-
1
-
-
13344277357
-
Early neonatal death in mice homozygous for a null allele of the insulin receptor gene
-
doi:10.1038/ng0196-106
-
Accili D, Drago J, Lee EJ, Johnson MD, Cool MH, Salvatore P, Asico LD, Jose PA, Taylor SI & Westphal H 1996 Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nature Genetics 12 106-109. (doi:10.1038/ng0196-106)
-
(1996)
Nature Genetics
, vol.12
, pp. 106-109
-
-
Accili, D.1
Drago, J.2
Lee, E.J.3
Johnson, M.D.4
Cool, M.H.5
Salvatore, P.6
Asico, L.D.7
Jose, P.A.8
Taylor, S.I.9
Westphal, H.10
-
2
-
-
0031851293
-
Definition, diagnosis and classification of diabetes mellitus and its complication. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation
-
doi:10.1002/(SICI)1096-9136(199807)15:7%3C;539::AID-DIA668%3E;3.0.CO;2-S
-
Alberti KG & Zimmet PZ 1998 Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabetic Medicine 15 539-553. (doi:10.1002/(SICI)1096-9136(199807)15:7%3C;539::AID-DIA668%3E;3.0.CO;2-S)
-
(1998)
Diabetic Medicine
, vol.15
, pp. 539-553
-
-
Alberti, K.G.1
Zimmet, P.Z.2
-
3
-
-
25144459980
-
The metabolic syndrome-a new worldwide definition
-
doi:10.1016/S0140-6736(05)67402-8
-
Alberti KG, Zimmet P & Shaw J 2005 The metabolic syndrome-a new worldwide definition. Lancet 366 1059-1062. (doi:10.1016/S0140-6736(05)67402-8)
-
(2005)
Lancet
, vol.366
, pp. 1059-1062
-
-
Alberti, K.G.1
Zimmet, P.2
Shaw, J.3
-
4
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Ba
-
doi:10.1016/S0960-9822(06)00122-9
-
Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB & Cohen P 1997 Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Ba. Current Biology 7 261-269. (doi:10.1016/S0960-9822(06)00122-9)
-
(1997)
Current Biology
, vol.7
, pp. 261-269
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
Holmes, A.B.4
Gaffney, P.R.5
Reese, C.B.6
Cohen, P.7
-
5
-
-
64749101898
-
Benefits and limitations of reducing glucagon action for the treatment of type 2 diabetes
-
doi:10.1152/ajpendo.90887.2008
-
Ali S & Drucker DJ 2009 Benefits and limitations of reducing glucagon action for the treatment of type 2 diabetes. American Journal of Physiology. Endocrinology and Metabolism 296 E415-E421. (doi:10.1152/ajpendo.90887.2008)
-
(2009)
American Journal of Physiology. Endocrinology and Metabolism
, vol.296
-
-
Ali, S.1
Drucker, D.J.2
-
6
-
-
0141727772
-
Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice
-
doi:10.1152/ajpendo.00156.2003
-
Altomonte J, Richter A, Harbaran S, Suriawinata J, Nakae J, Thung SN, Meseck M, Accili D & Dong H 2003 Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice. American Journal of Physiology. Endocrinology and Metabolism 285 E718-E728. (doi:10.1152/ajpendo.00156.2003)
-
(2003)
American Journal of Physiology. Endocrinology and Metabolism
, vol.285
-
-
Altomonte, J.1
Richter, A.2
Harbaran, S.3
Suriawinata, J.4
Nakae, J.5
Thung, S.N.6
Meseck, M.7
Accili, D.8
Dong, H.9
-
7
-
-
0028032895
-
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
-
doi:10.1038/372186a0
-
Araki E, Lipes MA, Patti ME, Bruning JC, Haag B III, Johnson RS & Kahn CR 1994 Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 372 186-190. (doi:10.1038/372186a0)
-
(1994)
Nature
, vol.372
, pp. 186-190
-
-
Araki, E.1
Lipes, M.A.2
Patti, M.E.3
Bruning, J.C.4
Haag I.I.I, B.5
Johnson, R.S.6
Kahn, C.R.7
-
8
-
-
84861564532
-
Liver-specific p70 S6 kinase depletion protects against hepatic steatosis and systemic insulin resistance
-
doi:10.1074/jbc.M112.365544
-
Bae EJ, Xu J, Oh DY, Bandyopadhyay G, Lagakos WS, Keshwani M & Olefsky JM 2012 Liver-specific p70 S6 kinase depletion protects against hepatic steatosis and systemic insulin resistance. Journal of Biological Chemistry 287 18769-18780. (doi:10.1074/jbc.M112.365544)
-
(2012)
Journal of Biological Chemistry
, vol.287
, pp. 18769-18780
-
-
Bae, E.J.1
Xu, J.2
Oh, D.Y.3
Bandyopadhyay, G.4
Lagakos, W.S.5
Keshwani, M.6
Olefsky, J.M.7
-
9
-
-
80455135061
-
Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice
-
doi:10.1016/j.cmet.2011.09.012
-
Banks AS, Kim-Muller JY, Mastracci TL, Kofler NM, Qiang L, Haeusler RA, Jurczak MJ, Laznik D, Heinrich G, Samuel VT et al. 2011 Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice. Cell Metabolism 14 587-597. (doi:10.1016/j.cmet.2011.09.012)
-
(2011)
Cell Metabolism
, vol.14
, pp. 587-597
-
-
Banks, A.S.1
Kim-Muller, J.Y.2
Mastracci, T.L.3
Kofler, N.M.4
Qiang, L.5
Haeusler, R.A.6
Jurczak, M.J.7
Laznik, D.8
Heinrich, G.9
Samuel, V.T.10
-
10
-
-
18844411108
-
Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action
-
doi:10.1038/nm1227
-
Bard-Chapeau EA, Hevener AL, Long S, Zhang EE, Olefsky JM & Feng GS 2005 Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action. Nature Medicine 11 567-571. (doi:10.1038/nm1227)
-
(2005)
Nature Medicine
, vol.11
, pp. 567-571
-
-
Bard-Chapeau, E.A.1
Hevener, A.L.2
Long, S.3
Zhang, E.E.4
Olefsky, J.M.5
Feng, G.S.6
-
11
-
-
0037456304
-
STAT3 signalling is required for leptin regulation of energy balance but not reproduction
-
doi:10.1038/nature01388
-
Bates SH, Stearns WH, Dundon TA, SchubertM, Tso AW, Wang Y, Banks AS, Lavery HJ, Haq AK, Maratos-Flier E et al. 2003 STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421 856-859. (doi:10.1038/nature01388)
-
(2003)
Nature
, vol.421
, pp. 856-859
-
-
Bates, S.H.1
Stearns, W.H.2
Dundon, T.A.3
Schubert, M.4
Tso, A.W.5
Wang, Y.6
Banks, A.S.7
Lavery, H.J.8
Haq, A.K.9
Maratos-Flier, E.10
-
13
-
-
84863283393
-
Metabolic stressinduced activation of FoxO1 triggers diabetic cardiomyopathy in mice
-
doi:10.1172/JCI60329
-
Battiprolu PK, Hojayev B, Jiang N, Wang ZV, Luo X, IglewskiM, Shelton JM, Gerard RD, Rothermel BA, Gillette TG et al. 2012 Metabolic stressinduced activation of FoxO1 triggers diabetic cardiomyopathy in mice. Journal of Clinical Investigation 122 1109-1118. (doi:10.1172/JCI60329)
-
(2012)
Journal of Clinical Investigation
, vol.122
, pp. 1109-1118
-
-
Battiprolu, P.K.1
Hojayev, B.2
Jiang, N.3
Wang, Z.V.4
Luo, X.5
Iglewski, M.6
Shelton, J.M.7
Gerard, R.D.8
Rothermel, B.A.9
Gillette, T.G.10
-
14
-
-
54849426651
-
Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy
-
doi:10.1016/j. cmet.2008.10.002
-
Bentzinger CF, Romanino K, Cloetta D, Lin S, Mascarenhas JB, Oliveri F, Xia J, Casanova E, Costa CF, BrinkMet al. 2008 Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metabolism 8 411-424. (doi:10.1016/j. cmet.2008.10.002)
-
(2008)
Cell Metabolism
, vol.8
, pp. 411-424
-
-
Bentzinger, C.F.1
Romanino, K.2
Cloetta, D.3
Lin, S.4
Mascarenhas, J.B.5
Oliveri, F.6
Xia, J.7
Casanova, E.8
Costa, C.F.9
BrinkMet, al.10
-
15
-
-
79957885392
-
PKCd regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans
-
doi:10.1172/JCI46045
-
Bezy O, Tran TT, Pihlajamaki J, Suzuki R, Emanuelli B, Winnay J, Mori MA, Haas J, Biddinger SB, Leitges M et al. 2011 PKCd regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans. Journal of Clinical Investigation 121 2504-2517. (doi:10.1172/JCI46045)
-
(2011)
Journal of Clinical Investigation
, vol.121
, pp. 2504-2517
-
-
Bezy, O.1
Tran, T.T.2
Pihlajamaki, J.3
Suzuki, R.4
Emanuelli, B.5
Winnay, J.6
Mori, M.A.7
Haas, J.8
Biddinger, S.B.9
Leitges, M.10
-
16
-
-
33645982255
-
From mice to men: insights into the insulin resistance syndromes
-
doi:10.1146/annurev.physiol.68.040104.124723
-
Biddinger SB & Kahn CR 2006 From mice to men: insights into the insulin resistance syndromes. Annual Review of Physiology 68 123-158. (doi:10.1146/annurev.physiol.68.040104.124723)
-
(2006)
Annual Review of Physiology
, vol.68
, pp. 123-158
-
-
Biddinger, S.B.1
Kahn, C.R.2
-
17
-
-
38649110496
-
Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis
-
doi:10.1016/j.cmet.2007.11.013
-
Biddinger SB, Hernandez-Ono A, Rask-Madsen C, Haas JT, Aleman JO, Suzuki R, Scapa EF, Agarwal C, Carey MC, Stephanopoulos G et al. 2008 Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metabolism 7 125-134. (doi:10.1016/j.cmet.2007.11.013)
-
(2008)
Cell Metabolism
, vol.7
, pp. 125-134
-
-
Biddinger, S.B.1
Hernandez-Ono, A.2
Rask-Madsen, C.3
Haas, J.T.4
Aleman, J.O.5
Suzuki, R.6
Scapa, E.F.7
Agarwal, C.8
Carey, M.C.9
Stephanopoulos, G.10
-
18
-
-
0033595011
-
Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
-
doi:10.1073/pnas.96.13.7421
-
Biggs WH III, Meisenhelder J, Hunter T, Cavenee WK & Arden KC 1999 Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. PNAS 96 7421-7426. (doi:10.1073/pnas.96.13.7421)
-
(1999)
PNAS
, vol.96
, pp. 7421-7426
-
-
Biggs I.I.I, W.H.1
Meisenhelder, J.2
Hunter, T.3
Cavenee, W.K.4
Arden, K.C.5
-
19
-
-
79952451443
-
Obesity, insulin resistance and free fatty acids
-
doi:10.1097/MED.0b013e3283444b09
-
Boden G 2011 Obesity, insulin resistance and free fatty acids. Current Opinion in Endocrinology, Diabetes, and Obesity 18 139-143. (doi:10.1097/MED.0b013e3283444b09)
-
(2011)
Current Opinion in Endocrinology, Diabetes, and Obesity
, vol.18
, pp. 139-143
-
-
Boden, G.1
-
20
-
-
19944433322
-
The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis
-
doi:10.2337/diabetes.54.2.402
-
Bost F, Aouadi M, Caron L, Even P, Belmonte N, Prot M, Dani C, Hofman P, Pages G, Pouyssegur J et al. 2005 The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis. Diabetes 54 402-411. (doi:10.2337/diabetes.54.2.402)
-
(2005)
Diabetes
, vol.54
, pp. 402-411
-
-
Bost, F.1
Aouadi, M.2
Caron, L.3
Even, P.4
Belmonte, N.5
Prot, M.6
Dani, C.7
Hofman, P.8
Pages, G.9
Pouyssegur, J.10
-
21
-
-
84862776702
-
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
-
doi:10.1038/nature10777
-
Bostrom P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Bostrom EA, Choi JH, Long JZ et al. 2012 A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481 463-468. (doi:10.1038/nature10777)
-
(2012)
Nature
, vol.481
, pp. 463-468
-
-
Bostrom, P.1
Wu, J.2
Jedrychowski, M.P.3
Korde, A.4
Ye, L.5
Lo, J.C.6
Rasbach, K.A.7
Bostrom, E.A.8
Choi, J.H.9
Long, J.Z.10
-
22
-
-
77949535836
-
Insulin enhances glucose-stimulated insulin secretion in healthy humans
-
doi:10.1073/pnas.1000002107
-
Bouche C, Lopez X, Fleischman A, Cypess AM, O'Shea S, Stefanovski D, Bergman RN, Rogatsky E, Stein DT, Kahn CR et al. 2010 Insulin enhances glucose-stimulated insulin secretion in healthy humans. PNAS 107 4770-4775. (doi:10.1073/pnas.1000002107)
-
(2010)
PNAS
, vol.107
, pp. 4770-4775
-
-
Bouche, C.1
Lopez, X.2
Fleischman, A.3
Cypess, A.M.4
O'Shea, S.5
Stefanovski, D.6
Bergman, R.N.7
Rogatsky, E.8
Stein, D.T.9
Kahn, C.R.10
-
23
-
-
84893050954
-
Differential role of insulin and IGF-1 receptors in brown and white adipose tissue and development of lipoatrophic diabetes
-
Boucher J & Kahn CR 2013 Differential role of insulin and IGF-1 receptors in brown and white adipose tissue and development of lipoatrophic diabetes. Diabetes 62 A37.
