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Volumn 32, Issue 8, 2012, Pages 1771-1776

Metabolic syndrome, insulin resistance, and roles of inflammation- mechanisms and therapeutic targets

Author keywords

anti inflammatory agents; atherosclerosis; immune system; insulin resistance; leukocytes

Indexed keywords

ADIPOCYTE; ADIPOSE TISSUE; ENDOTHELIUM CELL; HUMAN; IMMUNOCOMPETENT CELL; INFLAMMATION; INSULIN RESISTANCE; LEUKOCYTE; MACROPHAGE; METABOLIC SYNDROME X; MICROENVIRONMENT; NONHUMAN; OBESITY; PRIORITY JOURNAL; REVIEW; WHITE ADIPOSE TISSUE;

EID: 84864244872     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.111.241869     Document Type: Review
Times cited : (290)

References (57)
  • 1
    • 77950885686 scopus 로고    scopus 로고
    • The effects of salsalate on glycemic control in patients with type 2 diabetes: A randomized trial
    • TINSAL-T2D (Targeting Inflammation Using Salsalate In Type 2 Diabetes) Study Team
    • Goldfine AB, Fonseca V, Jablonski KA, Pyle L, Staten MA, Shoelson SE; TINSAL-T2D (Targeting Inflammation Using Salsalate in Type 2 Diabetes) Study Team. The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial. Ann Intern Med. 2010;152:346-357.
    • (2010) Ann Intern Med. , vol.152 , pp. 346-357
    • Goldfine, A.B.1    Fonseca, V.2    Jablonski, K.A.3    Pyle, L.4    Staten, M.A.5    Shoelson, S.E.6
  • 2
    • 56749164791 scopus 로고    scopus 로고
    • Nutrient sensing and inflammation in metabolic diseases
    • Hotamisligil GS, Erbay E. Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol. 2008;8:923-934.
    • (2008) Nat Rev Immunol , vol.8 , pp. 923-934
    • Hotamisligil, G.S.1    Erbay, E.2
  • 3
    • 33745571976 scopus 로고    scopus 로고
    • The immune response in atherosclerosis: A double-edged sword
    • DOI 10.1038/nri1882, PII N1882
    • Hansson GK, Libby P. The immune response in atherosclerosis: a double-edged sword. Nat Rev Immunol. 2006;6:508-519. (Pubitemid 43980523)
    • (2006) Nature Reviews Immunology , vol.6 , Issue.7 , pp. 508-519
    • Hansson, G.K.1    Libby, P.2
  • 4
    • 40049104892 scopus 로고    scopus 로고
    • Immunology of asthma and chronic obstructive pulmonary disease
    • DOI 10.1038/nri2254, PII NRI2254
    • Barnes PJ. Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol. 2008;8:183-192. (Pubitemid 351323287)
    • (2008) Nature Reviews Immunology , vol.8 , Issue.3 , pp. 183-192
    • Barnes, P.J.1
  • 7
    • 0036066485 scopus 로고    scopus 로고
    • High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes
    • Vozarova B, Weyer C, Lindsay RS, Pratley RE, Bogardus C, Tataranni PA. High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes. Diabetes. 2002;51:455-461. (Pubitemid 34764803)
    • (2002) Diabetes , vol.51 , Issue.2 , pp. 455-461
    • Vozarova, B.1    Weyer, C.2    Lindsay, R.S.3    Pratley, R.E.4    Bogardus, C.5    Antonio Tataranni, P.6
  • 8
    • 4644338458 scopus 로고    scopus 로고
    • Circulating mononuclear cells in the obese are in a proinflammatory state
    • DOI 10.1161/01.CIR.0000142055.53122.FA
    • Ghanim H, Aljada A, Hofmeyer D, Syed T, Mohanty P, Dandona P. Circulating mononuclear cells in the obese are in a proinflammatory state. Circulation. 2004;110:1564-1571. (Pubitemid 39297977)
    • (2004) Circulation , vol.110 , Issue.12 , pp. 1564-1571
    • Ghanim, H.1    Aljada, A.2    Hofmeyer, D.3    Syed, T.4    Mohanty, P.5    Dandona, P.6
  • 9
    • 68549130286 scopus 로고    scopus 로고
    • The role of interleukins in insulin resistance and type 2 diabetes mellitus
    • Fève B, Bastard JP. The role of interleukins in insulin resistance and type 2 diabetes mellitus. Nat Rev Endocrinol. 2009;5:305-311.
    • (2009) Nat Rev Endocrinol , vol.5 , pp. 305-311
    • Fève, B.1    Bastard, J.P.2
  • 10
    • 0038691972 scopus 로고    scopus 로고
    • Low-grade systemic inflammation and the development of type 2 diabetes: The atherosclerosis risk in communities study
    • Duncan BB, Schmidt MI, Pankow JS, Ballantyne CM, Couper D, Vigo A, Hoogeveen R, Folsom AR, Heiss G; Atherosclerosis Risk in Communities Study. Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study. Diabetes. 2003;52:1799-1805. (Pubitemid 36792473)
    • (2003) Diabetes , vol.52 , Issue.7 , pp. 1799-1805
    • Duncan, B.B.1    Schmidt, M.I.2    Pankow, J.S.3    Ballantyne, C.M.4    Couper, D.5    Vigo, A.6    Hoogeveen, R.7    Folsom, A.R.8    Heiss, G.9
