abdominal pain Eur. J. Pharmacol. 431 2001 35 41 (Pubitemid 33082149)
21. R. Kojima, H. Doihara, K. Nozawa, E. Kawabata-Shoda, T. Yokoyama, and H. Ito Characterization of two models of drug-induced constipation in mice and evaluation of mustard oil in these models Pharmacology 84 2009 227 233
22. K.Y. Kwan, A.J. Allchorne, M.A. Vollrath, A.P. Christensen, D.S. Zhang, C.J. Woolf, and D.P. Corey TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction Neuron 50 2006 277 289
23. + channels between the lumbar splanchnic and pelvic nerve innervations of mouse urinary bladder and colon Neuroscience 186 2011 179 187
24. I.M. Lang Noxious stimulation of emesis Dig. Dis. Sci. 44 1999 58S 63S (Pubitemid 29450793)
25. A.W. Leamy, P. Shukla, M.A. McAlexander, M.J. Carr, and S. Ghatta Curcumin ((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) activates and desensitizes the nociceptor ion channel TRPA1 Neurosci. Lett. 503 2011 157 162
26. L.X. Liang, Q. Zhang, W. Qian, and X.H. Hou Antinociceptive property of tegaserod in a rat model of chronic visceral hypersensitivity Chin. J. Dig. Dis. 6 2005 21 25 (Pubitemid 40467730)
27. G.F. Longstreth, W.G. Thompson, W.D. Chey, L.A. Houghton, F. Mearin, and R.C. Spiller Functional bowel disorders Gastroenterology 130 2006 1480 1491
28. K. Nagata, A. Duggan, G. Kumar, and J. Garcia-Anoveros Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing J. Neurosci. 25 2005 4052 4061 (Pubitemid 40563380)
29. K. Nozawa et al. TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells Proc. Natl. Acad. Sci. USA 106 2009 3408 3413
30. P. Pare, S. Ferrazzi, W.G. Thompson, E.J. Irvine, and L. Rance An epidemiological survey of constipation in canada: definitions, rates, demographics, and predictors of health care seeking Am. J. Gastroenterol. 96 2001 3130 3137 (Pubitemid 33095352)
31. G. Rindi, A.B. Leiter, A.S. Kopin, C. Bordi, and E. Solcia The "normal" endocrine cell of the gut: changing concepts and new evidences Ann. N.Y. Acad. Sci. 1014 2004 1 12 (Pubitemid 38594786)
32. Y.A. Saito, P Schoenfeld, and G.R. Locke 3rd The epidemiology of irritable bowel syndrome in North America: a systematic review Am. J. Gastroenterol. 97 2002 1910 1915
33. R. Spiller Recent advances in understanding the role of serotonin in gastrointestinal motility in functional bowel disorders: alterations in 5-HT signalling and metabolism in human disease Neurogastroenterol. Motility 19 Suppl. 2 2007 25 31 (Pubitemid 47037963)
34. A.M. Stephen, and J.H. Cummings Water-holding by dietary fibre in vitro and its relationship to faecal output in man Gut 20 1979 722 729 (Pubitemid 9253504)
35. J. Tack, S. Muller-Lissner, V. Stanghellini, G. Boeckxstaens, M.A. Kamm, M. Simren, J.P. Galmiche, and M. Fried Diagnosis and treatment of chronic constipation - a European perspective Neurogastroenterol. Motility 23 2011 697 710
36. L. Vyklicky, K. Novakova-Tousova, J. Benedikt, A. Samad, F. Touska, and V. Vlachova Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin Physiol. Res. 57 Suppl. 3 2008 S59 S68
37. W.E. Whitehead, O.S. Palsson, L. Gangarosa, M. Turner, and J. Tucker Lubiprostone does not influence visceral pain thresholds in patients with irritable bowel syndrome Neurogastroenterol. Motility 23 2011 944 (-e400)