Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice

American Journal of Physiology - Endocrinology and Metabolism

Volumn 285, Issue 4 48-4, 2003, Pages

  Altomonte, Jennifer ^a   Richter, Anja ^a   Harbaran, Sonal ^a   Suriawinata, Jenny ^a   Nakae, Jun ^b   Thung, Swan N ^a   Meseck, Marcia ^a   Accili, Domenico ^b   Dong, Hengjiang ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b Columbia University ^*  (United States)

Author keywords

Forkhead transcription factor; Gluconeogenesis; Mice; Type 2 diabetes

Indexed keywords

ADENOVIRUS VECTOR; COMPLEMENTARY DNA; GLUCOSE 6 PHOSPHATASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CONTROLLED STUDY; DIABETES MELLITUS; DIET RESTRICTION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INACTIVATION; GENE TARGETING; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HORMONE ACTION; HYPERGLYCEMIA; LIVER FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN EXPRESSION; RAT; VIRAL GENE DELIVERY SYSTEM;

EID: 0141727772     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00156.2003     Document Type: Article

References (34)

1. Andjelkovic M, Alessi DR, Meier R, Fernandez A, Lamb NJC, Frech M, Cron P, Cohen P, Lucocq JM, and Hemmings BA. Role of translocation in the activation and function of protein kinase B. J Biol Chem 272: 31515-31524, 1997.
2. Biggs WH III, Meisenhelder J, Hunter T, Cavenee WK, and Arden KC. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci USA 96: 7421-7426, 1999.
3. Boden G, Chen X, and Stein TP. Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitus. Am J Physiol Endocrinol Metab 280: E23-E30, 2001.
4. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, and Greenberg ME, Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell 96: 857-868, 1999.
5. Cichy SB, Uddin S, Danilkovich A, Guo S, Klippel A, and Unterman TG. Protein kinase B/Akt mediates effects of insulin on hepatic insulin-like growth factor-binding protein-1 gene expression through a conserved insulin response sequence. J Biol Chem 273: 6482-6487, 1998.
6. Dickens M, Svitek CA, Culbert AA, O'Brien RM, and Tavare JM. Central role for phosphatidylinositide 3-kinase in the repression of glucose-6-phosphatase gene transcription by insulin. J Biol Chem 273: 20144-20149, 1998.
7. Dong H, Altomonte J, Morral N, Meseck M, Thung SN, and Woo SLC. Basal insulin gene expression significantly improves conventional insulin therapy in type 1 diabetic rats. Diabetes 51: 130-138, 2002.
8. Dong H, Norral N, McEvoy R, Meseck M, Thung SN, and Woo SLC. Hepatic insulin expression improves glycemic control in type 1 diabetic rats. Diabetes Res Clin Pract 52: 153-163, 2001.
9. Durham SK, Suwanichkul A, Scheimann AO, Yee D, Jackson JG, Barr FG, and Powell DR. FKHR binds the insulin response element in the insulin-like growth factor binding protein-1 promoter. Endocrinology 140: 3140-3146, 1999.
10. Giaccari A, Morviducci L, Pastore L, Zorretta H, Sbraccia P, Maroccia E, Buongiorno A, and Tamburrano G. Relative contribution of glycogenolysis and gluconeogenesis to hepatic glucose production in control and diabetic rats. A re-examination in the presence of euglycaemia. Diabetologia 41: 307-314, 1998.
11. Gorlich D and Mattaj IW. Nucleocytoplasmic transport. Science 271: 1422-1437, 1996.
12. Goswami R, Lacson R, Yang E, Sam R, and Unterman T. Functional analysis of glucocorticoid and insulin response sequences in the rat insulin-like growth factor-binding protein-1 promoter. Endocrinology 134: 736-743, 1994.
13. Guo S, Rena G, Cichy S, He X, Cohen P, and Unterman T. Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence. J Biol Chem 274: 17184-17192, 1999.
