Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver

Journal of Clinical Investigation

Volumn 110, Issue 10, 2002, Pages 1483-1491

  Miyake, Kazuaki ^a   Ogawa, Wataru ^a   Matsumoto, Michihiro ^a   Nakamura, Takehiro ^a   Sakaue, Hiroshi ^a   Kasuga, Masato ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUCOSE; GLUCOSE 6 PHOSPHATE; GLYCOGEN; GLYCOGEN SYNTHASE; INSULIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PYRUVIC ACID; TRIACYLGLYCEROL;

ADENOVIRUS; ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; DIET RESTRICTION; DYSLIPIDEMIA; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE CONTROL; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; HOMEOSTASIS; HYPERINSULINEMIA; LIPID METABOLISM; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

EID: 0036853886     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0215880     Document Type: Article

References (41)

1. Ogawa, W., Matozaki, T., and Kasuga, M. 1998. Role of binding proteins to IRS-1 in insulin signalling. Mol. Cell. Biochem. 182:13-22.
2. Shepherd, P.R., Withers, D.J., and Siddle, K. 1998. Phosphoinositide 3-kinase: The key switch mechanism in insulin signalling. Biochem. J. 333:471-490.
3. Sakaue, H., et al. 1997. Phosphoinositide 3-kinase is required for insulin-induced but not for growth hormone- or hyperosmolarity-induced glucose uptake in 3T3-L1 adipocytes. Mol. Endocrinol. 11:1552-1562.
4. Kitamura, T., et al. 1999. Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt. Mol. Cell. Biol. 19:6286-6296.
5. Kotani, K., et al. 1999. Dominant negative forms of Akt (protein kinase B) and atypical protein kinase Cλ do not prevent insulin inhibition of phosphoenolpyruvate carboxykinase gene transcription. J. Biol. Chem. 274:21305-21322.
6. Matsumoto, M., et al. 2002. Role of the IRS-1 and PI 3-kinase signaling pathway in insulin-induced expression of SREBP-1c and glucokinase genes in rat hepatocytes. Diabetes. 51:1672-1680.
7. Heydrick, SJ., et al. 1993. Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice. J. Clin. Invest. 91:1358-1366.
8. Kim, Y.B., Nikoulina, S.E., Ciaraldi, T.P., Henry, R.R., and Kahn, B.B. 1999. Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. J. Clin. Invest. 104:733-741.
9. Tsuchida, A., et al. 2001. The effects of brain-derived neurotrophic factor on insulin signal transduction in the liver of diabetic mice. Diabetologia. 44:555-566.
10. Bi, L., Okabe, I., Bernard, D.J., Wynshaw-Boris, A., and Nussbaum, R.L., 1999. Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110α subunit of phosphoinositide 3-kinase. J. Biol. Chem. 274:10963-10968.
11. Fruman, D.A., et al. 2000. Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α. Nat. Genet. 26:379-382.
12. Mauvais-Jarvis, F., et al. 2002. Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. J. Clin. Invest. 109:141-149. doi:10.1172/JCI200213305.
13. Ueki, K., et al. 2002. Increased insulin sensitivity in mice lacking p85β subunit of phosphoinositide 3-kinase. Proc. Natl. Acad. Sci. USA. 99:419-424.
14. Terauchi, Y., et al. 1999. Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3-kinase. Nat. Genet. 21:230-235.
15. Abel, E.D., et al. 2001. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature. 409:729-733.
16. Kim, J. K., et al. 2001. Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4. J. Clin. Invest. 108:153-160. doi:10.1172/JCI200110294.
17. Hara, K., et al. 1994. 1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells. Proc. Natl. Acad. Sci. USA. 91:7415-7419.
18. Hassid, W.Z., and Abraham, S. 1957. Chemical procedures for analysis of polysaccharide. Methods Enzymol. 3:34-36.
