Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a wortmannin-sensitive pathway

Journal of Biological Chemistry

Volumn 274, Issue 23, 1999, Pages 15982-15985

  Nakae, Jun ^a   Park, Byung Chul ^a   Accili, Domenico ^a,b  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; SERINE DERIVATIVE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ARTICLE; CAENORHABDITIS ELEGANS; GENE MUTATION; MOLECULAR CLONING; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SUBSTITUTION; ANDROSTADIENES; ANIMALS; BLOOD PROTEINS; CELLS, CULTURED; CONSENSUS SEQUENCE; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HUMANS; INSULIN; LIVER; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SERINE; SIMIAN VIRUS 40; STRUCTURE-ACTIVITY RELATIONSHIP; THREONINE; TRANSCRIPTION FACTORS;

ANIMALIA; CAENORHABDITIS ELEGANS; INVERTEBRATA; MAMMALIA; MURINAE;

EID: 0033522897     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.23.15982     Document Type: Article

References (28)

1. Cheatham, B., and Kahn, C. R. (1995) Endocr. Rev. 16, 117-142
2. White, M. F. (1998) Mol. Cell. Biochem. 182, 3-11
3. Toker, A., and Cantley, L. C. (1997) Nature 387, 673-676
4. Kohn, A. D., Kovacina, K. S., and Roth, R. A. (1995) EMBO J. 14, 4288-4295
5. Kohn, A. D., Summers, S. A., Birnbaum, M. J., and Roth, R. A. (1996) J. Biol. Chem. 271, 31372-31378
6. Liao, J., Barthel, A., Nakatani, K., and Roth, R. A. (1998) J. Biol. Chem. 273, 27320-27324
7. Kitamura, T., Ogawa, W., Sakaue, H., Hino, Y., Kuroda, S., Takata, M., Matsumoto, M., Maeda, T., Konishi, H., Kikkawa, U., and Kasuga, M. (1998) Mol. Cell. Biol. 18, 3708-3717
8. Ueki, K., Yamamoto-Honda, R., Kaburagi, Y., Yamauchi, T., Tobe, K., Burgering, B. M., Coffer, P. J., Komuro, I., Akanuma, Y., Yazaki, Y., and Kadowaki, T. (1998) J. Biol. Chem. 273, 5315-5322
9. Kotani, K., Ogawa, W., Matsumoto, M., Kitamura, T., Sakaue, H., Hino, Y., Miyake, K., Sano, W., Akimoto, K., Ohno, S., and Kasuga, M. (1998) Mol. Cell. Biol. 18, 6971-6982
10. Standaert, M. L., Galloway, L., Karnam, P., Bandyopadhyay, G., Moscat, J., and Farese, R. V. (1997) J. Biol. Chem. 272, 30075-30082
11. Paradis, S., and Ruvkun, G. (1998) Genes Dev. 12, 2488-2498
12. Tissenbaum, H. A., and Ruvkun, G. (1998) Genetics 148, 703-717
13. Morris, J. Z., Tissenbaum, H. A., and Ruvkun, G. (1996) Nature 382, 536-539
14. Kimura, K. D., Tissenbaum, H. A., Liu, Y., and Ruvkun, G. (1997) Science 277, 942-946
15. Lin, K., Dorman, J. B., Rodan, A., and Kenyon, C. (1997) Science 278, 1319-1322
16. Ogg, S., Paradis, S., Gottlieb, S., Patterson, G. I., Lee, L., Tissenbaum, H. A., and Ruvkun, G. (1997) Nature 389, 994-999
17. Alessi, D. R., Caudwell, F. B., Andjelkovic, M., Hemmings, B. A., and Cohen, P. (1996) FEBS Lett. 399, 333-338
18. Anderson, M. J., Viars, C. S., Czekay, S., Cavenee, W. K., and Arden, K. C. (1998) Genomics 47, 187-199
19. Barr, F. G. (1997) Curr. Top. Microbiol. Immunol. 220, 113-129
20. Fredericks, W. J., Galili, N., Mukhopadhyay, S., Rovera, G., Bennicelli, J., Barr, F. G., and Rauscher, F. J. (1995) Mol. Cell. Biol. 15, 1522-1535
21. Rother, K. I., Imai, Y., Caruso, M., Beguinot, F., Formisano, P., and Accili, D. (1998) J. Biol. Chem. 273, 17491-17497
22. Kadowaki, H., Kadowaki, T., Wondisford, F. E., and Taylor, S. I. (1989) Gene (Amst.) 76, 161-186
23. Salvatore, P., Hanash, C. R., Kido, Y., Imai, Y., and Accili, D. (1998) J. Biol. Chem. 273, 6989-6997
24. Okada, T., Kawano, Y., Sakakibara, T., Hazeki, O., and Ui, M. (1994) J. Biol. Chem. 269, 3568-3573
25. Shimizu, Y., and Shimazu, T. (1994) Biochem. Biophys. Res. Commun. 202, 660-665
26. Abraham, R. T. (1996) Annu. Rev. Immunol. 14, 483-510
27. Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., and Greenberg, M. E. (1999) Cell 96, 857-868
28. Tomizawa, M., Nakae, J., Accili, D., and Rechler, M. M. (1999) Diabetes 48, in press (abstr.)