In vitro pharmacological characterization of a novel TRPA1 antagonist and proof of mechanism in a human dental pulp model

Journal of Pain Research

Volumn 6, Issue , 2013, Pages 59-70

  Nyman, Eva ^a   Franzén, Bo ^a   Nolting, Andreas ^a   Klement, Göran ^a   Liu, Gang ^a   Nilsson, Maria ^a   Rosén, Annika ^b   Björk, Charlotta ^a   Weigelt, Dirk ^a   Wollberg, Patrik ^a   Karila, Paul ^a   Raboisson, Patrick ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Antagonist; Calcitonin gene related peptide; CGRP; Chimeric proteins; Dental pulp; Inflammation; Neuropeptide; Pain; Pharmacology

Indexed keywords

2 CHLOROBENZYLIDENEMALONONITRILE; AZ 465; CALCITONIN GENE RELATED PEPTIDE; CALCIUM; CINNAMALDEHYDE; ION TRANSPORT AFFECTING AGENT; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; UNCLASSIFIED DRUG; ZINC;

ARTICLE; CALCIUM TRANSPORT; CHANNEL GATING; CONTROLLED STUDY; DRUG BINDING; DRUG STRUCTURE; EX VIVO STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INHIBITION KINETICS; NUCLEOTIDE SEQUENCE; PATCH CLAMP; PROTEIN EXPRESSION; PROTEIN SECRETION; TOOTH PULP;

EID: 84874694861     PISSN: 11787090     EISSN: None     Source Type: Journal    
DOI: 10.2147/JPR.S37567     Document Type: Article

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