The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

Current Biology

Volumn 10, Issue 8, 2000, Pages 439-448

  Williams, Michayla R ^a   Arthur, J Simon C ^a   Balendran, Anudharan ^a   Van der Kaay, Jeroen ^a   Poli, Valeria ^a   Cohen, Philip ^a   Alessi, Dario R ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 0034176579     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(00)00441-3     Document Type: Article

References (52)

1. Vanhaesebroeck B., Alessi D.R. The PI3K-PDK1 connection: more than just a road to PKB. Biochem J. 346:2000;561-576.
2. Shepherd P.R., Withers D.J., Siddle K. Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochem J. 333:1998;471-490.
3. Coffer P.J., Jin J., Woodgett J.R. Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J. 335:1998;1-13.
4. Pullen N., Thomas G. The modular phosphorylation and activation of p70s6k. FEBS Lett. 410:1997;78-82.
5. Proud C.G. p70 S6 kinase: an enigma with variations. Trends Biochem Sci. 21:1996;181-185.
6. Frodin M., Gammeltoft S. Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction. Mol Cell Endocrinol. 151:1999;65-77.
7. Mellor H., Parker P.J. The extended protein kinase C superfamily. Biochem J. 332:1998;281-292.
8. Smith C.M., Radzio-Andzelm E., Madhusudan Akamine P., Taylor S.S. The catalytic subunit of cAMP-dependent protein kinase: prototype for an extended network of communication. Prog Biophys Mol Biol. 71:1999;313-341.
9. Alessi D.R., Andjelkovic M., Caudwell B., Cron P., Morrice N., Cohen P.et al. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 15:1996;6541-6551.
10. Parekh D.B., Ziegler W., Parker P.J. Multiple pathways control protein kinase C phosphorylation. EMBO J. 19:2000;496-503.
11. Pearson R.B., Dennis P.B., Han J.W., Williamson N.A., Kozma S.C., Wettenhall R.E.et al. The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain. EMBO J. 14:1995;5279-5287.
12. Dalby K.N., Morrice N., Caudwell F.B., Avruch J., Cohen P. Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK. J Biol Chem. 273:1998;1496-1505.
13. Park J., Leong M.L., Buse P., Maiyar A.C., Firestone G.L., Hemmings B.A. Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. EMBO J. 18:1999;3024-3033.
14. Kobayashi T., Cohen P. Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2. Biochem J. 339:1999;319-328.
15. Belham C., Wu S., Avruch J. PDK1 - a kinase at the hub of things. Curr Biol. 9:1999;R93-R96.
16. Peterson R.T., Schreiber S.L. Keeping it all in the family. Curr Biol. 9:1999;R521-R524.
17. Alessi D.R., James S.R., Downes C.P., Holmes A.B., Gaffney P.R., Reese C.B.et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα Curr Biol. 7:1997;261-269.
18. Alessi D.R., Deak M., Casamayor A., Caudwell F.B., Morrice N., Norman D.G.et al. 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. Curr Biol. 7:1997;776-789.
19. Stokoe D., Stephens L.R., Copeland T., Gaffney P.R., Reese C.B., Painter G.F.et al. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science. 277:1997;567-570.
20. Stephens L., Anderson K., Stokoe D., Erdjument-Bromage H., Painter G.F., Holmes A.B.et al. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science. 279:1998;710-714.
21. Alessi D.R., Kozlowski M.T., Weng Q.P., Morrice N., Avruch J. 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro. Curr Biol. 8:1998;69-81.
22. Pullen N., Dennis P.B., Andjelkovic M., Dufner A., Kozma S.C., Hemmings B.A.et al. Phosphorylation and activation of p70s6k by PDK1. Science. 279:1998;707-710.
23. Richards S.A., Fu J., Romanelli A., Shimamura A., Blenis J. Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK. Curr Biol. 12:1999;810-820.
24. Jensen C.J., Buch M.B., Krag T.O., Hemmings B.A., Gammeltoft S., Frodin M. 90 kDa ribosomal S6 kinase Is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1. J Biol Chem. 274:1999;27168-27176.
25. Dutil E.M., Toker A., Newton A.C. Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1). Curr Biol. 8:1998;1366-1375.
26. Le Good J.A., Ziegler W.H., Parekh D.B., Alessi D.R., Cohen P., Parker P.J. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science. 281:1998;2042-2045.
