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Volumn 10, Issue 1-2, 2013, Pages

Molecular basis of insulin resistance: The role of IRS and Foxo1 in the control of diabetes mellitus and its complications

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; GLUCAGON LIKE PEPTIDE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; METFORMIN; SOMATOMEDIN C; TRANSCRIPTION FACTOR FKHR;

EID: 84880234110     PISSN: None     EISSN: 17406765     Source Type: Journal    
DOI: 10.1016/j.ddmec.2013.06.003     Document Type: Review
Times cited : (49)

References (53)
  • 1
    • 79751531393 scopus 로고    scopus 로고
    • Heart disease and stroke statistics - 2011 update: A report from the American Heart Association
    • V.L. Roger Heart disease and stroke statistics - 2011 update: a report from the American Heart Association Circulation 123 2011 e18 e209
    • (2011) Circulation , vol.123
    • Roger, V.L.1
  • 2
    • 78649326868 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy: Mechanisms and therapeutic targets
    • P.K. Battiprolu Diabetic cardiomyopathy: mechanisms and therapeutic targets Drug Discov. Today Disease Mech. 7 2010 e135 e143
    • (2010) Drug Discov. Today Disease Mech. , vol.7
    • Battiprolu, P.K.1
  • 3
    • 29144453326 scopus 로고    scopus 로고
    • Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
    • D.M. Nathan Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes N. Engl. J. Med. 353 2005 2643 2653
    • (2005) N. Engl. J. Med. , vol.353 , pp. 2643-2653
    • Nathan, D.M.1
  • 4
    • 79957580930 scopus 로고    scopus 로고
    • Diabetes: ACCORD: 5-year outcomes of intensive glycemic control
    • C. Wilson Diabetes: ACCORD: 5-year outcomes of intensive glycemic control Nat. Rev. Endocrinol. 7 2011 314
    • (2011) Nat. Rev. Endocrinol. , vol.7 , pp. 314
    • Wilson, C.1
  • 5
    • 50549202600 scopus 로고
    • The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
    • P.J. Randle The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus Lancet 1 1963 785 789
    • (1963) Lancet , vol.1 , pp. 785-789
    • Randle, P.J.1
  • 6
    • 13344277357 scopus 로고    scopus 로고
    • Early neonatal death in mice homozygous for a null allele of the insulin receptor gene
    • D. Accili Early neonatal death in mice homozygous for a null allele of the insulin receptor gene Nat. Genet. 12 1996 106 109
    • (1996) Nat. Genet. , vol.12 , pp. 106-109
    • Accili, D.1
  • 7
    • 4043106461 scopus 로고    scopus 로고
    • Transgenic rescue of insulin receptor-deficient mice
    • H. Okamoto Transgenic rescue of insulin receptor-deficient mice J. Clin. Invest. 114 2004 214 223
    • (2004) J. Clin. Invest. , vol.114 , pp. 214-223
    • Okamoto, H.1
  • 8
    • 79953218702 scopus 로고    scopus 로고
    • Reconstitution of insulin action in muscle, white adipose tissue, and brain of insulin receptor knock-out mice fails to rescue diabetes
    • H.V. Lin, and D. Accili Reconstitution of insulin action in muscle, white adipose tissue, and brain of insulin receptor knock-out mice fails to rescue diabetes J. Biol. Chem. 286 2011 9797 9804
    • (2011) J. Biol. Chem. , vol.286 , pp. 9797-9804
    • Lin, H.V.1    Accili, D.2
  • 9
    • 0033636523 scopus 로고    scopus 로고
    • Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
    • M.D. Michael Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction Mol. Cell 6 2000 87 97
    • (2000) Mol. Cell , vol.6 , pp. 87-97
    • Michael, M.D.1
  • 10
    • 0034703229 scopus 로고    scopus 로고
    • Role of brain insulin receptor in control of body weight and reproduction
    • J.C. Bruning Role of brain insulin receptor in control of body weight and reproduction Science 289 2000 2122 2125
    • (2000) Science , vol.289 , pp. 2122-2125
    • Bruning, J.C.1
  • 11
    • 0032214652 scopus 로고    scopus 로고
    • A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
    • J.C. Bruning A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance Mol. Cell 2 1998 559 569
    • (1998) Mol. Cell , vol.2 , pp. 559-569
    • Bruning, J.C.1
  • 12
    • 36248965746 scopus 로고    scopus 로고
