-
2
-
-
0344163759
-
The behaviour of 14c-cortisol and estimation of cortisol production rate in man
-
Cope CL, Black EG. The behaviour of 14c-cortisol and estimation of cortisol production rate in man. Clin Sci (Lond). 1958;17:147-163.
-
(1958)
Clin Sci (Lond).
, vol.17
, pp. 147-163
-
-
Cope, C.L.1
Black, E.G.2
-
3
-
-
0026096434
-
Daily cortisol production rate in man determined by stable isotope dilu-tion/mass spectrometry
-
Esteban NV, Loughlin T, Yergey AL, et al. Daily cortisol production rate in man determined by stable isotope dilu-tion/mass spectrometry. J Clin Endocrinol Metab. 1991; 72:39-45.
-
(1991)
J Clin Endocrinol Metab.
, vol.72
, pp. 39-45
-
-
Esteban, N.V.1
Loughlin, T.2
Yergey, A.L.3
-
4
-
-
0020022809
-
The serum transport of steroid hormones
-
Siiteri PK, Murai JT, Hammond GL, Nisker JA, Raymoure WJ, Kuhn RW. The serum transport of steroid hormones. Recent Prog Horm Res. 1982;38:457-510.
-
(1982)
Recent Prog Horm Res.
, vol.38
, pp. 457-510
-
-
Siiteri, P.K.1
Murai, J.T.2
Hammond, G.L.3
Nisker, J.A.4
Raymoure, W.J.5
Kuhn, R.W.6
-
5
-
-
0025141394
-
Differences between concentrations of salivary cortisol and cortisone and of free cortisol and cortisone in plasma during pregnancy and postpartum
-
Meulenberg PM, Hofman JA. Differences between concentrations of salivary cortisol and cortisone and of free cortisol and cortisone in plasma during pregnancy and postpartum. Clin Chem. 1990;36:70-75.
-
(1990)
Clin Chem.
, vol.36
, pp. 70-75
-
-
Meulenberg, P.M.1
Hofman, J.A.2
-
6
-
-
0021694134
-
11 β-Hydroxysteroid dehydrogenase: fact or fancy?
-
Monder C, Shackleton CH. 11 β-Hydroxysteroid dehydrogenase: fact or fancy? Steroids. 1984;44:383-417.
-
(1984)
Steroids
, vol.44
, pp. 383-417
-
-
Monder, C.1
Shackleton, C.H.2
-
7
-
-
0027346746
-
11 β-Hydroxysteroid dehydrogenase
-
Monder C, White PC. 11 β-Hydroxysteroid dehydrogenase. Vitam Horm. 1993;47:187-271.
-
(1993)
Vitam Horm.
, vol.47
, pp. 187-271
-
-
Monder, C.1
White, P.C.2
-
9
-
-
4043077286
-
β-Hydroxysteroid dehydrogenase type 1.a tissue-specific regulator of glucocorticoid response
-
Tomlinson JW, Walker EA, Bujalska IJ, et al. 11β-Hydroxysteroid dehydrogenase type 1.a tissue-specific regulator of glucocorticoid response Endocr Rev. 2004; 25:831-866.
-
(2004)
Endocr Rev.
, vol.25
, pp. 831-866
-
-
Tomlinson, J.W.1
Walker, E.A.2
Bujalska, I.J.3
-
10
-
-
0023761690
-
Localisation of 11 β-hydroxysteroid dehydrogenase-tissue specific protector of the mineralocorticoid receptor
-
Edwards CR, Stewart PM, Burt D, et al. Localisation of 11 β-hydroxysteroid dehydrogenase-tissue specific protector of the mineralocorticoid receptor. Lancet. 1988;2: 986-989.
-
(1988)
Lancet.
, vol.2
, pp. 986-989
-
-
Edwards, C.R.1
Stewart, P.M.2
Burt, D.3
-
11
-
-
0031022385
-
Molecular analysis of 11 β-hydroxysteroid dehydrogenase and its role in the syndrome of apparent mineralocorticoid excess
-
White PC, Mune T, Rogerson FM, Kayes KM, Agarwal AK. Molecular analysis of 11 β-hydroxysteroid dehydrogenase and its role in the syndrome of apparent mineralocorticoid excess. Steroids. 1997;62:83-88.
-
(1997)
Steroids.
, vol.62
, pp. 83-88
-
-
White, P.C.1
Mune, T.2
Rogerson, F.M.3
Kayes, K.M.4
Agarwal, A.K.5
-
12
-
-
0032611267
-
11 β-Hydroxysteroid dehydrogenase
-
Stewart PM, Krozowski ZS. 11 β-Hydroxysteroid dehydrogenase. Vitam Horm. 1999;57:249-324.
-
(1999)
Vitam Horm.
, vol.57
, pp. 249-324
-
-
Stewart, P.M.1
Krozowski, Z.S.2
-
13
-
-
0033214482
-
The N-terminal anchor sequences of 11β-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membrane
-
Odermatt A, Arnold P, Stauffer A, Frey BM, Frey FJ. The N-terminal anchor sequences of 11β-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membrane. J Biol Chem. 1999;274:28762-28770.
-
(1999)
J Biol Chem.
, vol.274
, pp. 28762-28770
-
-
Odermatt, A.1
Arnold, P.2
Stauffer, A.3
Frey, B.M.4
Frey, F.J.5
-
14
-
-
0028899788
-
Lumenal orientation and posttranslational modifications of the liver microsomal 11-β-hydroxysteroid dehydrogenase
-
Ozols J. Lumenal orientation and posttranslational modifications of the liver microsomal 11-β-hydroxysteroid dehydrogenase. J Biol Chem. 1995;270:2305-2312.
-
(1995)
J Biol Chem.
, vol.270
, pp. 2305-2312
-
-
Ozols, J.1
-
15
-
-
0024789306
-
Cloning and expression of rat cDNA encoding corticosteroid 11 β-dehydrogenase
-
Agarwal AK, Monder C, Eckstein B, White PC. Cloning and expression of rat cDNA encoding corticosteroid 11 β-dehydrogenase. J Biol Chem. 1989;264:18939-18943.
-
(1989)
J Biol Chem.
, vol.264
, pp. 18939-18943
-
-
Agarwal, A.K.1
Monder, C.2
Eckstein, B.3
White, P.C.4
-
16
-
-
0023792158
-
Purification and characterization of the corticosteroid 11 β-dehydrogenase component of the rat liver 11 β-hydroxysteroid dehydrogenase complex
-
Lakshmi V, Monder C. Purification and characterization of the corticosteroid 11 β-dehydrogenase component of the rat liver 11 β-hydroxysteroid dehydrogenase complex. Endocrinology. 1988;123:2390-2398.
-
(1988)
Endocrinology.
, vol.123
, pp. 2390-2398
-
-
Lakshmi, V.1
Monder, C.2
-
17
-
-
0024567253
-
Evidence for kinetically distinct forms of corticosteroid 11 β-dehydrogenase in rat liver microsomes
-
Monder C, Lakshmi V. Evidence for kinetically distinct forms of corticosteroid 11 β-dehydrogenase in rat liver microsomes. J Steroid Biochem. 1989;32:77-83.
-
(1989)
J Steroid Biochem.
, vol.32
, pp. 77-83
-
-
Monder, C.1
Lakshmi, V.2
-
18
-
-
0037133133
-
11β-hydroxysteroid dehydrogenase type 1 from human liver: dimerization and enzyme cooperativity support its postulated role as glucocorticoid reductase
-
Maser E, Volker B, Friebertshauser J. 11β-hydroxysteroid dehydrogenase type 1 from human liver: dimerization and enzyme cooperativity support its postulated role as glucocorticoid reductase. Biochemistry. 2002;41:2459-2465.
-
(2002)
Biochemistry.
, vol.41
, pp. 2459-2465
-
-
Maser, E.1
Volker, B.2
Friebertshauser, J.3
-
19
-
-
0028169395
-
Human kidney 11 β-hydroxysteroid dehydrogenase is a high affinity nicotinamide adenine dinucleotide-dependent enzyme and differs from the cloned type I isoform
-
Stewart PM, Murry BA, Mason JI. Human kidney 11 β-hydroxysteroid dehydrogenase is a high affinity nicotinamide adenine dinucleotide-dependent enzyme and differs from the cloned type I isoform. J Clin Endocrinol Metab. 1994;79:480-484.
-
(1994)
J Clin Endocrinol Metab.
, vol.79
, pp. 480-484
-
-
Stewart, P.M.1
Murry, B.A.2
Mason, J.I.3
-
20
-
-
0026095840
-
The human gene for 11 β-hydroxysteroid dehydrogenase
-
Tannin GM, Agarwal AK, Monder C, New MI, White PC. The human gene for 11 β-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization. J Biol Chem. 1991;266:16653-16658.
-
(1991)
Structure, tissue distribution, and chromosomal localization. J Biol Chem.
, vol.266
, pp. 16653-16658
-
-
Tannin, G.M.1
Agarwal, A.K.2
Monder, C.3
New, M.I.4
White, P.C.5
-
21
-
-
0036959901
-
Aswitch in dehydrogenase to reductase activity of 11 β-hydroxysteroid dehydrogenase type 1 upon differentiation ofhuman omental adipose stromal cells
-
Bujalska IJ, Walker EA, HewisonM,Stewart PM.Aswitch in dehydrogenase to reductase activity of 11 β-hydroxysteroid dehydrogenase type 1 upon differentiation ofhuman omental adipose stromal cells. J Clin Endocrinol Metab. 2002;87:1205-1210.
-
(2002)
J Clin Endocrinol Metab.
, vol.87
, pp. 1205-1210
-
-
Bujalska, I.J.1
Walker, E.A.2
Hewison, M.3
Stewart, P.M.4
-
22
-
-
85047683614
-
Minireview: 11β-hydroxysteroid dehydrogenase type 1-a tissue-specific amplifier of glucocorticoid action
-
Seckl JR, Walker BR. Minireview: 11β-hydroxysteroid dehydrogenase type 1-a tissue-specific amplifier of glucocorticoid action. Endocrinology. 2001;142:1371-1376.
-
(2001)
Endocrinology.
, vol.142
, pp. 1371-1376
-
-
Seckl, J.R.1
Walker, B.R.2
-
23
-
-
0033233116
-
11 β-hydroxysteroid dehydrogenase functions reversibly as an oxidoreductase in the rat hippocampus in vivo
-
Jellinck PH, Pavlides C, Sakai RR, McEwen BS. 11 β-hydroxysteroid dehydrogenase functions reversibly as an oxidoreductase in the rat hippocampus in vivo. J Steroid Biochem Mol Biol. 1999;71:139-144.
-
(1999)
J Steroid Biochem Mol Biol.
, vol.71
, pp. 139-144
-
-
Jellinck, P.H.1
Pavlides, C.2
Sakai, R.R.3
McEwen, B.S.4
-
24
-
-
0042667127
-
Mutations in the genes encoding 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency
-
Draper N, Walker EA, Bujalska IJ, et al. Mutations in the genes encoding 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency. Nat Genet. 2003;34:434-439.
-
(2003)
Nat Genet.
, vol.34
, pp. 434-439
-
-
Draper, N.1
Walker, E.A.2
Bujalska, I.J.3
-
25
-
-
0025325667
-
Corticosteroid 11 β-dehydrogenase of rat tissues: immunological studies
-
Monder C, Lakshmi V. Corticosteroid 11 β-dehydrogenase of rat tissues: immunological studies. Endocrinology. 1990;126:2435-2443.
-
(1990)
Endocrinology.
, vol.126
, pp. 2435-2443
-
-
Monder, C.1
Lakshmi, V.2
-
26
-
-
53749101646
-
Steroid biomarkers and genetic studies reveal inactivating mutations in hexose-6-phosphate dehydrogenase in patients with cortisone reductase deficiency
-
Lavery GG, Walker EA, Tiganescu A, et al. Steroid biomarkers and genetic studies reveal inactivating mutations in hexose-6-phosphate dehydrogenase in patients with cortisone reductase deficiency. J Clin Endocrinol Metab. 2008;93:3827-3832.
-
(2008)
J Clin Endocrinol Metab.