-
(2013)
Diabetes
, vol.62
-
-
Boucher, J.1
Kahn, C.R.2
-
24
-
-
14144250240
-
Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice
-
doi:10.1128/MCB.25.5. 1596-1607.2005
-
Brachmann SM, Ueki K, Engelman JA, Kahn RC & Cantley LC 2005 Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice. Molecular and Cellular Biology 25 1596-1607. (doi:10.1128/MCB.25.5. 1596-1607.2005)
-
(2005)
Molecular and Cellular Biology
, vol.25
, pp. 1596-1607
-
-
Brachmann, S.M.1
Ueki, K.2
Engelman, J.A.3
Kahn, R.C.4
Cantley, L.C.5
-
25
-
-
38649116056
-
Selective versus total insulin resistance: a pathogenic paradox
-
doi:10.1016/j.cmet. 2007.12.009
-
Brown MS & Goldstein JL 2008 Selective versus total insulin resistance: a pathogenic paradox. Cell Metabolism 7 95-96. (doi:10.1016/j.cmet. 2007.12.009)
-
(2008)
Cell Metabolism
, vol.7
, pp. 95-96
-
-
Brown, M.S.1
Goldstein, J.L.2
-
26
-
-
0032214652
-
A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
-
doi:10.1016/S1097-2765(00)80155-0
-
Bruning JC, Michael MD, Winnay JN, Hayashi T, Horsch D, Accili D, Goodyear LJ & Kahn CR 1998 A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Molecular Cell 2 559-569. (doi:10.1016/S1097-2765(00)80155-0)
-
(1998)
Molecular Cell
, vol.2
, pp. 559-569
-
-
Bruning, J.C.1
Michael, M.D.2
Winnay, J.N.3
Hayashi, T.4
Horsch, D.5
Accili, D.6
Goodyear, L.J.7
Kahn, C.R.8
-
27
-
-
0034703229
-
Role of brain insulin receptor in control of body weight and reproduction
-
doi:10.1126/science.289.5487.2122
-
Bruning JC, Gautam D, Burks DJ, Gillette J, Schubert M, Orban PC, Klein R, Krone W, Muller-Wieland D & Kahn CR 2000 Role of brain insulin receptor in control of body weight and reproduction. Science 289 2122-2125. (doi:10.1126/science.289.5487.2122)
-
(2000)
Science
, vol.289
, pp. 2122-2125
-
-
Bruning, J.C.1
Gautam, D.2
Burks, D.J.3
Gillette, J.4
Schubert, M.5
Orban, P.C.6
Klein, R.7
Krone, W.8
Muller-Wieland, D.9
Kahn, C.R.10
-
28
-
-
84867188555
-
Regulation of metabolism: a cross talk between gut microbiota and its human host
-
doi:10.1152/physiol.00023.2012
-
Burcelin R 2012 Regulation of metabolism: a cross talk between gut microbiota and its human host. Physiology 27 300-307. (doi:10.1152/physiol.00023.2012)
-
(2012)
Physiology
, vol.27
, pp. 300-307
-
-
Burcelin, R.1
-
29
-
-
14644427890
-
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
-
doi:10.1038/nm1166
-
Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J & Shoelson SE 2005 Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB. Nature Medicine 11 183-190. (doi:10.1038/nm1166)
-
(2005)
Nature Medicine
, vol.11
, pp. 183-190
-
-
Cai, D.1
Yuan, M.2
Frantz, D.F.3
Melendez, P.A.4
Hansen, L.5
Lee, J.6
Shoelson, S.E.7
-
31
-
-
38349018223
-
Activation of p38 mitogen-activated protein kinase abolishes insulin-mediated myocardial protection against ischemia-reperfusion injury
-
doi:10.1152/ajpendo.00571.2007
-
Chai W, Wu Y, Li G, Cao W, Yang Z & Liu Z 2008 Activation of p38 mitogen-activated protein kinase abolishes insulin-mediated myocardial protection against ischemia-reperfusion injury. American Journal of Physiology. Endocrinology and Metabolism 294 E183-E189. (doi:10.1152/ajpendo.00571.2007)
-
(2008)
American Journal of Physiology. Endocrinology and Metabolism
, vol.294
-
-
Chai, W.1
Wu, Y.2
Li, G.3
Cao, W.4
Yang, Z.5
Liu, Z.6
-
32
-
-
70449122132
-
Foxo1 integrates insulin signaling with mitochondrial function in the liver
-
doi:10.1038/nm.2049
-
Cheng Z, Guo S, Copps K, Dong X, Kollipara R, Rodgers JT, Depinho RA, Puigserver P & White MF 2009 Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nature Medicine 15 1307-1311. (doi:10.1038/nm.2049)
-
(2009)
Nature Medicine
, vol.15
, pp. 1307-1311
-
-
Cheng, Z.1
Guo, S.2
Copps, K.3
Dong, X.4
Kollipara, R.5
Rodgers, J.T.6
Depinho, R.A.7
Puigserver, P.8
White, M.F.9
-
33
-
-
0035368548
-
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ)
-
doi:10.1126/science.292. 5522.1728
-
Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, Crenshaw EB III, Kaestner KH, Bartolomei MS, Shulman GI & Birnbaum MJ 2001 Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ). Science 292 1728-1731. (doi:10.1126/science.292. 5522.1728)
-
(2001)
Science
, vol.292
, pp. 1728-1731
-
-
Cho, H.1
Mu, J.2
Kim, J.K.3
Thorvaldsen, J.L.4
Chu, Q.5
Crenshaw I.I.I, E.B.6
Kaestner, K.H.7
Bartolomei, M.S.8
Shulman, G.I.9
Birnbaum, M.J.10
-
34
-
-
0032513053
-
Protein kinase B/Akt mediates effects of insulin on hepatic insulin-like growth factor-binding protein-1 gene expression through a conserved insulin response sequence
-
doi:10.1074/jbc.273.11.6482
-
Cichy SB, Uddin S, Danilkovich A, Guo S, Klippel A & Unterman TG 1998 Protein kinase B/Akt mediates effects of insulin on hepatic insulin-like growth factor-binding protein-1 gene expression through a conserved insulin response sequence. Journal of Biological Chemistry 273 6482-6487. (doi:10.1074/jbc.273.11.6482)
-
(1998)
Journal of Biological Chemistry
, vol.273
, pp. 6482-6487
-
-
Cichy, S.B.1
Uddin, S.2
Danilkovich, A.3
Guo, S.4
Klippel, A.5
Unterman, T.G.6
-
35
-
-
84862888250
-
Effects of gastric bypass surgery in patients with type 2 diabetes and only mild obesity
-
doi:10.2337/dc11-2289
-
Cohen RV, Pinheiro JC, Schiavon CA, Salles JE, Wajchenberg BL & Cummings DE 2012 Effects of gastric bypass surgery in patients with type 2 diabetes and only mild obesity. Diabetes Care 35 1420-1428. (doi:10.2337/dc11-2289)
-
(2012)
Diabetes Care
, vol.35
, pp. 1420-1428
-
-
Cohen, R.V.1
Pinheiro, J.C.2
Schiavon, C.A.3
Salles, J.E.4
Wajchenberg, B.L.5
Cummings, D.E.6
-
36
-
-
84866122780
-
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
-
doi:10.1007/s00125-012-2644-8
-
Copps KD & White MF 2012 Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2. Diabetologia 55 2565-2582. (doi:10.1007/s00125-012-2644-8)
-
(2012)
Diabetologia
, vol.55
, pp. 2565-2582
-
-
Copps, K.D.1
White, M.F.2
-
37
-
-
57349096045
-
The metabolic syndrome
-
doi:10.1210/er.2008-0024
-
Cornier MA, Dabelea D, Hernandez TL, Lindstrom RC, Steig AJ, Stob NR, Van Pelt RE, Wang H & Eckel RH 2008 The metabolic syndrome. Endocrine Reviews 29 777-822. (doi:10.1210/er.2008-0024)
-
(2008)
Endocrine Reviews
, vol.29
, pp. 777-822
-
-
Cornier, M.A.1
Dabelea, D.2
Hernandez, T.L.3
Lindstrom, R.C.4
Steig, A.J.5
Stob, N.R.6
Van Pelt, R.E.7
Wang, H.8
Eckel, R.H.9
-
38
-
-
0026021161
-
Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease
-
doi:10.2337/diacare.14.3.173
-
DeFronzo RA & Ferrannini E 1991 Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14 173-194. (doi:10.2337/diacare.14.3.173)
-
(1991)
Diabetes Care
, vol.14
, pp. 173-194
-
-
DeFronzo, R.A.1
Ferrannini, E.2
-
39
-
-
84862004148
-
FoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1c
-
doi:10.1074/jbc.M112.347211
-
Deng X, Zhang W, O-Sullivan I, Williams JB, Dong Q, Park EA, Raghow R, Unterman TG & Elam MB 2013 FoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1c. Journal of Biological Chemistry 287 20132-20143. (doi:10.1074/jbc.M112.347211)
-
(2013)
Journal of Biological Chemistry
, vol.287
, pp. 20132-20143
-
-
Deng, X.1
Zhang, W.2
Sullivan, I.O.3
Williams, J.B.4
Dong, Q.5
Park, E.A.6
Raghow, R.7
Unterman, T.G.8
Elam, M.B.9
-
40
-
-
84862271958
-
Bariatric surgery for type 2 diabetes
-
doi:10.1016/S0140-6736(12)60401-2
-
Dixon JB, le RouxCW, Rubino F & Zimmet P 2012 Bariatric surgery for type 2 diabetes. Lancet 379 2300-2311. (doi:10.1016/S0140-6736(12)60401-2)
-
(2012)
Lancet
, vol.379
, pp. 2300-2311
-
-
Dixon, J.B.1
Le Roux, C.W.2
Rubino, F.3
Zimmet, P.4
-
41
-
-
23044467856
-
PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle
-
doi:10.1152/ajpendo. 00011.2005
-
Dong LQ & Liu F 2005 PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle. American Journal of Physiology. Endocrinology and Metabolism 289 E187-E196. (doi:10.1152/ajpendo. 00011.2005)
-
(2005)
American Journal of Physiology. Endocrinology and Metabolism
, vol.289
-
-
Dong, L.Q.1
Liu, F.2
-
42
-
-
45549090182
-
Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation
-
doi:10.1016/j.cmet.2008.06.006
-
Dong XC, Copps KD, Guo S, Li Y, Kollipara R, DePinho RA & White MF 2008 Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metabolism 8 65-76. (doi:10.1016/j.cmet.2008.06.006)
-
(2008)
Cell Metabolism
, vol.8
, pp. 65-76
-
-
Dong, X.C.1
Copps, K.D.2
Guo, S.3
Li, Y.4
Kollipara, R.5
DePinho, R.A.6
White, M.F.7
-
43
-
-
50049086521
-
The emerging genetic architecture of type 2 diabetes
-
doi:10.1016/j.cmet.2008.08.006
-
Doria A, Patti ME & Kahn CR 2008 The emerging genetic architecture of type 2 diabetes. Cell Metabolism 8 186-200. (doi:10.1016/j.cmet.2008.08.006)
-
(2008)
Cell Metabolism
, vol.8
, pp. 186-200
-
-
Doria, A.1
Patti, M.E.2
Kahn, C.R.3
-
44
-
-
58149328550
-
Effect of endothelium-specific insulin resistance on endothelial function in vivo
-
doi:10.2337/db07-1111
-
Duncan ER, Crossey PA, Walker S, Anilkumar N, Poston L, Douglas G, Ezzat VA, Wheatcroft SB, Shah AM & Kearney MT 2008 Effect of endothelium-specific insulin resistance on endothelial function in vivo. Diabetes 57 3307-3314. (doi:10.2337/db07-1111)
-
(2008)
Diabetes
, vol.57
, pp. 3307-3314
-
-
Duncan, E.R.1
Crossey, P.A.2
Walker, S.3
Anilkumar, N.4
Poston, L.5
Douglas, G.6
Ezzat, V.A.7
Wheatcroft, S.B.8
Shah, A.M.9
Kearney, M.T.10
-
45
-
-
17144380822
-
The metabolic syndrome
-
doi:10.1016/S0140-6736(05)66378-7
-
Eckel RH, Grundy SM & Zimmet PZ 2005 The metabolic syndrome. Lancet 365 1415-1428. (doi:10.1016/S0140-6736(05)66378-7)
-
(2005)
Lancet
, vol.365
, pp. 1415-1428
-
-
Eckel, R.H.1
Grundy, S.M.2
Zimmet, P.Z.3
-
46
-
-
84856106525
-
The Foxo family: partners in crime or silent heroes
-
doi:10.1210/en.2011-2080
-
Estall JL 2012 The Foxo family: partners in crime or silent heroes. Endocrinology 153 549-551. (doi:10.1210/en.2011-2080)
-
(2012)
Endocrinology
, vol.153
, pp. 549-551
-
-
Estall, J.L.1
-
47
-
-
41449088342
-
Regulation of cardiomyocyte proliferation and myocardial growth during development by FOXO transcription factors
-
doi:10.1161/CIRCRESAHA.107.163428
-
Evans-Anderson HJ, Alfieri CM & Yutzey KE 2008 Regulation of cardiomyocyte proliferation and myocardial growth during development by FOXO transcription factors. Circulation Research 102 686-694. (doi:10.1161/CIRCRESAHA.107.163428)
-
(2008)
Circulation Research
, vol.102
, pp. 686-694
-
-
Evans-Anderson, H.J.1
Alfieri, C.M.2
Yutzey, K.E.3
-
48
-
-
84856113332
-
A hepatocyte growth factor receptor (Met)-insulin receptor hybrid governs hepatic glucose metabolism
-
doi:10.1038/nm.2531
-
Fafalios A, Ma J, Tan X, Stoops J, Luo J, Defrances MC & Zarnegar R 2011 A hepatocyte growth factor receptor (Met)-insulin receptor hybrid governs hepatic glucose metabolism. Nature Medicine 17 1577-1584. (doi:10.1038/nm.2531)
-
(2011)
Nature Medicine
, vol.17
, pp. 1577-1584
-
-
Fafalios, A.1
Ma, J.2
Tan, X.3
Stoops, J.4
Luo, J.5
Defrances, M.C.6
Zarnegar, R.7
-
49
-
-
77955035304
-
Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism
-
doi:10.1016/j.cell.2010.06.003
-
Ferron M,Wei J, Yoshizawa T, Del Fattore A, DePinho RA, Teti A, Ducy P & Karsenty G 2010 Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell 142 296-308. (doi:10.1016/j.cell.2010.06.003)
-
(2010)
Cell
, vol.142
, pp. 296-308
-
-
Ferron, M.1
Wei, J.2
Yoshizawa, T.3
Del Fattore, A.4
DePinho, R.A.5
Teti, A.6
Ducy, P.7
Karsenty, G.8
-
50
-
-
77955082747
-
Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition
-
doi:10.1016/j.cell.2010.06.002
-
Fulzele K, Riddle RC, DiGirolamo DJ, Cao X,Wan C, Chen D, Faugere MC, Aja S, Hussain MA, Bruning JC et al. 2010 Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell 142 309-319. (doi:10.1016/j.cell.2010.06.002)
-
(2010)
Cell
, vol.142
, pp. 309-319
-
-
Fulzele, K.1
Riddle, R.C.2
DiGirolamo, D.J.3
Cao, X.4
Wan, C.5
Chen, D.6
Faugere, M.C.7
Aja, S.8
Hussain, M.A.9
Bruning, J.C.10
-
51
-
-
0030050975
-
Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogenactivated protein kinase signaling pathway
-
doi:10.1074/jbc.271.4.1890
-
Gabbay RA, Sutherland C, Gnudi L, Kahn BB, O'Brien RM, Granner DK & Flier JS 1996 Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogenactivated protein kinase signaling pathway. Journal of Biological Chemistry 271 1890-1897. (doi:10.1074/jbc.271.4.1890)
-
(1996)
Journal of Biological Chemistry
, vol.271
, pp. 1890-1897
-
-
Gabbay, R.A.1
Sutherland, C.2
Gnudi, L.3
Kahn, B.B.4
O'Brien, R.M.5
Granner, D.K.6
Flier, J.S.7
-
52
-
-
84881098074
-
Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo
-
doi:10.1073/pnas. 1311176110
-
Galbo T, Perry RJ, Jurczak MJ, Camporez JP, Alves TC, Kahn M, Guigni BA, Serr J, Zhang D, Bhanot S et al. 2013 Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo. PNAS 110 12780-12785. (doi:10.1073/pnas. 1311176110)
-
(2013)
PNAS
, vol.110
, pp. 12780-12785
-
-
Galbo, T.1
Perry, R.J.2
Jurczak, M.J.3
Camporez, J.P.4
Alves, T.C.5
Kahn, M.6
Guigni, B.A.7
Serr, J.8
Zhang, D.9
Bhanot, S.10
-
53
-
-
0037073679
-
Serine phosphorylation of insulin receptor substrate 1 by inhibitor κB kinase complex
-
doi:10.1074/jbc.M209459200
-
Gao Z, Hwang D, Bataille F, Lefevre M, York D, Quon MJ & Ye J 2002 Serine phosphorylation of insulin receptor substrate 1 by inhibitor κB kinase complex. Journal of Biological Chemistry 277 48115-48121. (doi:10.1074/jbc.M209459200)
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 48115-48121
-
-
Gao, Z.1
Hwang, D.2
Bataille, F.3
Lefevre, M.4
York, D.5
Quon, M.J.6
Ye, J.7
-
54
-
-
33845989841
-
Inactivation of PKCq leads to increased susceptibility to obesity and dietary insulin resistance in mice
-
doi:10.1152/ajpendo.00178.2006
-
