메뉴 건너뛰기




Volumn 23, Issue 1, 1999, Pages 32-40

Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; INSULIN RECEPTOR SUBSTRATE 1; SOMATOMEDIN C;

EID: 0032841435     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/12631     Document Type: Article
Times cited : (489)

References (36)
  • 1
    • 0028904053 scopus 로고
    • Insulin action and the insulin signaling network
    • Cheatham, B. & Kahn, C.R. Insulin action and the insulin signaling network. Endocr. Rev. 16, 117-142 (1995).
    • (1995) Endocr. Rev. , vol.16 , pp. 117-142
    • Cheatham, B.1    Kahn, C.R.2
  • 2
    • 0028957113 scopus 로고
    • Molecular and cellular aspects of the insulin-like growth factor I receptor
    • LeRoith, D., Werner, H., Beitner-Johnson, D. & Roberts, C. Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr. Rev. 16, 143-163 (1995).
    • (1995) Endocr. Rev. , vol.16 , pp. 143-163
    • LeRoith, D.1    Werner, H.2    Beitner-Johnson, D.3    Roberts, C.4
  • 4
    • 0028579733 scopus 로고
    • Oncogenes and the strategy of growth factors
    • Baserga, R. Oncogenes and the strategy of growth factors. Cell 79, 927-930 (1994).
    • (1994) Cell , vol.79 , pp. 927-930
    • Baserga, R.1
  • 5
    • 0028085078 scopus 로고
    • The insulin signaling system
    • White, M.F. & Kahn, C.R. The insulin signaling system. J. Biol. Chem. 269, 1-4 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 1-4
    • White, M.F.1    Kahn, C.R.2
  • 6
    • 0027516706 scopus 로고
    • IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol3′-kinase
    • Myers, M.G. Jr et al. IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol3′-kinase. Endocrinology 132, 1421-1430 (1993).
    • (1993) Endocrinology , vol.132 , pp. 1421-1430
    • Myers M.G., Jr.1
  • 7
    • 0027496895 scopus 로고
    • Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
    • Liu, J.P., Baker, J., Perkins, J.A., Robertson, E.J. & Efstratiadis, A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75, 59-72 (1993).
    • (1993) Cell , vol.75 , pp. 59-72
    • Liu, J.P.1    Baker, J.2    Perkins, J.A.3    Robertson, E.J.4    Efstratiadis, A.5
  • 8
    • 13344277357 scopus 로고    scopus 로고
    • Early neonatal death in mice homozygous for a null allele of the insulin receptor gene
    • Accili, D. et al. Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nature Genet. 12, 106-109 (1996).
    • (1996) Nature Genet. , vol.12 , pp. 106-109
    • Accili, D.1
  • 9
    • 0033524937 scopus 로고    scopus 로고
    • Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes
    • Kulkarni, R.N. et al. Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96, 329-339 (1999).
    • (1999) Cell , vol.96 , pp. 329-339
    • Kulkarni, R.N.1
  • 10
    • 0026595373 scopus 로고
    • The expression and function of IRS-1 in insulin signal transmission
    • Sun, X.J. et al. The expression and function of IRS-1 in insulin signal transmission. J. Biol. Chem. 267, 22662-22672 (1992).
    • (1992) J. Biol. Chem. , vol.267 , pp. 22662-22672
    • Sun, X.J.1
  • 11
    • 0029148591 scopus 로고
    • Role of IRS-2 in insulin and cytokine signaling
    • Sun, X.J. et al. Role of IRS-2 in insulin and cytokine signaling. Nature 377, 173-177 (1995).
    • (1995) Nature , vol.377 , pp. 173-177
    • Sun, X.J.1
  • 12
    • 0031803329 scopus 로고    scopus 로고
    • Amino acid polymorphisms are not associated with random type 2 diabetes among Caucasians
    • Bernal, D. et al. Amino acid polymorphisms are not associated with random type 2 diabetes among Caucasians. Diabetes 47, 976-979 (1998).
    • (1998) Diabetes , vol.47 , pp. 976-979
    • Bernal, D.1
  • 13
    • 0032567937 scopus 로고    scopus 로고
    • Disruption of IRS-2 causes type 2 diabetes in mice
    • Withers, D.J. et al. Disruption of IRS-2 causes type 2 diabetes in mice. Nature 391, 900-903 (1998).
    • (1998) Nature , vol.391 , pp. 900-903
    • Withers, D.J.1
  • 14
    • 0028032895 scopus 로고
    • Alternative pathway of insulin signalling in mice with targetted disruption of the IRS-1 gene
    • Araki, E. et al. Alternative pathway of insulin signalling in mice with targetted disruption of the IRS-1 gene. Nature 372, 186-190 (1994).
