Spinal 12-lipoxygenase-derived hepoxilin A 3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 17, 2012, Pages 6721-6726

  Gregus, Ann M ^a   Doolen, Suzanne ^c   Dumlao, Darren S ^b   Buczynski, Matthew W ^b   Takasusuki, Toshifumi ^a   Fitzsimmons, Bethany L ^a   Hua, Xiao Ying ^a   Taylor, Bradley K ^c   Dennis, Edward A ^b   Yaksh, Tony L ^a  

^a University of California at San Diego   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Central sensitization; Eicosanoid; Pain

Indexed keywords

ANALGESIC AGENT; ARACHIDONATE 12 LIPOXYGENASE; BAICALEIN; CARRAGEENAN; HC 030031; HEPOXILIN A; HEPOXILIN B; N (1,4 BENZODIOXAN 6 YL) 3 (4 TERT BUTYLPHENYL)ACRYLAMIDE; NORDIHYDROGUAIARETIC ACID; SUBSTANCE P; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; ZILEUTON;

ALLODYNIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM MOBILIZATION; HYPERALGESIA; HYPERESTHESIA; INFLAMMATION; MALE; MOUSE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL;

8,11,14-EICOSATRIENOIC ACID; ANIMALS; ARACHIDONATE 12-LIPOXYGENASE; HYPERALGESIA; INFLAMMATION; MICE; SPINAL CORD; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TRPV CATION CHANNELS;

EID: 84860207623     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1110460109     Document Type: Article

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