Methylglyoxal activates nociceptors through transient receptor potential channel A1 (TRPA1): A possible mechanism of metabolic neuropathies

Journal of Biological Chemistry

Volumn 287, Issue 34, 2012, Pages 28291-28306

  Eberhardt, Mirjam J ^a   Filipovic, Milos R ^a   Leffler, Andreas ^b   De La Roche, Jeanne ^b   Kistner, Katrin ^a   Fischer, Michael J ^a   Fleming, Thomas ^c   Zimmermann, Katharina ^a   Ivanovic Burmazovic, Ivana ^a   Nawroth, Peter P ^c   Bierhaus, Angelika ^c   Reeh, Peter W ^a   Sauer, Susanne K ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; COVALENT BONDS; HEALTH; METABOLISM; METABOLITES; NEURONS; PEPTIDES; SULFUR COMPOUNDS; TRANSIENTS;

ACTION POTENTIALS; CONDUCTION VELOCITY; MEDICINAL CHEMISTRY; METABOLIC DISORDERS; PERIPHERAL NERVES; POSSIBLE MECHANISMS; RECEPTOR CHANNELS; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

BINDING SITES;

METHYLGLYOXAL; NEUROPEPTIDE; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CALCIUM TRANSPORT; CELL ACTIVATION; CONTROLLED STUDY; DISULFIDE BOND; MOLECULAR PATHOLOGY; MOUSE; NERVE POTENTIAL; NEUROPATHIC PAIN; NOCICEPTIVE RECEPTOR; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN TRANSPORT; RECEPTOR UPREGULATION; SENSORY NERVE CONDUCTION;

EID: 84865209943     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.328674     Document Type: Article

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