Fatty acids modulate toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner

Journal of Biological Chemistry

Volumn 284, Issue 40, 2009, Pages 27384-27392

  Wong, Scott W ^a   Kwon, Myung Ja ^a   Choi, Augustine M K ^b   Kim, Hong Pyo ^b   Nakahira, Kiichi ^b   Hwang, Daniel H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR MOLECULE; CHRONIC DISEASE; DOCOSAHEXAENOIC ACID; INFLAMMATORY RESPONSE; LAURIC ACID; LIGAND RECOGNITION; LIPID A; LIPID RAFT; LIPOPOLYSACCHARIDES; MEDIATED SIGNALING PATHWAYS; NADPH OXIDASE; POLYUNSATURATED FATTY ACIDS; REACTIVE OXYGEN SPECIES; RECEPTOR ACTIVATION; SATURATED FATTY ACID; SIGNALING PATHWAYS; TARGET GENE EXPRESSION; TOLL-LIKE RECEPTOR 4; UNDERLYING MECHANISM;

BIOACTIVITY; DIMERIZATION; EMPLOYMENT; FATTY ACIDS; GENE EXPRESSION; OXYGEN; PIGMENTS; POLYSACCHARIDES; SIGNALING;

ACIDS;

DOCOSAHEXAENOIC ACID; LAURIC ACID; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN MD 2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; FATTY ACID; LAURIC ACID DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIMERIZATION; DOWNSTREAM PROCESSING; ENZYME ACTIVATION; LIPID RAFT; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; CELL MEMBRANE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; METABOLISM; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN TRANSPORT;

BACTERIA (MICROORGANISMS);

ANIMALS; CELL LINE; DOCOSAHEXAENOIC ACIDS; FATTY ACIDS; HUMANS; LAURIC ACIDS; LIPOPOLYSACCHARIDES; LYMPHOCYTE ANTIGEN 96; MEMBRANE MICRODOMAINS; MICE; NADPH OXIDASE; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 70350482557     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.044065     Document Type: Article

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