-
1
-
-
0003408870
-
-
National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland
-
National Diabetes Data Group. Diabetes in America (National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, 1995).
-
(1995)
Diabetes in America
-
-
-
2
-
-
0035936763
-
New perspectives into the molecular pathogenesis and treatment of type 2 diabetes
-
Saltiel, A.R. New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell 104, 517-529 (2001).
-
(2001)
Cell
, vol.104
, pp. 517-529
-
-
Saltiel, A.R.1
-
3
-
-
0028229508
-
Insulin resistance or insulin deficiency. Which is the primary cause of NIDDM?
-
Taylor, S.I., Accili, D. & Imai, Y. Insulin resistance or insulin deficiency. Which is the primary cause of NIDDM? Diabetes 43, 735-740 (1994).
-
(1994)
Diabetes
, vol.43
, pp. 735-740
-
-
Taylor, S.I.1
Accili, D.2
Imai, Y.3
-
4
-
-
0033779714
-
Free fatty acids and pathogenesis of type 2 diabetes mellitus
-
Bergman, R.N. & Ader, M. Free fatty acids and pathogenesis of type 2 diabetes mellitus, Trends Endocrinol. Metab. 11, 351-356 (2000).
-
(2000)
Trends Endocrinol. Metab.
, vol.11
, pp. 351-356
-
-
Bergman, R.N.1
Ader, M.2
-
5
-
-
0033694663
-
Molecular mechanisms of insulin resistance and the role of the adipocyte
-
Hotamisligil, G.S. Molecular mechanisms of insulin resistance and the role of the adipocyte. Int. J. Obes, Retat. Metab. Disord. 24 (Suppl. 4), S23-S27 (2000).
-
(2000)
Int. J. Obes, Retat. Metab. Disord.
, vol.24
, Issue.SUPPL. 4
-
-
Hotamisligil, G.S.1
-
6
-
-
0033636523
-
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
-
Michael, M.D. et al. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol. Cell 6, 87-97 (2000).
-
(2000)
Mol. Cell
, vol.6
, pp. 87-97
-
-
Michael, M.D.1
-
7
-
-
0032504257
-
Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes
-
Rother, K.I. et al. Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes. J. Biol, Chem. 273, 17491-17497 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 17491-17497
-
-
Rother, K.I.1
-
8
-
-
0032567937
-
Disruption of IRS-2 causes type 2 diabetes in mice
-
Withers, D.J. et al. Disruption of IRS-2 causes type 2 diabetes in mice. Nature 391, 900-904 (1998).
-
(1998)
Nature
, vol.391
, pp. 900-904
-
-
Withers, D.J.1
-
9
-
-
0033524937
-
Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes
-
Kulkarni, R.N. et al. Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96, 329-339 (1999).
-
(1999)
Cell
, vol.96
, pp. 329-339
-
-
Kulkarni, R.N.1
-
10
-
-
0033379267
-
Altered function of insulin receptor substrate-1 -deficient mouse islets and cultured β-cell lines
-
Kulkarni, R.N. et al. Altered function of insulin receptor substrate-1 -deficient mouse islets and cultured β-cell lines. J. Clin. Invest. 104, R69-75 (1999).
-
(1999)
J. Clin. Invest.
, vol.104
-
-
Kulkarni, R.N.1
-
11
-
-
0033755408
-
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory β-cell hyperplasia
-
Kubota, N. et al. Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory β-cell hyperplasia. Diabetes 49, 1880-1889 (2000).
-
(2000)
Diabetes
, vol.49
, pp. 1880-1889
-
-
Kubota, N.1
-
12
-
-
0035072595
-
Tissue-specific insulin resistance in type 2 diabetes: Lessons from gene-targeted mice
-
Nakae, J., Kido, Y. & Accili, D. Tissue-specific insulin resistance in type 2 diabetes: lessons from gene-targeted mice. Ann. Med. 33, 22-27 (2001).
-
(2001)
Ann. Med.
, vol.33
, pp. 22-27
-
-
Nakae, J.1
Kido, Y.2
Accili, D.3
-
13
-
-
0342614209
-
Unified nomenclature for the winged helix/forkhead transcription factors
-
Kaestner, K.H., Knochel, W. & Martinez, D.E, Unified nomenclature for the winged helix/forkhead transcription factors. Genes Dev. 14, 142-146 (2000).
-
(2000)
Genes Dev.
, vol.14
, pp. 142-146
-
-
Kaestner, K.H.1
Knochel, W.2
Martinez, D.E.3
-
14
-
-
0030657540
-
Daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
-
Lin, K., Dorman, J.B., Rodan, A. & Kenyon, C. Daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans, Science 278, 1319-1322 (1997).
-
(1997)
Science
, vol.278
, pp. 1319-1322
-
-
Lin, K.1
Dorman, J.B.2
Rodan, A.3
Kenyon, C.4
-
15
-
-
0030659557
-
The Forkhead transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C elegans
-
Ogg, S. et al. The Forkhead transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C elegans. Nature 389, 994-999 (1997).
