Specific C-receptors for itch in human skin

Journal of Neuroscience

Volumn 17, Issue 20, 1997, Pages 8003-8008

  Schmelz, Martin ^a   Schmidt, Roland ^b   Bickel, Andreas ^a   Handwerker, Hermann O ^a   Torebjörk, H Erik ^b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

C fibers; Histamine; Human; Microneurography; Nociceptors; Pruritus

Indexed keywords

ARTICLE; HUMAN; HUMAN EXPERIMENT; MICRONUCLEUS; NERVE FIBER C; NERVE STIMULATION; NOCICEPTION; NONMYELINATED NERVE; NORMAL HUMAN; PERONEUS NERVE; PRIORITY JOURNAL; PRURITUS; SENSORY NERVE; SKIN NERVE;

EID: 0030851736     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-20-08003.1997     Document Type: Article

References (34)

1. Baumann TK, Simone DA, Shain CM, LaMotte RH (1991) Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia. J Neurophysiol 66:212-227.
2. Beck PW, Handwerker HO, Zimmermann M (1974) Nervous outflow from the cat's foot during noxious radiant heat stimulation. Brain Res 67:373-386.
3. Bessou P, Perl ER (1969) Responses of cutaneous sensory units with unmyelinated fibers to noxious stimuli. J Neurophysiol 32:1025-1043.
4. Fleischer E, Handwerker HO, Joukhadar S (1983) Unmyelinated nociceptive units in two skin areas of the rat. Brain Res 267:81-92.
5. Forster C, Handwerker HO (1990) Automatic classification and analysis of microneurographic spike data using a PC/AT. J Neurosci Methods 31:109-118.
6. Fruhstorfer H, Hermanns M, Latzke L (1986) Effects of thermal stimulation on clinical and experimental itch. Pain 24:259-269.
7. Gybels J, Handwerker HO, Van Hees J (1979) A comparison between the discharges of human nociceptive nerve fibres and the subject's ratings of his sensations. J Physiol (Lond) 292:193-206.
8. Hallin RG, Torebjörk HE, Wiesenfeld Z (1982) Nociceptors and warm receptors innervated by C fibres in human skin. J Neurol Neurosurg Psychiatry 45:313-319.
9. Handwerker HO (1992) Pain and allodynia, itch and alloknesis: an alternative hypothesis. APS J 1:135-139.
10. Handwerker HO, Magerl W, Klemm F, Lang E, Westerman RA (1987) Quantitative evaluation of itch sensation. In: Fine afferent nerve fibres and pain (Schmidt RF, Vahle-Hinz C, eds), pp 463-473. Weinheim: VCH.
11. Handwerker HO, Forster C, Kirchhoff C (1991) Discharge patterns of human c-fibers induced by itching and burning stimuli. J Neurophysiol 66:307-315.
12. LaMotte RH (1992) Subpopulations of "nocifensor neurons" contributing to pain and allodynia, itch and alloknesis. APS J 1:115-126.
13. LaMotte RH, Campbell JN (1978) Comparison of responses of warm and nociceptive C-fiber afferents in monkey with human judgments of thermal pain. J Neurophysiol 41:509-528.
14. LaMotte RH, Simone DA, Baumann TK, Shain CN, Alreja M (1988) Hypothesis for novel classes of chemoreceptors mediating chemogenic pain and itch. In: Proceedings of the Vth world congress on pain (Dubner R, Gebhart GF, Bond M, eds), pp 529-535. Amsterdam: Elsevier.
15. Lynn B, Carpenter SE (1982) Primary afferent units from the hairy skin of the rat hind limb. Brain Res 238:29-43.
16. Magerl W, Westerman RA, Mohner B, Handwerker HO (1990) Properties of transdermal histamine iontophoresis: differential effects of season, gender, and body region. J Invest Dermatol 94:347-352.
17. Meyer RA, Campbell JN (1981) Evidence for two distinct classes of unmyelinated nociceptive afferents in monkey. Brain Res 224:149-152.
18. Schmelz M, Schmidt R, Ringkamp M, Handwerker HO, Torebjörk HE (1994) Sensitization of insensitive branches of C nociceptors in human skin. J Physiol (Lond) 480:389-394.
19. Schmelz M, Forster C, Schmidt R, Ringkamp M, Handwerker HO, Torebjörk HE (1995) Delayed-responses to electrical stimuli reflect c-fiber responsiveness in human microneurography. Exp Brain Res 104:331-336.
20. Schmidt R, Schmelz M, Forster C, Ringkamp M, Torebjörk HE, Handwerker HO (1995) Novel classes of responsive and unresponsive C nociceptors in human skin. J Neurosci 15:333-341.
21. Schmidt R, Schmelz M, Ringkamp M, Handwerker HO, Torebjörk HE (1997) Innervation territories of mechano-responsive C-nociceptor units in human skin. J Neurophysiol. in press.
22. Simone DA, Ngeow JY, Whitehouse J, Becerra Cabal L, Putterman GJ, LaMotte RH (1987) The magnitude and duration of itch produced by intracutaneous injections of histamine. Somatosens Res 5:81-92.
23. Simone DA, Nolano G, Wendelschafer-Crabb G, Kennedy WR (1996) Intradermal injection of capsaicin in humans: diminished pain sensation with rapid degeneration of intracutaneous nerve fibers. Soc Neurosci Abstr 22:1802.
24. Torebjörk HE (1974) Afferent C units responding to mechanical, thermal and chemical stimuli in human non-glabrous skin. Ada Physiol Scand 92:374-390.
25. Torebjörk HE, Hallin RG (1974) Responses in human A and C fibres to repeated electrical intradermal stimulation. J Neurol Neurosurg Psychiatry 37:653-664.
26. Torebjörk HE, Ochoa JL (1981) Pain and itch from C fiber stimulation. Soc Neurosci Abstr 7:228.
27. Torebjörk HE, Schmelz M, Handwerker HO (1996) Functional properties of human cutaneous nociceptors and their role in pain and hyperalgesia. In: Neurobiology of nociceptors (Belmonte C, Cervero F. eds), pp 349-369. Oxford: Oxford UP.
28. Tuckett RP (1982) Itch evoked by electrical stimulation of the skin. J Invest Dermatol 79:368-373.
29. Tuckett RP, Wei JY (1987) Response to an itch-producing substance in cat: II. Cutaneous receptor populations with unmyelinated axons. Brain Res 413:95-103.
30. Van Hees J, Gybels J (1972) Pain related to single afferent C-fibres from human skin. Brain Res 48:397-400.
31. Van Hees J, Gybels J (1981) C nociceptor activity in human nerve during painful and non painful skin stimulation. J Neurol Neurosurg Psychiatry 44:600-607.
32. von Frey M (1922) Zur Physiologie der Juckempfindung. Arch Neerland Physiol 7:142-145.
33. Wall PD, Cronly-Dillon JR (1960) Pain, itch and vibration. Arch Neurol 2:365-375.
34. Wallengren J (1993) The pathophysiology of itch. Eur J Dermatol 3: 643-647.