    • Mitochondrial gene expression and increased oxidative metabolism: Role in increased lifespan of fat-specific insulin receptor knock-out mice
    • M. Katic Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice Aging Cell 6 2007 827 839
    • (2007) Aging Cell , vol.6 , pp. 827-839
    • Katic, M.1
  • 13
    • 0344305782 scopus 로고    scopus 로고
    • Insulin signaling in health and disease
    • M.F. White Insulin signaling in health and disease Science 302 2003 1710 1711
    • (2003) Science , vol.302 , pp. 1710-1711
    • White, M.F.1
  • 14
    • 0031127305 scopus 로고    scopus 로고
    • Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
    • D.R. Alessi Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha Curr. Biol. 7 1997 261 269
    • (1997) Curr. Biol. , vol.7 , pp. 261-269
    • Alessi, D.R.1
  • 15
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • D.D. Sarbassov Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex Science 307 2005 1098 1101
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1
  • 16
    • 0033546192 scopus 로고    scopus 로고
    • Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence
    • S. Guo Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence J. Biol. Chem. 274 1999 17184 17192
    • (1999) J. Biol. Chem. , vol.274 , pp. 17184-17192
    • Guo, S.1
  • 17
    • 84862909028 scopus 로고    scopus 로고
    • Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice
    • K. Zhang Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice Endocrinology 153 2012 631 646
    • (2012) Endocrinology , vol.153 , pp. 631-646
    • Zhang, K.1
  • 18
    • 33748745399 scopus 로고    scopus 로고
    • Transcriptional genomics associates FOX transcription factors with human heart failure
    • S. Hannenhalli Transcriptional genomics associates FOX transcription factors with human heart failure Circulation 114 2006 1269 1276
    • (2006) Circulation , vol.114 , pp. 1269-1276
    • Hannenhalli, S.1
  • 19
    • 84863283393 scopus 로고    scopus 로고
    • Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice
    • P.K. Battiprolu Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice J. Clin. Invest. 122 2012 1109 1118
    • (2012) J. Clin. Invest. , vol.122 , pp. 1109-1118
    • Battiprolu, P.K.1
  • 20
    • 41449088342 scopus 로고    scopus 로고
    • Regulation of cardiomyocyte proliferation and myocardial growth during development by FOXO transcription factors
    • H.J. Evans-Anderson Regulation of cardiomyocyte proliferation and myocardial growth during development by FOXO transcription factors Circ. Res. 102 2008 686 694
    • (2008) Circ. Res. , vol.102 , pp. 686-694
    • Evans-Anderson, H.J.1
  • 21
    • 33751533918 scopus 로고    scopus 로고
    • The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling
    • S. Guo The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling Mol. Endocrinol. 20 2006 3389 3399
    • (2006) Mol. Endocrinol. , vol.20 , pp. 3389-3399
    • Guo, S.1
  • 22
    • 70249108137 scopus 로고    scopus 로고
    • The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis
    • S. Guo The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis Mol. Cell Biol. 29 2009 5070 5083
    • (2009) Mol. Cell Biol. , vol.29 , pp. 5070-5083
    • Guo, S.1
  • 23
    • 0028032895 scopus 로고
    • Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
    • E. Araki Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene Nature 372 1994 186 190
    • (1994) Nature , vol.372 , pp. 186-190
    • Araki, E.1
  • 24
    • 0032567937 scopus 로고    scopus 로고
    • Disruption of IRS-2 causes type 2 diabetes in mice
    • D.J. Withers Disruption of IRS-2 causes type 2 diabetes in mice Nature 391 1998 900 904
    • (1998) Nature , vol.391 , pp. 900-904
    • Withers, D.J.1
  • 25
    • 45549090182 scopus 로고    scopus 로고
    • Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation
    • X.C. Dong Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation Cell Metab. 8 2008 65 76
    • (2008) Cell Metab. , vol.8 , pp. 65-76
    • Dong, X.C.1
  • 26
    • 78751485448 scopus 로고    scopus 로고
    • Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways
    • Y.C. Long Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways Mol. Cell Biol. 31 2011 430 441
