Impaired nociception and pain sensation in mice lacking the capsaicin receptor

Science

Volumn 288, Issue 5464, 2000, Pages 306-313

  Caterina, M J ^a,c   Leffler, A ^b   Malmberg, A B ^a,d   Martin, W J ^a,e   Trafton, J ^a   Petersen Zeitz, K R ^a   Koltzenburg, M ^b   Basbaum, A I ^a   Julius, D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d ROCHE BIOSCIENCE   (United States)

^e MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATION CHANNEL; VANILLOID RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HEAT SENSITIVITY; HYPERALGESIA; INFLAMMATION; MECHANICAL STIMULATION; MOUSE; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PAIN; PRIORITY JOURNAL; SENSORY NERVE CELL; TISSUE INJURY;

ANIMALS; BODY TEMPERATURE; CALCIUM; CAPSAICIN; CELLS, CULTURED; DITERPENES; GANGLIA, SPINAL; GENE TARGETING; HEAT; HYDROGEN-ION CONCENTRATION; INFLAMMATION; MICE; MICE, KNOCKOUT; NERVE FIBERS; NEURONS; NEURONS, AFFERENT; NOCICEPTORS; PAIN; PAIN THRESHOLD; RECEPTORS, DRUG; SPINAL CORD; TRPV CATION CHANNELS;

ANIMALIA;

EID: 0034646740     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.288.5464.306     Document Type: Article

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60. We thank members of the Dallman lab for experimental advice and assistance and J. Poblete, L. Sun, G. Gerkoff, K. Schmidt, N. Kileen, and J. Meneses for expert technical advice and assistance. This work was supported by American Cancer Society and National Alliance for Research on Schizophrenia and Depression postdoctoral fellowships (M.J.C.), by NIH postdoctoral training grant NS07265 (W.J.M.), and by grants from Deutsche Forschungsgemeinschaft (SFB 353; M.K.), the National Institute of Neurological Disorders and Stroke, National Institute of Dental and Craniofacial Research, and the National Institute of Mental Health (D.J. and A.I.B.), and the Sandler Family Supporting Foundation (D.J.).