The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels

Nature

Volumn 430, Issue 7001, 2004, Pages 748-754

  Voets, Thomas ^a   Droogmans, Guy ^a   Wissenbach, Ulrich ^b   Janssens, Annelles ^a   Flockerzi, Veit ^b   Nilius, Bernd ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ENERGY; HEAT TREATMENT; POSITIVE IONS; SENSORS;

DEPOLARIZATION; MAMMALIAN SENSORY SYSTEMS;

NATURAL SCIENCES;

CAPSAICIN; MENTHOL; TRANSIENT RECEPTOR POTENTIAL CHANNEL; DRUG RECEPTOR; ION CHANNEL; LIGAND; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM8 PROTEIN, HUMAN; TUMOR PROTEIN;

MAMMAL; TEMPERATURE EFFECT;

ARTICLE; CHANNEL GATING; COLD SENSITIVITY; CONTROLLED STUDY; DEPOLARIZATION; ELECTRIC POTENTIAL; EMBRYO; ENERGY; HEAT SENSITIVITY; HUMAN; HUMAN CELL; KINETICS; MAMMAL; MEMBRANE POTENTIAL; NOCICEPTION; PRIORITY JOURNAL; SENSOR; SENSORY SYSTEM; TEMPERATURE DEPENDENCE; THERMAL STIMULATION; BIOLOGICAL MODEL; CELL LINE; CELL MEMBRANE POTENTIAL; COLD; DRUG EFFECT; DRUG POTENTIATION; ELECTRIC CONDUCTIVITY; GENETICS; HEAT; METABOLISM; PATCH CLAMP;

MAMMALIA;

CAPSAICIN; CELL LINE; COLD; ELECTRIC CONDUCTIVITY; HEAT; HUMANS; ION CHANNEL GATING; ION CHANNELS; LIGANDS; MEMBRANE POTENTIALS; MENTHOL; MODELS, BIOLOGICAL; NEOPLASM PROTEINS; PATCH-CLAMP TECHNIQUES; RECEPTORS, DRUG; TRPM CATION CHANNELS;

EID: 4043077669     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02732     Document Type: Article

References (31)

1. Julius, D. & Basbaum, A. I. Molecular mechanisms of nociception. Nature 413, 203-210 (2001).
2. Patapoutian, A., Peier, A. M., Story, G. M. & Viswanath, V. Thermo TRP channels and beyond: mechanisms of temperature sensation. Nature Rev. Neurosci. 4, 529-539 (2003).
3. Clapham, D. E. TRP channels as cellular sensors. Nature 426, 517-524 (2003).
4. Voets, T. & Nilius, B. TRPs make sense. J. Membr. Biol. 192, 1-8 (2003).
5. Watanabe, H. et al. Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells. J. Biol. Chem. 277, 47044-47051 (2002).
6. Güler, A. D. et al. Heat-evoked activation of the ion channel, TRPV4. J. Neurosci. 22, 6408-6414 (2002).
7. Xu, H. et al. TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature 418, 181-186 (2002).
8. Smith, G. D. et al. TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature 418, 186-190 (2002).
9. Peier, A. M. et al. A heat-sensitive TRP channel expressed in keratinocytes. Science 296, 2046-2049 (2002).
10. Caterina, M. J. et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389, 816-824 (1997).
11. Caterina, M. J., Rosen, T. A., Tominaga, M., Brake, A. J. & Julius, D. A capsaicin-receptor homologue with a high threshold for noxious heat. Nature 398, 436-441 (1999).
12. McKemy, D. D., Neuhäusser, W. M. & Julius, D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416, 52-58 (2002).
13. Peier, A. M. et al. A TRP channel that senses cold stimuli and menthol. Cell 108, 705-715 (2002).
14. Story, G. M. et al. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112, 819-829 (2003).
15. Jordt, S. E. et al. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427, 260-265 (2004).
16. Hille, B. Ion channels of Excitable Membranes (Sinauer Associates, Sunderland, Massachusetts, 2001).
17. 2+-activated nonselective cation channel mediating cell membrane depolarization. Cell 109, 397-407 (2002).
18. 2+-activated cation channel TRPM4. J. Biol. Chem. 278, 30813-30820 (2003).
19. 2+-activated monovalent selective cation channel. Curr. Biol. 13, 1153-1158 (2003).
20. Gunthorpe, M. J., Harries, M. H., Prinjha, R. K., Davis, J. B. & Randall, A. Voltage- and time-dependent properties of the recombinant rat vanilloid receptor (rVR1). J. Physiol. (Lond.) 525, 747-759 (2000).
21. Vlachova, V. et al. Functional role of C-terminal cytoplasmic tail of rat vanilloid receptor 1. J. Neurosci. 23, 1340-1350 (2003).
22. Tominaga, M. et al. The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21, 531-543 (1998).
23. Marsh, D. General features of phospholipid phase transitions. Chem. Phys. Lipids 57, 109-120 (1991).
24. Sigworth, F. J. Voltage gating of ion channels. Q. Rev. Biophys. 27, 1-40 (1994).
25. Tiwari, J. K. & Sikdar, S. K. Temperature-dependent conformational changes in a voltage-gated potassium channel. Eur. Biophys. J. 28, 338-345 (1999).
26. van Lunteren, E., Elmslie, K. S. & Jones, S. W. Effects of temperature on calcium current of bullfrog sympathetic neurons. J. Physiol. (Lond.) 466, 81-93 (1993).
27. Chung, M. K., Lee, H. & Caterina, M. J. Warm temperatures activate TRPV4 in mouse 308 keratinocytes. J. Biol. Chem. 278, 32037-32046 (2003).
28. Liu, B., Hui, K. & Qin, F. Thermodynamics of heat activation of single capsaicin ion channels VR1. Biophys. J. 85, 2988-3006 (2003).
29. Jordt, S. E., Tominaga, M. & Julius, D. Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proc. Natl Acad. Sci. USA 97, 8134-8139 (2000).
30. Zygmunt, P. M. et al. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 400, 452-457 (1999).
31. Behrendt, H. J., Germann, T., Gillen, C., Hatt, H. & Jostock, R. Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br. J. Pharmacol. 141, 737-745 (2004).