Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases

FASEB Journal

Volumn 23, Issue 4, 2009, Pages 1102-1114

  Bessac, Bret F ^a   Sivula, Michael ^a   Von Hehn, Christian A ^a   Caceres, Ana I ^a   Escalera, Jasmine ^a   Jordt, Sven Eric ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Analgesia; Nociception; Pain; Sensory neurons; TRP channels

Indexed keywords

2 (1,3 DIMETHYL 2,6 DIOXO 1,2,3,6 TETRAHYDRO 7H PURIN 7 YL) N (4 ISOPROPYLPHENYL)ACETAMIDE; 2 CHLOROBENZYLIDENEMALONONITRILE; 4 (4 CHLOROPHENYL) 3 METHYLBUT 3 EN 2 OXIME; ACETAMIDE DERIVATIVE; ACETONE; ALLYL ISOTHIOCYANATE; AP 18; BENZYL BROMIDE; BROMOACETONE; CALCIUM; CHLOROPICRIN; DIBENZ[B,F ][1,4]OXAZEPINE; DIBENZOXAZEPINE DERIVATIVE; DIPHENYLMETHANE 4,4' DIISOCYANATE; HC 030031; HEXAMETHYLENE DIISOCYANATE; ISOCYANIC ACID DERIVATIVE; METHYL ISOCYANATE; OXIME DERIVATIVE; PHENACYL CHLORIDE; PROTEIN INHIBITOR; TEAR GAS; TRANSIENT RECEPTOR POTENTIAL ANKYRIN 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL; UNCLASSIFIED DRUG; ANKTM1 PROTEIN, MOUSE; HYPOCHLOROUS ACID; OXIDIZING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EMBRYO; EXPOSURE; EYE; FEMALE; GENE DELETION; HUMAN; HUMAN CELL; IMAGING; IN VITRO STUDY; IN VIVO STUDY; MEMBRANE CURRENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENSORY NERVE CELL; SKIN; TOXICITY; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL LINE; CHO CELL; CRICETULUS; CYTOLOGY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HAMSTER; KIDNEY; MALE; METABOLISM; PATCH CLAMP; PRENATAL DEVELOPMENT; SPINAL GANGLION; TRIGEMINUS GANGLION;

MUS;

ANIMALS; CELL LINE; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; FEMALE; GANGLIA, SPINAL; HYPOCHLOROUS ACID; ISOCYANATES; KIDNEY; MALE; MICE; MICE, INBRED C57BL; NEURONS, AFFERENT; OXIDANTS; PATCH-CLAMP TECHNIQUES; TEAR GASES; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TRIGEMINAL GANGLION;

EID: 65349163523     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.08-117812     Document Type: Article

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