14. Hall RK, Yamasaki T, Kucera T, Waltner-Law M, O'Brien R, and Granner DK. Regulation of phosphoenlpyruvate carboxy-kinase and insulin-like growth factor-binding protein-1 gene expression by insulin. J Biol Chem 275: 30169-30175, 2000.
15. Huard J, Lochmüller H, Aesadi G, Jani A, Massie B, and Karpati G. The route of administration is a major determinant of the transduction efficiency of rat tissues by adenoviral recombinants. Gene Ther 2: 107-115, 1995.
16. Kahn A. Transcriptional regulation by glucose in the liver. Biochimie 79: 113-118, 1997.
17. Li WW, Dammerman MM, Smith JD, Metzger S, Breslow JL, and Leff T. Common genetic variation in the promoter of the human apo CIII gene abolishes regulation by insulin and may contribute to hypertriglyceridemia. J Clin Invest 96: 2601-2065, 1995.
18. Magnuson MA, Rothman DL, Katz LD, Shulman RG, and Shulman GI. Increased rate of gluconeogenesis in type II diabetes mellitus: a 13C nuclear magnetic resonance study. J Clin Invest 90: 1322-1327, 1992.
19. Nakae J, Barr V, and Accili D. Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR. EMBO J 19: 989-996, 2000.
20. Nakae J, Biggs WH, Kitamura T, Cavenee W, Wright CVE, Arden KC, and Accili D. Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat Genet 32: 245-253, 2002.
21. Nakae J, Kitamura T, Silver DL, and Accili D. The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J Clin Invest 108: 1359-1367, 2001.
22. Nakae J, Park B-C, and Accili D. Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a wortmannin-sensitive pathway. J Biol Chem 274: 15982-15985, 1999.
23. Nordlie RC, Foster JD, and Lange AJ. Regulation of glucose production by the liver. Annu Rev Nutr 19: 379-406, 1999.
24. O'Brien RM, Streeper RS, Ayala JE, Stadelmaier BT, and Hornbuckle LA. Insulin-regulated gene expression. Biochem Soc Trans 29: 552-557, 2001.
25. Pilkis SJ and Granner DK. Molecular physiology of the regulation of hepatic gluconeogenesis and glycogenolysis. Annu Rev Physiol 54: 885-909, 1992.
26. Rena G, Guo S, Cichy SC, Unterman TG, and Cohen P. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J Biol Chem 274: 17179-17183, 1999.
27. Schmoll D, Walker KS, Alessi DR, Grempler R, Burchell A, Guo S, Walther R, and Unterman TG. Regulation of glucose-6-phosphatase gene expression by protein kinase B alpha and the forkhead transcription factor FKHR. J Biol Chem: 36324-36333, 2000.
28. Scott DK, O'Doherty RM, Stafford JM, Newgard CB, and Granner DK. The repression of hormone-activated PEPCK gene expression by glucose is insulin-indepedent but requires glucose metabolism. J Biol Chem 273: 24145-24151, 1998.
29. Streeper RS, Svitek CA, Chapman S, Greenbaum LE, Taub R, and O'Brien RM. A multicomponent insulin response sequence mediates a strong repression of mouse glucose-6-phosphatase gene transcription by insulin. J Biol Chem 272: 11698-11701, 1997.
30. Tang ED, Nunez G, Barr FG, and Guan K-L. Negative regulation of the forkhead transcription factor FKHR by Akt. J Biol Chem 274: 16741-16746, 1999.
31. Tomizawa M, Kumar A, Perrot V, Nakae J, Accili D, and Rechler M. Insulin inhibits the activation of transcription by a C-terminal fragment of the forkhead transcription factor FKHR. J Biol Chem 275: 7289-7295, 2000.
32. Towle HC, Kaytor EN, and Shih HM. Regulation of the expression of lipogenic enzyme genes by carbohydrate. Annu Rev Nutr 17: 405-433, 1997.
33. Vallet V, Antoine B, Chafey P, Vandewalle A, and Kahn A. Overexpression of a truncated hepatocyte nuclear factor 3 protein inhibits expression of liver-specific genes in hepatoma cells. Mol Cell Biol 15: 5453-5460, 1995.
34. Wang JC, Stafford JM, Scott DK, Sutherland C, and Granner DK. The molecular physiology of hepatic nuclear factor 3 in the regulation of gluconeogenesis. J Biol Chem 275: 14717-14721, 2000.