, vol.93
, pp. 3827-3832
-
-
Lavery, G.G.1
Walker, E.A.2
Tiganescu, A.3
-
27
-
-
36349033013
-
Hypoglycemia with enhanced hepatic glycogen synthesis in recombinant mice lacking hexose-6-phosphate dehydrogenase
-
Lavery GG, Hauton D, Hewitt KN, et al. Hypoglycemia with enhanced hepatic glycogen synthesis in recombinant mice lacking hexose-6-phosphate dehydrogenase. Endocrinology. 2007;148:6100-6106.
-
(2007)
Endocrinology.
, vol.148
, pp. 6100-6106
-
-
Lavery, G.G.1
Hauton, D.2
Hewitt, K.N.3
-
28
-
-
34748824878
-
Abnormalities of glucose homeostasis and the hypothalamic-pituitary-adrenal axis in mice lacking hexose-6-phosphate dehydrogenase
-
Rogoff D, Ryder JW, Black K, et al. Abnormalities of glucose homeostasis and the hypothalamic-pituitary-adrenal axis in mice lacking hexose-6-phosphate dehydrogenase. Endocrinology. 2007;148:5072-5080.
-
(2007)
Endocrinology.
, vol.148
, pp. 5072-5080
-
-
Rogoff, D.1
Ryder, J.W.2
Black, K.3
-
29
-
-
34848854245
-
11β-Hydroxysteroid dehydrogenase type 1 regulation by intracellular glucose 6-phosphate provides evidence for a novel link between glucose metabolism and hypothalamo-pituitaryadrenal axis function
-
Walker EA, Ahmed A, Lavery GG, et al. 11β-Hydroxysteroid dehydrogenase type 1 regulation by intracellular glucose 6-phosphate provides evidence for a novel link between glucose metabolism and hypothalamo-pituitaryadrenal axis function. J Biol Chem. 2007;282:27030-27036.
-
(2007)
J Biol Chem.
, vol.282
, pp. 27030-27036
-
-
Walker, E.A.1
Ahmed, A.2
Lavery, G.G.3
-
30
-
-
84866303279
-
Biomarkers of hypothalamic-pituitary-adrenal axis activity in mice lacking 11β-HSD1 and H6PDH
-
Abrahams L, SemjonousNM,Guest P, et al. Biomarkers of hypothalamic-pituitary-adrenal axis activity in mice lacking 11β-HSD1 and H6PDH. J Endocrinol. 2012;214:367-372.
-
(2012)
J Endocrinol.
, vol.214
, pp. 367-372
-
-
Abrahams, L.1
Semjonous, N.M.2
Guest, P.3
-
31
-
-
79952763771
-
Cortisonereductase deficiency associated with heterozygous mutations in 11β-hydroxysteroid dehydrogenase type 1
-
Lawson AJ, Walker EA, Lavery GG, et al. Cortisonereductase deficiency associated with heterozygous mutations in 11β-hydroxysteroid dehydrogenase type 1. Proc Natl Acad Sci USA. 2011;108:4111-4116.
-
(2011)
Proc Natl Acad Sci USA.
, vol.108
, pp. 4111-4116
-
-
Lawson, A.J.1
Walker, E.A.2
Lavery, G.G.3
-
32
-
-
84874572089
-
Novel H6PDH mutations in two girls with premature adrenarche: 'apparent' and 'true'CRDcan be differentiated by urinary steroid profiling
-
Lavery GG, Idkowiak J, Sherlock M, et al. Novel H6PDH mutations in two girls with premature adrenarche: 'apparent' and 'true'CRDcan be differentiated by urinary steroid profiling. Eur J Endocrinol. 2013;168:K19-K26.
-
(2013)
Eur J Endocrinol.
, vol.168
-
-
Lavery, G.G.1
Idkowiak, J.2
Sherlock, M.3
-
33
-
-
0035111323
-
Intracellular regeneration of glucocorticoids by 11β-hydroxysteroid dehydrogenase (11β-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis: analysis of 11β-HSD-1-deficient mice
-
Harris HJ, Kotelevtsev Y, Mullins JJ, Seckl JR, Holmes MC. Intracellular regeneration of glucocorticoids by 11β-hydroxysteroid dehydrogenase (11β-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis: analysis of 11β-HSD-1-deficient mice. Endocrinology. 2001;142:114-120.
-
(2001)
Endocrinology.
, vol.142
, pp. 114-120
-
-
Harris, H.J.1
Kotelevtsev, Y.2
Mullins, J.J.3
Seckl, J.R.4
Holmes, M.C.5
-
34
-
-
78650812078
-
Hexose-6-phosphate dehydrogenase contributes to skeletal muscle homeostasis independent of 11β-hydroxysteroid dehydrogenase type 1
-
Semjonous NM, Sherlock M, Jeyasuria P, et al. Hexose-6-phosphate dehydrogenase contributes to skeletal muscle homeostasis independent of 11β-hydroxysteroid dehydrogenase type 1. Endocrinology. 2011;152:93-102.
-
(2011)
Endocrinology.
, vol.152
, pp. 93-102
-
-
Semjonous, N.M.1
Sherlock, M.2
Jeyasuria, P.3
-
35
-
-
71049155320
-
Hypotha lamic-pituitary-adrenal axis abnormalities in response to deletion of 11β-HSD1 is strain-dependent
-
Carter RN, Paterson JM, Tworowska U, et al. Hypotha lamic-pituitary-adrenal axis abnormalities in response to deletion of 11β-HSD1 is strain-dependent. J Neuroendocrinol. 2009;21:879-887.
-
(2009)
J Neuroendocrinol.
, vol.21
, pp. 879-887
-
-
Carter, R.N.1
Paterson, J.M.2
Tworowska, U.3
-
36
-
-
0025870302
-
Regional distribution of 11 β-hydroxysteroid dehydrogenase in rat brain
-
Lakshmi V, Sakai RR, McEwen BS, Monder C. Regional distribution of 11 β-hydroxysteroid dehydrogenase in rat brain. Endocrinology. 1991;128:1741-1748.
-
(1991)
Endocrinology.
, vol.128
, pp. 1741-1748
-
-
Lakshmi, V.1
Sakai, R.R.2
McEwen, B.S.3
Monder, C.4
-
37
-
-
0025088301
-
11 β-Hydroxysteroid dehydrogenase bioactivity and messengerRNAexpression in rat forebrain: localization in hypothalamus, hippocampus, and cortex
-
Moisan MP, Seckl JR, Edwards CR. 11 β-Hydroxysteroid dehydrogenase bioactivity and messengerRNAexpression in rat forebrain: localization in hypothalamus, hippocampus, and cortex. Endocrinology. 1990;127:1450-1455.
-
(1990)
Endocrinology.
, vol.127
, pp. 1450-1455
-
-
Moisan, M.P.1
Seckl, J.R.2
Edwards, C.R.3
-
38
-
-
84862748339
-
Lack of significant metabolic abnormalities in mice with liverspecific disruption of 11β-hydroxysteroid dehydrogenase type 1
-
Lavery GG, Zielinska AE, Gathercole LL, et al. Lack of significant metabolic abnormalities in mice with liverspecific disruption of 11β-hydroxysteroid dehydrogenase type 1. Endocrinology. 2012;153:3236-3248.
-
(2012)
Endocrinology.
, vol.153
, pp. 3236-3248
-
-
Lavery, G.G.1
Zielinska, A.E.2
Gathercole, L.L.3
-
39
-
-
2342510149
-
Metabolic syndrome without obesity: hepatic overexpression of 11β-hydroxysteroid dehydrogenase type 1 in transgenic mice
-
Paterson JM, Morton NM, Fievet C, et al. Metabolic syndrome without obesity: hepatic overexpression of 11β-hydroxysteroid dehydrogenase type 1 in transgenic mice. Proc Natl Acad Sci USA. 2004;101:7088-7093.
-
(2004)
Proc Natl Acad Sci USA.
, vol.101
, pp. 7088-7093
-
-
Paterson, J.M.1
Morton, N.M.2
Fievet, C.3
-
40
-
-
33745211631
-
Variants implicated in cortisone reductase deficiency do not contribute to susceptibility to common forms of polycystic ovary syndrome
-
Draper N, Powell BL, Franks S, Conway GS, Stewart PM, McCarthy MI. Variants implicated in cortisone reductase deficiency do not contribute to susceptibility to common forms of polycystic ovary syndrome. Clin Endocrinol (Oxf). 2006;65:64-70.
-
(2006)
Clin Endocrinol (Oxf).
, vol.65
, pp. 64-70
-
-
Draper, N.1
Powell, B.L.2
Franks, S.3
Conway, G.S.4
Stewart, P.M.5
McCarthy, M.I.6
-
41
-
-
84861737570
-
Association study of CYP17 and HSD11B1 in polycystic ovary syndrome utilizing comprehensive gene coverage
-
Chua AK, Azziz R, Goodarzi MO. Association study of CYP17 and HSD11B1 in polycystic ovary syndrome utilizing comprehensive gene coverage. Mol Hum Reprod. 2012;18:320-324.
-
(2012)
Mol Hum Reprod.
, vol.18
, pp. 320-324
-
-
Chua, A.K.1
Azziz, R.2
Goodarzi, M.O.3
-
42
-
-
80052877984
-
Genetic polymorphisms of the glucocorticoid receptor may affect the phenotype of women with anovulatory polycystic ovary syndrome
-
Valkenburg O, Uitterlinden AG, Themmen AP, et al. Genetic polymorphisms of the glucocorticoid receptor may affect the phenotype of women with anovulatory polycystic ovary syndrome. Hum Reprod. 2011;26:2902-2911.
-
(2011)
Hum Reprod.
, vol.26
, pp. 2902-2911
-
-
Valkenburg, O.1
Uitterlinden, A.G.2
Themmen, A.P.3
-
43
-
-
33846106489
-
Lack of association of the 11 β-hydroxysteroid dehydrogenase type 1 gene 83,557insA and hexose-6-phosphate dehydrogenase gene R453Q polymorphisms with body composition, adrenal androgen production, blood pressure, glucose metabolism, and dementia
-
Smit P, Dekker MJ, de Jong FJ, et al. Lack of association of the 11 β-hydroxysteroid dehydrogenase type 1 gene 83,557insA and hexose-6-phosphate dehydrogenase gene R453Q polymorphisms with body composition, adrenal androgen production, blood pressure, glucose metabolism, and dementia. J Clin Endocrinol Metab. 2007;92:359-362.
-
(2007)
J Clin Endocrinol Metab.
, vol.92
, pp. 359-362
-
-
Smit, P.1
Dekker, M.J.2
de Jong, F.J.3
-
44
-
-
26244456538
-
Genotypes at 11β-hydroxysteroid dehydrogenase type 11B1 and hexose-6-phosphate dehydrogenase loci are not risk factors for apparent cortisone reductase deficiency in a large population-based sample
-
White PC. Genotypes at 11β-hydroxysteroid dehydrogenase type 11B1 and hexose-6-phosphate dehydrogenase loci are not risk factors for apparent cortisone reductase deficiency in a large population-based sample. J Clin Endocrinol Metab. 2005;90:5880-5883.
-
(2005)
J Clin Endocrinol Metab.
, vol.90
, pp. 5880-5883
-
-
White, P.C.1
-
45
-
-
23044516980
-
A study of the hexose-6-phosphate dehydrogenase gene R453Q and 11 β-hydroxysteroid dehydrogenase type 1 gene 83557insA polymorphisms in the polycystic ovary syndrome
-
San Millan JL, Botella-Carretero JI, Alvarez-Blasco F, et al. A study of the hexose-6-phosphate dehydrogenase gene R453Q and 11 β-hydroxysteroid dehydrogenase type 1 gene 83557insA polymorphisms in the polycystic ovary syndrome. J Clin Endocrinol Metab. 2005;90:4157-4162.
-
(2005)
J Clin Endocrinol Metab.
