Reconstitution of insulin action in muscle, white adipose tissue, and brain of insulin receptor knock-out mice fails to rescue diabetes

Journal of Biological Chemistry

Volumn 286, Issue 11, 2011, Pages 9797-9804

  Lin, Hua V ^a,b   Accili, Domenico ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASE PROGRESSION; GLUCOSE PRODUCTION; GLUCOSE UPTAKE; IN-LINE; INSULIN ACTION; INSULIN RECEPTORS; INSULIN SIGNALING; KNOCK OUTS; RELATIVE IMPORTANCE; TYPE-2 DIABETES; WHITE ADIPOSE TISSUES;

GLUCOSE; HISTOLOGY; MUSCLE; SIGNALING;

INSULIN;

GLUCOSE; INSULIN; INSULIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; DYSLIPIDEMIA; FAILURE TO THRIVE; GLUCOSE TRANSPORT; HORMONE ACTION; LIPODYSTROPHY; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKELETAL MUSCLE; SURVIVAL; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE, WHITE; ANIMALS; BRAIN; DIABETES MELLITUS, TYPE 2; GLUCOSE TRANSPORTER TYPE 4; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, KNOCKOUT; MUSCLE, SKELETAL; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

MURINAE; MUS;

EID: 79953218702     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.210807     Document Type: Article

References (47)