    • (2011) Mol. Cell Biol. , vol.31 , pp. 430-441
    • Long, Y.C.1
  • 27
    • 0033546439 scopus 로고    scopus 로고
    • Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
    • G. Rena Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B J. Biol. Chem. 274 1999 17179 17183
    • (1999) J. Biol. Chem. , vol.274 , pp. 17179-17183
    • Rena, G.1
  • 28
    • 0033522897 scopus 로고    scopus 로고
    • Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway
    • J. Nakae Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway J. Biol. Chem. 274 1999 15982 15985
    • (1999) J. Biol. Chem. , vol.274 , pp. 15982-15985
    • Nakae, J.1
  • 29
    • 0141706357 scopus 로고    scopus 로고
    • Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation
    • H. Matsuzaki Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation Proc. Natl. Acad. Sci. U. S. A. 100 2003 11285 11290
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 11285-11290
    • Matsuzaki, H.1
  • 30
    • 0033595011 scopus 로고    scopus 로고
    • Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
    • W.H. Biggs 3rd Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1 Proc. Natl. Acad. Sci. U. S. A. 96 1999 7421 7426
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 7421-7426
    • Biggs III, W.H.1
  • 31
    • 1542267804 scopus 로고    scopus 로고
    • Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification
    • T. Hosaka Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification Proc. Natl. Acad. Sci. U. S. A. 101 2004 2975 2980
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 2975-2980
    • Hosaka, T.1
  • 32
    • 0030659557 scopus 로고    scopus 로고
    • The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
    • S. Ogg The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans Nature 389 1997 994 999
    • (1997) Nature , vol.389 , pp. 994-999
    • Ogg, S.1
  • 33
    • 34547097247 scopus 로고    scopus 로고
    • Brain IRS2 signaling coordinates life span and nutrient homeostasis
    • A. Taguchi Brain IRS2 signaling coordinates life span and nutrient homeostasis Science 317 2007 369 372
    • (2007) Science , vol.317 , pp. 369-372
    • Taguchi, A.1
  • 34
    • 84866122780 scopus 로고    scopus 로고
    • Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
    • K.D. Copps, and M.F. White Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 Diabetologia 55 2012 2565 2582
    • (2012) Diabetologia , vol.55 , pp. 2565-2582
    • Copps, K.D.1    White, M.F.2
  • 35
    • 70350439438 scopus 로고    scopus 로고
    • Insulin is a stronger inducer of insulin resistance than hyperglycemia in mice with type 1 diabetes mellitus (T1DM)
    • H.Y. Liu Insulin is a stronger inducer of insulin resistance than hyperglycemia in mice with type 1 diabetes mellitus (T1DM) J. Biol. Chem. 284 2009 27090 27100
    • (2009) J. Biol. Chem. , vol.284 , pp. 27090-27100
    • Liu, H.Y.1
  • 36
    • 9644260563 scopus 로고    scopus 로고
    • Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes
    • X. Lin Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes J. Clin. Invest. 114 2004 908 916
    • (2004) J. Clin. Invest. , vol.114 , pp. 908-916
    • Lin, X.1
  • 37
    • 0037456304 scopus 로고    scopus 로고
    • STAT3 signalling is required for leptin regulation of energy balance but not reproduction
    • S.H. Bates STAT3 signalling is required for leptin regulation of energy balance but not reproduction Nature 421 2003 856 859
    • (2003) Nature , vol.421 , pp. 856-859
    • Bates, S.H.1
  • 38
    • 84869050741 scopus 로고    scopus 로고
    • Central nervous system control of metabolism
    • M.G. Myers Jr., and D.P. Olson Central nervous system control of metabolism Nature 491 2012 357 363
    • (2012) Nature , vol.491 , pp. 357-363
    • Myers, Jr.M.G.1    Olson, D.P.2
  • 39
    • 82955239851 scopus 로고    scopus 로고
    • Impairment of central leptin-mediated PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity
    • J.P. Warne Impairment of central leptin-mediated PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity Cell Metab. 14 2011 791 803
    • (2011) Cell Metab. , vol.14 , pp. 791-803