, vol.90
, pp. 4157-4162
-
-
San Millan, J.L.1
Botella-Carretero, J.I.2
Alvarez-Blasco, F.3
-
46
-
-
33744954783
-
Genetic variation in 11β-hydroxysteroid dehydrogenase type 1 predicts adrenal hyperandrogenism among lean women with polycystic ovary syndrome
-
Gambineri A, Vicennati V, Genghini S, et al. Genetic variation in 11β-hydroxysteroid dehydrogenase type 1 predicts adrenal hyperandrogenism among lean women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2006;91:2295-2302.
-
(2006)
J Clin Endocrinol Metab.
, vol.91
, pp. 2295-2302
-
-
Gambineri, A.1
Vicennati, V.2
Genghini, S.3
-
47
-
-
79960167562
-
A combination of polymorphisms in HSD11B1 associates with in vivo 11β-HSD1 activity and metabolic syndrome in women with and without polycystic ovary syndrome
-
Gambineri A, Tomassoni F, Munarini A, et al. A combination of polymorphisms in HSD11B1 associates with in vivo 11β-HSD1 activity and metabolic syndrome in women with and without polycystic ovary syndrome. Eur J Endocrinol. 2011;165:283-292.
-
(2011)
Eur J Endocrinol.
, vol.165
, pp. 283-292
-
-
Gambineri, A.1
Tomassoni, F.2
Munarini, A.3
-
48
-
-
0347287039
-
Glucocorticoid-related genetic susceptibility for Alzheimer's disease
-
de Quervain DJ, Poirier R, Wollmer MA, et al. Glucocorticoid-related genetic susceptibility for Alzheimer's disease. Hum Mol Genet. 2004;13:47-52.
-
(2004)
Hum Mol Genet.
, vol.13
, pp. 47-52
-
-
de Quervain, D.J.1
Poirier, R.2
Wollmer, M.A.3
-
49
-
-
84856790664
-
The effect of common genetic variation in 11β-hydroxysteroid dehydrogenase type 1 on hypothalamic-pituitary-adrenal axis activity and incident depression
-
Dekker MJ, Tiemeier H, Luijendijk HJ, et al. The effect of common genetic variation in 11β-hydroxysteroid dehydrogenase type 1 on hypothalamic-pituitary-adrenal axis activity and incident depression. J Clin Endocrinol Metab. 2012;97:E233-E237.
-
(2012)
J Clin Endocrinol Metab.
, vol.97
-
-
Dekker, M.J.1
Tiemeier, H.2
Luijendijk, H.J.3
-
50
-
-
28444475613
-
Polymorphisms in the gene encoding 11B-hydroxysteroid dehydrogenase type 1 (HSD 11B1) and lifetime cognitive change
-
Deary IJ, Hayward C, Permana PA, et al. Polymorphisms in the gene encoding 11B-hydroxysteroid dehydrogenase type 1 (HSD 11B1) and lifetime cognitive change. Neurosci Lett. 2006;393:74-77.
-
(2006)
Neurosci Lett.
, vol.393
, pp. 74-77
-
-
Deary, I.J.1
Hayward, C.2
Permana, P.A.3
-
51
-
-
0042165967
-
Associations between a polymorphism in the 11 β hydroxysteroid dehydrogenase type I gene and body composition
-
Gelernter-Yaniv L, Feng N, Sebring NG, Hochberg Z, Yanovski JA. Associations between a polymorphism in the 11 β hydroxysteroid dehydrogenase type I gene and body composition. Int J Obes Relat Metab Disord. 2003;27: 983-986.
-
(2003)
Int J Obes Relat Metab Disord.
, vol.27
, pp. 983-986
-
-
Gelernter-Yaniv, L.1
Feng, N.2
Sebring, N.G.3
Hochberg, Z.4
Yanovski, J.A.5
-
52
-
-
84870992253
-
A gene variant of 11β-hydroxysteroid dehydrogenase type 1 is associated with obesity in children
-
Olza J, Gil-Campos M, Leis R, et al. A gene variant of 11β-hydroxysteroid dehydrogenase type 1 is associated with obesity in children. Int J Obes (Lond). 2012;36: 1558-1563.
-
(2012)
Int J Obes (Lond).
, vol.36
, pp. 1558-1563
-
-
Olza, J.1
Gil-Campos, M.2
Leis, R.3
-
53
-
-
3142661851
-
11β-Hydroxysteroid dehydrogenase type 1: genetic polymorphisms are associated with type 2 diabetes in Pima Indians independently of obesity and expression in adipocyte and muscle
-
Nair S, Lee YH, Lindsay RS, et al. 11β-Hydroxysteroid dehydrogenase type 1: genetic polymorphisms are associated with type 2 diabetes in Pima Indians independently of obesity and expression in adipocyte and muscle. Diabetologia. 2004;47:1088-1095.
-
(2004)
Diabetologia.
, vol.47
, pp. 1088-1095
-
-
Nair, S.1
Lee, Y.H.2
Lindsay, R.S.3
-
54
-
-
7244232607
-
Interaction between an 11βHSD1 gene variant and birth era modifies the risk of hypertension in Pima Indians
-
Franks PW, Knowler WC, Nair S, et al. Interaction between an 11βHSD1 gene variant and birth era modifies the risk of hypertension in Pima Indians. Hypertension. 2004; 44:681-688.
-
(2004)
Hypertension.
, vol.44
, pp. 681-688
-
-
Franks, P.W.1
Knowler, W.C.2
Nair, S.3
-
55
-
-
84856998881
-
Association between 11β-hydroxysteroid dehydrogenase type 1 gene polymorphisms and metabolic syndrome in Bosnian population
-
Dujic T, Bego T, Mlinar B, et al. Association between 11β-hydroxysteroid dehydrogenase type 1 gene polymorphisms and metabolic syndrome in Bosnian population. Biochem Med (Zagreb). 2012;22:76-85.
-
(2012)
Biochem Med (Zagreb).
, vol.22
, pp. 76-85
-
-
Dujic, T.1
Bego, T.2
Mlinar, B.3
-
56
-
-
70350230403
-
HSD11B1 polymorphisms predicted bone mineral density and fracture risk in postmenopausal women without a clinically apparent hypercortisolemia
-
Hwang JY, Lee SH, Kim GS, et al. HSD11B1 polymorphisms predicted bone mineral density and fracture risk in postmenopausal women without a clinically apparent hypercortisolemia. Bone. 2009;45:1098-1103.
-
(2009)
Bone.
, vol.45
, pp. 1098-1103
-
-
Hwang, J.Y.1
Lee, S.H.2
Kim, G.S.3
-
57
-
-
79959736881
-
Common variation at the 11-β hydroxysteroid dehydrogenase type 1 gene is associated with left ventricular mass
-
Rahman TJ, Mayosi BM, Hall D, et al. Common variation at the 11-β hydroxysteroid dehydrogenase type 1 gene is associated with left ventricular mass. Circ Cardiovasc Genet. 2011;4:156-162.
-
(2011)
Circ Cardiovasc Genet.
, vol.4
, pp. 156-162
-
-
Rahman, T.J.1
Mayosi, B.M.2
Hall, D.3
-
58
-
-
78650512109
-
Mutations of the hexose-6-phosphate dehydrogenase gene rarely cause hyperandrogenemic polycystic ovary syndrome
-
Qin KN, Rosenfield RL. Mutations of the hexose-6-phosphate dehydrogenase gene rarely cause hyperandrogenemic polycystic ovary syndrome. Steroids. 2011;76:135-139.
-
(2011)
Steroids.
, vol.76
, pp. 135-139
-
-
Qin, K.N.1
Rosenfield, R.L.2
-
59
-
-
84857797311
-
The R453Q and D151A polymorphisms of hexose-6-phosphate dehydrogenase gene (H6PD) influence the polycystic ovary syndrome (PCOS) and obesity
-
Martinez-Garcia MA, San-Millan JL, Escobar-Morreale HF. The R453Q and D151A polymorphisms of hexose-6-phosphate dehydrogenase gene (H6PD) influence the polycystic ovary syndrome (PCOS) and obesity. Gene. 2012; 497:38-44.
-
(2012)
Gene.
, vol.497
, pp. 38-44
-
-
Martinez-Garcia, M.A.1
San-Millan, J.L.2
Escobar-Morreale, H.F.3
-
60
-
-
80051660544
-
Genotype at the P554L variant of the hexose-6 phosphate dehydrogenase gene is associated with carotid intima-medial thickness
-
RahmanTJ, Walker EA, MayosiBM,et al. Genotype at the P554L variant of the hexose-6 phosphate dehydrogenase gene is associated with carotid intima-medial thickness. PLoS One. 2011;6:e23248.
-
(2011)
PLoS One.
, vol.6
-
-
Rahman, T.J.1
Walker, E.A.2
Mayosi, B.M.3
-
61
-
-
35748981184
-
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
-
Newport M, Sirugo G, Lyons E, et al. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet. 2007;39:1329-1337.
-
(2007)
Nat Genet.
, vol.39
, pp. 1329-1337
-
-
Newport, M.1
Sirugo, G.2
Lyons, E.3
-
62
-
-
77953808270
-
Tag-SNP analysis of the GFI1-EVI5-RPL5-FAM69 risk locus for multiple sclerosis
-
Alcina A, Fernandez O, Gonzalez JR, et al. Tag-SNP analysis of the GFI1-EVI5-RPL5-FAM69 risk locus for multiple sclerosis. Eur J Hum Genet. 2010;18:827-831.
-
(2010)
Eur J Hum Genet.
, vol.18
, pp. 827-831
-
-
Alcina, A.1
Fernandez, O.2
Gonzalez, J.R.3
-
63
-
-
33645750351
-
The basophil adenomas of the pituitary body and their clinical manifestations (pituitary basophilism)
-
Cushing H. The basophil adenomas of the pituitary body and their clinical manifestations (pituitary basophilism). Obes Res. 1994;2:486-508.
-
(1994)
Obes Res.
, vol.2
, pp. 486-508
-
-
Cushing, H.1
-
64
-
-
84867174123
-
Comparative diabetogenic action of the hypophysis from various animals
-
Houssay BA, Smyth FS, Foglia VG, Houssay AB. Comparative diabetogenic action of the hypophysis from various animals. J Exp Med. 1942;75:93-106.
-
(1942)
J Exp Med.
, vol.75
, pp. 93-106
-
-
Houssay, B.A.1
Smyth, F.S.2
Foglia, V.G.3
Houssay, A.B.4
-
65
-
-
0003683117
-
The effects of adrenalectomy and hypophysectomy upon experimental diabetes in the cat
-
Long CN, Lukens FD. The effects of adrenalectomy and hypophysectomy upon experimental diabetes in the cat. J Exp Med. 1936;63:465-490.
-
(1936)
J Exp Med.
, vol.63
, pp. 465-490
-
-
Long, C.N.1
Lukens, F.D.2
-
66
-
-
84884278864
-
Comparison of some metabolic and morphologic effects of cortisone and hydrocortisone given by continuous injection to rats
-
Ingle DJ, Meeks RC. Comparison of some metabolic and morphologic effects of cortisone and hydrocortisone given by continuous injection to rats. Am J Physiol. 1952;170: 77-80.
-
(1952)
Am J Physiol.
, vol.170
, pp. 77-80
-
-
Ingle, D.J.1
Meeks, R.C.2
-
67
-
-
84884216357
-
Some further studies on the relationship of adrenal cortical hormones to experimental diabetes
-
Ingle DJ. Some further studies on the relationship of adrenal cortical hormones to experimental diabetes. Diabetes. 1952;1:345-350.
-
(1952)
Diabetes.
, vol.1
, pp. 345-350
-
-
Ingle, D.J.1
-
68
-
-
50449135374
-
The endocrine control of the blood-sugar
-
Long CN. The endocrine control of the blood-sugar. Lancet. 1952;262:325-329.
-
(1952)
Lancet.
, vol.262
, pp. 325-329
-
-
Long, C.N.1
-
69
-
-
77956489883
-
Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes
-
Gathercole LL, Stewart PM. Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes. J Steroid Biochem Mol Biol. 2010;122:21-27.
-
(2010)
J Steroid Biochem Mol Biol.
