Type 2 diabetes - A matter of β-cell life and death?

Science

Volumn 307, Issue 5708, 2005, Pages 380-384

  Rhodes, Christopher J ^a,b  

^a PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; INSULIN; PROTEINS; SUBSTRATES; TISSUE;

APOPTOSIS; INSULIN RECEPTOR SUBSTRATE 2 (IRS-2); INSULIN RESISTANCE;

DISEASES;

INSULIN; INSULIN RECEPTOR SUBSTRATE 2; MAMMALIAN TARGET OF RAPAMYCIN;

MEDICINE;

APOPTOSIS; CELL DIVISION; CELL GROWTH; CELL LOSS; CELL SIZE; CELL SURVIVAL; HOMEOSTASIS; HUMAN; INSULIN RESISTANCE; INSULIN SYNTHESIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVIEW;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; APOPTOSIS; CELL COUNT; CELL DIVISION; CELL SIZE; CELL SURVIVAL; CYTOKINES; DIABETES MELLITUS, TYPE 2; HOMEOSTASIS; HUMANS; HYPERGLYCEMIA; HYPERLIPIDEMIAS; INSULIN; INSULIN RESISTANCE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISLETS OF LANGERHANS; LIPID METABOLISM; OBESITY; PHOSPHOPROTEINS; SIGNAL TRANSDUCTION;

EID: 12344323484     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1104345     Document Type: Review

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56. I thank S. Bonner-Weir, P. Butler, J. Leahy, and M. White for valuable discussions over the years. Supported by a NIH grant DK-55267. The author is on the β-cell Advisory Board of the Partnership formed by Amylin Pharmaceutical and Eli Lilly.