TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells

Nature

Volumn 432, Issue 7018, 2004, Pages 723-730

  Corey, David P ^a   Garcia Añoveros, Jaime ^c   Holt, Jeffrey R ^d   Kwan, Kelvin Y ^a   Lin, Shuh Yow ^a,e   Vollrath, Melissa A ^a   Amalfitano, Andrea ^g   Cheung, Eunice L M ^a   Derfler, Bruce H ^a   Duggan, Anne ^c   Géléoc, Gwénaëlle S G ^d   Gray, Paul A ^a,b   Hoffman, Matthew P ^h   Rehm, Heidi L ^f   Tamasauskas, Daniel ^a   Zhang, Duan Sun ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^f Harvard Partners Center for Genetics and Genomics   (United States)

^g DUKE UNIVERSITY MEDICAL CENTER   (United States)

^h NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DYES; FLUORESCENCE; IONS; PROTEINS; RNA; SENSORY PERCEPTION;

ION CHANNELS; MECHANICAL DEFLECTIONS; SENSORY HAIR BUNDLES; TRANSDUCTION;

CELLS;

ANTIBODY; FLUORESCENT DYE; ION CHANNEL; MESSENGER RNA; TRANSIENT RECEPTOR POTENTIAL CHANNEL;

BIOLOGY;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CHEMICAL LABELING; CONTROLLED STUDY; DEVELOPMENT; ELECTRICITY; EMBRYO; EPITHELIUM; GENE EXPRESSION; HAIR CELL; INHIBITION KINETICS; INNER EAR; MECHANOTRANSDUCTION; MOUSE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECORDING; TRANSIENT RECEPTOR POTENTIAL A1 CHANNEL; VERTEBRATE; ZEBRA FISH;

ANIMALIA; DANIO RERIO; VERTEBRATA;

EID: 10644290199     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03066     Document Type: Article

References (42)