, vol.122
, pp. 21-27
-
-
Gathercole, L.L.1
Stewart, P.M.2
-
70
-
-
0033018598
-
Cortisol effects on body mass, blood pressure, and cholesterol in the general population
-
Fraser R, Ingram MC, Anderson NH, Morrison C, Davies E, Connell JM. Cortisol effects on body mass, blood pressure, and cholesterol in the general population. Hypertension. 1999;33:1364-1368.
-
(1999)
Hypertension.
, vol.33
, pp. 1364-1368
-
-
Fraser, R.1
Ingram, M.C.2
Anderson, N.H.3
Morrison, C.4
Davies, E.5
Connell, J.M.6
-
71
-
-
0026685047
-
Cortisol secretion in relation to body fat distribution in obese premenopausal women
-
Marin P, Darin N, Amemiya T, Andersson B, Jern S, Bjorntorp P. Cortisol secretion in relation to body fat distribution in obese premenopausal women. Metabolism. 1992; 41:882-886.
-
(1992)
Metabolism.
, vol.41
, pp. 882-886
-
-
Marin, P.1
Darin, N.2
Amemiya, T.3
Andersson, B.4
Jern, S.5
Bjorntorp, P.6
-
73
-
-
0031800688
-
Pulsatile secretion of ACTH and cortisol in premenopausal women: effect of obesity and body fat distribution
-
Pasquali R, Biscotti D, Spinucci G, et al. Pulsatile secretion of ACTH and cortisol in premenopausal women: effect of obesity and body fat distribution. Clin Endocrinol (Oxf). 1998;48:603-612.
-
(1998)
Clin Endocrinol (Oxf).
, vol.48
, pp. 603-612
-
-
Pasquali, R.1
Biscotti, D.2
Spinucci, G.3
-
74
-
-
0030144120
-
Inhibition of cortisol secretion by dexamethasone in relation to body fat distribution: a dose-response study
-
Ljung T, Andersson B, Bengtsson BA, Bjorntorp P, Marin P. Inhibition of cortisol secretion by dexamethasone in relation to body fat distribution: a dose-response study. Obes Res. 1996;4:277-282.
-
(1996)
Obes Res.
, vol.4
, pp. 277-282
-
-
Ljung, T.1
Andersson, B.2
Bengtsson, B.A.3
Bjorntorp, P.4
Marin, P.5
-
75
-
-
0032990860
-
Cortisol metabolism in human obesity: impaired cortisone3cortisol conversion in subjects with central adiposity
-
Stewart PM, Boulton A, Kumar S, Clark PM, Shackleton CH. Cortisol metabolism in human obesity: impaired cortisone3cortisol conversion in subjects with central adiposity. J Clin Endocrinol Metab. 1999;84:1022-1027.
-
(1999)
J Clin Endocrinol Metab.
, vol.84
, pp. 1022-1027
-
-
Stewart, P.M.1
Boulton, A.2
Kumar, S.3
Clark, P.M.4
Shackleton, C.H.5
-
76
-
-
4544263736
-
11β-Hydroxysteroid dehydrogenase type 1 activity in lean and obese males with type 2 diabetes mellitus
-
Valsamakis G, Anwar A, Tomlinson JW, et al. 11β-Hydroxysteroid dehydrogenase type 1 activity in lean and obese males with type 2 diabetes mellitus. J Clin Endocrinol Metab. 2004;89:4755-4761.
-
(2004)
J Clin Endocrinol Metab.
, vol.89
, pp. 4755-4761
-
-
Valsamakis, G.1
Anwar, A.2
Tomlinson, J.W.3
-
77
-
-
24044436526
-
Relationship of non-alcoholic hepatic steatosis to cortisol secretion in diet-controlled type 2 diabetic patients
-
Targher G, Bertolini L, Zoppini G, Zenari L, Falezza G. Relationship of non-alcoholic hepatic steatosis to cortisol secretion in diet-controlled type 2 diabetic patients. Diabet Med. 2005;22:1146-1150.
-
(2005)
Diabet Med.
, vol.22
, pp. 1146-1150
-
-
Targher, G.1
Bertolini, L.2
Zoppini, G.3
Zenari, L.4
Falezza, G.5
-
78
-
-
10744221420
-
Body fat distribution and cortisol metabolism in healthy men: enhanced 5β-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver
-
Westerbacka J, Yki-Jarvinen H, Vehkavaara S, et al. Body fat distribution and cortisol metabolism in healthy men: enhanced 5β-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver. J Clin Endocrinol Metab. 2003;88:4924-4931.
-
(2003)
J Clin Endocrinol Metab.
, vol.88
, pp. 4924-4931
-
-
Westerbacka, J.1
Yki-Jarvinen, H.2
Vehkavaara, S.3
-
79
-
-
33644956181
-
Associations between liver histology and cortisol secretion in subjects with nonalcoholic fatty liver disease
-
Targher G, Bertolini L, Rodella S, Zoppini G, Zenari L, Falezza G. Associations between liver histology and cortisol secretion in subjects with nonalcoholic fatty liver disease. Clin Endocrinol (Oxf). 2006;64:337-341.
-
(2006)
Clin Endocrinol (Oxf).
, vol.64
, pp. 337-341
-
-
Targher, G.1
Bertolini, L.2
Rodella, S.3
Zoppini, G.4
Zenari, L.5
Falezza, G.6
-
80
-
-
10844271391
-
Relationship of nonalcoholic hepatic steatosis to overnight low-dose dexamethasone suppression test in obese individuals
-
Zoppini G, Targher G, Venturi C, Zamboni C, MuggeoM. Relationship of nonalcoholic hepatic steatosis to overnight low-dose dexamethasone suppression test in obese individuals. Clin Endocrinol (Oxf). 2004;61:711-715.
-
(2004)
Clin Endocrinol (Oxf).
, vol.61
, pp. 711-715
-
-
Zoppini, G.1
Targher, G.2
Venturi, C.3
Zamboni, C.4
Muggeo, M.5
-
81
-
-
0029905399
-
Induction of peroxisome proliferator-activated receptor γ during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPβ, C/EBPδ, and glucocorticoids
-
Wu Z, Bucher NL, Farmer SR. Induction of peroxisome proliferator-activated receptor γ during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPβ, C/EBPδ, and glucocorticoids. Mol Cell Biol. 1996;16: 4128-4136.
-
(1996)
Mol Cell Biol.
, vol.16
, pp. 4128-4136
-
-
Wu, Z.1
Bucher, N.L.2
Farmer, S.R.3
-
82
-
-
0026050219
-
Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells
-
Cao Z, Umek RM, McKnight SL. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 1991;5:1538-1552.
-
(1991)
Genes Dev.
, vol.5
, pp. 1538-1552
-
-
Cao, Z.1
Umek, R.M.2
McKnight, S.L.3
-
83
-
-
0026055103
-
Glucocorticoids induce a drastic inhibition of proliferation and stimulate differentiation of adult rat fat cell precursors
-
Gregoire F, Genart C, Hauser N, Remacle C. Glucocorticoids induce a drastic inhibition of proliferation and stimulate differentiation of adult rat fat cell precursors. Exp Cell Res. 1991;196:270-278.
-
(1991)
Exp Cell Res.
, vol.196
, pp. 270-278
-
-
Gregoire, F.1
Genart, C.2
Hauser, N.3
Remacle, C.4
-
84
-
-
0036875503
-
Human adipose tissue under in vitro inhibition of 11β-hydroxysteroid dehydrogenase type 1: differentiation and metabolism changes
-
Bader T, Zoumakis E, Friedberg M, Hiroi N, Chrousos GP, Hochberg Z. Human adipose tissue under in vitro inhibition of 11β-hydroxysteroid dehydrogenase type 1: differentiation and metabolism changes. Horm Metab Res. 2002;34:752-757.
-
(2002)
Horm Metab Res.
, vol.34
, pp. 752-757
-
-
Bader, T.1
Zoumakis, E.2
Friedberg, M.3
Hiroi, N.4
Chrousos, G.P.5
Hochberg, Z.6
-
85
-
-
0028037616
-
Hormonal regulation of hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytes
-
Slavin BG, Ong JM, Kern PA. Hormonal regulation of hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytes. J Lipid Res. 1994;35:1535-1541.
-
(1994)
J Lipid Res.
, vol.35
, pp. 1535-1541
-
-
Slavin, B.G.1
Ong, J.M.2
Kern, P.A.3
-
86
-
-
8744297386
-
Desnutrin, an adipocyte gene encoding a novel patatin domaincontaining protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis
-
Villena JA, Roy S, Sarkadi-Nagy E, Kim KH, Sul HS. Desnutrin, an adipocyte gene encoding a novel patatin domaincontaining protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis. J Biol Chem. 2004;279:47066-47075.
-
(2004)
J Biol Chem.
, vol.279
, pp. 47066-47075
-
-
Villena, J.A.1
Roy, S.2
Sarkadi-Nagy, E.3
Kim, K.H.4
Sul, H.S.5
-
87
-
-
80054113921
-
Regulation of lipogenesis by glucocorticoids and insulin in human adipose tissue
-
Gathercole LL, Morgan SA, Bujalska IJ, Hauton D, Stewart PM, Tomlinson JW. Regulation of lipogenesis by glucocorticoids and insulin in human adipose tissue. PLoS One. 2011;6:e26223.
-
(2011)
PLoS One.
, vol.6
-
-
Gathercole, L.L.1
Morgan, S.A.2
Bujalska, I.J.3
Hauton, D.4
Stewart, P.M.5
Tomlinson, J.W.6
-
88
-
-
0023202848
-
Glucocorticoids control phosphoenolpyruvate carboxykinase gene expression in a tissue specific manner
-
Nechushtan H, Benvenisty N, Brandeis R, Reshef L. Glucocorticoids control phosphoenolpyruvate carboxykinase gene expression in a tissue specific manner. Nucleic Acids Res. 1987;15:6405-6417.
-
(1987)
Nucleic Acids Res.
, vol.15
, pp. 6405-6417
-
-
Nechushtan, H.1
Benvenisty, N.2
Brandeis, R.3
Reshef, L.4
-
89
-
-
0038305987
-
Glucocorticoids repress transcription of phosphoenolpyruvate carboxykinase (GTP) gene in adipocytes by inhibiting its C/EBPmediated activation
-
Olswang Y, Blum B, Cassuto H, et al. Glucocorticoids repress transcription of phosphoenolpyruvate carboxykinase (GTP) gene in adipocytes by inhibiting its C/EBPmediated activation. J Biol Chem. 2003;278:12929-12936.
-
(2003)
J Biol Chem.
, vol.278
, pp. 12929-12936
-
-
Olswang, Y.1
Blum, B.2
Cassuto, H.3
-
90
-
-
2442490613
-
The human fatty acid synthase gene and de novo lipogenesis are coordinately regulated in human adipose tissue
-
Wang Y, Jones VB, Urs S, et al. The human fatty acid synthase gene and de novo lipogenesis are coordinately regulated in human adipose tissue. J Nutr. 2004;134: 1032-1038.
-
(2004)
J Nutr.
, vol.134
, pp. 1032-1038
-
-
Wang, Y.1
Jones, V.B.2
Urs, S.3
-
91
-
-
0018854541
-
Effects of insulin, glucocorticoids and adrenaline on the activity of rat adipose-tissue lipoprotein lipids
-
Ashby P, Robinson DS. Effects of insulin, glucocorticoids and adrenaline on the activity of rat adipose-tissue lipoprotein lipids. Biochem J. 1980;188:185-192.
-
(1980)
Biochem J.
, vol.188
, pp. 185-192
-
-
Ashby, P.1
Robinson, D.S.2
-
92
-
-
0036204548
-
Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes
-
Buren J, Liu HX, Jensen J, Eriksson JW. Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes. Eur J Endocrinol. 2002;146:419-429.
-
(2002)
Eur J Endocrinol.
, vol.146
, pp. 419-429
-
-
Buren, J.1
Liu, H.X.2
Jensen, J.3
Eriksson, J.W.4
-
93
-
-
2942675015
-
Glucocorticoids down-regulate glucose uptake capacity and insulin-signaling proteins in omental but not subcutaneous human adipocytes
-
Lundgren M, Buren J, Ruge T, Myrnas T, Eriksson JW. Glucocorticoids down-regulate glucose uptake capacity and insulin-signaling proteins in omental but not subcutaneous human adipocytes. J Clin Endocrinol Metab. 2004; 89:2989-2997.
