Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice

Molecular and Cellular Biology

Volumn 25, Issue 5, 2005, Pages 1596-1607

  Brachmann, Saskia M ^a   Ueki, Kohjiro ^b   Engelman, Jeffrey A ^a   Kahn, Ronald C ^b   Cantley, Lewis C ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P110; PROTEIN P110ALPHA; PROTEIN P110BETA; PROTEIN P85; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; DIET RESTRICTION; ENZYME ACTIVITY; FEMALE; GENE DELETION; GLUCOSE INTOLERANCE; HUMAN; HUMAN CELL; HYPERINSULINEMIA; IN VIVO STUDY; INSULIN SENSITIVITY; MALE; MAMMAL CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; RNA INTERFERENCE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BLOOD GLUCOSE; CATALYTIC DOMAIN; FASTING; GLUCOSE INTOLERANCE; HYPERINSULINISM; INSULIN; INSULIN RESISTANCE; INSULIN-LIKE GROWTH FACTOR I; ISOENZYMES; LIVER; MICE; MICE, KNOCKOUT; MUSCLE, SKELETAL; PROTEIN SUBUNITS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; SEQUENCE DELETION;

EID: 14144250240     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.25.5.1596-1607.2005     Document Type: Article

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