Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 20, 2009, Pages 8374-8379

  Andersson, David A ^a   Gentry, Clive ^a   Moss, Sian ^a   Bevan, Stuart ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Pain; Sensory neurons; TRP channels; Zinc

Indexed keywords

CLIOQUINOL; IONOPHORE; IRRITANT AGENT; OXIDIZING AGENT; PYRITHIONE ZINC; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; ZINC;

ALLODYNIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL POPULATION; CELL STIMULATION; CELLULAR DISTRIBUTION; CHEMOSENSITIVITY; COLD SENSITIVITY; CONCENTRATION (PARAMETERS); FEMALE; HYPERALGESIA; IN VIVO STUDY; INJECTION; MALE; MOUSE; NERVE CELL; NERVE CELL CULTURE; NOCICEPTIVE RECEPTOR; NONHUMAN; PRIORITY JOURNAL; SENSORY RECEPTOR; SPINAL GANGLION; SUBACUTE MYELOOPTIC NEUROPATHY; WILD TYPE;

ANIMALS; ANTIFUNGAL AGENTS; ANTIPARASITIC AGENTS; CELLS, CULTURED; CHELATING AGENTS; CLIOQUINOL; GANGLIA, SPINAL; HYPERALGESIA; MICE; NEURONS; PYRIDINES; TEMPERATURE SENSE; THIONES; TRANSIENT RECEPTOR POTENTIAL CHANNELS; ZINC;

MUS;

EID: 66249101637     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0812675106     Document Type: Article

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