1. Hudspeth, A. J. & Corey, D. P. Sensitivity, polarity, and conductance change in the response of vertebrate hair cells to controlled mechanical stimuli. Proc. Natl Acad. Sci. USA 74, 2407-2411 (1977).
2. Hudspeth, A. J. Extracellular current flow and the site of transduction by vertebrate hair cells. J. Neurosci. 2, 1-10 (1982).
3. Corey, D. P. & Hudspeth, A. J. Response latency of vertebrate hair cells. Biophys. J. 26, 499-506 (1979).
4. Corey, D. P. & Hudspeth, A. J. Kinetics of the receptor current in bullfrog saccular hair cells. J. Neurosci. 3, 962-976 (1983).
5. Sukharev, S. & Corey, D. P. Mechanosensitive channels: multiplicity of families and gating paradigms. Sci. STKE 2004, re4 (2004).
6. Corey, D. P. & Hudspeth, A. J. Ionic basis of the receptor potential in a vertebrate hair cell, Nature 281, 675-677 (1979).
7. Gale, J. E., Marcotti, W., Kennedy. H. J., Kros, C. J. & Richardson, G. P. FM1-43 dye behaves as a permeant blocker of the hair-cell mechanotransducer channel. J. Neurosci. 21, 7013-7025 (2001).
8. Meyers, J. R. et al. Lighting up the senses; FM1-43 loading of sensory cells through nonselective ion channels. J. Neurosci. 23, 4054-4065 (2003).
9. Garcia-Añoveros, J., Garcia, J. A., Liu, J.-D. & Corey, D. P. The nematode degenerin UNC-105 forms ion channels that are activated by degeneration- or hypercontraction-causing mutations. Neuron 20, 1231-1241 (1998).
10. Duggan, A., Garcia-Añoveros, J. & Corey, D. P. Insect mechanoreception; What a long, strange TRP it's been. Curr. Biol 10, R384-R387 (2000).
11. Clapham, D. E., Montell, C., Schultz, G. & Julius, D. International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels. Pharmacol. Rev. 55, 591-596 (2003).
12. Clapham, D. E. TRP channels as cellular sensors. Nature 426, 517-524 (2003).
13. Corey, D. P. New TRP channels in hearing and mechanosensation. Neuron 39, 585-588 (2003).
14. Walker, R. G., Willingham, A. T. & Zuker, C. S. A Drosophila mechanosensory transduction channel. Science 287, 2229-2234 (2000).
15. Sidi, S., Friedrich, R. W. & Nicolson, T. NompC TRP channel required for vertebrate sensory hair cell mechanotransduction. Science 301, 96-99 (2003).
16. Story, G. M. et al. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112, 819-829 (2003).
17. Jordt, S. E. et al. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427, 260-265 (2004).
18. Bandell, M. et al. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 41, 849-857 (2004).
19. Bermingham, N. A. et al. Math1: an essential gene for the generation of inner ear hair cells. Science 284, 1837-1841 (1999).
20. Di Palma, E. et al. Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice. Proc. Natl Acad. Sci. USA 99, 14994-14999 (2002).
21. Geleoc, G. S. & Holt, J. R. Developmental acquisition of sensory transduction in hair cells of the mouse inner ear. Nature Neurosci. 6, 1019-1020 (2003),
22. Denman-Johnson, K. & Forge, A, Establishment of hair bundle polarity and orientation in the developing vestibular system of the mouse. J. Neurocytol. 28, 821-835 (1999).
23. Hasson, T. et al. Unconventional myosins in inner-ear sensory epithelia. J. Cell Biol. 137, 1287-1307 (1997).
24. Siemens, J. et al. Cadherin 23 is a component of the tip link in hair-cell stereocilia. Nature 428, 950-955 (2004).
25. Reiners, J. et al. Differential distribution of harmonin isoforms and their possible role in Usher-1 protein complexes in mammalian photoreceptor cells. Invest. Ophthalmol. Vis. Sci. 44, 5006-5015 (2003).
26. Assad, J. A., Shepherd, G. M. & Corey, D. P. Tip-link integrity and mechanical transduction in vertebrate hair cells. Neuron 7, 985-994 (1991).
27. Holt, J. R. et al. Functional expression of exogenous proteins in mammalian sensory hair cells infected with adenoviral vectors. J. Neurophysiol. 81, 1881-1888 (1999).
28. Hodges, B. L. et al. Multiply deleted [E1, polymerase-, and pTP-] adenovirus vector persists despite deletion of the preterminal protein. J. Gene Med. 2, 250-259 (2000).
29. Luebke, A. E., Steiger, J. D., Hodges, B. L. & Amalfitano, A. A modified adenovirus can transfect cochlear hair cells in vivo without compromising cochlear function. Gene Ther. 8, 789-794 (2001).
30. Holt, J. R. Viral-mediated gene transfer to study the molecular physiology of the mammalian inner ear. Audiol Neurootol 7, 157-160 (2002).
31. Farris, H. E., LeBlanc, C. L., Goswami, J. & Ricci, A. J. Probing the pore of the auditory hair cell mechanotransducer channel in turtle. J. Physiol. 558, 769-792 (2004).
32. Gillespie, P. G. & Corey, D. P. Myosin and adaptation by hair cells. Neuron 19, 955-958 (1997).
33. Corey, D. P. & Sotomayor, M. Hearing: tightrope act. Nature 428, 901-903 (2004).
34. Howard, J. & Bechstedt, S. Hypothesis: a helix of ankyrin repeats of the NOMPC-TRP ion channel is the gating spring of mechanoreceptors. Curr. Biol. 14, R224-R226 (2004).
35. Howard, J. & Hudspeth, A. J. Compliance of the hair bundle associated with gating of mechanoelectrical transduction channels in the bullfrog's saccular hair cell. Neuron 1, 189-199 (1988).
36. Sollner, C. et al. Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells. Nature 428, 955-959 (2004).
37. Michaely, P., Tomchick, D. R., Machius, M. & Anderson, R. G. Crystal structure of a 12 ANK repeat stack from human ankyrinR. EMBO J. 21, 6387-6396 (2002).
38. Kachar, B., Parakkal, M., Kurc, M., Zhao, Y. & Gillespie, P. G. High-resolution structure of hair-cell tip links. Proc. Natl Acad. Sci. USA 97, 13336-13341 (2000).
39. Ricci, A. J., Wu, Y. C. & Fettiplace, R. The endogenous calcium buffer and the time course of transducer adaptation in auditory hair cells. J. Neurosci. 18, 8261-8277 (1998).
40. Hudspeth, A. J., Choe, Y., Mehta, A. D. & Martin, P. Putting ion channels to work: mechanoelectrical transduction, adaptation, and amplification by hair cells. Proc. Natl Acad. Sci. USA 97, 11765-11772 (2000).
41. Starr, C. J., Kappler, J. A., Chan, D. K., Kollmar, R. & Hudspeth, A. J. Mutation of the zebrafish choroideremia gene encoding Rab escort protein I devastates hair cells. Proc. Natl Acad. Sci. USA 101, 2572-2577 (2004).
42. He, T. C. et al. A simplified system for generating recombinant adenoviruses. Proc. Natl Acad. Sci. USA 95, 2509-2514 (1998).