Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

Biochemical Journal

Volumn 354, Issue 3, 2001, Pages 605-612

  Rena, G ^a   Prescott, A R ^a   Guo, S ^a   Cohen, P ^a   Unterman, T G ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

14 3 3 proteins; Apoptosis; FKHR; Insulin like growth factor 1; Protein kinase B

Indexed keywords

AMINO ACIDS; CELLS; DNA; INSULIN; PROTEINS;

PHOSPHORYLATION; TRANSACTIVATION;

MUTAGENESIS;

GLYCOGEN SYNTHASE KINASE 3; PROTEIN 14 3 3; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; TRANSACTIVATION;

14-3-3 PROTEINS; ACTIVE TRANSPORT, CELL NUCLEUS; CELL LINE; CELL NUCLEUS; DNA-BINDING PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; GLUTATHIONE TRANSFERASE; GREEN FLUORESCENT PROTEINS; HUMANS; INSULIN-LIKE GROWTH FACTOR I; LUMINESCENT PROTEINS; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; PHOSPHOSERINE; PHOSPHOTHREONINE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECOMBINANT FUSION PROTEINS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TYROSINE 3-MONOOXYGENASE;

EID: 0035868368     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3540605     Document Type: Article

References (27)

1. Mechanism of activation and function of protein kinase B
2. Cellular survival: A play in three Akts
3. The PI3K-PDK1 connection: More than just a road to PKB
4. Molecular basis for the substrate specificity of protein kinase B: Comparison with MAPKAP kinase-1 and p70 S6 kinase
5. Inhibition of glycogen synthase kinase-3 by insulin is mediated by Akt/PKB
6. Essential role for protein kinase B (PKB)in insulin-induced glycogen synthase kinase 3 inactivation - Characterization of a dominant-negative mutant of PKB
7. Insulin-induced phosphorylation and activation of cyclic nucieotide phosphodiesterase 3B by the serine-threonine kinase Akt
8. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
9. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
10. Direct control of the forkhead transcription factor AFX by protein kinase B
11. Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on sedne 253 through a wortmannin-sensitive pathway
12. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
13. Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B
14. Negative regulation of the forkhead transcription factor FKHR by Akt
15. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 Pl3 kinase to the DAF-16 transcription factor
16. Regulation of the forkhead transcription factor FKHR, but not the PAX3-FKHR fusion protein, by the serine/threonine kinase Akt
17. Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR
18. Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence
19. FKHR binds the insulin response element in the insulin-like growth factor binding protein-1 promoter
20. kip1
21. Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding
22. The structural basis for 14-3-3: Phosphopeptide binding specificity
23. Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine
24. Importins and exportins: How to get in and out of the nucleus
25. Analysis of hepatocyte nuclear factor-3β protein domains required for transcriptional activation and nuclear targetting
26. Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/Akt cell survival pathway
27. Insulin inhibits the activation of transcription by a C-terminal fragment of the forkhead transcription factor FKHR