Methylglyoxal activates the human transient receptor potential ankyrin 1 channel

Journal of Toxicological Sciences

Volumn 37, Issue 4, 2012, Pages 831-835

  Ohkawara, Susumu ^a   Tanaka Kagawa, Toshiko ^b   Furukawa, Yoko ^b   Jinno, Hideto ^b  

^a MUSASHINO UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Diabetic neuropathy; Methylglyoxal; TRPA1

Indexed keywords

CAPSAICIN; CARBONYL DERIVATIVE; CINNAMALDEHYDE; DIGLYCOALDEHYDE; GLYCERALDEHYDE; GLYOXAL; METHYLGLYOXAL; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; VANILLOID RECEPTOR 1;

CALCIUM TRANSPORT; CELL STRAIN HEK293; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETIC NEUROPATHY; HUMAN; HUMAN CELL; HUMAN TISSUE; LETTER; PROTEIN EXPRESSION;

EID: 84865658875     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.37.831     Document Type: Letter

References (27)

1. Andrè, E., Campi, B., Materazzi, S., Trevisani, M., Amadesi, S., Massi, D., Creminon, C., Vaksman, N., Nassini, R., Civelli, M., Baraldi, P.G., Poole, D.P., Bunnett, N.W., Geppetti, P. and Patacchini R. (2008): Cigarette smoke-induced neurogenic inflammation is mediated by alpha, beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J. Clin. Invest., 118, 2574-2582.
2. Andrè, E., Gatti, R., Trevisani, M., Preti, D., Baraldi, P.G., Patacchini, R and Geppetti, P. (2009): Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents. Br. J. Pharmacol., 158, 1621-1628.
3. Bautista, D.M., Movahed, P., Hinman, A., Axelsson, H.E., Sterner, O., Högestätt, E.D., Julius, D., Jordt, S.E. and Zygmunt, P.M. (2005): Pungent products from garlic activate the sensory ion channel TRPA1. Proc. Natl. Acad. Sci. USA, 102, 12248-12252.
4. Beisswenger, P.J., Howell, S.K., O'Dell, R.M., Wood, M.E., Touchette, A.D. and Szwergold, B.S. (2001): alpha-Dicarbonyls increase in the postprandial period and reflect the degree of hyperglycemia. Diabetes Care, 24, 726-732.
5. Brown, M.J. and Asbury, A.K. (1984): Diabetic neuropathy. Ann. Neurol., 15, 2-12.
6. Chaplen, F.W., Fahl, W.E. and Cameron, D.C. (1998): Evidence of high levels of methylglyoxal in cultured Chinese hamster ovary cells. Proc. Natl. Acad. Sci. USA, 95, 5533-5538.
7. Davies, M.G., Chambers, P.L. and Rowan, M.J. (1986): Effects of methylglyoxal on central and peripheral cholinergic responses. Arch. Toxicol. Suppl., 9, 46-50.
8. Fernyhough, P. and Calcutt, N.A. (2010): Abnormal calcium homeostasis in peripheral neuropathies. Cell Calcium, 47, 130-139.
9. Fukunaga, M., Miyata, S., Liu, B.F., Miyazaki, H., Hirota, Y., Higo, S., Hamada, Y., Ueyama, S. and Kasuga, M. (2004): Methylglyoxal induces apoptosis through activation of p38 MAPK in rat Schwann cells. Biochem. Biophys. Res. Commun., 320, 689-695.
10. Hinman, A., Chuang, H.H., Bautista, D.M. and Julius, D. (2006): TRP channel activation by reversible covalent modification. Proc. Natl. Acad. Sci., USA, 103, 19564-19568
11. Jensen, T.S., Backonja, M.M., Hernandez Jimenez, S.T., Tesfaye, S., Valensi, P. and Ziegler, D. (2006): New perspectives on the management of diabetic peripheral neuropathic pain. Diab. Vasc. Dis. Res., 3, 108-119.