19. Hohorst, H.J., 1965. D-Glucose-6-phosphate and D-fructose-6-phosphate. In Methods of Enzymatic Analysis. H.U. Bergmeyer, editor. Academic Press. New York, New York, USA. 134-138.
20. Takata, M., et al. 1999. Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BPI (PHAS-1). J. Biol. Chem. 274:20611-20618.
21. DiTullio, N.W., et al. 1974. 3-Mercaptopicolinic acid, an inhibitor of gluconeogenesis. Biochem. J. 138:387-394.
22. Podolin, D.A., Pagliassotti, M.J., Gleeson, T.T., and Mazzeo, R.S., 1994. Influence of endurance grinning on the age-related decline in hepatic glyconeogenesis. Mech. Ageing Dev. 75:81-93.
23. Memoli, K.A. 1996. A convenient preparation of 3-mercaptopicolinic acid. Tetrahedron Lett. 37:3617-3618.
24. Matsuda, T., Noguchi, T., Yamada, K., Takenaka, M., and Tanaka, T. 1990. Regulation of the gene expression of glucokinase and L-type pyruvate kinase in primary cultures of rat hepatocytes by hormones and carbohydrates. J. Biochem. (Tokyo). 108:778-784.
25. Shimano, H., et al. 1996. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-Ia. J. Clin. Invest. 98:1575-1584.
26. Beale, E.G., et al. 1985. Rat hepatic cytosolic phosphoenolpyruvate carboxykinase (GTP). Structures of the protein, messenger RNA, and gene. J. Biol. Chem. 260:10748-10760.
27. Shingu, R., et al. 1996. Expression and distribution of glucose-6-phosphatase catalytic subunit messenger RNA and its changes in the diabetic state. Res. Commun. Mol. Pathol. Pharmacol. 93:13-24.
28. Jaffe, H.A., et al. 1992. Adenovirus-mediated in vivo gene transfer and expression in normal rat liver. Nat. Genet. 1:372-378.
29. Trinh, K.Y., O'Doherty, R.M., Anderson, P., Lange, A,J., and Newgard, C.B. 1998. Perturbation of fuel homeostasis caused by overexpression of the glucose-6-phosphatase catalytic subunit in liver of normal rats. J. Biol. Chem. 273:31615-31620.
30. Azzout-Marniche, D., et al. 2000. Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes. Biochem. J. 350:389-393.
31. Dickens, M., Svitek, C.A., Culbert, A.A., O'Brien, R.M., and Tavare, J. M. 1998. Central role for phosphatidylinositide 3-kinase in the repression of glucose-6-phosphatase gene transcription by insulin. J. Biol. Chem. 273:20144-20149.
32. Flaim, K. E., et al. 1985. Direct effect of insulin on albumin gene expression in primary cultures of rat hepatocytes. Am. J. Physiol. 249:E447-E453.
33. Cross, D.A., Alessi, D.R., Cohen, P., Andjelkovich, M., and Hemmings, B. A. 1995. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature. 378:785-789.
34. DeFronzo, R.A. 1997. Pathogenesis of type 2 diabetes: Metabolic and molecular implications for identifying diabetic genes. Diabetes Rev. 5:177-269.
35. Michael, M.D., et al. 2000. Loss of insulin signalling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol. Cell. 6:87-97.
36. Radziuk, J., and Pye, S. 2001. Hepatic glucose uptake, gluconeogenesis and the regulation of glycogen synthesis. Diabet. Metab. Res. Rev. 17:250-272.
37. Jenkins, D.J. 1997. Carbohydrate tolerance and food frequency. Br. J. Nutr. 77(Suppl. 1):S71-S81.
38. Oliver, J.D., and Rogers, M.P. 1993. Stimulation of lipoprotein lipase synthesis by refeeding, insulin and dexamethasone. Biochem. J. 292:525-530.
39. Fisher, S.J., and Kahn, C.R. 2001. No evidence for an indirect effect of insulin to suppress glucose production in liver-specific insulin receptor knockout mice. Diabetes. 50(Suppl. 2):A50. (Abstr.)
40. Tamemoto, H., et al. 1994. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature. 372:182-186.
41. Araki, E., et al. 1994. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature. 372:186-190.