Gao Z, Wang Z, Zhang X, Butler AA, Zuberi A, Gawronska-Kozak B, Lefevre M, York D, Ravussin E, Berthoud HR et al. 2007 Inactivation of PKCq leads to increased susceptibility to obesity and dietary insulin resistance in mice. American Journal of Physiology. Endocrinology and Metabolism 292 E84-E91. (doi:10.1152/ajpendo.00178.2006)
-
(2007)
American Journal of Physiology. Endocrinology and Metabolism
, vol.292
-
-
Gao, Z.1
Wang, Z.2
Zhang, X.3
Butler, A.A.4
Zuberi, A.5
Gawronska-Kozak, B.6
Lefevre, M.7
York, D.8
Ravussin, E.9
Berthoud, H.R.10
-
55
-
-
34250021317
-
Genetic inactivation of RelA/p65 sensitizes adult mouse hepatocytes to TNF-induced apoptosis in vivo and in vitro
-
doi:10.1053/j.gastro.2007.03.033
-
Geisler F, Algul H, Paxian S & Schmid RM 2007 Genetic inactivation of RelA/p65 sensitizes adult mouse hepatocytes to TNF-induced apoptosis in vivo and in vitro. Gastroenterology 132 2489-2503. (doi:10.1053/j.gastro.2007.03.033)
-
(2007)
Gastroenterology
, vol.132
, pp. 2489-2503
-
-
Geisler, F.1
Algul, H.2
Paxian, S.3
Schmid, R.M.4
-
56
-
-
2542528670
-
A family with severe insulin resistance and diabetes due to a mutation in AKT2
-
doi:10.1126/science.1096706
-
George S, Rochford JJ,Wolfrum C, Gray SL, Schinner S,Wilson JC, Soos MA, Murgatroyd PR,Williams RM, Acerini CL et al. 2004 A family with severe insulin resistance and diabetes due to a mutation in AKT2. Science 304 1325-1328. (doi:10.1126/science.1096706)
-
(2004)
Science
, vol.304
, pp. 1325-1328
-
-
George, S.1
Rochford, J.J.2
Wolfrum, C.3
Gray, S.L.4
Schinner, S.5
Wilson, J.C.6
Soos, M.A.7
Murgatroyd, P.R.8
Williams, R.M.9
Acerini, C.L.10
-
57
-
-
79959933430
-
Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor
-
doi:10.1073/pnas.1019268108
-
Gonzalez E, Flier E, Molle D, Accili D & McGraw TE 2011 Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor. PNAS 108 10162-10167. (doi:10.1073/pnas.1019268108)
-
(2011)
PNAS
, vol.108
, pp. 10162-10167
-
-
Gonzalez, E.1
Flier, E.2
Molle, D.3
Accili, D.4
McGraw, T.E.5
-
58
-
-
0345086474
-
Free fatty acid-induced insulin resistance is associated with activation of protein kinase Cq and alterations in the insulin signaling cascade
-
doi:10.2337/diabetes.48.6.1270
-
Griffin ME, Marcucci MJ, Cline GW, Bell K, Barucci N, Lee D, Goodyear LJ, Kraegen EW, White MF & Shulman GI 1999 Free fatty acid-induced insulin resistance is associated with activation of protein kinase Cq and alterations in the insulin signaling cascade. Diabetes 48 1270-1274. (doi:10.2337/diabetes.48.6.1270)
-
(1999)
Diabetes
, vol.48
, pp. 1270-1274
-
-
Griffin, M.E.1
Marcucci, M.J.2
Cline, G.W.3
Bell, K.4
Barucci, N.5
Lee, D.6
Goodyear, L.J.7
Kraegen, E.W.8
White, M.F.9
Shulman, G.I.10
-
59
-
-
27444443876
-
Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
-
doi:10.1161/CIRCULATIONAHA.105. 169404
-
Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr et al. 2005 Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 112 2735-2752. (doi:10.1161/CIRCULATIONAHA.105. 169404)
-
(2005)
Circulation
, vol.112
, pp. 2735-2752
-
-
Grundy, S.M.1
Cleeman, J.I.2
Daniels, S.R.3
Donato, K.A.4
Eckel, R.H.5
Franklin, B.A.6
Gordon, D.J.7
Krauss, R.M.8
Savage, P.J.9
Smith Jr., S.C.10
-
60
-
-
84880234110
-
Molecular basis of insulin resistance: the role of IRS and Foxo1 in the control of diabetes mellitus and its complications
-
doi:10.1016/j.ddmec. 2013.06.003
-
Guo S 2013 Molecular basis of insulin resistance: the role of IRS and Foxo1 in the control of diabetes mellitus and its complications. Drug Discovery Today. Disease Mechanisms 10 e27-e33. (doi:10.1016/j.ddmec. 2013.06.003)
-
(2013)
Drug Discovery Today. Disease Mechanisms
, vol.10
-
-
Guo, S.1
-
61
-
-
0033546192
-
Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence
-
doi:10.1074/jbc.274.24.17184
-
Guo S, Rena G, Cichy S, He X, Cohen P & Unterman T 1999 Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence. Journal of Biological Chemistry 274 17184-17192. (doi:10.1074/jbc.274.24.17184)
-
(1999)
Journal of Biological Chemistry
, vol.274
, pp. 17184-17192
-
-
Guo, S.1
Rena, G.2
Cichy, S.3
He, X.4
Cohen, P.5
Unterman, T.6
-
62
-
-
33751533918
-
The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling
-
doi:10.1210/me.2006-0092
-
Guo S, Dunn SL & White MF 2006 The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling. Molecular Endocrinology 20 3389-3399. (doi:10.1210/me.2006-0092)
-
(2006)
Molecular Endocrinology
, vol.20
, pp. 3389-3399
-
-
Guo, S.1
Dunn, S.L.2
White, M.F.3
-
63
-
-
70249108137
-
The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis
-
doi:10.1128/MCB.00138-09
-
Guo S, Copps KD, Dong X, Park S, Cheng Z, Pocai A, Rossetti L, Sajan M, Farese RV & White MF 2009 The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis. Molecular and Cellular Biology 29 5070-5083. (doi:10.1128/MCB.00138-09)
-
(2009)
Molecular and Cellular Biology
, vol.29
, pp. 5070-5083
-
-
Guo, S.1
Copps, K.D.2
Dong, X.3
Park, S.4
Cheng, Z.5
Pocai, A.6
Rossetti, L.7
Sajan, M.8
Farese, R.V.9
White, M.F.10
-
64
-
-
77956244443
-
Hepatic FOXO1 ablation exacerbates lipid abnormalities during hyperglycemia
-
doi:10.1074/jbc.M109.062349
-
Haeusler R, Han S & Accili D 2010 Hepatic FOXO1 ablation exacerbates lipid abnormalities during hyperglycemia. Journal of Biological Chemistry 285 2686-2688. (doi:10.1074/jbc.M109.062349)
-
(2010)
Journal of Biological Chemistry
, vol.285
, pp. 2686-2688
-
-
Haeusler, R.1
Han, S.2
Accili, D.3
-
65
-
-
84860454425
-
Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c
-
doi:10.1016/j.cmet.2012.03.015
-
Hagiwara A, CornuM, Cybulski N, Polak P, Betz C, Trapani F, Terracciano L, Heim MH, Ruegg MA & Hall MN 2012 Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c. Cell Metabolism 15 725-738. (doi:10.1016/j.cmet.2012.03.015)
-
(2012)
Cell Metabolism
, vol.15
, pp. 725-738
-
-
Hagiwara, A.1
Cornu, M.2
Cybulski, N.3
Polak, P.4
Betz, C.5
Trapani, F.6
Terracciano, L.7
Heim, M.H.8
Ruegg, M.A.9
Hall, M.N.10
-
66
-
-
33748745399
-
Transcriptional genomics associates FOX transcription factors with human heart failure
-
doi:10.1161/CIRCULATIONAHA.106.632430
-
Hannenhalli S, PuttME, Gilmore JM,Wang J, Parmacek MS, Epstein JA, Morrisey EE,Margulies KB & Cappola TP 2006 Transcriptional genomics associates FOX transcription factors with human heart failure. Circulation 114 1269-1276. (doi:10.1161/CIRCULATIONAHA.106.632430)
-
(2006)
Circulation
, vol.114
, pp. 1269-1276
-
-
Hannenhalli, S.1
Putt, M.E.2
Gilmore, J.M.3
Wang, J.4
Parmacek, M.S.5
Epstein, J.A.6
Morrisey, E.E.7
Margulies, K.B.8
Cappola, T.P.9
-
67
-
-
34547895443
-
Phosphoinositide 3-kinases as a common platform for multi-hormone signaling
-
doi:10.1677/JOE-07-0097
-
Hirsch E, Costa C & Ciraolo E 2007 Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. Journal of Endocrinology 194 243-256. (doi:10.1677/JOE-07-0097)
-
(2007)
Journal of Endocrinology
, vol.194
, pp. 243-256
-
-
Hirsch, E.1
Costa, C.2
Ciraolo, E.3
-
68
-
-
72649089588
-
Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity
-
doi:10.1016/j.cmet.2009.11.008
-
Hoehn KL, Turner N, Swarbrick MM, Wilks D, Preston E, Phua Y, Joshi H, Furler SM, Larance M, Hegarty BD et al. 2010 Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity. Cell Metabolism 11 70-76. (doi:10.1016/j.cmet.2009.11.008)
-
(2010)
Cell Metabolism
, vol.11
, pp. 70-76
-
-
Hoehn, K.L.1
Turner, N.2
Swarbrick, M.M.3
Wilks, D.4
Preston, E.5
Phua, Y.6
Joshi, H.7
Furler, S.M.8
Larance, M.9
Hegarty, B.D.10
-
69
-
-
80053554640
-
Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation
-
doi:10.1016/j.cell.2011.08.034
-
Holzer RG, Park EJ, Li N, Tran H, Chen M, Choi C, Solinas G & KarinM2011 Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell 147 173-184. (doi:10.1016/j.cell.2011.08.034)
-
(2011)
Cell
, vol.147
, pp. 173-184
-
-
Holzer, R.G.1
Park, E.J.2
Li, N.3
Tran, H.4
Chen, M.5
Choi, C.6
Solinas, G.7
Karin, M.8
-
70
-
-
1542267804
-
Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification
-
doi:10.1073/pnas.0400093101
-
Hosaka T, Biggs WH III, Tieu D, Boyer AD, Varki NM, Cavenee WK & Arden KC 2004 Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. PNAS 101 2975-2980. (doi:10.1073/pnas.0400093101)
-
(2004)
PNAS
, vol.101
, pp. 2975-2980
-
-
Hosaka, T.1
Biggs I.I.I, W.H.2
Tieu, D.3
Boyer, A.D.4
Varki, N.M.5
Cavenee, W.K.6
Arden, K.C.7
-
71
-
-
56749164791
-
Nutrient sensing and inflammation in metabolic diseases
-
doi:10.1038/nri2449
-
Hotamisligil GS & Erbay E 2008 Nutrient sensing and inflammation in metabolic diseases. Nature Reviews. Immunology 8 923-934. (doi:10.1038/nri2449)
-
(2008)
Nature Reviews. Immunology
, vol.8
, pp. 923-934
-
-
Hotamisligil, G.S.1
Erbay, E.2
-
72
-
-
0027459878
-
Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance
-
doi:10.1126/science.7678183
-
Hotamisligil GS, Shargill NS & Spiegelman BM 1993 Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 259 87-91. (doi:10.1126/science.7678183)
-
(1993)
Science
, vol.259
, pp. 87-91
-
-
Hotamisligil, G.S.1
Shargill, N.S.2
Spiegelman, B.M.3
-
73
-
-
0030061922
-
IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α-and obesity-induced insulin resistance
-
doi:10.1126/science.271.5249.665
-
Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF & Spiegelman BM 1996 IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α-and obesity-induced insulin resistance. Science 271 665-668. (doi:10.1126/science.271.5249.665)
-
(1996)
Science
, vol.271
, pp. 665-668
-
-
Hotamisligil, G.S.1
Peraldi, P.2
Budavari, A.3
Ellis, R.4
White, M.F.5
Spiegelman, B.M.6
-
74
-
-
47749149232
-
O-GlcNAc regulates FoxO activation in response to glucose
-
doi:10.1074/jbc.M802240200
-
Housley MP, Rodgers JT, Udeshi ND, Kelly TJ, Shabanowitz J, Hunt DF, Puigserver P & Hart GW 2008 O-GlcNAc regulates FoxO activation in response to glucose. Journal of Biological Chemistry 283 16283-16292. (doi:10.1074/jbc.M802240200)
-
(2008)
Journal of Biological Chemistry
, vol.283
, pp. 16283-16292
-
-
Housley, M.P.1
Rodgers, J.T.2
Udeshi, N.D.3
Kelly, T.J.4
Shabanowitz, J.5
Hunt, D.F.6
Puigserver, P.7
Hart, G.W.8
-
75
-
-
13444252337
-
Skp2 inhibits FOXO1 in tumor suppression through ubiquitinmediated degradation
-
doi:10.1073/pnas.0406789102
-
Huang H, Regan KM, Wang F, Wang D, Smith DI, van Deursen JM & Tindall DJ 2005 Skp2 inhibits FOXO1 in tumor suppression through ubiquitinmediated degradation. PNAS 102 1649-1654. (doi:10.1073/pnas.0406789102)
-
(2005)
PNAS
, vol.102
, pp. 1649-1654
-
-
Huang, H.1
Regan, K.M.2
Wang, F.3
Wang, D.4
Smith, D.I.5
van Deursen, J.M.6
Tindall, D.J.7
-
76
-
-
84858285593
-
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human
-
doi:10.1038/nature10798
-
Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L, Kimura I, Leloire A, Liu N, Iida K et al. 2012 Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature 483 350-354. (doi:10.1038/nature10798)
-
(2012)
Nature
, vol.483
, pp. 350-354
-
-
Ichimura, A.1
Hirasawa, A.2
Poulain-Godefroy, O.3
Bonnefond, A.4
Hara, T.5
Yengo, L.6
Kimura, I.7
Leloire, A.8
Liu, N.9
Iida, K.10
-
77
-
-
2342483040
-
SREBPs suppress IRS-2-mediated insulin signalling in the liver
-
doi:10.1038/ncb1111
-
Ide T, Shimano H, Yahagi N, Matsuzaka T, Nakakuki M, Yamamoto T, Nakagawa Y, Takahashi A, Suzuki H, Sone H et al. 2004 SREBPs suppress IRS-2-mediated insulin signalling in the liver. Nature Cell Biology 6 351-357. (doi:10.1038/ncb1111)
-
(2004)
Nature Cell Biology
, vol.6
, pp. 351-357
-
-
Ide, T.1
Shimano, H.2
Yahagi, N.3
Matsuzaka, T.4
Nakakuki, M.5
Yamamoto, T.6
Nakagawa, Y.7
Takahashi, A.8
Suzuki, H.9
Sone, H.10
-
78
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
doi:10.1038/ncb839
-
Inoki K, Li Y, Zhu T, Wu J & Guan KL 2002 TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nature Cell Biology 4 648-657. (doi:10.1038/ncb839)
-
(2002)
Nature Cell Biology
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
79
-
-
79551597189
-
Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity
-
doi:10.1007/s00125-010-1944-0
-
Jager J, Corcelle V, Gremeaux T, Laurent K, Waget A, Pages G, Binetruy B, Le Marchand-Brustel Y, Burcelin R, Bost F et al. 2011 Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity. Diabetologia 54 180-189. (doi:10.1007/s00125-010-1944-0)
-
(2011)
Diabetologia
, vol.54
, pp. 180-189
-
-
Jager, J.1
Corcelle, V.2
Gremeaux, T.3
Laurent, K.4
Waget, A.5
Pages, G.6
Binetruy, B.7
Le Marchand-Brustel, Y.8
Burcelin, R.9
Bost, F.10
-
80
-
-
84879559745
-
Hepatic ERK activity plays a role in energy metabolism
-
doi:10.1016/j.mce.2013.05.021
-
Jiao P, Feng B, Li Y, He Q & Xu H 2013 Hepatic ERK activity plays a role in energy metabolism. Molecular and Cellular Endocrinology 375 157-166. (doi:10.1016/j.mce.2013.05.021)
-
(2013)
Molecular and Cellular Endocrinology
, vol.375
, pp. 157-166
-
-
Jiao, P.1
Feng, B.2
Li, Y.3
He, Q.4
Xu, H.5
-
81
-
-
34547397081
-
SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation
-
doi:10.1016/j.cmet.2007.07.003
-
Jing E, Gesta S & Kahn CR 2007 SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Cell Metabolism 6 105-114. (doi:10.1016/j.cmet.2007.07.003)
-
(2007)
Cell Metabolism
, vol.6
, pp. 105-114
-
-
Jing, E.1
Gesta, S.2
Kahn, C.R.3
-
82
-
-
84874045511
-
The origins and drivers of insulin resistance
-
doi:10.1016/j.cell.2013.01.041
-
Johnson AM & Olefsky JM 2013 The origins and drivers of insulin resistance. Cell 152 673-684. (doi:10.1016/j.cell.2013.01.041)
-
(2013)
Cell
, vol.152
, pp. 673-684
-
-
Johnson, A.M.1
Olefsky, J.M.2
-
83
-
-
0029879127
-
Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality
-
Joshi RL, Lamothe B, Cordonnier N, Mesbah K, Monthioux E, Jami J & Bucchini D 1996 Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality. EMBO Journal 15 1542-1547.
