TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids

Pharmacological Research

Volumn 63, Issue 1, 2011, Pages 30-36

  Sadofsky, Laura R ^a   Boa, Andrew N ^a   Maher, Sarah A ^b   Birrell, Mark A ^b   Belvisi, Maria G ^b   Morice, Alyn H ^a  

^a UNIVERSITY OF HULL   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Cysteine covalent modification; Direct addition; N Hydroxysuccinyl esters; Transient receptor potential ankyrin 1; TRPA1

Indexed keywords

ACROLEIN; ACRYLAMIDE; ACRYLIC ACID; ACRYLIC ACID METHYL ESTER; CINNAMIC ACID; CYSTEINE; ESTER DERIVATIVE; KETONE DERIVATIVE; MESITYL OXIDE; METHYLVINYL KETONE; N HYDROXYSUCCINYL ESTER; OXIDE; PROPIONIC ACID; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CALCIUM SIGNALING; CHANNEL GATING; CHEMICAL INTERACTION; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; COVALENT BOND; HUMAN; HUMAN CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESIDUE ANALYSIS; VAGUS NERVE;

ACRYLATES; ANIMALS; CALCIUM CHANNELS; CALCIUM SIGNALING; CINNAMATES; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTERS; GUINEA PIGS; HEK293 CELLS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MEMBRANE POTENTIALS; MOLECULAR STRUCTURE; NERVE TISSUE PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; TRANSFECTION; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TRPV CATION CHANNELS; VAGUS NERVE;

EID: 79151472205     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2010.11.004     Document Type: Article

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