S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-α signaling through IKK2

Journal of Biological Chemistry

Volumn 283, Issue 51, 2008, Pages 35375-35382

  Zhang, Jin ^a   Gao, Zhanguo ^a   Yin, Jun ^a   Quon, Michael J ^b   Ye, Jianping ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANIMAL CELL CULTURE; CHEMICAL REACTIONS; CONTROL THEORY; FEEDBACK; GLUCOSE; HORMONES; INSULIN;

ADIPOCYTES; ADIPOSE TISSUES; CYTOKINE; DOMINANT NEGATIVES; GLUCOSE UPTAKES; HEPATOCYTES; IN VITRO KINASE ASSAYS; INSULIN ACTIONS; INSULIN RESISTANCES; NEGATIVE FEEDBACKS; NEW MECHANISMS; OBESE MOUSE; PHOSPHORYLATION SITES; PROTEIN DEGRADATIONS; SERINE KINASES; SERINE RESIDUES; SIGNALING PATHWAYS;

PHOSPHORYLATION;

GLUCOSE; I KAPPA B KINASE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; PROTEIN IKK2; S6 KINASE; SERINE; THREONINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ASSAY; GENE MUTATION; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; IN VITRO STUDY; INSULIN RESISTANCE; LIVER CELL; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; SIGNAL TRANSDUCTION;

ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; CELL LINE; GENE KNOCKDOWN TECHNIQUES; HEPATOCYTES; HUMANS; I-KAPPA B KINASE; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; MICE; MICE, OBESE; PHOSPHORYLATION; POINT MUTATION; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

MUS; RODENTIA;

EID: 58149094542     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M806480200     Document Type: Article

References (50)