-
(1996)
EMBO Journal
, vol.15
, pp. 1542-1547
-
-
Joshi, R.L.1
Lamothe, B.2
Cordonnier, N.3
Mesbah, K.4
Monthioux, E.5
Jami, J.6
Bucchini, D.7
-
84
-
-
24144484876
-
The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes
-
doi:10.2337/diacare.28.9.2289
-
Kahn R, Buse J, Ferrannini E & SternM2005 The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 28 2289-2304. (doi:10.2337/diacare.28.9.2289)
-
(2005)
Diabetes Care
, vol.28
, pp. 2289-2304
-
-
Kahn, R.1
Buse, J.2
Ferrannini, E.3
Stern, M.4
-
85
-
-
33845881411
-
Mechanisms linking obesity to insulin resistance and type 2 diabetes
-
doi:10.1038/nature05482
-
Kahn SE, Hull RL & Utzschneider KM 2006 Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444 840-846. (doi:10.1038/nature05482)
-
(2006)
Nature
, vol.444
, pp. 840-846
-
-
Kahn, S.E.1
Hull, R.L.2
Utzschneider, K.M.3
-
86
-
-
0020507888
-
Characterization of the insulin receptor kinase purified from human placental membranes
-
Kasuga M, Fujita-Yamaguchi Y, Blithe DL, White MF & Kahn CR 1983 Characterization of the insulin receptor kinase purified from human placental membranes. Journal of Biological Chemistry 258 10973-10980.
-
(1983)
Journal of Biological Chemistry
, vol.258
, pp. 10973-10980
-
-
Kasuga, M.1
Fujita-Yamaguchi, Y.2
Blithe, D.L.3
White, M.F.4
Kahn, C.R.5
-
87
-
-
36248965746
-
Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice
-
doi:10.1111/j.1474-9726.2007.00346.x
-
Katic M, Kennedy AR, Leykin I, Norris A, McGettrick A, Gesta S, Russell SJ, Bluher M, Maratos-Flier E & Kahn CR 2007 Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice. Aging Cell 6 827-839. (doi:10.1111/j.1474-9726.2007.00346.x)
-
(2007)
Aging Cell
, vol.6
, pp. 827-839
-
-
Katic, M.1
Kennedy, A.R.2
Leykin, I.3
Norris, A.4
McGettrick, A.5
Gesta, S.6
Russell, S.J.7
Bluher, M.8
Maratos-Flier, E.9
Kahn, C.R.10
-
88
-
-
79959201412
-
Human nutrition, the gut microbiome and the immune system
-
doi:10.1038/nature10213
-
Kau AL, Ahern PP, Griffin NW, Goodman AL & Gordon JI 2011 Human nutrition, the gut microbiome and the immune system. Nature 474 327-336. (doi:10.1038/nature10213)
-
(2011)
Nature
, vol.474
, pp. 327-336
-
-
Kau, A.L.1
Ahern, P.P.2
Griffin, N.W.3
Goodman, A.L.4
Gordon, J.I.5
-
89
-
-
2642683510
-
Differential regulation of insulin receptor substrates-1 and-2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse
-
doi:10.1172/JCI119872
-
Kerouz NJ, Horsch D, Pons S & Kahn CR 1997 Differential regulation of insulin receptor substrates-1 and-2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse. Journal of Clinical Investigation 100 3164-3172. (doi:10.1172/JCI119872)
-
(1997)
Journal of Clinical Investigation
, vol.100
, pp. 3164-3172
-
-
Kerouz, N.J.1
Horsch, D.2
Pons, S.3
Kahn, C.R.4
-
90
-
-
27944467785
-
'New'-clear functions of PDK1: beyond a master kinase in the cytosol?
-
doi:10.1002/jcb.20651
-
Kikani CK, Dong LQ & Liu F 2005 "New"-clear functions of PDK1: beyond a master kinase in the cytosol? Journal of Cellular Biochemistry 96 1157-1162. (doi:10.1002/jcb.20651)
-
(2005)
Journal of Cellular Biochemistry
, vol.96
, pp. 1157-1162
-
-
Kikani, C.K.1
Dong, L.Q.2
Liu, F.3
-
91
-
-
80755148700
-
FoxO6 integrates insulin signaling with gluconeogenesis in the liver
-
doi:10.2337/db11-0548
-
Kim DH, Perdomo G, Zhang T, Slusher S, Lee S, Phillips BE, Fan Y, Giannoukakis N, Gramignoli R, Strom S et al. 2011 FoxO6 integrates insulin signaling with gluconeogenesis in the liver. Diabetes 60 2763-2774. (doi:10.2337/db11-0548)
-
(2011)
Diabetes
, vol.60
, pp. 2763-2774
-
-
Kim, D.H.1
Perdomo, G.2
Zhang, T.3
Slusher, S.4
Lee, S.5
Phillips, B.E.6
Fan, Y.7
Giannoukakis, N.8
Gramignoli, R.9
Strom, S.10
-
93
-
-
84884594284
-
The role of FOXO1 in β-cell failure and type 2 diabetes mellitus
-
doi:10.1038/nrendo. 2013.157
-
Kitamura T 2013 The role of FOXO1 in β-cell failure and type 2 diabetes mellitus. Nature Reviews. Endocrinology 9 615-623. (doi:10.1038/nrendo. 2013.157)
-
(2013)
Nature Reviews. Endocrinology
, vol.9
, pp. 615-623
-
-
Kitamura, T.1
-
94
-
-
33646590947
-
Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake
-
doi:10.1038/nm1392
-
Kitamura T, Feng Y, Kitamura YI, Chua SC Jr, Xu AW, Barsh GS, Rossetti L & Accili D 2006 Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nature Medicine 12 534-540. (doi:10.1038/nm1392)
-
(2006)
Nature Medicine
, vol.12
, pp. 534-540
-
-
Kitamura, T.1
Feng, Y.2
Kitamura, Y.I.3
Chua Jr., S.C.4
Xu, A.W.5
Barsh, G.S.6
Rossetti, L.7
Accili, D.8
-
95
-
-
35448981935
-
Autophagy: from phenomenology to molecular understanding in less than a decade
-
doi:10.1038/nrm2245
-
Klionsky DJ 2007 Autophagy: from phenomenology to molecular understanding in less than a decade. Nature Reviews. Molecular Cell Biology 8 931-937. (doi:10.1038/nrm2245)
-
(2007)
Nature Reviews. Molecular Cell Biology
, vol.8
, pp. 931-937
-
-
Klionsky, D.J.1
-
96
-
-
45549087567
-
Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding
-
doi:10.1016/j.cmet.2008.05.007
-
Kubota N, Kubota T, Itoh S, Kumagai H, Kozono H, Takamoto I, Mineyama T, Ogata H, Tokuyama K, Ohsugi M et al. 2008 Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding. Cell Metabolism 8 49-64. (doi:10.1016/j.cmet.2008.05.007)
-
(2008)
Cell Metabolism
, vol.8
, pp. 49-64
-
-
Kubota, N.1
Kubota, T.2
Itoh, S.3
Kumagai, H.4
Kozono, H.5
Takamoto, I.6
Mineyama, T.7
Ogata, H.8
Tokuyama, K.9
Ohsugi, M.10
-
97
-
-
79952142784
-
Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle
-
doi:10.1016/j.cmet.2011.01.018
-
Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T et al. 2011 Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle. Cell Metabolism 13 294-307. (doi:10.1016/j.cmet.2011.01.018)
-
(2011)
Cell Metabolism
, vol.13
, pp. 294-307
-
-
Kubota, T.1
Kubota, N.2
Kumagai, H.3
Yamaguchi, S.4
Kozono, H.5
Takahashi, T.6
Inoue, M.7
Itoh, S.8
Takamoto, I.9
Sasako, T.10
-
98
-
-
0033524937
-
Tissue-specific knockout of the insulin receptor in pancreatic b cells creates an insulin secretory defect similar to that in type 2 diabetes
-
doi:10.1016/S0092-8674(00)80546-2
-
Kulkarni RN, Bruning JC, Winnay JN, Postic C, Magnuson MA & Kahn CR 1999 Tissue-specific knockout of the insulin receptor in pancreatic b cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96 329-339. (doi:10.1016/S0092-8674(00)80546-2)
-
(1999)
Cell
, vol.96
, pp. 329-339
-
-
Kulkarni, R.N.1
Bruning, J.C.2
Winnay, J.N.3
Postic, C.4
Magnuson, M.A.5
Kahn, C.R.6
-
99
-
-
37549000623
-
Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances basal glycogen synthase activity
-
doi:10.1128/MCB.01405-07
-
Kumar A, Harris TE, Keller SR, Choi KM, Magnuson MA & Lawrence JC Jr 2008 Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances basal glycogen synthase activity. Molecular and Cellular Biology 28 61-70. (doi:10.1128/MCB.01405-07)
-
(2008)
Molecular and Cellular Biology
, vol.28
, pp. 61-70
-
-
Kumar, A.1
Harris, T.E.2
Keller, S.R.3
Choi, K.M.4
Magnuson, M.A.5
Lawrence Jr., J.C.6
-
100
-
-
77953200528
-
Fat cell-specific ablation of Rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism
-
doi:10.2337/db09-1061
-
Kumar A, Lawrence JC Jr, Jung DY, Ko HJ, Keller SR, Kim JK, Magnuson MA & Harris TE 2010 Fat cell-specific ablation of Rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes 59 1397-1406. (doi:10.2337/db09-1061)
-
(2010)
Diabetes
, vol.59
, pp. 1397-1406
-
-
Kumar, A.1
Lawrence Jr., J.C.2
Jung, D.Y.3
Ko, H.J.4
Keller, S.R.5
Kim, J.K.6
Magnuson, M.A.7
Harris, T.E.8
-
101
-
-
80053627289
-
Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
-
doi:10.1073/pnas.1113359108
-
Kumashiro N, Erion DM, Zhang D, Kahn M, Beddow SA, Chu X, Still CD, Gerhard GS, Han X, Dziura J et al. 2011 Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease. PNAS 108 16381-16385. (doi:10.1073/pnas.1113359108)
-
(2011)
PNAS
, vol.108
, pp. 16381-16385
-
-
Kumashiro, N.1
Erion, D.M.2
Zhang, D.3
Kahn, M.4
Beddow, S.A.5
Chu, X.6
Still, C.D.7
Gerhard, G.S.8
Han, X.9
Dziura, J.10
-
102
-
-
42649105106
-
O-GlcNAc modification of FoxO1 increases its transcriptional activity: a role in the glucotoxicity phenomenon?