-
(2004)
J Clin Endocrinol Metab.
, vol.89
, pp. 2989-2997
-
-
Lundgren, M.1
Buren, J.2
Ruge, T.3
Myrnas, T.4
Eriksson, J.W.5
-
94
-
-
0033820515
-
Dexamethasoneinduced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction
-
Sakoda H, Ogihara T, Anai M, et al. Dexamethasoneinduced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction. Diabetes. 2000;49:1700-1708.
-
(2000)
Diabetes.
, vol.49
, pp. 1700-1708
-
-
Sakoda, H.1
Ogihara, T.2
Anai, M.3
-
95
-
-
0028024916
-
Dexamethasone down-regulation of insulin receptor substrate-1 in 3T3-L1 adipocytes
-
Turnbow MA, Keller SR, Rice KM, Garner CW. Dexamethasone down-regulation of insulin receptor substrate-1 in 3T3-L1 adipocytes. J Biol Chem. 1994;269:2516-2520.
-
(1994)
J Biol Chem.
, vol.269
, pp. 2516-2520
-
-
Turnbow, M.A.1
Keller, S.R.2
Rice, K.M.3
Garner, C.W.4
-
97
-
-
73549120403
-
Insulin sensitization of human preadipocytes through glucocorticoid hormone induction of forkhead transcription factors
-
Tomlinson JJ, Boudreau A, Wu DM, et al. Insulin sensitization of human preadipocytes through glucocorticoid hormone induction of forkhead transcription factors. Mol Endocrinol. 2010;24:104-113.
-
(2010)
Mol Endocrinol.
, vol.24
, pp. 104-113
-
-
Tomlinson, J.J.1
Boudreau, A.2
Wu, D.M.3
-
98
-
-
0030936556
-
Does central obesity reflect "Cushing's disease of the omentum"?
-
Bujalska IJ, Kumar S, Stewart PM. Does central obesity reflect "Cushing's disease of the omentum"? Lancet. 1997; 349:1210-1213.
-
(1997)
Lancet
, vol.349
, pp. 1210-1213
-
-
Bujalska, I.J.1
Kumar, S.2
Stewart, P.M.3
-
99
-
-
0025676247
-
Epithelial and adipose cells isolated from mammary glands of pregnant and lactating rats differ in 11 β-hydroxysteroid dehydrogenase activity
-
Quirk SJ, Slattery JA, Funder JW. Epithelial and adipose cells isolated from mammary glands of pregnant and lactating rats differ in 11 β-hydroxysteroid dehydrogenase activity. J Steroid Biochem Mol Biol. 1990;37:529-534.
-
(1990)
J Steroid Biochem Mol Biol.
, vol.37
, pp. 529-534
-
-
Quirk, S.J.1
Slattery, J.A.2
Funder, J.W.3
-
100
-
-
85047681877
-
Regulation of expression of 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines
-
Tomlinson JW, Moore J, Cooper MS, et al. Regulation of expression of 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines. Endocrinology. 2001;142:1982-1989.
-
(2001)
Endocrinology.
, vol.142
, pp. 1982-1989
-
-
Tomlinson, J.W.1
Moore, J.2
Cooper, M.S.3
-
101
-
-
0034163768
-
Insulin attenuates the stimulatory effects of tumor necrosis factor α on 11β-hydroxysteroid dehydrogenase 1 in human adipose stromal cells
-
Handoko K, Yang K, Strutt B, Khalil W, Killinger D. Insulin attenuates the stimulatory effects of tumor necrosis factor α on 11β-hydroxysteroid dehydrogenase 1 in human adipose stromal cells. J Steroid Biochem Mol Biol. 2000;72:163-168.
-
(2000)
J Steroid Biochem Mol Biol.
, vol.72
, pp. 163-168
-
-
Handoko, K.1
Yang, K.2
Strutt, B.3
Khalil, W.4
Killinger, D.5
-
102
-
-
0037238703
-
Modulation of 11 β-hydroxysteroid dehydrogenase type 1 in mature human subcutaneous adipocytes by hypothalamic messengers
-
Friedberg M, Zoumakis E, Hiroi N, Bader T, Chrousos GP, Hochberg Z. Modulation of 11 β-hydroxysteroid dehydrogenase type 1 in mature human subcutaneous adipocytes by hypothalamic messengers. J Clin Endocrinol Metab. 2003;88:385-393.
-
(2003)
J Clin Endocrinol Metab.
, vol.88
, pp. 385-393
-
-
Friedberg, M.1
Zoumakis, E.2
Hiroi, N.3
Bader, T.4
Chrousos, G.P.5
Hochberg, Z.6
-
103
-
-
69949092969
-
Omental adipose tissue type 1 11 β-hydroxysteroid dehydrogenase oxoreductase activity, body fat distribution, and metabolic alterations in women
-
Veilleux A, Rheaume C, Daris M, Luu-The V, Tchernof A. Omental adipose tissue type 1 11 β-hydroxysteroid dehydrogenase oxoreductase activity, body fat distribution, and metabolic alterations in women. J Clin Endocrinol Metab. 2009;94:3550-3557.
-
(2009)
J Clin Endocrinol Metab.
, vol.94
, pp. 3550-3557
-
-
Veilleux, A.1
Rheaume, C.2
Daris, M.3
Luu-The, V.4
Tchernof, A.5
-
104
-
-
43849098723
-
A novel selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis
-
Bujalska IJ, Gathercole LL, Tomlinson JW, et al. A novel selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis. J Endocrinol. 2008; 197:297-307.
-
(2008)
J Endocrinol.
, vol.197
, pp. 297-307
-
-
Bujalska, I.J.1
Gathercole, L.L.2
Tomlinson, J.W.3
-
105
-
-
0033305631
-
Differentiation of adipose stromal cells: the roles of glucocorticoids and 11β-hydroxysteroid dehydrogenase
-
Bujalska IJ, Kumar S, Hewison M, Stewart PM. Differentiation of adipose stromal cells: the roles of glucocorticoids and 11β-hydroxysteroid dehydrogenase. Endocrinology. 1999;140:3188-3196.
-
(1999)
Endocrinology.
, vol.140
, pp. 3188-3196
-
-
Bujalska, I.J.1
Kumar, S.2
Hewison, M.3
Stewart, P.M.4
-
106
-
-
0034519393
-
Mechanisms of dysregulation of 11 β-hydroxysteroid dehydrogenase type 1 in obese Zucker rats
-
Livingstone DE, Kenyon CJ, Walker BR. Mechanisms of dysregulation of 11 β-hydroxysteroid dehydrogenase type 1 in obese Zucker rats. J Endocrinol. 2000;167:533-539.
-
(2000)
J Endocrinol.
, vol.167
, pp. 533-539
-
-
Livingstone, D.E.1
Kenyon, C.J.2
Walker, B.R.3
-
107
-
-
0034463972
-
Understanding the role of glucocorticoids in obesity: tissue-specific alterations of corticosterone metabolism in obese Zucker rats
-
Livingstone DE, Jones GC, Smith K, et al. Understanding the role of glucocorticoids in obesity: tissue-specific alterations of corticosterone metabolism in obese Zucker rats. Endocrinology. 2000;141:560-563.
-
(2000)
Endocrinology.
, vol.141
, pp. 560-563
-
-
Livingstone, D.E.1
Jones, G.C.2
Smith, K.3
-
108
-
-
78649748000
-
A novel genetically-obese rat model with elevated 11 β-hydroxysteroid dehydrogenase type 1 activity in subcutaneous adipose tissue
-
Prasad SS, Prashanth A, Kumar CP, Reddy SJ, Giridharan NV, Vajreswari A. A novel genetically-obese rat model with elevated 11 β-hydroxysteroid dehydrogenase type 1 activity in subcutaneous adipose tissue. Lipids Health Dis. 2010;9:132.
-
(2010)
Lipids Health Dis.
, vol.9
, pp. 132
-
-
Prasad, S.S.1
Prashanth, A.2
Kumar, C.P.3
Reddy, S.J.4
Giridharan, N.V.5
Vajreswari, A.6
-
109
-
-
34047199047
-
Bezafibrate regulates the expression and enzyme activity of 11 β-hydroxysteroid dehydrogenase type 1 in murine adipose tissue and 3T3-L1 adipocytes
-
Nakano S, Inada Y, Masuzaki H, et al. Bezafibrate regulates the expression and enzyme activity of 11 β-hydroxysteroid dehydrogenase type 1 in murine adipose tissue and 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab. 2007;292:E1213-E1222.
-
(2007)
Am J Physiol Endocrinol Metab.
, vol.292
-
-
Nakano, S.1
Inada, Y.2
Masuzaki, H.3
-
110
-
-
12344333357
-
Reduced adipose glucocorticoid reactivation and increased hepatic glucocorticoid clearance as an early adaptation to high-fat feeding in Wistar rats
-
Drake AJ, Livingstone DE, Andrew R, Seckl JR, Morton NM, Walker BR. Reduced adipose glucocorticoid reactivation and increased hepatic glucocorticoid clearance as an early adaptation to high-fat feeding in Wistar rats. Endocrinology. 2005;146:913-919.
-
(2005)
Endocrinology.
, vol.146
, pp. 913-919
-
-
Drake, A.J.1
Livingstone, D.E.2
Andrew, R.3
Seckl, J.R.4
Morton, N.M.5
Walker, B.R.6
-
111
-
-
1842552244
-
Regulation of 11β-HSD genes in human adipose tissue: influence of central obesity and weight loss
-
Engeli S, Bohnke J, Feldpausch M, et al. Regulation of 11β-HSD genes in human adipose tissue: influence of central obesity and weight loss. Obes Res. 2004;12:9-17.
-
(2004)
Obes Res.
, vol.12
, pp. 9-17
-
-
Engeli, S.1
Bohnke, J.2
Feldpausch, M.3
-
112
-
-
33745186881
-
Glucocorticoid metabolism within superficial subcutaneous rather than visceral adipose tissue is associated with features of the metabolic syndrome in South African women
-
Goedecke JH, Wake DJ, Levitt NS, et al. Glucocorticoid metabolism within superficial subcutaneous rather than visceral adipose tissue is associated with features of the metabolic syndrome in South African women. Clin Endocrinol (Oxf). 2006;65:81-87.
-
(2006)
Clin Endocrinol (Oxf).
, vol.65
, pp. 81-87
-
-
Goedecke, J.H.1
Wake, D.J.2
Levitt, N.S.3
-
113
-
-
4544260173
-
Overexpression of 11β-hydroxysteroid dehydrogenase-1 in adipose tissue is associated with acquired obesity and features of insulin resistance: studies in young adult monozygotic twins
-
Kannisto K, Pietilainen KH, Ehrenborg E, et al. Overexpression of 11β-hydroxysteroid dehydrogenase-1 in adipose tissue is associated with acquired obesity and features of insulin resistance: studies in young adult monozygotic twins. J Clin Endocrinol Metab. 2004;89:4414-4421.
-
(2004)
J Clin Endocrinol Metab.
, vol.89
, pp. 4414-4421
-
-
Kannisto, K.1
Pietilainen, K.H.2
Ehrenborg, E.3
-
114
-
-
0037902924
-
Subcutaneous adipose 11 β-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in Pima Indians and Caucasians
-
Lindsay RS, Wake DJ, Nair S, et al. Subcutaneous adipose 11 β-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in Pima Indians and Caucasians. J Clin Endocrinol Metab. 2003;88:2738-2744.
-
(2003)
J Clin Endocrinol Metab.
, vol.88
, pp. 2738-2744
-
-
Lindsay, R.S.1
Wake, D.J.2
Nair, S.3
-
115
-
-
0036075081
-
Expression of the mRNA coding for 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue from obese patients: an in situ hybridization study
-
Paulmyer-Lacroix O, Boullu S, Oliver C, AlessiMC,Grino M. Expression of the mRNA coding for 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue from obese patients: an in situ hybridization study. J Clin Endocrinol Metab. 2002;87:2701-2705.
