Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation

Pain

Volumn 152, Issue 7, 2011, Pages 1621-1631

  Nassini, Romina ^a   Gees, Maarten ^b   Harrison, Selena ^a   De Siena, Gaetano ^a   Materazzi, Serena ^a   Moretto, Nadia ^c   Failli, Paola ^a   Preti, Delia ^d   Marchetti, Nicola ^d   Cavazzini, Alberto ^d   Mancini, Francesca ^a   Pedretti, Pamela ^a   Nilius, Bernd ^b   Patacchini, Riccardo ^c   Geppetti, Pierangelo ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c Chiesi Farmaceutici ^*  (Italy)

^d UNIVERSITY OF FERRARA   (Italy)

Author keywords

Cold and mechanical hyperalgesia; Oxaliplatin; Oxidative stress; Primary sensory neurons; TRPA1

Indexed keywords

CALCIUM; CISPLATIN; GLUTATHIONE; HC 030031; OXALIPLATIN; PROTEIN INHIBITOR; REACTIVE OXYGEN METABOLITE; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLD SENSITIVITY; CONTROLLED STUDY; DRUG POTENCY; GUINEA PIG; LUNG ARTERY; MOUSE; NERVE ENDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; ATROPINE; CALCITONIN GENE-RELATED PEPTIDE; CALCIUM; CAPSAICIN; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CISPLATIN; CRICETINAE; CRICETULUS; DIPEPTIDES; DISEASE MODELS, ANIMAL; DRUG INTERACTIONS; GANGLIA, SPINAL; GENE EXPRESSION REGULATION; GUINEA PIGS; HYPERALGESIA; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORGANOPLATINUM COMPOUNDS; PAIN MEASUREMENT; PULMONARY ARTERY; QUINAZOLINES; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSORY RECEPTOR CELLS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUPEROXIDES; TISSUE CULTURE TECHNIQUES; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 79958744029     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2011.02.051     Document Type: Article

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