-
1
-
-
79751531393
-
Heart disease and stroke statistics - 2011 update: A report from the American Heart Association
-
V.L. Roger Heart disease and stroke statistics - 2011 update: a report from the American Heart Association Circulation 123 2011 e18 e209
-
(2011)
Circulation
, vol.123
-
-
Roger, V.L.1
-
2
-
-
78649326868
-
Diabetic cardiomyopathy: Mechanisms and therapeutic targets
-
P.K. Battiprolu Diabetic cardiomyopathy: mechanisms and therapeutic targets Drug Discov. Today Disease Mech. 7 2010 e135 e143
-
(2010)
Drug Discov. Today Disease Mech.
, vol.7
-
-
Battiprolu, P.K.1
-
3
-
-
29144453326
-
Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
-
D.M. Nathan Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes N. Engl. J. Med. 353 2005 2643 2653
-
(2005)
N. Engl. J. Med.
, vol.353
, pp. 2643-2653
-
-
Nathan, D.M.1
-
4
-
-
79957580930
-
Diabetes: ACCORD: 5-year outcomes of intensive glycemic control
-
C. Wilson Diabetes: ACCORD: 5-year outcomes of intensive glycemic control Nat. Rev. Endocrinol. 7 2011 314
-
(2011)
Nat. Rev. Endocrinol.
, vol.7
, pp. 314
-
-
Wilson, C.1
-
5
-
-
50549202600
-
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
-
P.J. Randle The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus Lancet 1 1963 785 789
-
(1963)
Lancet
, vol.1
, pp. 785-789
-
-
Randle, P.J.1
-
6
-
-
13344277357
-
Early neonatal death in mice homozygous for a null allele of the insulin receptor gene
-
D. Accili Early neonatal death in mice homozygous for a null allele of the insulin receptor gene Nat. Genet. 12 1996 106 109
-
(1996)
Nat. Genet.
, vol.12
, pp. 106-109
-
-
Accili, D.1
-
7
-
-
4043106461
-
Transgenic rescue of insulin receptor-deficient mice
-
H. Okamoto Transgenic rescue of insulin receptor-deficient mice J. Clin. Invest. 114 2004 214 223
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 214-223
-
-
Okamoto, H.1
-
8
-
-
79953218702
-
Reconstitution of insulin action in muscle, white adipose tissue, and brain of insulin receptor knock-out mice fails to rescue diabetes
-
H.V. Lin, and D. Accili Reconstitution of insulin action in muscle, white adipose tissue, and brain of insulin receptor knock-out mice fails to rescue diabetes J. Biol. Chem. 286 2011 9797 9804
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 9797-9804
-
-
Lin, H.V.1
Accili, D.2
-
9
-
-
0033636523
-
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
-
M.D. Michael Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction Mol. Cell 6 2000 87 97
-
(2000)
Mol. Cell
, vol.6
, pp. 87-97
-
-
Michael, M.D.1
-
10
-
-
0034703229
-
Role of brain insulin receptor in control of body weight and reproduction
-
J.C. Bruning Role of brain insulin receptor in control of body weight and reproduction Science 289 2000 2122 2125
-
(2000)
Science
, vol.289
, pp. 2122-2125
-
-
Bruning, J.C.1
-
11
-
-
0032214652
-
A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
-
J.C. Bruning A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance Mol. Cell 2 1998 559 569
-
(1998)
Mol. Cell
, vol.2
, pp. 559-569
-
-
Bruning, J.C.1
-
12
-
-
36248965746
-
Mitochondrial gene expression and increased oxidative metabolism: Role in increased lifespan of fat-specific insulin receptor knock-out mice
-
M. Katic Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice Aging Cell 6 2007 827 839
-
(2007)
Aging Cell
, vol.6
, pp. 827-839
-
-
Katic, M.1
-
13
-
-
0344305782
-
Insulin signaling in health and disease
-
M.F. White Insulin signaling in health and disease Science 302 2003 1710 1711
-
(2003)
Science
, vol.302
, pp. 1710-1711
-
-
White, M.F.1
-
14
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
-
D.R. Alessi Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha Curr. Biol. 7 1997 261 269
-
(1997)
Curr. Biol.