-
(1997)
Nature
, vol.389
, pp. 994-999
-
-
Ogg, S.1
-
16
-
-
0032538315
-
Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span
-
Apfeld, J. & Kenyon, C. Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span. Cell 95, 199-210 (1998).
-
(1998)
Cell
, vol.95
, pp. 199-210
-
-
Apfeld, J.1
Kenyon, C.2
-
17
-
-
0034967720
-
Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
-
Lin, K., Hsin, H., Libina, N. & Kenyon, C,. Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nature Genet. 28, 139-145 (2001).
-
(2001)
Nature Genet.
, vol.28
, pp. 139-145
-
-
Lin, K.1
Hsin, H.2
Libina, N.3
Kenyon, C.4
-
18
-
-
13344277357
-
Early neonatal death in mice homozygous for a null allele of the insulin receptor gene
-
Accili, D. et al. Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nature Genet. 12, 106-109 (1996).
-
(1996)
Nature Genet.
, vol.12
, pp. 106-109
-
-
Accili, D.1
-
19
-
-
0033522897
-
Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a wortmannin-sensitive pathway
-
Nakae, J., Park, B.-C. & Accili, D. Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a wortmannin-sensitive pathway. J. Biol. Chem. 274, 15982-15985 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 15982-15985
-
-
Nakae, J.1
Park, B.-C.2
Accili, D.3
-
20
-
-
0032518255
-
Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily
-
Anderson, M.J., Viars, C.S., Czekay, S., Cavenee, W.K. & Arden, K.C. Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. Genomics 47, 187-199 (1998).
-
(1998)
Genomics
, vol.47
, pp. 187-199
-
-
Anderson, M.J.1
Viars, C.S.2
Czekay, S.3
Cavenee, W.K.4
Arden, K.C.5
-
21
-
-
12944335299
-
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
-
Nasrin, N. et al. DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells. Proc. Natl Acad. Sci. USA 97, 10412-10417 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 10412-10417
-
-
Nasrin, N.1
-
22
-
-
0038155702
-
Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles
-
Bruning, J.C. et al. Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell 88, 561-572 (1997).
-
(1997)
Cell
, vol.88
, pp. 561-572
-
-
Bruning, J.C.1
-
23
-
-
0034079629
-
Genetic modifiers of the insulin resistance phenotype
-
Kido, Y., Philippe, N., Schaeffer, A.A. & Accili, D. Genetic modifiers of the insulin resistance phenotype. Diabetes 49, 589-596 (2000).
-
(2000)
Diabetes
, vol.49
, pp. 589-596
-
-
Kido, Y.1
Philippe, N.2
Schaeffer, A.A.3
Accili, D.4
-
24
-
-
0033966768
-
Tissue-specific insulin resistance in mice with combined mutations of Insulin Receptor, IRS-1 and IRS-2
-
Kido, Y. et al. Tissue-specific insulin resistance in mice with combined mutations of Insulin Receptor, IRS-1 and IRS-2. J. Clin. Invest. 105, 199-205 (2000).
-
(2000)
J. Clin. Invest.
, vol.105
, pp. 199-205
-
-
Kido, Y.1
-
25
-
-
0035900778
-
Foxa3 (Hepatocyte Nuclear Factor 3γ) is required for the regulation of hepatic glut 2 expression and the maintenance of glucose homeostasis during a prolonged fast
-
Shen, W., Scearce, L.M., Brestelli, J.E., Sund, N.J. & Kaestner, K.H. Foxa3 (Hepatocyte Nuclear Factor 3γ) is required for the regulation of hepatic glut2 expression and the maintenance of glucose homeostasis during a prolonged fast. J. Biol. Chem. 276, 42812-42817 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 42812-42817
-
-
Shen, W.1
Scearce, L.M.2
Brestelli, J.E.3
Sund, N.J.4
Kaestner, K.H.5
-
26
-
-
84879890659
-
The forkhead transcription factor FKHR inhibits adipocyte differentiation
-
Nakae, J., Kitamura, T., Biggs, W., Arden, K. & Accili, D. The forkhead transcription factor FKHR inhibits adipocyte differentiation. Diabetes 50 (Suppl. 2), A22 (2001).
-
(2001)
Diabetes
, vol.50
, Issue.SUPPL. 2
-
-
Nakae, J.1
Kitamura, T.2
Biggs, W.3
Arden, K.4
Accili, D.5
-
27
-
-
0032752063
-
Cellular survival: A play in three Akts
-
Datta, S.R., Brunet, A. & Greenberg, M.E. Cellular survival: a play in three Akts. Genes Dev. 13, 2905-2927 (1999).
-
(1999)
Genes Dev.
, vol.13
, pp. 2905-2927
-
-
Datta, S.R.1
Brunet, A.2
Greenberg, M.E.3
-
28
-
-
0034161544
-
Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR
-
Nakae, J., Barr, V. & Accili, D. Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR, EMBO J. 19, 989-996 (2000).