-
(2002)
J Clin Endocrinol Metab.
, vol.87
, pp. 2701-2705
-
-
Paulmyer-Lacroix, O.1
Boullu, S.2
Oliver, C.3
Alessi, M.C.4
Grino, M.5
-
116
-
-
0035051205
-
Tissue-specific dysregulation of cortisol metabolism in human obesity
-
Rask E, Olsson T, Soderberg S, et al. Tissue-specific dysregulation of cortisol metabolism in human obesity. J Clin Endocrinol Metab. 2001;86:1418-1421.
-
(2001)
J Clin Endocrinol Metab.
, vol.86
, pp. 1418-1421
-
-
Rask, E.1
Olsson, T.2
Soderberg, S.3
-
117
-
-
0036324073
-
Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11β-hydroxysteroid dehydrogenase type 1 activity
-
Rask E, Walker BR, Soderberg S, et al. Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11β-hydroxysteroid dehydrogenase type 1 activity. J Clin Endocrinol Metab. 2002;87:3330-3336.
-
(2002)
J Clin Endocrinol Metab.
, vol.87
, pp. 3330-3336
-
-
Rask, E.1
Walker, B.R.2
Soderberg, S.3
-
118
-
-
14644388141
-
Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11β-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone
-
Sandeep TC, Andrew R, Homer NZ, Andrews RC, Smith K, Walker BR. Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11β-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone. Diabetes. 2005;54:872-879.
-
(2005)
Diabetes.
, vol.54
, pp. 872-879
-
-
Sandeep, T.C.1
Andrew, R.2
Homer, N.Z.3
Andrews, R.C.4
Smith, K.5
Walker, B.R.6
-
119
-
-
73949158787
-
Overexpression of 11β-hydroxysteroid dehydrogenase type 1 in hepatic and visceral adipose tissue is associated with metabolic disorders in morbidly obese patients
-
Baudrand R, Carvajal CA, Riquelme A, et al. Overexpression of 11β-hydroxysteroid dehydrogenase type 1 in hepatic and visceral adipose tissue is associated with metabolic disorders in morbidly obese patients. Obes Surg. 2010;20:77-83.
-
(2010)
Obes Surg.
, vol.20
, pp. 77-83
-
-
Baudrand, R.1
Carvajal, C.A.2
Riquelme, A.3
-
120
-
-
33846888049
-
11β-Hydroxysteroid dehydrogenase type 1 mRNA is increased in both visceral and subcutaneous adipose tissue of obese patients
-
Desbriere R, Vuaroqueaux V, Achard V, et al. 11β-Hydroxysteroid dehydrogenase type 1 mRNA is increased in both visceral and subcutaneous adipose tissue of obese patients. Obesity (Silver Spring). 2006;14:794-798.
-
(2006)
Obesity (Silver Spring).
, vol.14
, pp. 794-798
-
-
Desbriere, R.1
Vuaroqueaux, V.2
Achard, V.3
-
121
-
-
34250634952
-
Omental 11β-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity
-
Michailidou Z, Jensen MD, Dumesic DA, et al. Omental 11β-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity. Obesity (Silver Spring). 2007;15:1155-1163.
-
(2007)
Obesity (Silver Spring).
, vol.15
, pp. 1155-1163
-
-
Michailidou, Z.1
Jensen, M.D.2
Dumesic, D.A.3
-
122
-
-
34548621405
-
11β-HSD type 1 expression in human adipose tissue: impact of gender, obesity, and fat localization
-
Paulsen SK, Pedersen SB, Fisker S, Richelsen B. 11β-HSD type 1 expression in human adipose tissue: impact of gender, obesity, and fat localization. Obesity (Silver Spring). 2007;15:1954-1960.
-
(2007)
Obesity (Silver Spring).
, vol.15
, pp. 1954-1960
-
-
Paulsen, S.K.1
Pedersen, S.B.2
Fisker, S.3
Richelsen, B.4
-
123
-
-
0036882136
-
Expression of 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity
-
Tomlinson JW, Sinha B, Bujalska I, Hewison M, Stewart PM. Expression of 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity. J Clin Endocrinol Metab. 2002;87:5630-5635.
-
(2002)
J Clin Endocrinol Metab.
, vol.87
, pp. 5630-5635
-
-
Tomlinson, J.W.1
Sinha, B.2
Bujalska, I.3
Hewison, M.4
Stewart, P.M.5
-
124
-
-
0031283178
-
11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress
-
Kotelevtsev Y, Holmes MC, Burchell A, et al. 11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress. Proc Natl Acad Sci USA. 1997;94:14924-14929.
-
(1997)
Proc Natl Acad Sci USA.
, vol.94
, pp. 14924-14929
-
-
Kotelevtsev, Y.1
Holmes, M.C.2
Burchell, A.3
-
125
-
-
12144291638
-
Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 β-hydroxysteroid dehydrogenase type 1-deficient mice
-
Morton NM, Paterson JM, Masuzaki H, et al. Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 β-hydroxysteroid dehydrogenase type 1-deficient mice. Diabetes. 2004;53:931-938.
-
(2004)
Diabetes.
, vol.53
, pp. 931-938
-
-
Morton, N.M.1
Paterson, J.M.2
Masuzaki, H.3
-
126
-
-
33745897922
-
Translocation of long chain fatty acids across the plasma membrane-lipid rafts and fatty acid transport proteins
-
Ehehalt R, Fullekrug J, Pohl J, Ring A, Herrmann T, Stremmel W. Translocation of long chain fatty acids across the plasma membrane-lipid rafts and fatty acid transport proteins. Mol Cell Biochem. 2006;284:135-140.
-
(2006)
Mol Cell Biochem.
, vol.284
, pp. 135-140
-
-
Ehehalt, R.1
Fullekrug, J.2
Pohl, J.3
Ring, A.4
Herrmann, T.5
Stremmel, W.6
-
127
-
-
18244363982
-
Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes
-
Maeda K, Cao H, Kono K, et al. Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metab. 2005;1: 107-119.
-
(2005)
Cell Metab.
, vol.1
, pp. 107-119
-
-
Maeda, K.1
Cao, H.2
Kono, K.3
-
128
-
-
0035824440
-
A transgenic model of visceral obesity and the metabolic syndrome
-
Masuzaki H, Paterson J, Shinyama H, et al. A transgenic model of visceral obesity and the metabolic syndrome. Science. 2001;294:2166-2170.
-
(2001)
Science.
, vol.294
, pp. 2166-2170
-
-
Masuzaki, H.1
Paterson, J.2
Shinyama, H.3
-
129
-
-
85047693986
-
Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice
-
Masuzaki H, Yamamoto H, Kenyon CJ, et al. Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. J Clin Invest. 2003; 112:83-90.
-
(2003)
J Clin Invest.
, vol.112
, pp. 83-90
-
-
Masuzaki, H.1
Yamamoto, H.2
Kenyon, C.J.3
-
130
-
-
15944394711
-
Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity
-
Kershaw EE, MortonNM,Dhillon H, Ramage L, Seckl JR, Flier JS. Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity. Diabetes. 2005;54: 1023-1031.
-
(2005)
Diabetes.
, vol.54
, pp. 1023-1031
-
-
Kershaw, E.E.1
Morton, N.M.2
Dhillon, H.3
Ramage, L.4
Seckl, J.R.5
Flier, J.S.6
-
131
-
-
0037382786
-
Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
-
Marchesini G, Bugianesi E, Forlani G, et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology. 2003;37:917-923.
-
(2003)
Hepatology.
, vol.37
, pp. 917-923
-
-
Marchesini, G.1
Bugianesi, E.2
Forlani, G.3
-
132
-
-
11144264156
-
Nonalcoholic fatty liver disease: a review of current understanding and future impact
-
Charlton M. Nonalcoholic fatty liver disease: a review of current understanding and future impact. Clin Gastroenterol Hepatol. 2004;2:1048-1058.
-
(2004)
Clin Gastroenterol Hepatol.
, vol.2
, pp. 1048-1058
-
-
Charlton, M.1
-
133
-
-
0346728586
-
Hepatic steatosis in Cushing's syndrome: a radiological assessment using computed tomography
-
Rockall AG, Sohaib SA, Evans D, et al. Hepatic steatosis in Cushing's syndrome: a radiological assessment using computed tomography. Eur J Endocrinol. 2003;149:543-548.
-
(2003)
Eur J Endocrinol.
, vol.149
, pp. 543-548
-
-
Rockall, A.G.1
Sohaib, S.A.2
Evans, D.3
-
135
-
-
0032747485
-
Subacute severe steatohepatitis during prednisolone therapy for systemic lupus erythematosis
-
Nanki T, Koike R, Miyasaka N. Subacute severe steatohepatitis during prednisolone therapy for systemic lupus erythematosis. Am J Gastroenterol. 1999;94:3379.
-
(1999)
Am J Gastroenterol.
, vol.94
, pp. 3379
-
-
Nanki, T.1
Koike, R.2
Miyasaka, N.3
-
136
-
-
0020630564
-
The effects of glucocorticoids on insulin-stimulated lipogenesis in primary cultures of rat hepatocytes
-
Amatruda JM, Danahy SA, Chang CL. The effects of glucocorticoids on insulin-stimulated lipogenesis in primary cultures of rat hepatocytes. Biochem J. 1983;212:135-141.
-
(1983)
Biochem J.
, vol.212
, pp. 135-141
-
-
Amatruda, J.M.1
Danahy, S.A.2
Chang, C.L.3
-
137
-
-
77953631114
-
Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription
-
Zhao LF, Iwasaki Y, Zhe W, et al. Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription. Endocr J. 2010;57:317-324.
-
(2010)
Endocr J.
, vol.57
, pp. 317-324
-
-
Zhao, L.F.1
Iwasaki, Y.2
Zhe, W.3
-
138
-
-
1642545652
-
Regulation of the enzymes of hepatic microsomal triacylglycerol lipolysis and re-esterification by the glucocorticoid dexamethasone
-
Dolinsky VW, Douglas DN, Lehner R, Vance DE. Regulation of the enzymes of hepatic microsomal triacylglycerol lipolysis and re-esterification by the glucocorticoid dexamethasone. Biochem J. 2004;378:967-974.
-
(2004)
Biochem J.
, vol.378
, pp. 967-974
-
-
Dolinsky, V.W.1
Douglas, D.N.2
Lehner, R.3
Vance, D.E.4
-
139
-
-
0015432606
-
Tissue effects of glucocorticoids
-
Baxter JD, Forsham PH. Tissue effects of glucocorticoids. Am J Med. 1972;53:573-589.
-
(1972)
Am J Med.
, vol.53
, pp. 573-589
-
-
Baxter, J.D.1
Forsham, P.H.2
-
140
-
-
0037216466
-
Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets
-
Schwarz JM, Linfoot P, Dare D, Aghajanian K. Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets. Am J Clin Nutr. 2003;77:43-50.
-
(2003)
Am J Clin Nutr.
, vol.77
, pp. 43-50
-
-
Schwarz, J.M.1
Linfoot, P.2
Dare, D.3
Aghajanian, K.4
-
141
-
-
0031762902
-
Immunohistochemical localization of type 1 11β-hydroxysteroid dehydrogenase in human tissues
-
Ricketts ML, Verhaeg JM, Bujalska I, Howie AJ, Rainey WE, Stewart PM. Immunohistochemical localization of type 1 11β-hydroxysteroid dehydrogenase in human tissues. J Clin Endocrinol Metab. 1998;83:1325-1335.
-
(1998)
J Clin Endocrinol Metab.
, vol.83
, pp. 1325-1335
-
-
Ricketts, M.L.1
Verhaeg, J.M.2
Bujalska, I.3
Howie, A.J.4
Rainey, W.E.5
Stewart, P.M.6
-
142
-
-
0028973283
-
11 β-Hydroxysteroid dehydrogenase is an exclusive 11 β-reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations
-
Jamieson PM, Chapman KE, Edwards CR, Seckl JR. 11 β-Hydroxysteroid dehydrogenase is an exclusive 11 β-reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations. Endocrinology. 1995;136:4754-4761.
-
(1995)
Endocrinology.
