5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals

Journal of Neuroscience

Volumn 32, Issue 18, 2012, Pages 6364-6372

  Sisignano, Marco ^a   Park, Chul Kyu ^c   Angioni, Carlo ^a   Zhang, Dong Dong ^a   von Hehn, Christian ^b   Cobos, Enrique J ^b   Ghasemlou, Nader ^b   Xu, Zhen Zhong ^c   Kumaran, Vigneswara ^e   Lu, Ruirui ^a   Grant, Andrew ^e   Fischer, Michael J M ^f   Schmidtko, Achim ^a   Reeh, Peter ^d   Ji, Ru Rong ^c   Woolf, Clifford J ^b   Geisslinger, Gerd ^a   Scholich, Klaus ^a   Brenneis, Christian ^a,b  

^a GOETHE UNIVERSITY   (Germany)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^e KING'S COLLEGE LONDON   (United Kingdom)

^f UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5, 6 EPOXY 8, 11, 14 ICOSATRIENOIC ACID; ACETONITRILE; ALLYL ISOTHIOCYANATE; CAPSAICIN; CYSTEINE; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CALCIUM TRANSPORT; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EXCITATORY POSTSYNAPTIC POTENTIAL; HUMAN; HUMAN CELL; HYPERSENSITIVITY; KNOCKOUT MOUSE; LIQUID CHROMATOGRAPHY; MALE; MOUSE; NERVE ENDING; NOCICEPTIVE RECEPTOR; NOCICEPTIVE STIMULATION; NONHUMAN; PAIN; PRIORITY JOURNAL; SENSORY NERVE CELL; SPINAL CORD; SPINAL GANGLION; SYNAPTIC TRANSMISSION; TANDEM MASS SPECTROMETRY;

8,11,14-EICOSATRIENOIC ACID; ACTION POTENTIALS; AFFERENT PATHWAYS; ANIMALS; CELLS, CULTURED; HYPERALGESIA; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SENSORY RECEPTOR CELLS;

EID: 84860318535     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5793-11.2012     Document Type: Article

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