  • 12
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-α: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993;259:87-91. (Pubitemid 23036092)
    • (1993) Science , vol.259 , Issue.5091 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 16
    • 34147167977 scopus 로고    scopus 로고
    • Improved insulin sensitivity by anti-TNFα antibody treatment in patients with rheumatic diseases [2]
    • DOI 10.1136/ard.2006.062323
    • Huvers FC, Popa C, Netea MG, van den Hoogen FH, Tack CJ. Improved insulin sensitivity by anti-TNFalpha antibody treatment in patients with rheumatic diseases. Ann Rheum Dis. 2007;66:558-559. (Pubitemid 46580485)
    • (2007) Annals of the Rheumatic Diseases , vol.66 , Issue.4 , pp. 558-559
    • Huvers, F.C.1    Popa, C.2    Netea, M.G.3    Van Den Hoogen, F.H.4    Tack, C.J.5
  • 17
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol. 2008;8:958-969.
    • (2008) Nat Rev Immunol , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 18
    • 28544446111 scopus 로고    scopus 로고
    • Monocyte and macrophage heterogeneity
    • DOI 10.1038/nri1733
    • Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol. 2005;5:953-964. (Pubitemid 41746764)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.12 , pp. 953-964
    • Gordon, S.1    Taylor, P.R.2
  • 19
    • 41549107522 scopus 로고    scopus 로고
    • Cytokine Signaling Modules in Inflammatory Responses
    • DOI 10.1016/j.immuni.2008.03.002, PII S1074761308001179
    • O'Shea JJ, Murray PJ. Cytokine signaling modules in inflammatory responses. Immunity. 2008;28:477-487. (Pubitemid 351467044)
    • (2008) Immunity , vol.28 , Issue.4 , pp. 477-487
    • O'Shea, J.J.1    Murray, P.J.2
  • 23
    • 0037963473 scopus 로고    scopus 로고
    • Blood monocytes consist of two principal subsets with distinct migratory properties
    • DOI 10.1016/S1074-7613(03)00174-2
    • Geissmann F, Jung S, Littman DR. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity. 2003;19:71-82. (Pubitemid 36859902)
    • (2003) Immunity , vol.19 , Issue.1 , pp. 71-82
    • Geissmann, F.1    Jung, S.2    Littman, D.R.3
  • 25
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • DOI 10.1172/JCI29881
    • Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest. 2007;117:175-184. (Pubitemid 46048464)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.1 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 26
    • 58149347227 scopus 로고    scopus 로고
    • Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes
    • Lumeng CN, DelProposto JB, Westcott DJ, Saltiel AR. Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes. 2008;57:3239-3246.
    • (2008) Diabetes , vol.57 , pp. 3239-3246
    • Lumeng, C.N.1    DelProposto, J.B.2    Westcott, D.J.3    Saltiel, A.R.4
  • 30
    • 52749092267 scopus 로고    scopus 로고
    • Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals
    • Patsouris D, Li PP, Thapar D, Chapman J, Olefsky JM, Neels JG. Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab. 2008;8:301-309.
    • (2008) Cell Metab , vol.8 , pp. 301-309
    • Patsouris, D.1    Li, P.P.2    Thapar, D.3    Chapman, J.4    Olefsky, J.M.5    Neels, J.G.6
  • 31
    • 34548354722 scopus 로고    scopus 로고
    • Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive pro-inflammatory mediator production
    • DOI 10.1038/sj.ijo.0803632, PII 0803632
    • Zeyda M, Farmer D, Todoric J, Aszmann O, Speiser M, Györi G, Zlabinger GJ, Stulnig TM. Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive pro-inflammatory mediator production. Int J Obes (Lond). 2007;31:1420-1428. (Pubitemid 47339934)
    • (2007) International Journal of Obesity , vol.31 , Issue.9 , pp. 1420-1428
    • Zeyda, M.1    Farmer, D.2    Todoric, J.3    Aszmann, O.4    Speiser, M.5    Gyori, G.6    Zlabinger, G.J.7    Stulnig, T.M.8
  • 34
    • 65649117802 scopus 로고    scopus 로고
    • Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity
    • Duffaut C, Galitzky J, Lafontan M, Bouloumié A. Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity. Biochem Biophys Res Commun. 2009;384:482-485.
    • (2009) Biochem Biophys Res Commun , vol.384 , pp. 482-485
    • Duffaut, C.1    Galitzky, J.2    Lafontan, M.3    Bouloumié, A.4
  • 36
    • 53149119231 scopus 로고    scopus 로고
    • Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding
    • Elgazar-Carmon V, Rudich A, Hadad N, Levy R. Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding. J Lipid Res. 2008;49:1894-1903.
    • (2008) J Lipid Res , vol.49 , pp. 1894-1903
    • Elgazar-Carmon, V.1    Rudich, A.2    Hadad, N.3    Levy, R.4
  • 42
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkβ
    • DOI 10.1126/science.1061620
    • Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, Shoelson SE. Reversal of obesity-and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science. 2001;293:1673-1677. (Pubitemid 32807849)
    • (2001) Science , vol.293 , Issue.5535 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3    Hansen, L.4    Li, Z.-W.5    Karin, M.6    Shoelson, S.E.7
  • 43
    • 28944446431 scopus 로고    scopus 로고
    • The many faces of ppargamma
    • Lehrke M, Lazar MA. The many faces of PPARgamma. Cell. 2005;123:993-999.
    • (2005) Cell , vol.123 , pp. 993-999
    • Lehrke, M.1    Lazar, M.A.2
  • 46
    • 52349105273 scopus 로고    scopus 로고
    • A predominant role for parenchymal c-jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity
    • Vallerie SN, Furuhashi M, Fucho R, Hotamisligil GS. A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity. PLoS ONE. 2008;3:e3151.
    • (2008) PLoS ONE , vol.3
    • Vallerie, S.N.1    Furuhashi, M.2    Fucho, R.3    Hotamisligil, G.S.4
  • 48
    • 64749086158 scopus 로고    scopus 로고
    • Preserved glucose tolerance in high-fat-fed c57bl/6 mice transplanted with ppargamma-/-, ppardelta-/-, ppargammadelta-/-, or lxralphabeta-/-bone marrow
    • Marathe C, Bradley MN, Hong C, Chao L, Wilpitz D, Salazar J, Tontonoz P. Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARgamma-/-, PPARdelta-/-, PPARgammadelta-/-, or LXRalphabeta-/-bone marrow. J Lipid Res. 2009;50:214-224.
    • (2009) J Lipid Res , vol.50 , pp. 214-224
    • Marathe, C.1    Bradley, M.N.2    Hong, C.3    Chao, L.4    Wilpitz, D.5    Salazar, J.6    Tontonoz, P.7
  • 53
    • 0029906375 scopus 로고    scopus 로고
    • Effects of an engineered human anti-TNF-α antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM
    • Ofei F, Hurel S, Newkirk J, Sopwith M, Taylor R. Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM. Diabetes. 1996;45:881-885. (Pubitemid 26225502)
    • (1996) Diabetes , vol.45 , Issue.SUPPL. , pp. 881-885
    • Ofei, F.1    Hurel, S.2    Newkirk, J.3    Sopwith, M.4    Taylor, R.5
  • 54
    • 0034454915 scopus 로고    scopus 로고
    • No increased insulin sensitivity after a single intravenous administration of a recombinant human tumor necrosis factor receptor: Fc fusion protein in obese insulin-resistant patients
    • DOI 10.1210/jc.85.3.1316
    • Paquot N, Castillo MJ, Lefèbvre PJ, Scheen AJ. No increased insulin sensitivity after a single intravenous administration of a recombinant human tumor necrosis factor receptor: Fc fusion protein in obese insulin-resistant patients. J Clin Endocrinol Metab. 2000;85:1316-1319. (Pubitemid 32269392)
    • (2000) Journal of Clinical Endocrinology and Metabolism , vol.85 , Issue.3 , pp. 1316-1319
    • Paquot, N.1    Castillo, M.J.2    Lefebvre, P.J.3    Scheen, A.J.4
  • 55
    • 78650917112 scopus 로고    scopus 로고
    • Tnf-alpha antagonism with etanercept decreases glucose and increases the proportion of high molecular weight adiponectin in obese subjects with features of the metabolic syndrome
    • Stanley TL, Zanni MV, Johnsen S, Rasheed S, Makimura H, Lee H, Khor VK, Ahima RS, Grinspoon SK. TNF-alpha antagonism with etanercept decreases glucose and increases the proportion of high molecular weight adiponectin in obese subjects with features of the metabolic syndrome. J Clin Endocrinol Metab. 2011;96:E146-E150.
    • (2011) J Clin Endocrinol Metab. , vol.96
    • Stanley, T.L.1    Zanni, M.V.2    Johnsen, S.3    Rasheed, S.4    Makimura, H.5    Lee, H.6    Khor, V.K.7    Ahima, R.S.8    Grinspoon, S.K.9
  • 56
    • 38949119419 scopus 로고    scopus 로고
    • Salsalate improves glycemia and inflammatory parameters in obese young adults
    • DOI 10.2337/dc07-1338
    • Fleischman A, Shoelson SE, Bernier R, Goldfine AB. Salsalate improves glycemia and inflammatory parameters in obese young adults. Diabetes Care. 2008;31:289-294. (Pubitemid 351213338)
    • (2008) Diabetes Care , vol.31 , Issue.2 , pp. 289-294
    • Fleischman, A.1    Shoelson, S.E.2    Bernier, R.3    Goldfine, A.B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.