, vol.136
, pp. 4754-4761
-
-
Jamieson, P.M.1
Chapman, K.E.2
Edwards, C.R.3
Seckl, J.R.4
-
143
-
-
0031965002
-
Regulation of 11 β-hydroxysteroid dehydrogenase type 1 in primary cultures of rat and human hepatocytes
-
Ricketts ML, Shoesmith KJ, Hewison M, Strain A, Eggo MC, Stewart PM. Regulation of 11 β-hydroxysteroid dehydrogenase type 1 in primary cultures of rat and human hepatocytes. J Endocrinol. 1998;156:159-168.
-
(1998)
J Endocrinol.
, vol.156
, pp. 159-168
-
-
Ricketts, M.L.1
Shoesmith, K.J.2
Hewison, M.3
Strain, A.4
Eggo, M.C.5
Stewart, P.M.6
-
144
-
-
84857365181
-
Liver upregulation of genes involved in cortisol production and action is associated with metabolic syndrome in morbidly obese patients
-
Torrecilla E, Fernandez-Vazquez G, Vicent D, et al. Liver upregulation of genes involved in cortisol production and action is associated with metabolic syndrome in morbidly obese patients. Obes Surg. 2012;22:478-486.
-
(2012)
Obes Surg.
, vol.22
, pp. 478-486
-
-
Torrecilla, E.1
Fernandez-Vazquez, G.2
Vicent, D.3
-
145
-
-
61449225726
-
Hepatic 11β-HSD1 mRNA expression in fatty liver and nonalcoholic steatohepatitis
-
Konopelska S, Kienitz T, Hughes B, et al. Hepatic 11β-HSD1 mRNA expression in fatty liver and nonalcoholic steatohepatitis. Clin Endocrinol (Oxf). 2009;70:554-560.
-
(2009)
Clin Endocrinol (Oxf).
, vol.70
, pp. 554-560
-
-
Konopelska, S.1
Kienitz, T.2
Hughes, B.3
-
146
-
-
84856679119
-
Overexpression of 11β-hydroxysteroid dehydrogenase type 1 in visceral adipose tissue and portal hypercortisolism in non-alcoholic fatty liver disease
-
Candia R, Riquelme A, Baudrand R, et al. Overexpression of 11β-hydroxysteroid dehydrogenase type 1 in visceral adipose tissue and portal hypercortisolism in non-alcoholic fatty liver disease. Liver Int. 2012;32:392-399.
-
(2012)
Liver Int.
, vol.32
, pp. 392-399
-
-
Candia, R.1
Riquelme, A.2
Baudrand, R.3
-
147
-
-
84857403547
-
A switch in hepatic cortisol metabolism across the spectrum of non alcoholic fatty liver disease
-
Ahmed A, Rabbitt E, Brady T, et al. A switch in hepatic cortisol metabolism across the spectrum of non alcoholic fatty liver disease. PLoS One. 2012;7:e29531.
-
(2012)
PLoS One.
, vol.7
-
-
Ahmed, A.1
Rabbitt, E.2
Brady, T.3
-
148
-
-
12144250997
-
Increased glucocorticoid receptor and 11β-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the phenotype of type 2 diabetes in db/db mice
-
Liu Y, Nakagawa Y, Wang Y, et al. Increased glucocorticoid receptor and 11β-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the phenotype of type 2 diabetes in db/db mice. Diabetes. 2005;54: 32-40.
-
(2005)
Diabetes.
, vol.54
, pp. 32-40
-
-
Liu, Y.1
Nakagawa, Y.2
Wang, Y.3
-
149
-
-
0035798621
-
Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11β-hydroxysteroid dehydrogenase type 1 null mice
-
Morton NM, Holmes MC, Fievet C, et al. Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11β-hydroxysteroid dehydrogenase type 1 null mice. J Biol Chem. 2001;276:41293-41300.
-
(2001)
J Biol Chem.
, vol.276
, pp. 41293-41300
-
-
Morton, N.M.1
Holmes, M.C.2
Fievet, C.3
-
150
-
-
0031059756
-
Effects of glucocorticoid excess on the sensitivity of glucose transport and metabolism to insulin in rat skeletal muscle
-
Dimitriadis G, Leighton B, Parry-Billings M, et al. Effects of glucocorticoid excess on the sensitivity of glucose transport and metabolism to insulin in rat skeletal muscle. Biochem J. 1997;321:707-712.
-
(1997)
Biochem J.
, vol.321
, pp. 707-712
-
-
Dimitriadis, G.1
Leighton, B.2
Parry-Billings, M.3
-
151
-
-
70350540686
-
11β-Hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle
-
Morgan SA, Sherlock M, Gathercole LL, et al. 11β-Hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle. Diabetes. 2009;58:2506-2015.
-
(2009)
Diabetes.
, vol.58
, pp. 2506-2015
-
-
Morgan, S.A.1
Sherlock, M.2
Gathercole, L.L.3
-
152
-
-
65649147217
-
Glucocorticoid-mediated effects on metabolism are reversed by targeting 11 β hydroxysteroid dehydrogenase type 1 in human skeletal muscle
-
Salehzadeh F, Al-Khalili L, Kulkarni SS, Wang M, Lönnqvist F, Krook A. Glucocorticoid-mediated effects on metabolism are reversed by targeting 11 β hydroxysteroid dehydrogenase type 1 in human skeletal muscle. Diabetes Metab Res Rev. 2009;25:250-258.
-
(2009)
Diabetes Metab Res Rev.
, vol.25
, pp. 250-258
-
-
Salehzadeh, F.1
Al-Khalili, L.2
Kulkarni, S.S.3
Wang, M.4
Lönnqvist, F.5
Krook, A.6
-
153
-
-
61549099632
-
Alteration of 11 β-hydroxysteroid dehydrogenase type 1 in skeletal muscle in a rat model of type 2 diabetes
-
Zhang M, Lv XY, Li J, Xu ZG, Chen L. Alteration of 11 β-hydroxysteroid dehydrogenase type 1 in skeletal muscle in a rat model of type 2 diabetes. Mol Cell Biochem. 2009; 324:147-155.
-
(2009)
Mol Cell Biochem.
, vol.324
, pp. 147-155
-
-
Zhang, M.1
Lv, X.Y.2
Li, J.3
Xu, Z.G.4
Chen, L.5
-
154
-
-
26044458939
-
Increased expression of 11β-hydroxysteroid dehydrogenase type 1 in type 2 diabetic myotubes
-
doi: 10.1210/er.2012-1050 edrv.endojournals.org 549
-
Abdallah BM, Beck-Nielsen H, Gaster M. Increased expression of 11β-hydroxysteroid dehydrogenase type 1 in type 2 diabetic myotubes. Eur J Clin Invest. 2005;35:627-634. doi: 10.1210/er.2012-1050 edrv.endojournals.org 549
-
(2005)
Eur J Clin Invest.
, vol.35
, pp. 627-634
-
-
Abdallah, B.M.1
Beck-Nielsen, H.2
Gaster, M.3
-
155
-
-
0035000828
-
Regulation of glucocorticoid receptor α and β isoforms and type I 11β-hydroxysteroid dehydrogenase expression in human skeletal muscle cells: a key role in the pathogenesis of insulin resistance?
-
Whorwood CB, Donovan SJ, Wood PJ, Phillips DI. Regulation of glucocorticoid receptor α and β isoforms and type I 11β-hydroxysteroid dehydrogenase expression in human skeletal muscle cells: a key role in the pathogenesis of insulin resistance? J Clin Endocrinol Metab. 2001;6: 2296-2308.
-
(2001)
J Clin Endocrinol Metab
, vol.6
, pp. 2296-2308
-
-
Whorwood, C.B.1
Donovan, S.J.2
Wood, P.J.3
Phillips, D.I.4
-
156
-
-
79953272271
-
Morphofunctional alterations in endocrine pancreas of short-and longterm dexamethasone-treated rats
-
Rafacho A, Abrantes JL, Ribeiro DL, et al. Morphofunctional alterations in endocrine pancreas of short-and longterm dexamethasone-treated rats.HormMetab Res. 2011; 43:275-281.
-
(2011)
HormMetab Res.
, vol.43
, pp. 275-281
-
-
Rafacho, A.1
Abrantes, J.L.2
Ribeiro, D.L.3
-
157
-
-
0036314864
-
Is reduced first-phase insulin release the earliest detectable abnormality in individuals destined to develop type 2 diabetes?
-
Gerich JE. Is reduced first-phase insulin release the earliest detectable abnormality in individuals destined to develop type 2 diabetes? Diabetes. 2002;51(suppl 1):S117-S121.
-
(2002)
Diabetes
, vol.51
, Issue.1
-
-
Gerich, J.E.1
-
158
-
-
79957900616
-
Dynamics of insulin secretion and the clinical implications for obesity and diabetes
-
Seino S, Shibasaki T, Minami K. Dynamics of insulin secretion and the clinical implications for obesity and diabetes. J Clin Invest. 2011;121:2118-2125.
-
(2011)
J Clin Invest.
, vol.121
, pp. 2118-2125
-
-
Seino, S.1
Shibasaki, T.2
Minami, K.3
-
159
-
-
53549105499
-
11β-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets
-
Swali A, Walker EA, Lavery GG, Tomlinson JW, Stewart PM. 11β-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets. Diabetologia. 2008;51:2003-2011.
-
(2008)
Diabetologia.
, vol.51
, pp. 2003-2011
-
-
Swali, A.1
Walker, E.A.2
Lavery, G.G.3
Tomlinson, J.W.4
Stewart, P.M.5
-
161
-
-
21744451489
-
Regulation of 11 β-hydroxysteroid dehydrogenase type 1 and glucose-stimulated insulin secretion in pancreatic islets of Langerhans
-
Ortsater H, Alberts P, Warpman U, Engblom LO, Abrahmsen L, Bergsten P. Regulation of 11 β-hydroxysteroid dehydrogenase type 1 and glucose-stimulated insulin secretion in pancreatic islets of Langerhans. Diabetes Metab Res Rev. 2005;21:359-366.
-
(2005)
Diabetes Metab Res Rev.
, vol.21
, pp. 359-366
-
-
Ortsater, H.1
Alberts, P.2
Warpman, U.3
Engblom, L.O.4
Abrahmsen, L.5
Bergsten, P.6
-
162
-
-
60249098462
-
Short-term glucocorticoid treatment increases insulin secretion in islets derived from lean mice through multiple pathways and mechanisms
-
Hult M, Ortsater H, Schuster G, et al. Short-term glucocorticoid treatment increases insulin secretion in islets derived from lean mice through multiple pathways and mechanisms. Mol Cell Endocrinol. 2009;301:109-116.
-
(2009)
Mol Cell Endocrinol.
, vol.301
, pp. 109-116
-
-
Hult, M.1
Ortsater, H.2
Schuster, G.3
-
163
-
-
0030777777
-
Pancreatic β cells are important targets for the diabetogenic effects of glucocorticoids
-
Delaunay F, Khan A, Cintra A, et al. Pancreatic β cells are important targets for the diabetogenic effects of glucocorticoids. J Clin Invest. 1997;100:2094-2098.
-
(1997)
J Clin Invest.
, vol.100
, pp. 2094-2098
-
-
Delaunay, F.1
Khan, A.2
Cintra, A.3
-
164
-
-
80052009174
-
Modulation of pancreatic islets-stress axis by hypothalamic releasing hormones and 11β-hydroxysteroid dehydrogenase
-
Schmid J, Ludwig B, Schally AV, et al. Modulation of pancreatic islets-stress axis by hypothalamic releasing hormones and 11β-hydroxysteroid dehydrogenase. Proc Natl Acad Sci USA. 2011;108:13722-13727.
-
(2011)
Proc Natl Acad Sci USA.
, vol.108
, pp. 13722-13727
-
-
Schmid, J.1
Ludwig, B.2
Schally, A.V.3
-
165
-
-
0034634085
-
Type 1 11β-hydroxysteroid dehydrogenase mediates glucocorticoid activation and insulin release in pancreatic islets
-
Davani B, Khan A, Hult M, et al. Type 1 11β-hydroxysteroid dehydrogenase mediates glucocorticoid activation and insulin release in pancreatic islets. J Biol Chem. 2000; 275:34841-34844.