-
doi:10.1016/j.biochi.2008.03.005
-
Kuo M, Zilberfarb V, Gangneux N, Christeff N & Issad T 2008 O-GlcNAc modification of FoxO1 increases its transcriptional activity: a role in the glucotoxicity phenomenon? Biochimie 90 679-685. (doi:10.1016/j.biochi.2008.03.005)
-
(2008)
Biochimie
, vol.90
, pp. 679-685
-
-
Kuo, M.1
Zilberfarb, V.2
Gangneux, N.3
Christeff, N.4
Issad, T.5
-
103
-
-
0037474274
-
c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade
-
doi:10.1074/jbc.M208359200
-
Lee YH, Giraud J, Davis RJ & White MF 2003 c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. Journal of Biological Chemistry 278 2896-2902. (doi:10.1074/jbc.M208359200)
-
(2003)
Journal of Biological Chemistry
, vol.278
, pp. 2896-2902
-
-
Lee, Y.H.1
Giraud, J.2
Davis, R.J.3
White, M.F.4
-
104
-
-
79551600048
-
Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice
-
doi:10.2337/db10-0426
-
Lee Y, Wang MY, Du XQ, Charron MJ & Unger RH 2011 Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice. Diabetes 60 391-397. (doi:10.2337/db10-0426)
-
(2011)
Diabetes
, vol.60
, pp. 391-397
-
-
Lee, Y.1
Wang, M.Y.2
Du, X.Q.3
Charron, M.J.4
Unger, R.H.5
-
105
-
-
33646934067
-
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span
-
doi:10.1016/j.cell.2006.03.046
-
Lehtinen MK, Yuan Z, Boag PR, Yang Y, Villen J, Becker EB, DiBacco S, de la Iglesia N, Gygi S, Blackwell TK et al. 2006 A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 125 987-1001. (doi:10.1016/j.cell.2006.03.046)
-
(2006)
Cell
, vol.125
, pp. 987-1001
-
-
Lehtinen, M.K.1
Yuan, Z.2
Boag, P.R.3
Yang, Y.4
Villen, J.5
Becker, E.B.6
DiBacco, S.7
de la Iglesia, N.8
Gygi, S.9
Blackwell, T.K.10
-
106
-
-
18844461232
-
p38 MAP kinase mediates inflammatory cytokine induction in cardiomyocytes and extracellular matrix remodeling in heart
-
doi:10.1161/01.CIR.0000165117.71483.0C
-
Li M, Georgakopoulos D, Lu G, Hester L, Kass DA, Hasday J & Wang Y 2005 p38 MAP kinase mediates inflammatory cytokine induction in cardiomyocytes and extracellular matrix remodeling in heart. Circulation 111 2494-2502. (doi:10.1161/01.CIR.0000165117.71483.0C)
-
(2005)
Circulation
, vol.111
, pp. 2494-2502
-
-
Li, M.1
Georgakopoulos, D.2
Lu, G.3
Hester, L.4
Kass, D.A.5
Hasday, J.6
Wang, Y.7
-
107
-
-
77649264504
-
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
-
doi:10.1073/pnas.0914798107
-
Li S, Brown MS & Goldstein JL 2010 Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. PNAS 107 3441-3446. (doi:10.1073/pnas.0914798107)
-
(2010)
PNAS
, vol.107
, pp. 3441-3446
-
-
Li, S.1
Brown, M.S.2
Goldstein, J.L.3
-
108
-
-
0842288445
-
Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice
-
doi:10.2337/diabetes.53.2.410
-
Liang Y, Osborne MC, Monia BP, Bhanot S, Gaarde WA, Reed C, She P, Jetton TL & Demarest KT 2004 Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice. Diabetes 53 410-417. (doi:10.2337/diabetes.53.2.410)
-
(2004)
Diabetes
, vol.53
, pp. 410-417
-
-
Liang, Y.1
Osborne, M.C.2
Monia, B.P.3
Bhanot, S.4
Gaarde, W.A.5
Reed, C.6
She, P.7
Jetton, T.L.8
Demarest, K.T.9
-
109
-
-
79953218702
-
Reconstitution of insulin action in muscle, white adipose tissue, and brain of insulin receptor knock-out mice fails to rescue diabetes
-
doi:10.1074/jbc.M110.210807
-
Lin HV & Accili D 2011 Reconstitution of insulin action in muscle, white adipose tissue, and brain of insulin receptor knock-out mice fails to rescue diabetes. Journal of Biological Chemistry 286 9797-9804. (doi:10.1074/jbc.M110.210807)
-
(2011)
Journal of Biological Chemistry
, vol.286
, pp. 9797-9804
-
-
Lin, H.V.1
Accili, D.2
-
110
-
-
9644260563
-
Dysregulation of insulin receptor substrate 2 in b cells and brain causes obesity and diabetes
-
doi:10.1172/JCI22217
-
Lin X, Taguchi A, Park S, Kushner JA, Li F, Li Y & White MF 2004 Dysregulation of insulin receptor substrate 2 in b cells and brain causes obesity and diabetes. Journal of Clinical Investigation 114 908-916. (doi:10.1172/JCI22217)
-
(2004)
Journal of Clinical Investigation
, vol.114
, pp. 908-916
-
-
Lin, X.1
Taguchi, A.2
Park, S.3
Kushner, J.A.4
Li, F.5
Li, Y.6
White, M.F.7
-
111
-
-
70350439438
-
Insulin is a stronger inducer of insulin resistance than hyperglycemia in mice with type 1 diabetes mellitus (T1DM)
-
doi:10.1074/jbc.M109.016675
-
Liu HY, Cao SY, Hong T, Han J, Liu Z & Cao W 2009a Insulin is a stronger inducer of insulin resistance than hyperglycemia in mice with type 1 diabetes mellitus (T1DM). Journal of Biological Chemistry 284 27090-27100. (doi:10.1074/jbc.M109.016675)
-
(2009)
Journal of Biological Chemistry
, vol.284
, pp. 27090-27100
-
-
Liu, H.Y.1
Cao, S.Y.2
Hong, T.3
Han, J.4
Liu, Z.5
Cao, W.6
-
112
-
-
71449091240
-
Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin
-
doi:10.1074/jbc.M109.033936
-
Liu HY, Han J, Cao SY, Hong T, Zhuo D, Shi J, Liu Z & Cao W 2009b Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin. Journal of Biological Chemistry 284 31484-31492. (doi:10.1074/jbc.M109.033936)
-
(2009)
Journal of Biological Chemistry
, vol.284
, pp. 31484-31492
-
-
Liu, H.Y.1
Han, J.2
Cao, S.Y.3
Hong, T.4
Zhuo, D.5
Shi, J.6
Liu, Z.7
Cao, W.8
-
113
-
-
78751485448
-
Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways
-
doi:10.1128/MCB.00983-10
-
Long YC, Cheng Z, Copps KD & White MF 2011 Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways. Molecular and Cellular Biology 31 430-441. (doi:10.1128/MCB.00983-10)
-
(2011)
Molecular and Cellular Biology
, vol.31
, pp. 430-441
-
-
Long, Y.C.1
Cheng, Z.2
Copps, K.D.3
White, M.F.4
-
114
-
-
84857934301
-
Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1
-
doi:10.1038/nm.2686
-
Lu M, Wan M, Leavens KF, Chu Q, Monks BR, Fernandez S, Ahima RS, Ueki K, Kahn CR & Birnbaum MJ 2012 Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1. Nature Medicine 18 388-395. (doi:10.1038/nm.2686)
-
(2012)
Nature Medicine
, vol.18
, pp. 388-395
-
-
Lu, M.1
Wan, M.2
Leavens, K.F.3
Chu, Q.4
Monks, B.R.5
Fernandez, S.6
Ahima, R.S.7
Ueki, K.8
Kahn, C.R.9
Birnbaum, M.J.10
-
115
-
-
84869792655
-
NF-κB essential modifier is required for hepatocyte proliferation and the oval cell reaction after partial hepatectomy in mice
-
doi:10.1053/j.gastro.2012.08.030.e11
-
Malato Y, Ehedego H, Al-Masaoudi M, Cubero FJ, Bornemann J, Gassler N, Liedtke C, Beraza N & Trautwein C 2012 NF-κB essential modifier is required for hepatocyte proliferation and the oval cell reaction after partial hepatectomy in mice. Gastroenterology 143 1597-1608.e11. (doi:10.1053/j.gastro.2012.08.030)
-
(2012)
Gastroenterology
, vol.143
, pp. 1597-1608
-
-
Malato, Y.1
Ehedego, H.2
Al-Masaoudi, M.3
Cubero, F.J.4
Bornemann, J.5
Gassler, N.6
Liedtke, C.7
Beraza, N.8
Trautwein, C.9
-
116
-
-
33744948514
-
Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis
-
doi:10.1074/jbc.M510660200
-
Malhi H, Bronk SF,Werneburg NW & Gores GJ 2006 Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. Journal of Biological Chemistry 281 12093-12101. (doi:10.1074/jbc.M510660200)
-
(2006)
Journal of Biological Chemistry
, vol.281
, pp. 12093-12101
-
-
Malhi, H.1
Bronk, S.F.2
Werneburg, N.W.3
Gores, G.J.4
-
117
-
-
34548349302
-
Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver
-
doi:10.1016/j.cmet.2007.08.006
-
Matsumoto M, Pocai A, Rossetti L, Depinho RA & Accili D 2007 Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell Metabolism 6 208-216. (doi:10.1016/j.cmet.2007.08.006)
-
(2007)
Cell Metabolism
, vol.6
, pp. 208-216
-
-
Matsumoto, M.1
Pocai, A.2
Rossetti, L.3
Depinho, R.A.4
Accili, D.5
-
118
-
-
0141706357
-
Insulininduced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation
-
doi:10.1073/pnas.1934283100
-
Matsuzaki H, Daitoku H, Hatta M, Tanaka K & Fukamizu A 2003 Insulininduced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation. PNAS 100 11285-11290. (doi:10.1073/pnas.1934283100)
-
(2003)
PNAS
, vol.100
, pp. 11285-11290
-
-
Matsuzaki, H.1
Daitoku, H.2
Hatta, M.3
Tanaka, K.4
Fukamizu, A.5
-
119
-
-
23844485211
-
Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation
-
doi:10.1073/pnas.0502738102
-
Matsuzaki H, Daitoku H, Hatta M, Aoyama H, Yoshimochi K & Fukamizu A 2005 Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation. PNAS 102 11278-11283. (doi:10.1073/pnas.0502738102)
-
(2005)
PNAS
, vol.102
, pp. 11278-11283
-
-
Matsuzaki, H.1
Daitoku, H.2
Hatta, M.3
Aoyama, H.4
Yoshimochi, K.5
Fukamizu, A.6
-
120
-
-
84866944897
-
RTEF-1 attenuates blood glucose levels by regulating insulin-like growth factor binding protein-1 in the endothelium
-
doi:10.1161/CIRCRESAHA.112.268110
-
Messmer-Blust AF, Philbrick MJ, Guo S, Wu J, He P & Li J 2012 RTEF-1 attenuates blood glucose levels by regulating insulin-like growth factor binding protein-1 in the endothelium. Circulation Research 111 991-1001. (doi:10.1161/CIRCRESAHA.112.268110)
-
(2012)
Circulation Research
, vol.111
, pp. 991-1001
-
-
Messmer-Blust, A.F.1
Philbrick, M.J.2
Guo, S.3
Wu, J.4
He, P.5
Li, J.6
-
121
-
-
0033636523
-
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
-
doi:10.1016/S1097-2765(05)00015-8
-
Michael MD, Kulkarni RN, Postic C, Previs SF, Shulman GI, Magnuson MA & Kahn CR 2000 Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Molecular Cell 6 87-97. (doi:10.1016/S1097-2765(05)00015-8)
-
(2000)
Molecular Cell
, vol.6
, pp. 87-97
-
-
Michael, M.D.1
Kulkarni, R.N.2
Postic, C.3
Previs, S.F.4
Shulman, G.I.5
Magnuson, M.A.6
Kahn, C.R.7
-
122
-
-
79955815135
-
Class IIa histone deacetylases are hormone-activated regulators of FOXO andmammalian glucose homeostasis
-
doi:10.1016/j.cell.2011.03.043
-
Mihaylova MM, Vasquez DS, Ravnskjaer K, Denechaud PD, Yu RT, Alvarez JG, Downes M, Evans RM,Montminy M& Shaw RJ 2011 Class IIa histone deacetylases are hormone-activated regulators of FOXO andmammalian glucose homeostasis. Cell 145 607-621. (doi:10.1016/j.cell.2011.03.043)
-
(2011)
Cell
, vol.145
, pp. 607-621
-
-
Mihaylova, M.M.1
Vasquez, D.S.2
Ravnskjaer, K.3
Denechaud, P.D.4
Yu, R.T.5
Alvarez, J.G.6
Downes, M.7
Evans, R.M.8
Montminy, M.9
Shaw, R.J.10
-
123
-
-
0036853886
-
Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver
-
doi:10.1172/JCI15880
-
Miyake K, Ogawa W, Matsumoto M, Nakamura T, Sakaue H & Kasuga M 2002 Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver. Journal of Clinical Investigation 110 1483-1491. (doi:10.1172/JCI15880)
-
(2002)
Journal of Clinical Investigation
, vol.110
, pp. 1483-1491
-
-
Miyake, K.1
Ogawa, W.2
Matsumoto, M.3
Nakamura, T.4
Sakaue, H.5
Kasuga, M.6
-
124
-
-
13544253065
-
Metabolic syndrome: a clinical and molecular perspective
-
doi:10.1146/annurev.med.56.082103.104751
-
Moller DE & Kaufman KD 2005 Metabolic syndrome: a clinical and molecular perspective. Annual Review of Medicine 56 45-62. (doi:10.1146/annurev.med.56.082103.104751)
-
(2005)
Annual Review of Medicine
, vol.56
, pp. 45-62
-
-
Moller, D.E.1
Kaufman, K.D.2
-
125
-
-
13444252573
-
Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulinregulated gene expression and liver failure
-
doi:10.1042/BJ20041782
-
Mora A, Lipina C, Tronche F, Sutherland C & Alessi DR 2005 Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulinregulated gene expression and liver failure. Biochemical Journal 385 639-648. (doi:10.1042/BJ20041782)
-
(2005)
Biochemical Journal
, vol.385
, pp. 639-648
-
-
Mora, A.1
Lipina, C.2
Tronche, F.3
Sutherland, C.4
Alessi, D.R.5
-
126
-
-
1342264308
-
Mammalian SIRT1 represses forkhead transcription factors
-
doi:10.1016/S0092-8674(04)00126-6
-
Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, Gu W, Bultsma Y, McBurney M & Guarente L 2004 Mammalian SIRT1 represses forkhead transcription factors. Cell 116 551-563. (doi:10.1016/S0092-8674(04)00126-6)
-
(2004)
Cell
, vol.116
, pp. 551-563
-
-
Motta, M.C.1
Divecha, N.2
Lemieux, M.3
Kamel, C.4
Chen, D.5
Gu, W.6
Bultsma, Y.7
McBurney, M.8
Guarente, L.9
-
127
-
-
50449085395
-
An integrated view of insulin resistance and endothelial dysfunction
-
ix-x, doi:10.1016/j.ecl.2008.06.001
-
Muniyappa R, Iantorno M & Quon MJ 2008 An integrated view of insulin resistance and endothelial dysfunction. Endocrinology and Metabolism Clinics of North America 37 685-711 (ix-x). (doi:10.1016/j.ecl.2008.06.001)
-
(2008)
Endocrinology and Metabolism Clinics of North America
, vol.37
, pp. 685-711
-
-
Muniyappa, R.1
Iantorno, M.2
Quon, M.J.3
-
128
-
-
84860430699
-
Lipid-induced mitochondrial stress and insulin action in muscle
-
doi:10.1016/j.cmet.2012.04.010
-
Muoio DM & Neufer PD 2012 Lipid-induced mitochondrial stress and insulin action in muscle. Cell Metabolism 15 595-605. (doi:10.1016/j.cmet.2012.04.010)
-
(2012)
Cell Metabolism
, vol.15
, pp. 595-605
-
-
Muoio, D.M.1
Neufer, P.D.2
-
129
-
-
84869050741
-
Central nervous system control of metabolism
-
doi:10.1038/nature11705
-
Myers MG Jr & Olson DP 2012 Central nervous system control of metabolism. Nature 491 357-363. (doi:10.1038/nature11705)
-
(2012)
Nature
, vol.491
, pp. 357-363
-
-
Myers Jr., M.G.1
Olson, D.P.2
-
130
-
-
0033522897
-
Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway
-
doi:10.1074/jbc.274.23.15982
-
Nakae J, Park BC & Accili D 1999 Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway. Journal of Biological Chemistry 274 15982-15985. (doi:10.1074/jbc.274.23.15982)
-
(1999)
Journal of Biological Chemistry
, vol.274
, pp. 15982-15985
-
-
Nakae, J.1
Park, B.C.2
Accili, D.3
-
131
-
-
0036787607
-
Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
-
doi:10.1038/ng890
-
Nakae J, Biggs WH III, Kitamura T, Cavenee WK, Wright CV, Arden KC & Accili D 2002 Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nature Genetics 32 245-253. (doi:10.1038/ng890)
-
(2002)
Nature Genetics
, vol.32
, pp. 245-253
-
-
Nakae, J.1
Biggs I.I.I, W.H.2
Kitamura, T.3
Cavenee, W.K.4
Wright, C.V.5
Arden, K.C.6
Accili, D.7
-
133
-
-
29144453326
-
Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
-
doi:10.1056/NEJMoa052187
-
Nathan DM, Cleary PA, Backlund JY, Genuth SM, Lachin JM, Orchard TJ, Raskin P & Zinman B 2005 Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. New England Journal of Medicine 353 2643-2653. (doi:10.1056/NEJMoa052187)
-
(2005)
New England Journal of Medicine
, vol.353
, pp. 2643-2653
-
-
Nathan, D.M.1
Cleary, P.A.2
Backlund, J.Y.3
Genuth, S.M.4
Lachin, J.M.5
Orchard, T.J.6
Raskin, P.7
Zinman, B.8
-
134
-
-
0037126526
-
Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report
-
National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III).
-
National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) 2002 Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 106 3143-3421.