    • (1994) Nature , vol.372 , pp. 186-190
    • Araki, E.1
  • 15
    • 0029897280 scopus 로고    scopus 로고
    • Insulin signaling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice
    • Yamauchi, T. et al. Insulin signaling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice. Mol. Cell. Biol. 16, 3074-3084 (1996).
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 3074-3084
    • Yamauchi, T.1
  • 16
    • 0028032894 scopus 로고
    • Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1
    • Tamemoto, H. et al. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 372, 182-186 (1994).
    • (1994) Nature , vol.372 , pp. 182-186
    • Tamemoto, H.1
  • 17
    • 0026321596 scopus 로고
    • Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene
    • Herrera, P.L. et al. Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene. Development 113, 1257-1265 (1991).
    • (1991) Development , vol.113 , pp. 1257-1265
    • Herrera, P.L.1
  • 18
    • 0031196719 scopus 로고    scopus 로고
    • The insulin-like growth factor-I receptor and apoptosis. Implications for the aging process
    • LeRoith, D., Parrizas, M. & Blakesley, V.A. The insulin-like growth factor-I receptor and apoptosis. Implications for the aging process. Endocrine 7, 103-105 (1997).
    • (1997) Endocrine , vol.7 , pp. 103-105
    • LeRoith, D.1    Parrizas, M.2    Blakesley, V.A.3
  • 19
    • 0031741145 scopus 로고    scopus 로고
    • The pleckstrin homology and phosphotyrosine binding domains of insulin receptor substrate 1 mediate inhibition of apoptosis by insulin
    • Yenush, L., Zanella, C., Uchida, T., Bernal, D. & White, M.F. The pleckstrin homology and phosphotyrosine binding domains of insulin receptor substrate 1 mediate inhibition of apoptosis by insulin. Mol. Cell. Biol. 18, 6784-6794 (1998).
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 6784-6794
    • Yenush, L.1    Zanella, C.2    Uchida, T.3    Bernal, D.4    White, M.F.5
  • 20
    • 0028845665 scopus 로고
    • Apoptosis contributes to the involution of β cell mass in the post partum rat pancreas
    • Scaglia, L., Smith, F.E. & Bonner-Weir, S. Apoptosis contributes to the involution of β cell mass in the post partum rat pancreas. Endocrinology 136, 5461-5468 (1995).
    • (1995) Endocrinology , vol.136 , pp. 5461-5468
    • Scaglia, L.1    Smith, F.E.2    Bonner-Weir, S.3
  • 21
    • 0030903840 scopus 로고    scopus 로고
    • Apoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat
    • Scaglia, L., Cahill, C.J., Finegood, D.T. & Bonner-Weir, S. Apoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat. Endocrinology 138, 1736-1741 (1997).
    • (1997) Endocrinology , vol.138 , pp. 1736-1741
    • Scaglia, L.1    Cahill, C.J.2    Finegood, D.T.3    Bonner-Weir, S.4
  • 22
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta, S.R. et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231-241 (1997).
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1
  • 23
    • 0040973209 scopus 로고    scopus 로고
    • Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1 deficient cells
    • Bruning, J.C., Winnay, J., Cheatham, B. & Kahn, C.R. Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1 deficient cells. Mol. Cell. Biol. 17, 1513-1521 (1997).
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 1513-1521
    • Bruning, J.C.1    Winnay, J.2    Cheatham, B.3    Kahn, C.R.4
  • 24
    • 0032504257 scopus 로고    scopus 로고
    • Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes
    • Rother, K.I. et al. Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes. J. Biol. Chem. 273, 17491-17497 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 17491-17497
    • Rother, K.I.1
  • 25
    • 0029559161 scopus 로고
    • Glucose-and insulin-induced phosphorylation of the insulin receptor and its primary substrates IRS-1 and IRS-2 in rat pancreatic islets
    • Velloso, L.A., Carneiro, E.M., Crepaldi, S.C., Boschero, A.C. & Saad, M.J. Glucose-and insulin-induced phosphorylation of the insulin receptor and its primary substrates IRS-1 and IRS-2 in rat pancreatic islets. Growth Regul. 377, 353-357 (1995).