-
(2000)
EMBO J.
, vol.19
, pp. 989-996
-
-
Nakae, J.1
Barr, V.2
Accili, D.3
-
29
-
-
0025008962
-
Distinct positive and negative elements control the limited hepatocyte and choroid plexus expression of transthyretin in transgenic mice
-
Yan, C., Costa, R.H., Darnell, J.E., Jr., Chen, J.D. & Van Dyke, T.A. Distinct positive and negative elements control the limited hepatocyte and choroid plexus expression of transthyretin in transgenic mice. EMBO J. 9, 869-878 (1990).
-
(1990)
EMBO J.
, vol.9
, pp. 869-878
-
-
Yan, C.1
Costa, R.H.2
Darnell J.E., Jr.3
Chen, J.D.4
Van Dyke, T.A.5
-
30
-
-
0035800759
-
The roles of atf 3 in glucose homeostasis. A transgenic mouse model with liver dysfunction and defects in endocrine pancreas
-
Allen-Jennings, A.E., Hartman, M.G., Kociba, G.J. & Hai, T. The roles of atf3 in glucose homeostasis. A transgenic mouse model with liver dysfunction and defects in endocrine pancreas. J. Biol. Chem. 276, 29507-29514 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 29507-29514
-
-
Allen-Jennings, A.E.1
Hartman, M.G.2
Kociba, G.J.3
Hai, T.4
-
31
-
-
0024579185
-
Transthyretin immunoreactivity in human and porcine liver, choroid plexus, and pancreatic islets
-
Jacobsson, B. et al. Transthyretin immunoreactivity in human and porcine liver, choroid plexus, and pancreatic islets. J. Histochem. Cytochem. 37, 31-37 (1989).
-
(1989)
J. Histochem. Cytochem.
, vol.37
, pp. 31-37
-
-
Jacobsson, B.1
-
32
-
-
0033126490
-
Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo
-
Cherrington, A.D. Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo. Diabetes 48, 1198-1214 (1999).
-
(1999)
Diabetes
, vol.48
, pp. 1198-1214
-
-
Cherrington, A.D.1
-
33
-
-
0034608816
-
In vitro cultivation of human islets from expanded ductal tissue
-
Bonner-Weir, S. et al. In vitro cultivation of human islets from expanded ductal tissue. Proc. Natl. Acad. Sci. USA 97, 7999-8004 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 7999-8004
-
-
Bonner-Weir, S.1
-
34
-
-
0031841517
-
Extra-insular β cells associated with ductules are frequent in adult human pancreas
-
Bouwens, L. & Pipeleers, D.G. Extra-insular β cells associated with ductules are frequent in adult human pancreas. Diabetologia 41, 629-633 (1998).
-
(1998)
Diabetologia
, vol.41
, pp. 629-633
-
-
Bouwens, L.1
Pipeleers, D.G.2
-
35
-
-
0033009460
-
The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration
-
Sharma, A. et al. The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes 48, 507-513 (1999).
-
(1999)
Diabetes
, vol.48
, pp. 507-513
-
-
Sharma, A.1
-
36
-
-
0035185021
-
The forkhead transcription factor Foxol (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression
-
Nakae, J., Kitamura, T., Silver, D.L. & Accili, D. The forkhead transcription factor Foxol (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J. Clin. Invest. 108, 1359-1367 (2001).
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 1359-1367
-
-
Nakae, J.1
Kitamura, T.2
Silver, D.L.3
Accili, D.4
-
37
-
-
0001451494
-
The transcription factor FKHR regulates pancreatic β cell survival
-
Kitamura, T. et al. The transcription factor FKHR regulates pancreatic β cell survival. Diabetes 50 (Suppl. 2), A345 (2001).
-
(2001)
Diabetes
, vol.50
, Issue.SUPPL. 2
-
-
Kitamura, T.1
-
38
-
-
0033849842
-
Insights into insulin resistance and type 2 diabetes from knockout mouse models
-
Kadowaki, T. Insights into insulin resistance and type 2 diabetes from knockout mouse models. J. Clin. Invest. 106, 459-465 (2000).
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 459-465
-
-
Kadowaki, T.1
-
39
-
-
0033770540
-
Life and death of the pancreatic β cells
-
Bonner-Weir, S. Life and death of the pancreatic β cells. Trends Endocrinol Metab. 11, 375-378 (2000).
-
(2000)
Trends Endocrinol. Metab.
, vol.11
, pp. 375-378
-
-
Bonner-Weir, S.1
-
40
-
-
0034941125
-
Preserved pancreatic β-cell development and function in mice lacking the insulin receptor-related receptor
-
Kitamura, T. et al. Preserved pancreatic β-cell development and function in mice lacking the insulin receptor-related receptor. Mol. Cell. Biol. 21, 5624-5630 (2001).
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 5624-5630
-
-
Kitamura, T.1
|