12. Jordt, S.E., Bautista, D.M., Chuang, H.H., McKemy, D.D., Zygmunt, P.M., Högestätt, E.D., Meng, I.D. and Julius, D. (2004): Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature, 427, 260-265.
13. Kuhla, B., Lüth, H.J., Haferburg, D., Weick, M., Reichenbach, A., Arendt, T. and Münch, G. (2006): Pathological effects of glyoxalase I inhibition in SH-SY5Y neuroblastoma cells. J. Neurosci. Res., 83, 1591-1600.
14. Kwan, K.Y., Allchorne, A.J., Vollrath, M.A., Christensen, A.P., Zhang, D.S., Woolf, C.J. and Corey, D.P. (2006): TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron, 50, 277-289.
15. Lapolla, A., Flamini, R., Dalla Vedova, A., Senesi, A., Reitano, R., Fedele, D., Basso, E., Seraglia, R. and Traldi, P. (2003): Glyoxal and methylglyoxal levels in diabetic patients: quantitative determination by a new GC/MS method. Clin. Chem. Lab. Med., 41, 1166-1173.
16. Levine, J.D. and Alessandri-Haber, N. (2007): TRP channels: targets for the relief of pain. Biochim. Biophys. Acta., 1772, 989-1003.
17. 2+ dependence in rat trigeminal ganglion cells. J. Neurophysiol., 75, 1503-1514.
18. Lo, T.W., Westwood, M.E., McLellan, A.C., Selwood, T. and Thornalley, P.J. (1994): Binding and modification of proteins by methylglyoxal under physiological conditions. A kinetic and mechanistic study with N α-acetylarginine, N alpha-acetylcysteine, and Nα-acetyllysine, and bovine serum albumin. J. Biol. Chem., 269, 32299-32305.
19. Macpherson, L.J., Geierstanger, B.H., Viswanath, V., Bandell, M., Eid, S.R., Hwang, S. and Patapoutian, A. (2005): The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin. Curr. Biol., 15, 929-934.
20. Macpherson, L.J., Dubin, A.E., Evans, M.J., Marr F., Schultz, P.G., Cravatt, B.F. and Patapoutian, A. (2007): Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature, 445, 541-545.
21. Ohkawara, S., Tanaka-Kagawa, T., Furukawa, Y., Nishimura, T. and Jinno, H. (2010): Activation of the human transient receptor potential vanilloid subtype 1 by essential oils. Biol. Pharm. Bull., 33, 1434-1437.
22. Simon, S.A. and Liedtke, W. (2008): How irritating: the role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airways. J. Clin. Invest., 118, 2383-2386.
23. Story, G.M., Peier, A.M., Reeve, A.J., Eid, S.R., Mosbacher, J., Hricik, T.R., Earley, T.J., Hergarden, A.C., Andersson, D.A., Hwang, S.W., McIntyre, P., Jegla, T., Bevan, S. and Patapoutian, A. (2003): ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell, 112, 819-829
24. Tóth, A., Wang, Y., Kedei, N., Tran, R., Pearce, L.V., Kang, S.U., Jin, M.K., Choi, H.K., Lee, J. and Blumberg P.M. (2005): Different vanilloid agonists cause different patterns of calcium response in CHO cells heterologously expressing rat TRPV1. Life Sci., 76, 2921-2932.
25. Vinik, A.I., Park, T.S., Stansberry, K.B. and Pittenger, G.L. (2000): Diabetic neuropathies. Diabetologia, 43, 957-973.
26. Wei, H., Hämäläinen, M.M., Saarnilehto, M., Koivisto, A. and Pertovaara, A. (2009): Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals. Anesthesiology, 111, 147-154.
27. Winter, J., Dray, A., Wood, J.N., Yeats, J.C. and Bevan, S. (1990): Cellular mechanism of action of resiniferatoxin: a potent sensory neuron excitotoxin. Brain Res., 520, 131-140.