Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation

Pain

Volumn 152, Issue 5, 2011, Pages 1165-1172

  Chen, Jun ^a   Joshi, Shailen K ^a   Didomenico, Stanley ^a   Perner, Richard J ^a   Mikusa, Joe P ^a   Gauvin, Donna M ^a   Segreti, Jason A ^a   Han, Ping ^a   Zhang, Xu Feng ^a   Niforatos, Wende ^a   Bianchi, Bruce R ^a   Baker, Scott J ^a   Zhong, Chengmin ^a   Simler, Gricelda H ^a   McDonald, Heath A ^a   Schmidt, Robert G ^a   McGaraughty, Steve P ^a   Chu, Katharine L ^a   Faltynek, Connie R ^a   Kort, Michael E ^a   Reilly, Regina M ^a   Kym, Philip R ^a   more..

^a ABBOTT LABORATORIES   (United States)

Author keywords

Blockade; Noxious cold; Pain; Temperature regulation; Temperature sensation; TRPA1

Indexed keywords

A 967079; G PROTEIN COUPLED RECEPTOR; RECEPTOR BLOCKING AGENT; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; UNCLASSIFIED DRUG;

ALLODYNIA; ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; COLD ALLODYNIA; COLD SENSATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EXPOSURE; DRUG HALF LIFE; ELECTROPHYSIOLOGY; IC 50; MALE; NERVE INJURY; NOCICEPTIVE STIMULATION; NONHUMAN; OSTEOARTHRITIS; PAIN; PATHOLOGICAL PAIN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; TELEMETRY; THERMOREGULATION;

ANIMALS; BLOOD PRESSURE; BODY TEMPERATURE; BODY TEMPERATURE REGULATION; CALCITONIN GENE-RELATED PEPTIDE; CALCIUM; CALCIUM CHANNELS; CELLS, CULTURED; COLD TEMPERATURE; DISEASE MODELS, ANIMAL; DRUG INTERACTIONS; GANGLIA, SPINAL; HEART RATE; HUMANS; HYPERALGESIA; INHIBITORY CONCENTRATION 50; ISOTHIOCYANATES; MAGNETIC RESONANCE IMAGING; MALE; MICE; NERVE TISSUE PROTEINS; NEURONS; OXIMES; PAIN; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; SENSATION; SENSORY THRESHOLDS; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TRITIUM; TRPV CATION CHANNELS;

EID: 79954576919     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2011.01.049     Document Type: Article

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