    • Warne, J.P.1
  • 40
    • 84860451500 scopus 로고    scopus 로고
    • IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action
    • M. Sadagurski IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action Cell Metab. 15 2012 703 712
    • (2012) Cell Metab. , vol.15 , pp. 703-712
    • Sadagurski, M.1
  • 41
    • 33646590947 scopus 로고    scopus 로고
    • Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake
    • T. Kitamura Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake Nat. Med. 12 2006 534 540
    • (2006) Nat. Med. , vol.12 , pp. 534-540
    • Kitamura, T.1
  • 42
    • 84861976352 scopus 로고    scopus 로고
    • FoxO1 target Gpr17 activates AgRP neurons to regulate food intake
    • H. Ren FoxO1 target Gpr17 activates AgRP neurons to regulate food intake Cell 149 2012 1314 1326
    • (2012) Cell , vol.149 , pp. 1314-1326
    • Ren, H.1
  • 43
    • 70350369729 scopus 로고    scopus 로고
    • The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake
    • L. Plum The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake Nat. Med. 15 2009 1195 1201
    • (2009) Nat. Med. , vol.15 , pp. 1195-1201
    • Plum, L.1
  • 44
    • 0036787607 scopus 로고    scopus 로고
    • Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
    • J. Nakae Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1 Nat. Genet. 32 2002 245 253
    • (2002) Nat. Genet. , vol.32 , pp. 245-253
    • Nakae, J.1
  • 45
    • 84866389264 scopus 로고    scopus 로고
    • Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure
    • C. Talchai Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure Cell 150 2012 1223 1234
    • (2012) Cell , vol.150 , pp. 1223-1234
    • Talchai, C.1
  • 46
    • 58149328550 scopus 로고    scopus 로고
    • Effect of endothelium-specific insulin resistance on endothelial function in vivo
    • E.R. Duncan Effect of endothelium-specific insulin resistance on endothelial function in vivo Diabetes 57 2008 3307 3314
    • (2008) Diabetes , vol.57 , pp. 3307-3314
    • Duncan, E.R.1
  • 47
    • 77955292064 scopus 로고    scopus 로고
    • Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein e null mice
    • C. Rask-Madsen Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice Cell Metab. 11 2010 379 389
    • (2010) Cell Metab. , vol.11 , pp. 379-389
    • Rask-Madsen, C.1
  • 48
    • 79952142784 scopus 로고    scopus 로고
    • Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle
    • T. Kubota Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle Cell Metab. 13 2011 294 307
    • (2011) Cell Metab. , vol.13 , pp. 294-307
    • Kubota, T.1
  • 49
    • 84858066279 scopus 로고    scopus 로고
    • FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis
    • K. Tsuchiya FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis Cell Metab. 15 2012 372 381
    • (2012) Cell Metab. , vol.15 , pp. 372-381
    • Tsuchiya, K.1
  • 50
    • 84866944897 scopus 로고    scopus 로고
    • RTEF-1 attenuates blood glucose levels by regulating insulin-like growth factor binding protein-1 in the endothelium
    • A.F. Messmer-Blust RTEF-1 attenuates blood glucose levels by regulating insulin-like growth factor binding protein-1 in the endothelium Circ. Res. 111 2012 991 1001
    • (2012) Circ. Res. , vol.111 , pp. 991-1001
    • Messmer-Blust, A.F.1
  • 51
    • 77955035304 scopus 로고    scopus 로고
    • Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism
    • M. Ferron Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism Cell 142 2010 296 308
    • (2010) Cell , vol.142 , pp. 296-308
    • Ferron, M.1
  • 52
    • 77955082747 scopus 로고    scopus 로고
    • Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition
    • K. Fulzele Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition Cell 142 2010 309 319
    • (2010) Cell , vol.142 , pp. 309-319
    • Fulzele, K.1
  • 53
    • 74949089660 scopus 로고    scopus 로고
    • FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice
    • M.T. Rached FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice J. Clin. Invest. 120 2010 357 368
    • (2010) J. Clin. Invest. , vol.120 , pp. 357-368
    • Rached, M.T.1


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