TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism

Pflugers Archiv European Journal of Physiology

Volumn 463, Issue 4, 2012, Pages 561-569

  Materazzi, Serena ^a   Fusi, Camilla ^a   Benemei, Silvia ^a   Pedretti, Pamela ^a   Patacchini, Riccardo ^b   Nilius, Bernd ^c   Prenen, Jean ^c   Creminon, Christophe ^d   Geppetti, Pierangelo ^a   Nassini, Romina ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b Chiesi Farmaceutici ^*  (Italy)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d DIF   (France)

Author keywords

Cold and mechanical hyperalgesia; Oxidative stress; Paclitaxel; Primary sensory neurons; TRPA1

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; GLUTATHIONE; PACLITAXEL; REACTIVE OXYGEN METABOLITE; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; VANILLOID RECEPTOR 4;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLD SENSITIVITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME RELEASE; HABITUATION; MALE; MOUSE; NERVE ENDING; NONHUMAN; OXIDATIVE STRESS; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SPINAL GANGLION;

ACETANILIDES; ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; CAPSAICIN; COLD TEMPERATURE; DRUG HYPERSENSITIVITY; GLUTATHIONE; HYPERALGESIA; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MORPHOLINES; PACLITAXEL; PERIPHERAL NERVOUS SYSTEM DISEASES; PURINES; PYRROLES; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TRPV CATION CHANNELS;

EID: 84862622177     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-011-1071-x     Document Type: Article

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