-
(2002)
Circulation
, vol.106
, pp. 3143-3421
-
-
-
135
-
-
84861978076
-
Host-gut microbiota metabolic interactions
-
doi:10.1126/science.1223813
-
Nicholson JK, Holmes E, Kinross J, Burcelin R, Gibson G, Jia W & Pettersson S 2012 Host-gut microbiota metabolic interactions. Science 336 1262-1267. (doi:10.1126/science.1223813)
-
(2012)
Science
, vol.336
, pp. 1262-1267
-
-
Nicholson, J.K.1
Holmes, E.2
Kinross, J.3
Burcelin, R.4
Gibson, G.5
Jia, W.6
Pettersson, S.7
-
136
-
-
0036913187
-
Hypothalamic insulin signaling is required for inhibition of glucose production
-
doi:10.1038/nm1202-798
-
Obici S, Zhang BB, Karkanias G & Rossetti L 2002 Hypothalamic insulin signaling is required for inhibition of glucose production. Nature Medicine 8 1376-1382. (doi:10.1038/nm1202-798)
-
(2002)
Nature Medicine
, vol.8
, pp. 1376-1382
-
-
Obici, S.1
Zhang, B.B.2
Karkanias, G.3
Rossetti, L.4
-
137
-
-
0030659557
-
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C
-
doi:10.1038/40194
-
Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA & Ruvkun G 1997 The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389 994-999. (doi:10.1038/40194)
-
(1997)
elegans. Nature
, vol.389
, pp. 994-999
-
-
Ogg, S.1
Paradis, S.2
Gottlieb, S.3
Patterson, G.I.4
Lee, L.5
Tissenbaum, H.A.6
Ruvkun, G.7
-
138
-
-
77956165390
-
GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects
-
doi:10.1016/j.cell.2010.07.041
-
Oh DY, Talukdar S, Bae EJ, Imamura T, Morinaga H, Fan W, Li P, Lu WJ, Watkins SM & Olefsky JM 2010 GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell 142 687-698. (doi:10.1016/j.cell.2010.07.041)
-
(2010)
Cell
, vol.142
, pp. 687-698
-
-
Oh, D.Y.1
Talukdar, S.2
Bae, E.J.3
Imamura, T.4
Morinaga, H.5
Fan, W.6
Li, P.7
Lu, W.J.8
Watkins, S.M.9
Olefsky, J.M.10
-
139
-
-
4043106461
-
Transgenic rescue of insulin receptor-deficient mice
-
doi:10.1172/JCI21645
-
Okamoto H, Nakae J, Kitamura T, Park BC, Dragatsis I & Accili D 2004 Transgenic rescue of insulin receptor-deficient mice. Journal of Clinical Investigation 114 214-223. (doi:10.1172/JCI21645)
-
(2004)
Journal of Clinical Investigation
, vol.114
, pp. 214-223
-
-
Okamoto, H.1
Nakae, J.2
Kitamura, T.3
Park, B.C.4
Dragatsis, I.5
Accili, D.6
-
140
-
-
84867067610
-
Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase
-
doi:10.1073/pnas.1213343109
-
Owen JL, Zhang Y, Bae SH, Farooqi MS, Liang G, Hammer RE, Goldstein JL & Brown MS 2012 Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase. PNAS 109 16184-16189. (doi:10.1073/pnas.1213343109)
-
(2012)
PNAS
, vol.109
, pp. 16184-16189
-
-
Owen, J.L.1
Zhang, Y.2
Bae, S.H.3
Farooqi, M.S.4
Liang, G.5
Hammer, R.E.6
Goldstein, J.L.7
Brown, M.S.8
-
141
-
-
84864657351
-
Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
-
doi:10.1038/nm.2851
-
Pal D, Dasgupta S, Kundu R, Maitra S, Das G, Mukhopadhyay S, Ray S, Majumdar SS & Bhattacharya S 2012 Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nature Medicine 18 1279-1285. (doi:10.1038/nm.2851)
-
(2012)
Nature Medicine
, vol.18
, pp. 1279-1285
-
-
Pal, D.1
Dasgupta, S.2
Kundu, R.3
Maitra, S.4
Das, G.5
Mukhopadhyay, S.6
Ray, S.7
Majumdar, S.S.8
Bhattacharya, S.9
-
142
-
-
69049099087
-
Genetic disruption of AMPK signaling abolishes both contraction-and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle
-
doi:10.1152/ajpendo.00115.2009
-
Pehmoller C, Treebak JT, Birk JB, Chen S, Mackintosh C, Hardie DG, Richter EA & Wojtaszewski JF 2009 Genetic disruption of AMPK signaling abolishes both contraction-and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism 297 E665-E675. (doi:10.1152/ajpendo.00115.2009)
-
(2009)
American Journal of Physiology. Endocrinology and Metabolism
, vol.297
-
-
Pehmoller, C.1
Treebak, J.T.2
Birk, J.B.3
Chen, S.4
Mackintosh, C.5
Hardie, D.G.6
Richter, E.A.7
Wojtaszewski, J.F.8
-
143
-
-
24344499875
-
The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription
-
doi:10.1210/me.2004-0292
-
Perrot V & Rechler MM 2005 The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription. Molecular Endocrinology 19 2283-2298. (doi:10.1210/me.2004-0292)
-
(2005)
Molecular Endocrinology
, vol.19
, pp. 2283-2298
-
-
Perrot, V.1
Rechler, M.M.2
-
144
-
-
79961165137
-
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway
-
doi:10.1016/j.cell.2011.06.034
-
Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN et al. 2011 mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell 146 408-420. (doi:10.1016/j.cell.2011.06.034)
-
(2011)
Cell
, vol.146
, pp. 408-420
-
-
Peterson, T.R.1
Sengupta, S.S.2
Harris, T.E.3
Carmack, A.E.4
Kang, S.A.5
Balderas, E.6
Guertin, D.A.7
Madden, K.L.8
Carpenter, A.E.9
Finck, B.N.10
-
145
-
-
70350369729
-
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake
-
doi:10.1038/nm.2026
-
Plum L, Lin HV, Dutia R, Tanaka J, Aizawa KS, Matsumoto M, Kim AJ, Cawley NX, Paik JH, Loh YP et al. 2009 The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake. Nature Medicine 15 1195-1201. (doi:10.1038/nm.2026)
-
(2009)
Nature Medicine
, vol.15
, pp. 1195-1201
-
-
Plum, L.1
Lin, H.V.2
Dutia, R.3
Tanaka, J.4
Aizawa, K.S.5
Matsumoto, M.6
Kim, A.J.7
Cawley, N.X.8
Paik, J.H.9
Loh, Y.P.10
-
146
-
-
84891685859
-
Myocardial loss of IRS1 and IRS2 causes heart failure and Is controlled by p38α MAPK during insulin resistance
-
doi:10.2337/db13-0095
-
Qi Y, Xu Z, Zhu Q, Thomas C, Kumar R, Feng H, Dostal DE, White MF, Baker KM & Guo S 2013 Myocardial loss of IRS1 and IRS2 causes heart failure and Is controlled by p38α MAPK during insulin resistance. Diabetes 62 3887-3900. (doi:10.2337/db13-0095)
-
(2013)
Diabetes
, vol.62
, pp. 3887-3900
-
-
Qi, Y.1
Xu, Z.2
Zhu, Q.3
Thomas, C.4
Kumar, R.5
Feng, H.6
Dostal, D.E.7
White, M.F.8
Baker, K.M.9
Guo, S.10
-
147
-
-
74949089660
-
FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice
-
doi:10.1172/JCI39901
-
Rached MT, Kode A, Silva BC, Jung DY, Gray S, Ong H, Paik JH, DePinho RA, Kim JK, Karsenty G et al. 2010 FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice. Journal of Clinical Investigation 120 357-368. (doi:10.1172/JCI39901)
-
(2010)
Journal of Clinical Investigation
, vol.120
, pp. 357-368
-
-
Rached, M.T.1
Kode, A.2
Silva, B.C.3
Jung, D.Y.4
Gray, S.5
Ong, H.6
Paik, J.H.7
DePinho, R.A.8
Kim, J.K.9
Karsenty, G.10
-
148
-
-
50549202600
-
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
-
doi:10.1016/S0140-6736(63)91500-9
-
Randle PJ, Garland PB, Hales CN & Newsholme EA 1963 The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1 785-789. (doi:10.1016/S0140-6736(63)91500-9)
-
(1963)
Lancet
, vol.1
, pp. 785-789
-
-
Randle, P.J.1
Garland, P.B.2
Hales, C.N.3
Newsholme, E.A.4
-
149
-
-
84865472821
-
Tissue-specific insulin signaling, metabolic syndrome, and cardiovascular disease
-
doi:10.1161/ATVBAHA.111.241919
-
Rask-Madsen C & Kahn CR 2012 Tissue-specific insulin signaling, metabolic syndrome, and cardiovascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology 32 2052-2059. (doi:10.1161/ATVBAHA.111.241919)
-
(2012)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.32
, pp. 2052-2059
-
-
Rask-Madsen, C.1
Kahn, C.R.2
-
150
-
-
77955292064
-
Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice
-
doi:10.1016/j.cmet.2010.03.013
-
Rask-Madsen C, Li Q, Freund B, Feather D, Abramov R, Wu IH, Chen K, Yamamoto-Hiraoka J, Goldenbogen J, Sotiropoulos KB et al. 2010 Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metabolism 11 379-389. (doi:10.1016/j.cmet.2010.03.013)
-
(2010)
Cell Metabolism
, vol.11
, pp. 379-389
-
-
Rask-Madsen, C.1
Li, Q.2
Freund, B.3
Feather, D.4
Abramov, R.5
Wu, I.H.6
Chen, K.7
Yamamoto-Hiraoka, J.8
Goldenbogen, J.9
Sotiropoulos, K.B.10
-
152
-
-
22844449583
-
The insulin resistance syndrome: definition and dietary approaches to treatment
-
doi:10.1146/annurev.nutr.24.012003.132155
-
Reaven GM 2005a The insulin resistance syndrome: definition and dietary approaches to treatment. Annual Review of Nutrition 25 391-406. (doi:10.1146/annurev.nutr.24.012003.132155)
-
(2005)
Annual Review of Nutrition
, vol.25
, pp. 391-406
-
-
Reaven, G.M.1
-
153
-
-
22144496594
-
Why syndrome X? From Harold Himsworth to the insulin resistance syndrome Cell
-
doi:10.1016/j.cmet.2004.12.001
-
Reaven GM 2005b Why syndrome X? From Harold Himsworth to the insulin resistance syndrome Cell Metabolism 1 9-14. (doi:10.1016/j.cmet.2004.12.001)
-
(2005)
Metabolism
, vol.1
, pp. 9-14
-
-
Reaven, G.M.1
-
154
-
-
84861976352
-
FoxO1 target Gpr17 activates AgRP neurons to regulate food intake
-
doi:10.1016/j.cell.2012.04.032
-
Ren H, Orozco IJ, Su Y, Suyama S, Gutierrez-Juarez R, Horvath TL, Wardlaw SL, Plum L, Arancio O & Accili D 2012 FoxO1 target Gpr17 activates AgRP neurons to regulate food intake. Cell 149 1314-1326. (doi:10.1016/j.cell.2012.04.032)
-
(2012)
Cell
, vol.149
, pp. 1314-1326
-
-
Ren, H.1
Orozco, I.J.2
Su, Y.3
Suyama, S.4
Gutierrez-Juarez, R.5
Horvath, T.L.6
Wardlaw, S.L.7
Plum, L.8
Arancio, O.9
Accili, D.10
-
155
-
-
0033546439
-
Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
-
doi:10.1074/jbc.274.24.17179
-
Rena G, Guo S, Cichy SC, Unterman TG & Cohen P 1999 Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. Journal of Biological Chemistry 274 17179-17183. (doi:10.1074/jbc.274.24.17179)
-
(1999)
Journal of Biological Chemistry
, vol.274
, pp. 17179-17183
-
-
Rena, G.1
Guo, S.2
Cichy, S.C.3
Unterman, T.G.4
Cohen, P.5
-
156
-
-
0035868368
-
Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targeting
-
doi:10.1042/0264-6021:3540605
-
Rena G, Prescott AR, Guo S, Cohen P & Unterman TG 2001 Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targeting. Biochemical Journal 354 605-612. (doi:10.1042/0264-6021:3540605)
-
(2001)
Biochemical Journal
, vol.354
, pp. 605-612
-
-
Rena, G.1
Prescott, A.R.2
Guo, S.3
Cohen, P.4
Unterman, T.G.5
-
157
-
-
0036566003
-
Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion
-
doi:10. 1093/emboj/21.9.2263
-
Rena G, Woods YL, Prescott AR, Peggie M, Unterman TG, Williams MR & Cohen P 2002 Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion. EMBO Journal 21 2263-2271. (doi:10. 1093/emboj/21.9.2263)
-
(2002)
EMBO Journal
, vol.21
, pp. 2263-2271
-
-
Rena, G.1
Woods, Y.L.2
Prescott, A.R.3
Peggie, M.4
Unterman, T.G.5
Williams, M.R.6
Cohen, P.7
-
158
-
-
12344323484
-
Type 2 diabetes-a matter of β-cell life and death?
-
doi:10.1126/science.1104345
-
Rhodes CJ 2005 Type 2 diabetes-a matter of β-cell life and death? Science 307 380-384. (doi:10.1126/science.1104345)
-
(2005)
Science
, vol.307
, pp. 380-384
-
-
Rhodes, C.J.1
-
159
-
-
84883687796
-
Direct autocrine action of insulin on β-cells: does it make physiological sense?
