Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents

FASEB Journal

Volumn 24, Issue 12, 2010, Pages 4904-4916

  Nassini, Romina ^a   Materazzi, Serena ^a   Andrè, Eunice ^a,h   Sartiani, Laura ^a   Aldini, Giancarlo ^b   Trevisani, Marcello ^c   Carnini, Chiara ^d   Massi, Daniela ^a   Pedretti, Pamela ^a   Carini, Marina ^b   Cerbai, Elisabetta ^a   Preti, Delia ^e   Villetti, Gino ^d   Civelli, Maurizio ^d   Trevisan, Gabriela ^a   Azzari, Chiara ^a   Stokesberry, Susan ^f   Sadofsky, Laura ^g   McGarvey, Lorcan ^f   Patacchini, Riccardo ^d   Geppetti, Pierangelo ^a   more..

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c PharmEste srl   (Italy)

^d CHIESI FARMACEUTICI S P A   (Italy)

^e UNIVERSITY OF FERRARA   (Italy)

^f QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^g UNIVERSITY OF HULL   (United Kingdom)

^h FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE   (Brazil)

Author keywords

Asthma; Chronic obstructive pulmonary disease; Primary sensory neurons; Substance P

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CHEMOKINE; CYTOKINE; MYELOPEROXIDASE; N ACETYL 1,4 BENZOQUINONE IMINE; PARACETAMOL; SUBSTANCE P; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1;

ANGIONEUROTIC EDEMA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTHMA; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MALE; MOUSE; NERVE ENDING; NERVE EXCITABILITY; NEUROBLASTOMA CELL; NEUROGENIC INFLAMMATION; NEUTROPHIL COUNT; NEUTROPHILIA; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; RAT; REPEATED DRUG DOSE; SENSORY NERVE; SINGLE DRUG DOSE; SKIN INFLAMMATION;

ACETAMINOPHEN; ACROLEIN; ANALGESICS, NON-NARCOTIC; ANIMALS; ASTHMA; BENZOQUINONES; BRONCHOALVEOLAR LAVAGE; CALCIUM; CELL LINE; CHROMATOGRAPHY, LIQUID; GUINEA PIGS; HUMANS; IMINES; IMMUNOHISTOCHEMISTRY; MALE; MICE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

MUS; RODENTIA;

EID: 78649744386     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-162438     Document Type: Article

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