, vol.7
, pp. 261-269
-
-
Alessi, D.R.1
-
15
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
D.D. Sarbassov Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex Science 307 2005 1098 1101
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
-
16
-
-
0033546192
-
Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence
-
S. Guo Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence J. Biol. Chem. 274 1999 17184 17192
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 17184-17192
-
-
Guo, S.1
-
17
-
-
84862909028
-
Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice
-
K. Zhang Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice Endocrinology 153 2012 631 646
-
(2012)
Endocrinology
, vol.153
, pp. 631-646
-
-
Zhang, K.1
-
18
-
-
33748745399
-
Transcriptional genomics associates FOX transcription factors with human heart failure
-
S. Hannenhalli Transcriptional genomics associates FOX transcription factors with human heart failure Circulation 114 2006 1269 1276
-
(2006)
Circulation
, vol.114
, pp. 1269-1276
-
-
Hannenhalli, S.1
-
19
-
-
84863283393
-
Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice
-
P.K. Battiprolu Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice J. Clin. Invest. 122 2012 1109 1118
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 1109-1118
-
-
Battiprolu, P.K.1
-
20
-
-
41449088342
-
Regulation of cardiomyocyte proliferation and myocardial growth during development by FOXO transcription factors
-
H.J. Evans-Anderson Regulation of cardiomyocyte proliferation and myocardial growth during development by FOXO transcription factors Circ. Res. 102 2008 686 694
-
(2008)
Circ. Res.
, vol.102
, pp. 686-694
-
-
Evans-Anderson, H.J.1
-
21
-
-
33751533918
-
The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling
-
S. Guo The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling Mol. Endocrinol. 20 2006 3389 3399
-
(2006)
Mol. Endocrinol.
, vol.20
, pp. 3389-3399
-
-
Guo, S.1
-
22
-
-
70249108137
-
The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis
-
S. Guo The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis Mol. Cell Biol. 29 2009 5070 5083
-
(2009)
Mol. Cell Biol.
, vol.29
, pp. 5070-5083
-
-
Guo, S.1
-
23
-
-
0028032895
-
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
-
E. Araki Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene Nature 372 1994 186 190
-
(1994)
Nature
, vol.372
, pp. 186-190
-
-
Araki, E.1
-
24
-
-
0032567937
-
Disruption of IRS-2 causes type 2 diabetes in mice
-
D.J. Withers Disruption of IRS-2 causes type 2 diabetes in mice Nature 391 1998 900 904
-
(1998)
Nature
, vol.391
, pp. 900-904
-
-
Withers, D.J.1
-
25
-
-
45549090182
-
Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation
-
X.C. Dong Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation Cell Metab. 8 2008 65 76
-
(2008)
Cell Metab.
, vol.8
, pp. 65-76
-
-
Dong, X.C.1
-
26
-
-
78751485448
-
Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways
-
Y.C. Long Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways Mol. Cell Biol. 31 2011 430 441
-
(2011)
Mol. Cell Biol.
, vol.31
, pp. 430-441
-
-
Long, Y.C.1
-
27
-
-
0033546439
-
Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
-
G. Rena Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B J. Biol. Chem. 274 1999 17179 17183
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 17179-17183
-
-
Rena, G.1
-
28
-
-
0033522897
-
Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway
-
J. Nakae Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway J. Biol. Chem. 274 1999 15982 15985
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 15982-15985
-
-
Nakae, J.1
-
29
-
-
0141706357
-
Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation
-
H. Matsuzaki Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation Proc. Natl. Acad. Sci. U. S. A. 100 2003 11285 11290
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 11285-11290
-
-
Matsuzaki, H.1
-
30
-
-
0033595011
-
Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
-
W.H. Biggs 3rd Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1 Proc. Natl. Acad. Sci. U. S. A. 96 1999 7421 7426
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 7421-7426
-
-
Biggs III, W.H.1
-
31
-
-
1542267804
-
Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification
-
T. Hosaka Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification Proc. Natl. Acad. Sci. U. S. A. 101 2004 2975 2980
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 2975-2980
-
-
Hosaka, T.1
-
32
-
-
0030659557
-
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
-
S. Ogg The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans Nature 389 1997 994 999
-
(1997)
Nature
, vol.389
, pp. 994-999
-
-
Ogg, S.1
-
33
-
-
34547097247
-
Brain IRS2 signaling coordinates life span and nutrient homeostasis
-
A. Taguchi Brain IRS2 signaling coordinates life span and nutrient homeostasis Science 317 2007 369 372
-
(2007)
Science
, vol.317
, pp. 369-372
-
-
Taguchi, A.1
-
34
-
-
84866122780
-
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
-
K.D. Copps, and M.F. White Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 Diabetologia 55 2012 2565 2582
-
(2012)
Diabetologia
, vol.55
, pp. 2565-2582
-
-
Copps, K.D.1
White, M.F.2
-
35
-
-
70350439438
-
Insulin is a stronger inducer of insulin resistance than hyperglycemia in mice with type 1 diabetes mellitus (T1DM)
-
H.Y. Liu Insulin is a stronger inducer of insulin resistance than hyperglycemia in mice with type 1 diabetes mellitus (T1DM) J. Biol. Chem. 284 2009 27090 27100
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 27090-27100
-
-
Liu, H.Y.1
-
36
-
-
9644260563
-
Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes
-
X. Lin Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes J. Clin. Invest. 114 2004 908 916
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 908-916
-
-
Lin, X.1
-
37
-
-
0037456304
-
STAT3 signalling is required for leptin regulation of energy balance but not reproduction
-
S.H. Bates STAT3 signalling is required for leptin regulation of energy balance but not reproduction Nature 421 2003 856 859
-
(2003)
Nature
, vol.421
, pp. 856-859
-
-
Bates, S.H.1
-
38
-
-
84869050741
-
Central nervous system control of metabolism
-
M.G. Myers Jr., and D.P. Olson Central nervous system control of metabolism Nature 491 2012 357 363
-
(2012)
Nature
, vol.491
, pp. 357-363
-
-
Myers, Jr.M.G.1
Olson, D.P.2
-
39
-
-
82955239851
-
Impairment of central leptin-mediated PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity
-
J.P. Warne Impairment of central leptin-mediated PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity Cell Metab. 14 2011 791 803
-
(2011)
Cell Metab.
