Regulation of Insulin/Insulin-like Growth Factor-1 Signaling by Proteasome-mediated Degradation of Insulin Receptor Substrate-2

Journal of Biological Chemistry

Volumn 276, Issue 43, 2001, Pages 40362-40367

  Rui, Liangyou ^b   Fisher, Tracey L ^b   Thomas, Jeffrey ^b   White, Morris F ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; PROTEINS; SUBSTRATES; TISSUE;

FIBROBLASTS;

INSULIN;

2 MORPHOLINO 8 PHENYLCHROMONE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; INSULIN; INSULIN RECEPTOR SUBSTRATE 2; LACTACYSTIN; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEASOME; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; SOMATOMEDIN C; UBIQUITIN; WORTMANNIN; AKT1 PROTEIN, HUMAN; ATP DEPENDENT 26S PROTEASE; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 2 PROTEIN; INSULIN RECEPTOR SUBSTRATE-2 PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; ONCOPROTEIN; PEPTIDE HYDROLASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE;

ANIMAL CELL; ARTICLE; BODY GROWTH; CELL SURVIVAL; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FIBROBLAST; METABOLISM; MOUSE; NONHUMAN; OSMOTIC STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; REGULATORY MECHANISM; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; ADIPOCYTE; ANIMAL; CELL CULTURE; DOWN REGULATION; DRUG EFFECT; FEEDBACK SYSTEM; HUMAN; LIVER CELL CARCINOMA; LIVER TUMOR; NON INSULIN DEPENDENT DIABETES MELLITUS; OSMOTIC PRESSURE;

ANIMALIA; APOGON BRACHYGRAMMUS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADIPOCYTES; ANIMALS; CARCINOMA, HEPATOCELLULAR; DIABETES MELLITUS, TYPE 2; DOWN-REGULATION; FEEDBACK; FIBROBLASTS; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER NEOPLASMS, EXPERIMENTAL; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; OSMOTIC PRESSURE; PEPTIDE HYDROLASES; PHOSPHOPROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; UBIQUITIN;

EID: 0035955629     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M105332200     Document Type: Article

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