Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel

Pain

Volumn 154, Issue 12, 2013, Pages 2750-2758

  Materazzi, Serena ^a   Benemei, Silvia ^a   Fusi, Camilla ^a   Gualdani, Roberta ^a   De Siena, Gaetano ^a   Vastani, Nisha ^b   Andersson, David A ^b   Trevisan, Gabriela ^a   Moncelli, Maria Rosa ^a   Wei, Xiaomei ^c   Dussor, Gregory ^c   Pollastro, Federica ^d   Patacchini, Riccardo ^e   Appendino, Giovanni ^d   Geppetti, Pierangelo ^a   Nassini, Romina ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^e CHIESI FARMACEUTICI S P A   (Italy)

Author keywords

CGRP; Migraine; Parthenolide; TRPA1

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; PARTHENOLIDE; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DESENSITIZATION; HUMAN; HUMAN CELL; MALE; MOUSE; NERVE ENDING; NONHUMAN; NUCLEOPHILICITY; PARTIAL AGONISM; PRIORITY JOURNAL; RAT; TRIGEMINAL NERVE; VASODILATATION;

CGRP; MIGRAINE; PARTHENOLIDE; TRPA1;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHO CELLS; CRICETINAE; CRICETULUS; DRUG DELIVERY SYSTEMS; FLOWERS; HEK293 CELLS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NOCICEPTION; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; SESQUITERPENES; TANACETUM PARTHENIUM; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TRIGEMINAL GANGLION; TRIGEMINAL NERVE; VASODILATION;

EID: 84889014509     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2013.08.002     Document Type: Article

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