1. Hotamisligil, G. S. (1999) Exp. Clin. Endocrinol. Diabetes 107, 119-125
2. Peraldi, P., and Spiegelman, B. (1998) Mol. Cell Biochem. 182, 169-175
3. Peraldi, P., Xu, M., and Spiegelman, B. M. (1997) J. Clin. Investig. 100, 1863-1869
4. Engelman, J. A., Berg, A. H., Lewis, R. Y., Lisanti, M. P., and Scherer, P. E. (2000) Mol. Endocrinol. 14, 1557-1569
5. Rui, L., Aguirre, V., Kim, J. K., Shulman, G. I., Lee, A., Corbould, A., Dunaif, A., and White, M. F. (2001) J. Clin. Investig. 107, 181-189
6. Gao, Z., Hwang, D., Bataille, F., Lefevre, M., York, D., Quon, M. J., and Ye, J. (2002) J. Biol. Chem. 277, 48115-48121
7. Gao, Z., Zuberi, A., Quon, M., Dong, Z., and Ye, J. (2003) J. Biol. Chem. 278, 24944-24950
8. Aguirre, V., Uchida, T., Yenush, L., Davis, R., and White, M. F. (2000) J. Biol. Chem. 275, 9047-9054
9. De Fea, K., and Roth, R. A. (1997) J. Biol. Chem. 272, 31400-31406
10. De Fea, K., and Roth, R. A. (1997) Biochemistry 36, 12939-12947
11. Ravichandran, L. V., Esposito, D. L., Chen, J., and Quon, M. J. (2001) J. Biol. Chem. 276, 3543-3549
12. Bourbon, N. A., Sandirasegarane, L., and Kester, M. (2002) J. Biol. Chem. 277, 3286-3292
13. Liu, Y. F., Paz, K., Herschkovitz, A., Alt, A., Tennenbaum, T., Sampson, S. R., Ohba, M., Kuroki, T., LeRoith, D., and Zick, Y. (2001) J. Biol. Chem. 276, 14459-14465
14. Li, Y., Soos, T. J., Li, X., Wu, J., DeGennaro, M., Sun, X., Littman, D. R., Birnbaum, M. J., and Polakiewicz, R. D. (2004) J. Biol. Chem. 279, 45304-45307
15. Gao, Z., Zhang, X., Zuberi, A., Hwang, D., Quon, M. J., Lefevre, M., and Ye, J. (2004) Mol. Endocrinol. 18, 2024-2034
16. Paz, K., Liu, Y. F., Shorer, H., Hemi, R., LeRoith, D., Quan, M., Kanety, H., Seger, R., and Zick, Y. (1999) J. Biol. Chem. 274, 28816-28822
17. Ozes, O. N., Akca, H., Mayo, L. D., Gustin, J. A., Maehama, T., Dixon, J. E., and Donner, D. B. (2001) Proc. Natl. Acad. Sci. U. S. A 98, 4640-4645
18. Eldar-Finkelman, H., and Krebs, E. G. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 9660-9664
19. Liberman, Z., and Eldar-Finkelman, H. (2005) J. Biol. Chem. 280, 4422-4428
20. Ilouz, R., Kowalsman, N., Eisenstein, M., and Eldar-Finkelman, H. (2006) J. Biol. Chem. 281, 30621-30630
21. Kim, J. A., Yeh, D. C., Ver, M., Li, Y., Carranza, A., Conrads, T. P., Veenstra, T. D., Harrington, M. A., and Quon, M. J. (2005) J. Biol. Chem. 280, 23173-23183
22. Haruta, T., Uno, T., Kawahara, J., Takano, A., Egawa, K., Sharma, P. M., Olefsky, J. M., and Kobayashi, M. (2000) Mol. Endocrinol. 14, 783-794
23. Harrington, L. S., Findlay, G. M., Gray, A., Tolkacheva, T., Wigfield, S., Rebholz, H., Barnett, J., Leslie, N. R., Cheng, S., Shepherd, P. R., Gout, I., Downes, C. P., and Lamb, R. F. (2004) J. Cell Biol. 166, 213-223
24. Carlson, C. J., White, M. F., and Rondinone, C. M. (2004) Biochem. Biophys. Res. Commun. 316, 533-539
25. Tremblay, F., Brule, S., Hee Um, S., Li, Y., Masuda, K., Roden, M., Sun, X. J., Krebs, M., Polakiewicz, R. D., Thomas, G., and Marette, A. (2007) Proc. Natl. Acad. Sci. U. S. A. 104, 14056-14061
26. Um, S. H., Frigerio, F., Watanabe, M., Picard, F., Joaquin, M., Sticker, M., Fumagalli, S., Allegrini, P. R., Kozma, S. C., Auwerx, J., and Thomas, G. (2004) Nature 431, 200-205
27. Tremblay, F., and Marette, A. (2001) J. Biol. Chem. 276, 38052-38060
28. Tremblay, F., Krebs, M., Dombrowski, L., Brehm, A., Bernroider, E., Roth, E., Nowotny, P., Waldhausl, W., Marette, A., and Roden, M. (2005) Diabetes 54, 2674-2684
29. Giraud, J., Leshan, R. L., Lee, Y.-H., and White, M. F. (2004) J. Biol. Chem. 279, 3447-3454
30. Um, S. H., D'Alessio, D., and Thomas, G. (2006) Cell Metab. 3, 393-402
31. Khamzina, L., Veilleux, A., Bergeron, S., and Marette, A. (2005) Endocrinology 146, 1473-1481
32. Lee, D.-F., Kuo, H.-P., Chen, C.-T., Hsu, J.-M., Chou, C.-K., Wei, Y., Sun, H.-L., Li, L.-Y., Ping, B., Huang, W.-C., He, X., Hung, J.-Y., Lai, C.-C., Ding, Q., Su, J.-L., Yang, J.-Y., Sahin, A. A., Hortobagyi, G. N., Tsai, F.-J., Tsai, C.-H., and Hung, M.-C. (2007) Cell 130, 440-455
33. Greene, M. W., Sakaue, H., Wang, L., Alessi, D. R., and Roth, R. A. (2003) J. Biol. Chem. 278, 8199-8211
34. Gao, Z., He, Q., Peng, B., Chiao, P. J., and Ye, J. (2006) J. Biol. Chem. 281, 4540-4547
35. Schalm, S. S., and Blenis, J. (2002) Curr. Biol. 12, 632-639
36. Ye, J., Gao, Z., Yin, J., and He, H. (2007) Am. J. Physiol. Endocrinol. Metab. 293, E1118-E1128
37. Cong, L. N., Chen, H., Li, Y., Zhou, L., McGibbon, M. A., Taylor, S. I., and Quon, M. J. (1997) Mol. Endocrinol. 11, 1881-1890
38. Ye, J. (2007) Endocr. Metab. Immune Disord Drug Targets 7, 65-74
39. Li, J., DeFea, K., and Roth, R. A. (1999) J. Biol. Chem. 274, 9351-9356
40. Takano, A., Usui, I., Haruta, T., Kawahara, J., Uno, T., Iwata, M., and Kobayashi, M. (2001) Mol. Cell. Biol. 21, 5050-5062
41. Ueno, M., Carvalheira, J. B., Tambascia, R. C., Bezerra, R. M., Amaral, M. E., Carneiro, E. M., Folli, F., Franchini, K. G., and Saad, M. J. (2005) Diabetologia 48, 506-518
42. Patti, M. E., and Kahn, B. B. (2004) Nat. Med. 10, 1049-1050
43. Dan, H. C., Adli, M., and Baldwin, A. S. (2007) Cancer Res. 67, 6263-6269
44. Xie, P., Browning, D. D., Hay, N., Mackman, N., and Ye, R. D. (2000) J. Biol. Chem. 275, 24907-24914
45. Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z. W., Karin, M., and Shoelson, S. E. (2001) Science 293, 1673-1677
46. Nakajima, K., Yamauchi, K., Shigematsu, S., Ikeo, S., Komatsu, M., Aizawa, T., and Hashizume, K. (2000) J. Biol. Chem. 275, 20880-20886
47. Dey, D., Mukherjee, M., Basu, D., Datta, M., Roy, S. S., Bandyopadhyay, A., and Bhattacharya, S. (2005) Cell Physiol Biochem. 16, 217-228
48. Jiang, G., Dallas-Yang, Q., Liu, F., Moller, D. E., and Zhang, B. B. (2002) J. Biol. Chem. 278, 180-186
49. White, M. F. (2002) Am. J. Physiol. Endocrinol. Metab. 283, E413-E422
50. Araki, E., Sun, X. J., Haag, B. L., 3rd, Chuang, L. M., Zhang, Y., Yang-Feng, T. L., White, M. F., and Kahn, C. R. (1993) Diabetes 42, 1041-1054