Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38α MAPK during insulin resistance

Diabetes

Volumn 62, Issue 11, 2013, Pages 3887-3900

  Qi, Yajuan ^a,b   Xu, Zihui ^a,c   Zhu, Qinglei ^a   Thomas, Candice ^a   Kumar, Rajesh ^a   Feng, Hao ^a   Dostal, David E ^a   White, Morris F ^d   Baker, Kenneth M ^a   Guo, Shaodong ^a  

^a TEXAS A M COLLEGE OF MEDICINE   (United States)

^b HEBEI UNITED UNIVERSITY   (China)

^c THIRD MILITARY MEDICAL UNIVERSITY   (China)

^d BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MITOGEN ACTIVATED PROTEIN KINASE 14; PROTEIN KINASE B; TRANSCRIPTION FACTOR FKHR; INSULIN RECEPTOR SUBSTRATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME ACTIVATION; GENE EXPRESSION; HEART FAILURE; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART VENTRICLE SIZE; HYPERINSULINEMIA; INSULIN RESISTANCE; KNOCKOUT MOUSE; MOUSE; NEWBORN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN CONTENT; SIGNAL TRANSDUCTION; ANIMAL; DEFICIENCY; DRUG EFFECTS; GENETICS; HYPERINSULINISM; METABOLISM; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; RAT; DRUG EFFECT;

ANIMALS; ENERGY METABOLISM; HEART FAILURE; HYPERINSULINISM; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 14; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION;

EID: 84891685859     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-0095     Document Type: Article

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