1. Accili, D. (2004) Diabetes 53, 1633-1642
2. Nandi, A., Kitamura, Y., Kahn, C. R., and Accili, D. (2004) Physiol. Rev. 84, 623-647
3. Okamoto, H., and Accili, D. (2003) J. Biol. Chem. 278, 28359-28362
4. Okamoto, H., Nakae, J., Kitamura, T., Park, B. C., Dragatsis, I., and Accili, D. (2004) J. Clin. Invest. 114, 214-223
5. Okamoto, H., Obici, S., Accili, D., and Rossetti, L. (2005) J. Clin. Invest. 115, 1314-1322
6. Kitamura, T., Kitamura, Y., Nakae, J., Giordano, A., Cinti, S., Kahn, C. R., Efstratiadis, A., and Accili, D. (2004) J. Clin. Invest. 113, 209-219
7. Accili, D., Drago, J., Lee, E. J., Johnson, M. D., Cool, M. H., Salvatore, P., Asico, L. D., José, P. A., Taylor, S. I., and Westphal, H. (1996) Nat. Genet. 12, 106-109
8. Zhu, Y., Romero, M. I., Ghosh, P., Ye, Z., Charnay, P., Rushing, E. J., Marth, J. D., and Parada, L. F. (2001) Genes Dev. 15, 859-876
9. Lin, H. V., Kim, J. Y., Pocai, A., Rossetti, L., Shapiro, L., Scherer, P. E., and Accili, D. (2007) Diabetes 56, 1969-1976
10. Matsumoto, M., Pocai, A., Rossetti, L., Depinho, R. A., and Accili, D. (2007) Cell Metab. 6, 208-216
11. Kitamura, Y. I., Kitamura, T., Kruse, J. P., Raum, J. C., Stein, R., Gu, W., and Accili, D. (2005) Cell Metab. 2, 153-163
12. Okamoto, H., Hribal, M. L., Lin, H. V., Bennett, W. R., Ward, A., and Accili, D. (2006) J. Clin. Invest. 116, 775-782
13. Seino, S., and Bell, G. I. (1989) Biochem. Biophys. Res. Commun. 159, 312-316
14. Moller, D. E., Yokota, A., Caro, J. F., and Flier, J. S. (1989) Mol. Endocrinol. 3, 1263-1269
15. Vannucci, S. J., Koehler-Stec, E. M., Li, K., Reynolds, T. H., Clark, R., and Simpson, I. A. (1998) Brain Res. 797, 1-11
16. Sankar, R., Thamotharan, S., Shin, D., Moley, K. H., and Devaskar, S. U. (2002) Brain Res. Mol. Brain Res. 107, 157-165
17. Komori, T., Morikawa, Y., Tamura, S., Doi, A., Nanjo, K., and Senba, E. (2005) Brain Res. 1049, 34-42
18. Joshi, R. L., Lamothe, B., Cordonnier, N., Mesbah, K., Monthioux, E., Jami, J., and Bucchini, D. (1996) EMBO J. 15, 1542-1547
19. Kitamura, T., Kitamura, Y. I., Funahashi, Y., Shawber, C. J., Castrillon, D. H., Kollipara, R., DePinho, R. A., Kitajewski, J., and Accili, D. (2007) J. Clin. Invest. 117, 2477-2485
20. Lin, J., Wu, H., Tarr, P. T., Zhang, C. Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., Lowell, B. B., Bassel-Duby, R., and Spiegelman, B. M. (2002) Nature 418, 797-801
21. Cinti, S., Eberbach, S., Castellucci, M., and Accili, D. (1998) Diabetologia 41, 171-177
22. Shimomura, I., Hammer, R. E., Richardson, J. A., Ikemoto, S., Bashmakov, Y., Goldstein, J. L., and Brown, M. S. (1998) Genes Dev. 12, 3182-3194
23. Pajvani, U. B., Trujillo, M. E., Combs, T. P., Iyengar, P., Jelicks, L., Roth, K. A., Kitsis, R. N., and Scherer, P. E. (2005) Nat. Med. 11, 797-803
24. Shimomura, I., Matsuda, M., Hammer, R. E., Bashmakov, Y., Brown, M. S., and Goldstein, J. L. (2000) Mol. Cell. 6, 77-86
25. Matsumoto, M., Han, S., Kitamura, T., and Accili, D. (2006) J. Clin. Invest. 116, 2464-2472
26. Biddinger, S. B., Hernandez-Ono, A., Rask-Madsen, C., Haas, J. T., Alemán, J. O., Suzuki, R., Scapa, E. F., Agarwal, C., Carey, M. C., Stephanopoulos, G., Cohen, D. E., King, G. L., Ginsberg, H. N., and Kahn, C. R. (2008) Cell Metab. 7, 125-134
27. Okada, T., Liew, C. W., Hu, J., Hinault, C., Michael, M. D., Krtzfeldt, J., Yin, C., Holzenberger, M., Stoffel, M., and Kulkarni, R. N. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 8977-8982
28. Xuan, S., Szabolcs, M., Cinti, F., Perincheri, S., Accili, D., and Efstratiadis, A. (2010) J. Biol. Chem. 285, 41044-41050
29. Kido, Y., Nakae, J., Hribal, M. L., Xuan, S., Efstratiadis, A., and Accili, D. (2002) J. Biol. Chem. 277, 36740-36747
30. Buteau, J., Shlien, A., Foisy, S., and Accili, D. (2007) J. Biol. Chem. 282, 287-293
31. Kawamori, D., Kaneto, H., Nakatani, Y., Matsuoka, T. A., Matsuhisa, M., Hori, M., and Yamasaki, Y. (2006) J. Biol. Chem. 281, 1091-1098
32. Petersen, K. F., Dufour, S., Savage, D. B., Bilz, S., Solomon, G., Yonemitsu, S., Cline, G. W., Befroy, D., Zemany, L., Kahn, B. B., Papademetris, X., Rothman, D. L., and Shulman, G. I. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 12587-12594
33. Lauro, D., Kido, Y., Castle, A. L., Zarnowski, M. J., Hayashi, H., Ebina, Y., and Accili, D. (1998) Nat. Genet. 20, 294-298
34. Brüning, J. C., Michael, M. D., Winnay, J. N., Hayashi, T., Hörsch, D., Accili, D., Goodyear, L. J., and Kahn, C. R. (1998) Mol. Cell. 2, 559-569
35. Blüher, M., Michael, M. D., Peroni, O. D., Ueki, K., Carter, N., Kahn, B. B., and Kahn, C. R. (2002) Dev. Cell. 3, 25-38
36. Kotani, K., Peroni, O. D., Minokoshi, Y., Boss, O., and Kahn, B. B. (2004) J. Clin. Invest. 114, 1666-1675
37. Obici, S., Feng, Z., Karkanias, G., Baskin, D. G., and Rossetti, L. (2002) Nat. Neurosci. 5, 566-572
38. Lin, H. V., Plum, L., Ono, H., Gutiérrez-Juárez, R., Shanabrough, M., Borok, E., Horvath, T. L., Rossetti, L., and Accili, D. (2010) Diabetes 59, 337-346
39. Könner, A. C., Janoschek, R., Plum, L., Jordan, S. D., Rother, E., Ma, X., Xu, C., Enriori, P., Hampel, B., Barsh, G. S., Kahn, C. R., Cowley, M. A., Ashcroft, F. M., and Brüning, J. C. (2007) Cell Metab. 5, 438-449
40. Pocai, A., Lam, T. K., Gutierrez-Juarez, R., Obici, S., Schwartz, G. J., Bryan, J., Aguilar-Bryan, L., and Rossetti, L. (2005) Nature 434, 1026-1031
41. Maher, F., Vannucci, S. J., and Simpson, I. A. (1994) FASEB J. 8, 1003-1011
42. Monnier, L., Colette, C., Dunseath, G. J., and Owens, D. R. (2007) Diabetes Care. 30, 263-269
43. Kulkarni, R. N., Brüning, J. C., Winnay, J. N., Postic, C., Magnuson, M. A., and Kahn, C. R. (1999) Cell 96, 329-339
44. Ueki, K., Okada, T., Hu, J., Liew, C. W., Assmann, A., Dahlgren, G. M., Peters, J. L., Shackman, J. G., Zhang, M., Artner, I., Satin, L. S., Stein, R., Holzenberger, M., Kennedy, R. T., Kahn, C. R., and Kulkarni, R. N. (2006) Nat. Genet. 38, 583-588
45. Nakae, J., Kido, Y., and Accili, D. (2001) Endocr. Rev. 22, 818-835
46. Girard, J., Ferré, P., Pégorier, J. P., and Duée, P. H. (1992) Physiol. Rev. 72, 507-562
47. Lin, H. V., Ren, H., Samuel, V. T., Lee, H. Y., Lu, T. Y., Shulman, G. I., and Accili, D. (2011) Diabetes, in press