Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

Diabetologia

Volumn 55, Issue 10, 2012, Pages 2565-2582

  Copps, K D ^a   White, M F ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Degradation; Dyslipidaemia; Hyperinsulinaemia; Insulin receptor substrate; Insulin resistance; Mammalian target of rapamycin complex 1; Metabolic syndrome; Review; Serine phosphorylation; Sympathetic activity

Indexed keywords

AUTACOID; G PROTEIN COUPLED RECEPTOR KINASE 2; GLYCOGEN SYNTHASE KINASE 3; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; I KAPPA B KINASE BETA; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOTRANSFERASE; POLO LIKE KINASE; PROTEIN KINASE B; PROTEIN KINASE C; RHO ASSOCIATED COILED COIL CONTAINING PROTEIN KINASE 1; RHO KINASE; S6 KINASE; SALT INDUCIBLE KINASE 2; SERINE; STRESS ACTIVATED PROTEIN KINASE; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ENZYME REGULATION; FEEDBACK SYSTEM; HORMONAL REGULATION; HUMAN; HYPERINSULINEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; MEDIATOR RELEASE; METABOLIC DISORDER; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; SYMPATHETIC TONE;

ANIMALS; DIABETES MELLITUS; HUMANS; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MODELS, ANIMAL; PHOSPHORYLATION; SERINE; SIGNAL TRANSDUCTION; THREONINE;

EID: 84866122780     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2644-8     Document Type: Review

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