27. Chou M.M., Hou W., Johnson J., Graham L.K., Lee M.H., Chen C.S.et al. Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. Curr Biol. 8:1998;1069-1077.
28. Dong L.Q., Zhang R.B., Langlais P., He H., Clark M., Zhu L.et al. Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta. J Biol Chem. 274:1999;8117-8122.
29. Dong L.Q., Landa L.R., Wick M.J., Zhu L., Mukai H., Ono Y.et al. Phosphorylation of PKN by PDK1 mediates insulin signals to the actin cytoskeleton. Proc Natl Acad Sci USA. 2000;405in press.
30. Flynn P., Mellor H., Parker P.J. Rho-GTPase control of PRK activation by PDK1. J Biol Chem. 275:2000;. in press.
31. Cheng X., Ma Y., Moore M., Hemmings B.A., Taylor S.S. Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase. Proc Natl Acad Sci USA. 95:1998;9849-9854.
32. Deak M., Clifton A.D., Lucocq L.M., Alessi D.R. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 17:1998;4426-4441.
33. Stein S.C., Woods A., Jones N.A., Davison M.D., Carling D. The regulation of AMP-activated protein kinase by phosphorylation. Biochem J. 345:2000;437-443.
34. Balendran A., Casamayor A., Deak M., Paterson A., Gaffney P., Currie R.et al. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2. Curr Biol. 9:1999;393-404.
35. Balendran A., Currie R.A., Armstrong C.G., Avruch J., Alessi D.R. Evidence that PDK1 mediates the phosphorylation of p70 S6 kinase in vivo at Thr412 as well as Thr252. J Biol Chem. 274:1999;37400-37406.
36. Alessi D.R., Cohen P. Mechanism of activation and function of protein kinase B. Curr Opin Genet Dev. 8:1998;55-62.
37. Jefferies H.B., Fumagalli S., Dennis P.B., Reinhard C., Pearson R.B., Thomas G. Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k. EMBO J. 16:1997;3693-3704.
38. Stambolic V., Woodgett J.R. Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation. Biochem J. 303:1994;701-704.
39. Shaw M., Cohen P. Role of protein kinase B and the MAP kinase cascade in mediating the EGF-dependent inhibition of glycogen synthase kinase 3 in Swiss 3T3 cells. FEBS Lett. 461:1999;120-124.
40. Hardie D.G., Carling D. The AMP-activated protein kinase - fuel gauge of the mammalian cell? Eur J Biochem. 246:1997;259-273.
41. Corton J.M., Gillespie J.G., Hardie D.G. Role of the AMP-activated protein kinase in the cellular stress response. Curr Biol. 4:1994;315-324.
42. Inagaki M., Schmelzle T., Yamaguchi K., Irie K., Hall M.N., Matsumoto K. PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast. Mol Cell Biol. 19:1999;8344-8352.
43. Casamayor A., Torrance P.D., Kobayashi T., Thorner J., Alessi D.R. Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol. 9:1999;186-197.
44. Niederberger C., Schweingruber M.E. A Schizosaccharomyces pombe gene, ksg1, that shows structural homology to the human phosphoinositide-dependent protein kinase PDK1, is essential for growth, mating and sporulation. Mol Gen Genet. 261:1999;177-183.
45. Toker A., Newton A.C. Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site. J Biol Cell. 275:2000;8271-8274.
46. Li J., DeFea K., Roth R.A. Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway. J Biol Chem. 274:1999;9351-9356.
47. Biondi R.M., Cheung P.C., Casamayor A., Deak M., Currie R.A., Alessi D.R. Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA. EMBO J. 19:2000;979-988.
48. Currie R.A., Walker K.S., Gray A., Deak M., Casamayor A., Downes C.P.et al. Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1. Biochem J. 337:1999;575-583.
49. Alessi D.R., Cuenda A., Cohen P., Dudley D.T., Saltiel A.R. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem. 270:1995;27489-27494.
50. Douville E., Downward J. EGF-induced SOS phosphorylation in PC12 cells involves P90 RSK-2. Oncogene. 15:1997;373-383.
51. Zimmermann S., Moelling K. Phosphorylation and regulation of raf by akt (Protein kinase B). Science. 286:1999;1741-1744.
52. Kohn A.D., Takeuchi F., Roth R.A. Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation. J Biol Chem. 271:1996;21920-21926.