The molecular basis for species-specific activation of human TRPA1 protein by protons involves poorly conserved residues within transmembrane domains 5 and 6

Journal of Biological Chemistry

Volumn 288, Issue 28, 2013, Pages 20280-20292

  De La Roche, Jeanne ^a   Eberhardt, Mirjam J ^a,b   Klinger, Alexandra B ^b   Stanslowsky, Nancy ^a   Wegner, Florian ^a   Koppert, Wolfgang ^a   Reeh, Peter W ^b   Lampert, Angelika ^b   Fischer, Michael J M ^b   Leffler, Andreas ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACID-SENSING ION CHANNELS; ACIDIC PH VALUES; CONCENTRATION-DEPENDENT; CONSERVED RESIDUES; DORSAL ROOT GANGLION NEURONS; INTERACTION SITE; SENSORY AFFERENTS; TRANS-MEMBRANE DOMAINS;

ACTIVATION ANALYSIS; AMINO ACIDS; ENZYME ACTIVITY; MAMMALS; NEURONS; PHYSIOLOGY; SENSORS;

PROTONS;

CYSTEINE; N (4 ISOPROPYLPHENYL) 2 (1,2,3,6 TETRAHYDRO 1,3 DIMETHYL 2,6 DIOXO 7H PURIN 7 YL)ACETAMIDE; PROTON; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1;

ACIDOSIS; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DRUG TARGETING; ELECTROPHILICITY; GENETIC CONSERVATION; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; NERVE CELL STIMULATION; NONHUMAN; PAIN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTON TRANSPORT; RESIDUE ANALYSIS; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; SPINAL GANGLION;

ACID-SENSING ION CHANNELS (ASIC); ACIDOSIS; NOCICEPTOR; PAIN; PATCH CLAMP; SPECIES SPECIFICITY; TRP CHANNELS;

ANIMALS; BINDING SITES; CALCIUM; CALCIUM CHANNELS; CAPSAICIN; CELLS, CULTURED; GANGLIA, SPINAL; HEK293 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; IONOMYCIN; MACACA MULATTA; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MONOTERPENES; MUTATION; NERVE TISSUE PROTEINS; NEURONS; POTASSIUM; PROTONS; RATS; SPECIES SPECIFICITY; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84880072362     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.479337     Document Type: Article

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