-
doi:10.2337/db13-0246
-
Rhodes CJ, White MF, Leahy JL & Kahn SE 2013 Direct autocrine action of insulin on β-cells: does it make physiological sense? Diabetes 62 2157-2163. (doi:10.2337/db13-0246)
-
(2013)
Diabetes
, vol.62
, pp. 2157-2163
-
-
Rhodes, C.J.1
White, M.F.2
Leahy, J.L.3
Kahn, S.E.4
-
160
-
-
79751531393
-
Heart disease and stroke statistics-2011 update: a report from the American Heart Association
-
doi:10.1161/CIR. 0013e3182009701
-
Roger VL, Go AS, Lloyd-Jones DM, Adams RJ, Berry JD, Brown TM, Carnethon MR, Dai S, de Simone G, Ford ES et al. 2011 Heart disease and stroke statistics-2011 update: a report from the American Heart Association. Circulation 123 e18-e209. (doi:10.1161/CIR. 0b013e3182009701)
-
(2011)
Circulation
, vol.123
-
-
Roger, V.L.1
Go, A.S.2
Lloyd-Jones, D.M.3
Adams, R.J.4
Berry, J.D.5
Brown, T.M.6
Carnethon, M.R.7
Dai, S.8
de Simone, G.9
Ford, E.S.10
-
161
-
-
84864244872
-
Metabolic syndrome, insulin resistance, and roles of inflammation-mechanisms and therapeutic targets
-
doi:10.1161/ATVBAHA.111.241869
-
Romeo GR, Lee J & Shoelson SE 2012 Metabolic syndrome, insulin resistance, and roles of inflammation-mechanisms and therapeutic targets. Arteriosclerosis, Thrombosis, and Vascular Biology 32 1771-1776. (doi:10.1161/ATVBAHA.111.241869)
-
(2012)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.32
, pp. 1771-1776
-
-
Romeo, G.R.1
Lee, J.2
Shoelson, S.E.3
-
162
-
-
0030890580
-
Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus
-
doi:10.1073/pnas.94.8.4171
-
Rondinone CM, Wang LM, Lonnroth P, Wesslau C, Pierce JH & Smith U 1997 Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus. PNAS 94 4171-4175. (doi:10.1073/pnas.94.8.4171)
-
(1997)
PNAS
, vol.94
, pp. 4171-4175
-
-
Rondinone, C.M.1
Wang, L.M.2
Lonnroth, P.3
Wesslau, C.4
Pierce, J.H.5
Smith, U.6
-
163
-
-
77649136496
-
Metabolic surgery to treat type 2 diabetes: clinical outcomes and mechanisms of action
-
doi:10.1146/annurev.med. 051308.105148
-
Rubino F, Schauer PR, Kaplan LM & Cummings DE 2010 Metabolic surgery to treat type 2 diabetes: clinical outcomes and mechanisms of action. Annual Review of Medicine 61 393-411. (doi:10.1146/annurev.med. 051308.105148)
-
(2010)
Annual Review of Medicine
, vol.61
, pp. 393-411
-
-
Rubino, F.1
Schauer, P.R.2
Kaplan, L.M.3
Cummings, D.E.4
-
164
-
-
0035955629
-
Regulation of insulin/insulinlike growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2
-
doi:10.1074/jbc.M105332200
-
Rui L, Fisher TL, Thomas J & White MF 2001 Regulation of insulin/insulinlike growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2. Journal of Biological Chemistry 276 40362-40367. (doi:10.1074/jbc.M105332200)
-
(2001)
Journal of Biological Chemistry
, vol.276
, pp. 40362-40367
-
-
Rui, L.1
Fisher, T.L.2
Thomas, J.3
White, M.F.4
-
165
-
-
77949266016
-
Human IL6 enhances leptin action in mice
-
doi:10.1007/s00125-009-1580-8
-
Sadagurski M, Norquay L, Farhang J, D'Aquino K, Copps K & White MF 2010 Human IL6 enhances leptin action in mice. Diabetologia 53 525-535. (doi:10.1007/s00125-009-1580-8)
-
(2010)
Diabetologia
, vol.53
, pp. 525-535
-
-
Sadagurski, M.1
Norquay, L.2
Farhang, J.3
D'Aquino, K.4
Copps, K.5
White, M.F.6
-
166
-
-
84860451500
-
IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action
-
doi:10.1016/j.cmet.2012.04.011
-
Sadagurski M, Leshan RL, Patterson C, Rozzo A, Kuznetsova A, Skorupski J, Jones JC, Depinho RA, Myers MG Jr & White MF 2012 IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action. Cell Metabolism 15 703-712. (doi:10.1016/j.cmet.2012.04.011)
-
(2012)
Cell Metabolism
, vol.15
, pp. 703-712
-
-
Sadagurski, M.1
Leshan, R.L.2
Patterson, C.3
Rozzo, A.4
Kuznetsova, A.5
Skorupski, J.6
Jones, J.C.7
Depinho, R.A.8
Myers Jr., M.G.9
White, M.F.10
-
167
-
-
84857861919
-
Mechanisms for insulin resistance: common threads and missing links
-
doi:10.1016/j.cell.2012.02.017
-
Samuel VT & Shulman GI 2012 Mechanisms for insulin resistance: common threads and missing links. Cell 148 852-871. (doi:10.1016/j.cell.2012.02.017)
-
(2012)
Cell
, vol.148
, pp. 852-871
-
-
Samuel, V.T.1
Shulman, G.I.2
-
168
-
-
77953868236
-
Lipid-induced insulin resistance: unravelling the mechanism
-
doi:10.1016/S0140-6736(10)60408-4
-
Samuel VT, Petersen KF & Shulman GI 2010 Lipid-induced insulin resistance: unravelling the mechanism. Lancet 375 2267-2277. (doi:10.1016/S0140-6736(10)60408-4)
-
(2010)
Lancet
, vol.375
, pp. 2267-2277
-
-
Samuel, V.T.1
Petersen, K.F.2
Shulman, G.I.3
-
169
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
doi:10.1126/science.1106148
-
Sarbassov DD, Guertin DA, Ali SM & Sabatini DM 2005 Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307 1098-1101. (doi:10.1126/science.1106148)
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
170
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
doi:10.1016/j.molcel.2006.03.029
-
Sarbassov DD, Ali SM, Sengupta S, Sheen JH, Hsu PP, Bagley AF, Markhard AL & Sabatini DM 2006 Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Molecular Cell 22 159-168. (doi:10.1016/j.molcel.2006.03.029)
-
(2006)
Molecular Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
Sheen, J.H.4
Hsu, P.P.5
Bagley, A.F.6
Markhard, A.L.7
Sabatini, D.M.8
-
171
-
-
0034680839
-
Regulation of glucose-6-phosphatase gene expression by protein kinase Ba and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and-independent effects of insulin on promoter activity
-
doi:10.1074/jbc.M003616200
-
Schmoll D,Walker KS, Alessi DR, Grempler R, Burchell A, Guo S, Walther R & Unterman TG 2000 Regulation of glucose-6-phosphatase gene expression by protein kinase Ba and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and-independent effects of insulin on promoter activity. Journal of Biological Chemistry 275 36324-36333. (doi:10.1074/jbc.M003616200)
-
(2000)
Journal of Biological Chemistry
, vol.275
, pp. 36324-36333
-
-
Schmoll, D.1
Walker, K.S.2
Alessi, D.R.3
Grempler, R.4
Burchell, A.5
Guo, S.6
Walther, R.7
Unterman, T.G.8
-
172
-
-
70350500068
-
FoxO transcription factors promote autophagy in cardiomyocytes
-
doi:10.1074/jbc.M109.024406
-
Sengupta A, Molkentin JD & Yutzey KE 2009 FoxO transcription factors promote autophagy in cardiomyocytes. Journal of Biological Chemistry 284 28319-28331. (doi:10.1074/jbc.M109.024406)
-
(2009)
Journal of Biological Chemistry
, vol.284
, pp. 28319-28331
-
-
Sengupta, A.1
Molkentin, J.D.2
Yutzey, K.E.3
-
173
-
-
78649348967
-
Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
-
doi:10.1016/j.molcel.2010.09.026
-
Sengupta S, Peterson TR & Sabatini DM 2010 Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Molecular Cell 40 310-322. (doi:10.1016/j.molcel.2010.09.026)
-
(2010)
Molecular Cell
, vol.40
, pp. 310-322
-
-
Sengupta, S.1
Peterson, T.R.2
Sabatini, D.M.3
-
174
-
-
79953186624
-
FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress
-
doi:10.1074/jbc.M110.179242
-
Sengupta A, Molkentin JD, Paik JH, DePinho RA & Yutzey KE 2011 FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress. Journal of Biological Chemistry 286 7468-7478. (doi:10.1074/jbc.M110.179242)
-
(2011)
Journal of Biological Chemistry
, vol.286
, pp. 7468-7478
-
-
Sengupta, A.1
Molkentin, J.D.2
Paik, J.H.3
DePinho, R.A.4
Yutzey, K.E.5
-
175
-
-
84858228682
-
FoxO1 is required in endothelial but not myocardial cell lineages during cardiovascular development
-
doi:10.1002/dvdy.23759
-
Sengupta A, Chakraborty S, Paik J, Yutzey KE & Evans-Anderson HJ 2012 FoxO1 is required in endothelial but not myocardial cell lineages during cardiovascular development. Developmental Dynamics 241 803-813. (doi:10.1002/dvdy.23759)
-
(2012)
Developmental Dynamics
, vol.241
, pp. 803-813
-
-
Sengupta, A.1
Chakraborty, S.2
Paik, J.3
Yutzey, K.E.4
Evans-Anderson, H.J.5
-
176
-
-
84874235143
-
Conservation and divergence in the transcriptional programs of the human and mouse immune systems
-
doi:10.1073/pnas.1222738110
-
Shay T, Jojic V, Zuk O, Rothamel K, Puyraimond-Zemmour D, Feng T, Wakamatsu E, Benoist C, Koller D & Regev A 2013 Conservation and divergence in the transcriptional programs of the human and mouse immune systems. PNAS 110 2946-2951. (doi:10.1073/pnas.1222738110)
-
(2013)
PNAS
, vol.110
, pp. 2946-2951
-
-
Shay, T.1
Jojic, V.2
Zuk, O.3
Rothamel, K.4
Puyraimond-Zemmour, D.5
Feng, T.6
Wakamatsu, E.7
Benoist, C.8
Koller, D.9
Regev, A.10
-
178
-
-
77949273315
-
The metabolic syndrome: useful concept or clinical tool?
-
doi:10.1007/s00125-009-1620-4
-
Simmons RK, Alberti KG, Gale EA, Colagiuri S, Tuomilehto J, Qiao Q, Ramachandran A, Tajima N, Brajkovich Mirchov I, Ben-Nakhi A et al. 2010 The metabolic syndrome: useful concept or clinical tool? Report of a WHO Expert Consultation Diabetologia 53 600-605. (doi:10.1007/s00125-009-1620-4)
-
(2010)
Report of a WHO Expert Consultation Diabetologia
, vol.53
, pp. 600-605
-
-
Simmons, R.K.1
Alberti, K.G.2
Gale, E.A.3
Colagiuri, S.4
Tuomilehto, J.5
Qiao, Q.6
Ramachandran, A.7
Tajima, N.8
Brajkovich Mirchov, I.9
Ben-Nakhi, A.10
-
179
-
-
84855367738
-
Bariatric surgery and long-term cardiovascular events
-
doi:10.1001/jama.2011.1914
-
Sjostrom L, Peltonen M, Jacobson P, Sjostrom CD, Karason K, Wedel H, Ahlin S, Anveden A, Bengtsson C, Bergmark G et al. 2012 Bariatric surgery and long-term cardiovascular events. Journal of the American Medical Association 307 56-65. (doi:10.1001/jama.2011.1914)
-
(2012)
Journal of the American Medical Association
, vol.307
, pp. 56-65
-
-
Sjostrom, L.1
Peltonen, M.2
Jacobson, P.3
Sjostrom, C.D.4
Karason, K.5
Wedel, H.6
Ahlin, S.7
Anveden, A.8
Bengtsson, C.9
Bergmark, G.10
-
180
-
-
33750877987
-
Immunoneutralization of endogenous glucagon reduces hepatic glucose output and improves long-termglycemic control in diabetic ob/ob mice
-
doi:10.2337/db06-0222
-
Sorensen H, Brand CL, Neschen S, Holst JJ, Fosgerau K, Nishimura E & Shulman GI 2006 Immunoneutralization of endogenous glucagon reduces hepatic glucose output and improves long-termglycemic control in diabetic ob/ob mice. Diabetes 55 2843-2848. (doi:10.2337/db06-0222)
-
(2006)
Diabetes
, vol.55
, pp. 2843-2848
-
-
Sorensen, H.1
Brand, C.L.2
Neschen, S.3
Holst, J.J.4
Fosgerau, K.5
Nishimura, E.6
Shulman, G.I.7
-
181
-
-
61349133020
-
Phosphorylation of IRS proteins: Yin-Yang regulation of insulin signaling
-
doi:10.1016/S0083-6729(08)00613-4
-
Sun X & Liu F 2009 Phosphorylation of IRS proteins: Yin-Yang regulation of insulin signaling. Vitamins and Hormones 80 351-387. (doi:10.1016/S0083-6729(08)00613-4)
-
(2009)
Vitamins and Hormones
, vol.80
, pp. 351-387
-
-
Sun, X.1
Liu, F.2
-
182
-
-
0025813375
-
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
-
doi:10.1038/352073a0
-
Sun XJ, Rothenberg P, Kahn CR, Backer JM, Araki E, Wilden PA, Cahill DA, Goldstein BJ & White MF 1991 Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352 73-77. (doi:10.1038/352073a0)
-
(1991)
Nature
, vol.352
, pp. 73-77
-
-
Sun, X.J.1
Rothenberg, P.2
Kahn, C.R.3
Backer, J.M.4
Araki, E.5
Wilden, P.A.6
Cahill, D.A.7
Goldstein, B.J.8
White, M.F.9
-
183
-
-
79960091427
-
Myocardial AKT: the omnipresent nexus
-
doi:10.1152/physrev.00024.2010
-
Sussman MA, Volkers M, Fischer K, Bailey B, Cottage CT, Din S, Gude N, Avitabile D, Alvarez R, Sundararaman B et al. 2011 Myocardial AKT: the omnipresent nexus. Physiological Reviews 91 1023-1070. (doi:10.1152/physrev.00024.2010)
-
(2011)
Physiological Reviews
, vol.91
, pp. 1023-1070
-
-
Sussman, M.A.1
Volkers, M.2
Fischer, K.3
Bailey, B.4
Cottage, C.T.5
Din, S.6
Gude, N.7
Avitabile, D.8
Alvarez, R.9
Sundararaman, B.10
-
184
-
-
34547097247
-
Brain IRS2 signaling coordinates life span and nutrient homeostasis
-
doi:10.1126/science.1142179
-
Taguchi A, Wartschow LM & White MF 2007 Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 317 369-372. (doi:10.1126/science.1142179)
-
(2007)
Science
, vol.317
, pp. 369-372
-
-
Taguchi, A.1
Wartschow, L.M.2
White, M.F.3
-
185
-
-
79955608146
-
Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16
-
doi:10.1016/j.cmet.2011.03.017
-
Takahashi Y, Daitoku H, Hirota K, Tamiya H, Yokoyama A, Kako K, Nagashima Y, Nakamura A, Shimada T, Watanabe S et al. 2011 Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16. Cell Metabolism 13 505-516. (doi:10.1016/j.cmet.2011.03.017)
-
(2011)
Cell Metabolism
, vol.13
, pp. 505-516
-
-
Takahashi, Y.1
Daitoku, H.2
Hirota, K.3
Tamiya, H.4
Yokoyama, A.5
Kako, K.6
Nagashima, Y.7
Nakamura, A.8
Shimada, T.9
Watanabe, S.10
-
186
-
-
84866389264
-
Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure
-
doi:10.1016/j.cell.2012.07.029
-
Talchai C, Xuan S, Lin HV, Sussel L & Accili D 2012 Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure. Cell 150 1223-1234. (doi:10.1016/j.cell.2012.07.029)
-
(2012)
Cell
, vol.150
, pp. 1223-1234
-
-
Talchai, C.1
Xuan, S.2
Lin, H.V.3
Sussel, L.4
Accili, D.5
-
187
-
-
44349161745
-
Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulatedsignalingnexus inmouse skeletalmuscle
-
doi:10.1074/jbc.M708839200
-
TaylorEB,AnD,KramerHF,YuH, FujiiNL,RoecklKS, Bowles N, HirshmanMF, Xie J, Feener EP et al.2008Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulatedsignalingnexus inmouse skeletalmuscle. Journal of Biological Chemistry 283 9787-9796. (doi:10.1074/jbc.M708839200)
-
(2008)
Journal of Biological Chemistry
, vol.283
, pp. 9787-9796
-
-
Taylor, E.B.1
An, D.2
Kramer, H.F.3
Yu, H.4
Fujii, N.L.5
Roeckl, K.S.6
Bowles, N.7
Hirshman, M.F.8
Xie, J.9
Feener, E.P.10
-
188
-
-
84858066279
-
FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis
-
doi:10.1016/j.cmet.2012.01.018
-
Tsuchiya K, Tanaka J, Shuiqing Y, Welch CL, DePinho RA, Tabas I, Tall AR, Goldberg IJ & Accili D 2012 FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis. Cell Metabolism 15 372-381. (doi:10.1016/j.cmet.2012.01.018)
-
(2012)
Cell Metabolism
, vol.15
, pp. 372-381
-
-
Tsuchiya, K.1
Tanaka, J.2
Shuiqing, Y.3
Welch, C.L.4
DePinho, R.A.5
Tabas, I.6
Tall, A.R.7
Goldberg, I.J.8
Accili, D.9
-
189
-
-
33746101818
-
Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance
-
doi:10.1073/pnas.0603509103
-
Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M & Hotamisligil GS 2006 Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. PNAS 103 10741-10746. (doi:10.1073/pnas.0603509103)
-
(2006)
PNAS
, vol.103
, pp. 10741-10746
-
-
Tuncman, G.1
Hirosumi, J.2
Solinas, G.3
Chang, L.4
Karin, M.5