, vol.14
, pp. 791-803
-
-
Warne, J.P.1
-
40
-
-
84860451500
-
IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action
-
M. Sadagurski IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action Cell Metab. 15 2012 703 712
-
(2012)
Cell Metab.
, vol.15
, pp. 703-712
-
-
Sadagurski, M.1
-
41
-
-
33646590947
-
Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake
-
T. Kitamura Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake Nat. Med. 12 2006 534 540
-
(2006)
Nat. Med.
, vol.12
, pp. 534-540
-
-
Kitamura, T.1
-
42
-
-
84861976352
-
FoxO1 target Gpr17 activates AgRP neurons to regulate food intake
-
H. Ren FoxO1 target Gpr17 activates AgRP neurons to regulate food intake Cell 149 2012 1314 1326
-
(2012)
Cell
, vol.149
, pp. 1314-1326
-
-
Ren, H.1
-
43
-
-
70350369729
-
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake
-
L. Plum The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake Nat. Med. 15 2009 1195 1201
-
(2009)
Nat. Med.
, vol.15
, pp. 1195-1201
-
-
Plum, L.1
-
44
-
-
0036787607
-
Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
-
J. Nakae Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1 Nat. Genet. 32 2002 245 253
-
(2002)
Nat. Genet.
, vol.32
, pp. 245-253
-
-
Nakae, J.1
-
45
-
-
84866389264
-
Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure
-
C. Talchai Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure Cell 150 2012 1223 1234
-
(2012)
Cell
, vol.150
, pp. 1223-1234
-
-
Talchai, C.1
-
46
-
-
58149328550
-
Effect of endothelium-specific insulin resistance on endothelial function in vivo
-
E.R. Duncan Effect of endothelium-specific insulin resistance on endothelial function in vivo Diabetes 57 2008 3307 3314
-
(2008)
Diabetes
, vol.57
, pp. 3307-3314
-
-
Duncan, E.R.1
-
47
-
-
77955292064
-
Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein e null mice
-
C. Rask-Madsen Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice Cell Metab. 11 2010 379 389
-
(2010)
Cell Metab.
, vol.11
, pp. 379-389
-
-
Rask-Madsen, C.1
-
48
-
-
79952142784
-
Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle
-
T. Kubota Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle Cell Metab. 13 2011 294 307
-
(2011)
Cell Metab.
, vol.13
, pp. 294-307
-
-
Kubota, T.1
-
49
-
-
84858066279
-
FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis
-
K. Tsuchiya FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis Cell Metab. 15 2012 372 381
-
(2012)
Cell Metab.
, vol.15
, pp. 372-381
-
-
Tsuchiya, K.1
-
50
-
-
84866944897
-
RTEF-1 attenuates blood glucose levels by regulating insulin-like growth factor binding protein-1 in the endothelium
-
A.F. Messmer-Blust RTEF-1 attenuates blood glucose levels by regulating insulin-like growth factor binding protein-1 in the endothelium Circ. Res. 111 2012 991 1001
-
(2012)
Circ. Res.
, vol.111
, pp. 991-1001
-
-
Messmer-Blust, A.F.1
-
51
-
-
77955035304
-
Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism
-
M. Ferron Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism Cell 142 2010 296 308
-
(2010)
Cell
, vol.142
, pp. 296-308
-
-
Ferron, M.1
-
52
-
-
77955082747
-
Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition
-
K. Fulzele Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition Cell 142 2010 309 319
-
(2010)
Cell
, vol.142
, pp. 309-319
-
-
Fulzele, K.1
-
53
-
-
74949089660
-
FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice
-
M.T. Rached FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice J. Clin. Invest. 120 2010 357 368
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 357-368
-
-
Rached, M.T.1
|