    • (1995) Growth Regul. , vol.377 , pp. 353-357
    • Velloso, L.A.1    Carneiro, E.M.2    Crepaldi, S.C.3    Boschero, A.C.4    Saad, M.J.5
  • 26
    • 0031749006 scopus 로고    scopus 로고
    • A specific increased expression of insulin receptor substrate 2 in pancreatic β-cell lines is involved with mediating serum-stimulated β-cell growth
    • Schuppin, G.T. et al. A specific increased expression of insulin receptor substrate 2 in pancreatic β-cell lines is involved with mediating serum-stimulated β-cell growth. Diabetes 47, 1074-1085 (1998).
    • (1998) Diabetes , vol.47 , pp. 1074-1085
    • Schuppin, G.T.1
  • 27
    • 0032504211 scopus 로고    scopus 로고
    • IGF-1 stimulated pancreatic β-cell growth is glucose dependent: Synergistic activation of IRS-mediated signal transduction pathways by glucose and IGF-1 in INS-1 cells
    • Hugl, S.R., White, M.F. & Rhodes, C.J. IGF-1 stimulated pancreatic β-cell growth is glucose dependent: synergistic activation of IRS-mediated signal transduction pathways by glucose and IGF-1 in INS-1 cells. J. Biol. Chem. 273, 17771-17779 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 17771-17779
    • Hugl, S.R.1    White, M.F.2    Rhodes, C.J.3
  • 28
    • 0030611168 scopus 로고    scopus 로고
    • Tyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptor
    • Sawka-Verhelle, D. et al. Tyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptor. J. Biol. Chem. 272, 16414-16420 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 16414-16420
    • Sawka-Verhelle, D.1
  • 29
    • 0029866195 scopus 로고    scopus 로고
    • Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786
    • Sawka-Verhelle, D., Tartare-Deckert, S., White, M.F. & Van Obberghen, E. Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786. J. Biol. Chem. 271, 5980-5983 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 5980-5983
    • Sawka-Verhelle, D.1    Tartare-Deckert, S.2    White, M.F.3    Van Obberghen, E.4
  • 30
    • 0030750728 scopus 로고    scopus 로고
    • Pancreatic islet expression studies and polymorphic DNA markers in the genes encoding hepatocyte nuclear factor-3α, -3β, -3γ, -4γ, and -6
    • Vaisse, C., Kim, J., Espinosa, R. III, Lebeau, M.M. & Stoffel, M. Pancreatic islet expression studies and polymorphic DNA markers in the genes encoding hepatocyte nuclear factor-3α, -3β, -3γ, -4γ, and -6. Diabetes 48, 1364-1367 (1997).
    • (1997) Diabetes , vol.48 , pp. 1364-1367
    • Vaisse, C.1    Kim, J.2    Espinosa R. III3    Lebeau, M.M.4    Stoffel, M.5
  • 31
    • 0032525981 scopus 로고    scopus 로고
    • β-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes
    • Ahlgren, U., Jonsson, J., Jonsson, L., Simu, K. & Edlund, H. β-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes. Genes Dev. 12, 1763-1768 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 1763-1768
    • Ahlgren, U.1    Jonsson, J.2    Jonsson, L.3    Simu, K.4    Edlund, H.5
  • 32
    • 0031738115 scopus 로고    scopus 로고
    • Transcribing pancreas
    • Edlund, H. Transcribing pancreas. Diabetes 47, 1817-1823 (1998).
    • (1998) Diabetes , vol.47 , pp. 1817-1823
    • Edlund, H.1
  • 33
    • 0030907390 scopus 로고    scopus 로고
    • Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1
    • Sharma, S. et al. Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1. Mol. Cell. Biol. 17, 2598-2604 (1997).
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 2598-2604
    • Sharma, S.1
  • 34
    • 0028869514 scopus 로고
    • Expression of murine STF-1, a putative insulin gene transcription factor, in β cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny
    • Guz, Y. et al. Expression of murine STF-1, a putative insulin gene transcription factor, in β cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development 121, 11-18 (1995).
    • (1995) Development , vol.121 , pp. 11-18
    • Guz, Y.1
  • 35
    • 0027423419 scopus 로고
    • Role of insulin-like growth factors in embryonic and postnatal growth
    • Baker, J., Liu, J.P., Robertson, E.J. & Efstratiadis, A. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 75, 73-82 (1993).
    • (1993) Cell , vol.75 , pp. 73-82
    • Baker, J.1    Liu, J.P.2    Robertson, E.J.3    Efstratiadis, A.4
  • 36
    • 0026515343 scopus 로고
    • Pancreatic β-cell growth and diabetes mellitus
    • Swenne, I. Pancreatic β-cell growth and diabetes mellitus. Diabetologia 35, 193-201 (1992).
    • (1992) Diabetologia , vol.35 , pp. 193-201
    • Swenne, I.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.