Hotamisligil, G.S.6
-
190
-
-
4544220704
-
Absence of S6K1 protects against age-and diet-induced obesity while enhancing insulin sensitivity
-
doi:10.1038/nature02866
-
Um SH, Frigerio F,WatanabeM, Picard F, Joaquin M, Sticker M, Fumagalli S, Allegrini PR, Kozma SC, Auwerx J et al. 2004 Absence of S6K1 protects against age-and diet-induced obesity while enhancing insulin sensitivity. Nature 431 200-205. (doi:10.1038/nature02866)
-
(2004)
Nature
, vol.431
, pp. 200-205
-
-
Um, S.H.1
Frigerio, F.2
Watanabe, M.3
Picard, F.4
Joaquin, M.5
Sticker, M.6
Fumagalli, S.7
Allegrini, P.R.8
Kozma, S.C.9
Auwerx, J.10
-
191
-
-
84880217156
-
The genetic influence on body fat distribution
-
doi:10.1016/j.ddmec.2013.05.003
-
Wagner R, Machicao F, Fritsche A, Stefan N, Haring H & Staiger H 2013 The genetic influence on body fat distribution. Drug Discovery Today. Disease Mechanisms 10 e5-e13. (doi:10.1016/j.ddmec.2013.05.003)
-
(2013)
Drug Discovery Today. Disease Mechanisms
, vol.10
-
-
Wagner, R.1
Machicao, F.2
Fritsche, A.3
Stefan, N.4
Haring, H.5
Staiger, H.6
-
192
-
-
77649253906
-
Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity
-
doi:10.1073/pnas.0914897107
-
Wang Y, Inoue H, Ravnskjaer K, Viste K,Miller N, Liu Y, Hedrick S, Vera L & Montminy M 2010 Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity. PNAS 107 3087-3092. (doi:10.1073/pnas.0914897107)
-
(2010)
PNAS
, vol.107
, pp. 3087-3092
-
-
Wang, Y.1
Inoue, H.2
Ravnskjaer, K.3
Viste, K.4
Miller, N.5
Liu, Y.6
Hedrick, S.7
Vera, L.8
Montminy, M.9
-
193
-
-
82955239851
-
Impairment of central leptinmediated PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity
-
doi:10.1016/j.cmet.2011.11.001
-
Warne JP, Alemi F, Reed AS, Varonin JM, Chan H, Piper ML, Mullin ME, Myers MG Jr, Corvera CU & Xu AW2011 Impairment of central leptinmediated PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity. Cell Metabolism 14 791-803. (doi:10.1016/j.cmet.2011.11.001)
-
(2011)
Cell Metabolism
, vol.14
, pp. 791-803
-
-
Warne, J.P.1
Alemi, F.2
Reed, A.S.3
Varonin, J.M.4
Chan, H.5
Piper, M.L.6
Mullin, M.E.7
Myers Jr., M.G.8
Corvera, C.U.9
Xu, A.W.10
-
194
-
-
0344305782
-
Insulin signaling in health and disease
-
doi:10.1126/science.1092952
-
White MF 2003 Insulin signaling in health and disease. Science 302 1710-1711. (doi:10.1126/science.1092952)
-
(2003)
Science
, vol.302
, pp. 1710-1711
-
-
White, M.F.1
-
196
-
-
0022347547
-
Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells
-
doi:10.1038/318183a0
-
White MF, Maron R & Kahn CR 1985 Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells. Nature 318 183-186. (doi:10.1038/318183a0)
-
(1985)
Nature
, vol.318
, pp. 183-186
-
-
White, M.F.1
Maron, R.2
Kahn, C.R.3
-
197
-
-
82955247909
-
IDF diabetes atlas: global estimatesof theprevalence ofdiabetes for 20112030
-
doi:10.1016/j.diabres.2011.10.029
-
Whiting DR, Guariguata L,Weil C & Shaw J 2011 IDF diabetes atlas: global estimatesof theprevalence ofdiabetes for 2011and2030. Diabetes Research and Clinical Practice 94 311-321. (doi:10.1016/j.diabres.2011.10.029)
-
(2011)
Diabetes Research and Clinical Practice
, vol.94
, pp. 311-321
-
-
Whiting, D.R.1
Guariguata, L.2
Weil, C.3
Shaw, J.4
-
198
-
-
0034176579
-
The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
-
doi:10.1016/S0960-9822(00)00441-3
-
Williams MR, Arthur JS, Balendran A, van der Kaay J, Poli V, Cohen P & Alessi DR 2000 The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells. Current Biology 10 439-448. (doi:10.1016/S0960-9822(00)00441-3)
-
(2000)
Current Biology
, vol.10
, pp. 439-448
-
-
Williams, M.R.1
Arthur, J.S.2
Balendran, A.3
van der Kaay, J.4
Poli, V.5
Cohen, P.6
Alessi, D.R.7
-
199
-
-
79957580930
-
Diabetes: ACCORD: 5-year outcomes of intensive glycemic control. Nature Reviews
-
doi:10.1038/nrendo.2011.67
-
Wilson C 2011 Diabetes: ACCORD: 5-year outcomes of intensive glycemic control.Nature Reviews. Endocrinology7314. (doi:10.1038/nrendo.2011.67)
-
(2011)
Endocrinology
, pp. 7314
-
-
Wilson, C.1
-
200
-
-
0032567937
-
Disruption of IRS-2 causes type 2 diabetes in mice
-
doi:10.1038/36116
-
Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI et al. 1998 Disruption of IRS-2 causes type 2 diabetes in mice. Nature 391 900-904. (doi:10.1038/36116)
-
(1998)
Nature
, vol.391
, pp. 900-904
-
-
Withers, D.J.1
Gutierrez, J.S.2
Towery, H.3
Burks, D.J.4
Ren, J.M.5
Previs, S.6
Zhang, Y.7
Bernal, D.8
Pons, S.9
Shulman, G.I.10
-
201
-
-
0032841435
-
Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling
-
doi:10.1038/12631
-
Withers DJ, Burks DJ, Towery HH, Altamuro SL, Flint CL & White MF 1999 Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling. Nature Genetics 23 32-40. (doi:10.1038/12631)
-
(1999)
Nature Genetics
, vol.23
, pp. 32-40
-
-
Withers, D.J.1
Burks, D.J.2
Towery, H.H.3
Altamuro, S.L.4
Flint, C.L.5
White, M.F.6
-
202
-
-
70350482557
-
Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner
-
doi:10.1074/jbc.M109.044065
-
Wong SW, Kwon MJ, Choi AM, Kim HP, Nakahira K & Hwang DH 2009 Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner. Journal of Biological Chemistry 284 27384-27392. (doi:10.1074/jbc.M109.044065)
-
(2009)
Journal of Biological Chemistry
, vol.284
, pp. 27384-27392
-
-
Wong, S.W.1
Kwon, M.J.2
Choi, A.M.3
Kim, H.P.4
Nakahira, K.5
Hwang, D.H.6
-
203
-
-
0018621289
-
Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons
-
doi:10.1038/282503a0
-
Woods SC, Lotter EC, McKay LD & Porte D Jr 1979 Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature 282 503-505. (doi:10.1038/282503a0)
-
(1979)
Nature
, vol.282
, pp. 503-505
-
-
Woods, S.C.1
Lotter, E.C.2
McKay, L.D.3
Porte Jr., D.4
-
204
-
-
0035340356
-
329 in vitro, a novel in vivo phosphorylation site
-
329 in vitro, a novel in vivo phosphorylation site. Biochemical Journal 355 597-607.
-
(2001)
Biochemical Journal
, vol.355
, pp. 597-607
-
-
Woods, Y.L.1
Rena, G.2
Morrice, N.3
Barthel, A.4
Becker, W.5
Guo, S.6
Unterman, T.G.7
Cohen, P.8
-
205
-
-
0037147215
-
Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic β-cells (INS-1)
-
doi:10.1074/jbc.M208756200
-
Wrede CE, Dickson LM, Lingohr MK, Briaud I & Rhodes CJ 2002 Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic β-cells (INS-1). Journal of Biological Chemistry 277 49676-49684. (doi:10.1074/jbc.M208756200)
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 49676-49684
-
-
Wrede, C.E.1
Dickson, L.M.2
Lingohr, M.K.3
Briaud, I.4
Rhodes, C.J.5
-
206
-
-
78049448761
-
MAPK phosphatase-3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice
-
doi:10.1172/JCI43250
-
Wu Z, Jiao P, Huang X, Feng B, Feng Y, Yang S, Hwang P, Du J, Nie Y, Xiao G et al. 2010 MAPK phosphatase-3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice. Journal of Clinical Investigation 120 3901-3911. (doi:10.1172/JCI43250)
-
(2010)
Journal of Clinical Investigation
, vol.120
, pp. 3901-3911
-
-
Wu, Z.1
Jiao, P.2
Huang, X.3
Feng, B.4
Feng, Y.5
Yang, S.6
Hwang, P.7
Du, J.8
Nie, Y.9
Xiao, G.10
-
207
-
-
70349675632
-
Molecular insights and therapeutic targets for diabetic endothelial dysfunction
-
doi:10.1161/CIRCULATIONAHA.108.835223
-
Xu J & ZouMH2009 Molecular insights and therapeutic targets for diabetic endothelial dysfunction. Circulation 120 1266-1286. (doi:10.1161/CIRCULATIONAHA.108.835223)
-
(2009)
Circulation
, vol.120
, pp. 1266-1286
-
-
Xu, J.1
Zou, M.H.2
-
208
-
-
0036792050
-
Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins
-
doi:10. 1073/pnas.162488899
-
Yabe D, Brown MS & Goldstein JL 2002 Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. PNAS 99 12753-12758. (doi:10. 1073/pnas.162488899)
-
(2002)
PNAS
, vol.99
, pp. 12753-12758
-
-
Yabe, D.1
Brown, M.S.2
Goldstein, J.L.3
-
209
-
-
0000380542
-
Immunoassay of endogenous plasma insulin in man
-
doi:10.1172/JCI104130
-
Yalow RS & Berson SA 1960 Immunoassay of endogenous plasma insulin in man. Journal of Clinical Investigation 39 1157-1175. (doi:10.1172/JCI104130)
-
(1960)
Journal of Clinical Investigation
, vol.39
, pp. 1157-1175
-
-
Yalow, R.S.1
Berson, S.A.2
-
210
-
-
53949087832
-
Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt
-
doi:10.1016/j.molcel.2008.09.013
-
Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y & Fukamizu A 2008 Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt. Molecular Cell 32 221-231. (doi:10.1016/j.molcel.2008.09.013)
-
(2008)
Molecular Cell
, vol.32
, pp. 221-231
-
-
Yamagata, K.1
Daitoku, H.2
Takahashi, Y.3
Namiki, K.4
Hisatake, K.5
Kako, K.6
Mukai, H.7
Kasuya, Y.8
Fukamizu, A.9
-
211
-
-
43149103684
-
PP2A regulates the pro-apoptotic activity of FOXO1
-
doi:10.1074/jbc.M708083200
-
Yan L, Lavin VA, Moser LR, Cui Q, Kanies C & Yang E 2008 PP2A regulates the pro-apoptotic activity of FOXO1. Journal of Biological Chemistry 283 7411-7420. (doi:10.1074/jbc.M708083200)
-
(2008)
Journal of Biological Chemistry
, vol.283
, pp. 7411-7420
-
-
Yan, L.1
Lavin, V.A.2
Moser, L.R.3
Cui, Q.4
Kanies, C.5
Yang, E.6
-
212
-
-
16344384026
-
Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation
-
doi:10.1038/sj.emboj.7600570
-
Yang Y, Hou H, Haller EM, Nicosia SV & BaiW2005 Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation. EMBO Journal 24 1021-1032. (doi:10.1038/sj.emboj.7600570)
-
(2005)
EMBO Journal
, vol.24
, pp. 1021-1032
-
-
Yang, Y.1
Hou, H.2
Haller, E.M.3
Nicosia, S.V.4
Bai, W.5
-
213
-
-
84874527555
-
Inflammation during obesity is not all bad: evidence from animal and human studies
-
doi:10.1152/ajpendo.00266.2012
-
Ye J & McGuinness OP 2013 Inflammation during obesity is not all bad: evidence from animal and human studies. American Journal of Physiology. Endocrinology and Metabolism 304 E466-E477. (doi:10.1152/ajpendo.00266.2012)
-
(2013)
American Journal of Physiology. Endocrinology and Metabolism
, vol.304
-
-
Ye, J.1
McGuinness, O.P.2
-
214
-
-
0035823515
-
Gene-and activation-specific mechanisms for insulin inhibition of basal and glucocorticoid-induced insulin-like growth factor binding protein-1 and phosphoenolpyruvate carboxykinase transcription. Roles of forkhead and insulin response sequences
-
doi:10.1074/jbc.M101215200
-
Yeagley D, Guo S, Unterman T & Quinn PG 2001 Gene-and activation-specific mechanisms for insulin inhibition of basal and glucocorticoid-induced insulin-like growth factor binding protein-1 and phosphoenolpyruvate carboxykinase transcription. Roles of forkhead and insulin response sequences. Journal of Biological Chemistry 276 33705-33710. (doi:10.1074/jbc.M101215200)
-
(2001)
Journal of Biological Chemistry
, vol.276
, pp. 33705-33710
-
-
Yeagley, D.1
Guo, S.2
Unterman, T.3
Quinn, P.G.4
-
215
-
-
79960960007
-
Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways
-
doi:10.1016/j.cmet.2011.06.002
-
Yecies JL, Zhang HH, Menon S, Liu S, Yecies D, Lipovsky AI, Gorgun C, Kwiatkowski DJ, Hotamisligil GS, Lee CH et al. 2011 Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metabolism 14 21-32. (doi:10.1016/j.cmet.2011.06.002)
-
(2011)
Cell Metabolism
, vol.14
, pp. 21-32
-
-
Yecies, J.L.1
Zhang, H.H.2
Menon, S.3
Liu, S.4
Yecies, D.5
Lipovsky, A.I.6
Gorgun, C.7
Kwiatkowski, D.J.8
Hotamisligil, G.S.9
Lee, C.H.10
-
216
-
-
65649149752
-
Regulation of neuronal cell death by MST1-FOXO1 signaling
-
doi:10.1074/jbc.M900461200
-
Yuan Z, Lehtinen MK, Merlo P, Villen J, Gygi S & Bonni A 2009 Regulation of neuronal cell death by MST1-FOXO1 signaling. Journal of Biological Chemistry 284 11285-11292. (doi:10.1074/jbc.M900461200)
-
(2009)
Journal of Biological Chemistry
, vol.284
, pp. 11285-11292
-
-
Yuan, Z.1
Lehtinen, M.K.2
Merlo, P.3
Villen, J.4
Gygi, S.5
Bonni, A.6
-
217
-
-
0035957414
-
Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulinrepressed genes
-
doi:10.1073/pnas.071054598
-
Zhang J, Ou J, Bashmakov Y, Horton JD, Brown MS & Goldstein JL 2001 Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulinrepressed genes. PNAS 98 3756-3761. (doi:10.1073/pnas.071054598)
-
(2001)
PNAS
, vol.98
, pp. 3756-3761
-
-
Zhang, J.1
Ou, J.2
Bashmakov, Y.3
Horton, J.D.4
Brown, M.S.5
Goldstein, J.L.6
-
218
-
-
0037160050
-
Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding
-
doi:10.1074/jbc.M208063200
-
Zhang X, Gan L, Pan H, Guo S, He X, Olson ST, Mesecar A, Adam S & Unterman TG 2002 Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding. Journal of Biological Chemistry 277 45276-45284. (doi:10.1074/jbc.M208063200)
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 45276-45284
-
-
Zhang, X.1
Gan, L.2
Pan, H.3
Guo, S.4
He, X.5
Olson, S.T.6
Mesecar, A.7
Adam, S.8
Unterman, T.G.9
-
219
-
-
33744515637
-
FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression
-
doi:10.1074/jbc.M600272200
-
Zhang W, Patil S, Chauhan B, Guo S, Powell DR, Le J, Klotsas A, Matika R, Xiao X, Franks R et al. 2006 FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression. Journal of Biological Chemistry 281 10105-10117. (doi:10.1074/jbc.M600272200)
-
(2006)
Journal of Biological Chemistry
, vol.281
, pp. 10105-10117
-
-
Zhang, W.1
Patil, S.2
Chauhan, B.3
Guo, S.4
Powell, D.R.5
Le, J.6
Klotsas, A.7
Matika, R.8
Xiao, X.9
Franks, R.10
-
220
-
-
58149094542
-
S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-α signaling through IKK2
-
doi:10.1074/jbc.M806480200
-
Zhang J, Gao Z, Yin J, Quon MJ & Ye J 2008 S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-α signaling through IKK2. Journal of Biological Chemistry 283 35375-35382. (doi:10.1074/jbc.M806480200)
-
(2008)
Journal of Biological Chemistry
, vol.283
, pp. 35375-35382
-
-
Zhang, J.1
Gao, Z.2
Yin, J.3
Quon, M.J.4
Ye, J.5
-
221
-
-
84862909028
-
Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice
-
doi:10.1210/en.2011-1527
-
Zhang K, Li L, Qi Y, Zhu X, Gan B, DePinho RA, Averitt T & Guo S 2012 Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice. Endocrinology 153 631-646. (doi:10.1210/en.2011-1527)
-
(2012)
Endocrinology
, vol.153
, pp. 631-646
-
-
Zhang, K.1
Li, L.2
Qi, Y.3
Zhu, X.4
Gan, B.5
DePinho, R.A.6
Averitt, T.7
Guo, S.8
-
222
-
-
79960281918
-
IDF's view of bariatric surgery in type 2 diabetes
-
doi:10.1016/S0140-6736(11)61027-1
-
Zimmet P, Alberti KG, Rubino F & Dixon JB 2011 IDF's view of bariatric surgery in type 2 diabetes. Lancet 378 108-110. (doi:10.1016/S0140-6736(11)61027-1)
-
(2011)
Lancet
, vol.378
, pp. 108-110
-
-
Zimmet, P.1
Alberti, K.G.2
Rubino, F.3
Dixon, J.B.4
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