-
(2000)
J Biol Chem.
, vol.275
, pp. 34841-34844
-
-
Davani, B.1
Khan, A.2
Hult, M.3
-
166
-
-
0347064002
-
Increased expression and activity of 11β-HSD-1 in diabetic islets and prevention with troglitazone
-
Duplomb L, Lee Y, Wang MY, et al. Increased expression and activity of 11β-HSD-1 in diabetic islets and prevention with troglitazone. Biochem Biophys Res Commun. 2004; 313:594-599.
-
(2004)
Biochem Biophys Res Commun.
, vol.313
, pp. 594-599
-
-
Duplomb, L.1
Lee, Y.2
Wang, M.Y.3
-
167
-
-
84863155270
-
Optimal elevation of β-cell 11β-hydroxysteroid dehydrogenase type 1 is a compensatory mechanism that prevents high fat diet-induced β-cell failure
-
Turban S, Liu X, Ramage L, et al. Optimal elevation of β-cell 11β-hydroxysteroid dehydrogenase type 1 is a compensatory mechanism that prevents high fat diet-induced β-cell failure. Diabetes. 2012;61:642-652.
-
(2012)
Diabetes.
, vol.61
, pp. 642-652
-
-
Turban, S.1
Liu, X.2
Ramage, L.3
-
168
-
-
62549154977
-
Dynamic regulation of mitochondrial function by glucocorticoids
-
Du J, Wang Y, Hunter R, et al. Dynamic regulation of mitochondrial function by glucocorticoids. Proc Natl Acad Sci USA. 2009;106:3543-3548.
-
(2009)
Proc Natl Acad Sci USA.
, vol.106
, pp. 3543-3548
-
-
Du, J.1
Wang, Y.2
Hunter, R.3
-
169
-
-
18044398761
-
The metabolic syndrome and cardiovascular risk in Cushing's syndrome
-
Pivonello R, Faggiano A, Lombardi G, Colao A. The metabolic syndrome and cardiovascular risk in Cushing's syndrome. Endocrinol Metab Clin North Am. 2005;34:327-339, viii.
-
(2005)
Endocrinol Metab Clin North Am.
, vol.34
, pp. 327-339
-
-
Pivonello, R.1
Faggiano, A.2
Lombardi, G.3
Colao, A.4
-
170
-
-
23944493717
-
11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice
-
Hermanowski-Vosatka A, Balkovec JM, Cheng K, et al. 11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice. J Exp Med. 2005;202:517-527.
-
(2005)
J Exp Med.
, vol.202
, pp. 517-527
-
-
Hermanowski-Vosatka, A.1
Balkovec, J.M.2
Cheng, K.3
-
171
-
-
0036226833
-
Signal transduction mechanisms mediating rapid, nongenomic effects of cortisol on prolactin release
-
Borski RJ, Hyde GN, Fruchtman S. Signal transduction mechanisms mediating rapid, nongenomic effects of cortisol on prolactin release. Steroids. 2002;67:539-548.
-
(2002)
Steroids.
, vol.67
, pp. 539-548
-
-
Borski, R.J.1
Hyde, G.N.2
Fruchtman, S.3
-
172
-
-
0034617277
-
Estrogens and glucocorticoids inhibit endothelial vascular cell adhesion molecule-1 expression by different transcriptional mechanisms
-
Simoncini T, Maffei S, Basta G, et al. Estrogens and glucocorticoids inhibit endothelial vascular cell adhesion molecule-1 expression by different transcriptional mechanisms. Circ Res. 2000;87:19-25.
-
(2000)
Circ Res.
, vol.87
, pp. 19-25
-
-
Simoncini, T.1
Maffei, S.2
Basta, G.3
-
173
-
-
26844433194
-
Antiinflammatory action of glucocorticoids-new mechanisms for old drugs
-
Rhen T, Cidlowski JA. Antiinflammatory action of glucocorticoids-new mechanisms for old drugs.NEngl J Med. 2005;353:1711-1723.
-
(2005)
NEngl J Med.
, vol.353
, pp. 1711-1723
-
-
Rhen, T.1
Cidlowski, J.A.2
-
174
-
-
0031611278
-
Localization of 2 11β-OH steroid dehydrogenase isoforms in aortic endothelial cells
-
Brem AS, Bina RB, King TC, Morris DJ. Localization of 2 11β-OH steroid dehydrogenase isoforms in aortic endothelial cells. Hypertension. 1998;31:459-462.
-
(1998)
Hypertension.
, vol.31
, pp. 459-462
-
-
Brem, A.S.1
Bina, R.B.2
King, T.C.3
Morris, D.J.4
-
175
-
-
0025786149
-
11-β-Hydroxysteroid dehydrogenase in vascular smooth-muscle and heart: implications for cardiovascular responses to glucocorticoids
-
Walker BR, Yau JL, Brett LP, et al. 11-β-Hydroxysteroid dehydrogenase in vascular smooth-muscle and heart: implications for cardiovascular responses to glucocorticoids. Endocrinology. 1991;129:3305-3312.
-
(1991)
Endocrinology.
, vol.129
, pp. 3305-3312
-
-
Walker, B.R.1
Yau, J.L.2
Brett, L.P.3
-
176
-
-
0026777230
-
Glucocorticoids and blood pressure: a role for the cortisol/ cortisone shuttle in the control of vascular tone in man
-
Walker BR, Connacher AA, Webb DJ, Edwards CR. Glucocorticoids and blood pressure: a role for the cortisol/ cortisone shuttle in the control of vascular tone in man. Clin Sci (Lond). 1992;83:171-178.
-
(1992)
Clin Sci (Lond).
, vol.83
, pp. 171-178
-
-
Walker, B.R.1
Connacher, A.A.2
Webb, D.J.3
Edwards, C.R.4
-
177
-
-
0029069545
-
Bidirectional activity of 11 β-hydroxysteroid dehydrogenase in vascular smooth muscle cells
-
Brem AS, Bina RB, King T, Morris DJ. Bidirectional activity of 11 β-hydroxysteroid dehydrogenase in vascular smooth muscle cells. Steroids. 1995;60:406-410.
-
(1995)
Steroids.
, vol.60
, pp. 406-410
-
-
Brem, A.S.1
Bina, R.B.2
King, T.3
Morris, D.J.4
-
178
-
-
84872035788
-
11 β-Hydroxysteroid dehydrogenase type 1 gene expression is increased in ascending aorta tissue of metabolic syndrome patients with coronary artery disease
-
Atalar F, Vural B, Ciftci C, et al. 11 β-Hydroxysteroid dehydrogenase type 1 gene expression is increased in ascending aorta tissue of metabolic syndrome patients with coronary artery disease. Genet Mol Res. 2012;11:3122-3132.
-
(2012)
Genet Mol Res.
, vol.11
, pp. 3122-3132
-
-
Atalar, F.1
Vural, B.2
Ciftci, C.3
-
179
-
-
0020572581
-
Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone
-
Folkman J, Langer R, Linhardt RJ, Haudenschild C, Taylor S. Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone. Science. 1983;221:719-725.
-
(1983)
Science.
, vol.221
, pp. 719-725
-
-
Folkman, J.1
Langer, R.2
Linhardt, R.J.3
Haudenschild, C.4
Taylor, S.5
-
180
-
-
79251521493
-
Glucocorticoid-mediated inhibition of angiogenic changes in human endothelial cells is not caused by reductions in cell proliferation or migration
-
Logie JJ, Ali S, Marshall KM, Heck MM, Walker BR, Hadoke PW. Glucocorticoid-mediated inhibition of angiogenic changes in human endothelial cells is not caused by reductions in cell proliferation or migration. PLoS One. 2010;5:e14476.
-
(2010)
PLoS One.
, vol.5
-
-
Logie, J.J.1
Ali, S.2
Marshall, K.M.3
Heck, M.M.4
Walker, B.R.5
Hadoke, P.W.6
-
181
-
-
0343819855
-
Steroid therapy of a proliferating hemangioma: histochemical and molecular changes
-
Hasan Q, Tan ST, Gush J, Peters SG, Davis PF. Steroid therapy of a proliferating hemangioma: histochemical and molecular changes. Pediatrics. 2000;105:117-121.
-
(2000)
Pediatrics.
, vol.105
, pp. 117-121
-
-
Hasan, Q.1
Tan, S.T.2
Gush, J.3
Peters, S.G.4
Davis, P.F.5
-
182
-
-
33744823251
-
Glucocorticoids suppress tumor angiogenesis and in vivo growth of prostate cancer cells
-
Yano A, Fujii Y, Iwai A, Kageyama Y, Kihara K. Glucocorticoids suppress tumor angiogenesis and in vivo growth of prostate cancer cells. Clin Cancer Res. 2006;12:3003-3009.
-
(2006)
Clin Cancer Res.
, vol.12
, pp. 3003-3009
-
-
Yano, A.1
Fujii, Y.2
Iwai, A.3
Kageyama, Y.4
Kihara, K.5
-
183
-
-
70349928658
-
Glucocorticoid therapy and risk of bladder cancer
-
Dietrich K, Schned A, Fortuny J, et al. Glucocorticoid therapy and risk of bladder cancer. Br J Cancer. 2009;101: 1316-1320.
-
(2009)
Br J Cancer.
, vol.101
, pp. 1316-1320
-
-
Dietrich, K.1
Schned, A.2
Fortuny, J.3
-
184
-
-
84856728017
-
Increased angiogenesis protects against adipose hypoxia and fibrosis in metabolic disease-resistant 11β-hydroxysteroid dehydrogenase type 1 (HSD1)-deficient mice
-
Michailidou Z, Turban S, Miller E, et al. Increased angiogenesis protects against adipose hypoxia and fibrosis in metabolic disease-resistant 11β-hydroxysteroid dehydrogenase type 1 (HSD1)-deficient mice. J Biol Chem. 2012; 287:4188-4197.
-
(2012)
J Biol Chem.
, vol.287
, pp. 4188-4197
-
-
Michailidou, Z.1
Turban, S.2
Miller, E.3
-
185
-
-
24744448423
-
Preventing local regeneration of glucocorticoids by 11 β-hydroxysteroid dehydrogenase type 1 enhances angiogenesis
-
Small GR, Hadoke PW, Sharif I, et al. Preventing local regeneration of glucocorticoids by 11 β-hydroxysteroid dehydrogenase type 1 enhances angiogenesis. Proc Natl Acad Sci USA. 2005;102:12165-12170.
-
(2005)
Proc Natl Acad Sci USA.
, vol.102
, pp. 12165-12170
-
-
Small, G.R.1
Hadoke, P.W.2
Sharif, I.3
-
186
-
-
0034094875
-
Use of oral corticosteroids and risk of fractures
-
van Staa TP, Leufkens HG, Abenhaim L, Zhang B, Cooper C. Use of oral corticosteroids and risk of fractures. J Bone Miner Res. 2000;15:993-1000.
-
(2000)
J Bone Miner Res.
, vol.15
, pp. 993-1000
-
-
van Staa, T.P.1
Leufkens, H.G.2
Abenhaim, L.3
Zhang, B.4
Cooper, C.5
-
188
-
-
4043086277
-
Sensitivity of bone to glucocorticoids
-
Cooper MS. Sensitivity of bone to glucocorticoids. Clin Sci (Lond). 2004;107:111-123.
-
(2004)
Clin Sci (Lond).
, vol.107
, pp. 111-123
-
-
Cooper, M.S.1
-
189
-
-
0034455103
-
Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis
-
Manolagas SC. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev. 2000;21:115-137.
-
(2000)
Endocr Rev.
, vol.21
, pp. 115-137
-
-
Manolagas, S.C.1
-
190
-
-
77956277161
-
Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor
-
Rauch A, Seitz S, Baschant U, et al. Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor. Cell Metab. 2010;11:517-531.
-
(2010)
Cell Metab.
, vol.11
, pp. 517-531
-
-
Rauch, A.1
Seitz, S.2
Baschant, U.3
-
192
-
-
0032145240
-
Osteoprogenitor cells in cell populations derived from mouse and rat calvaria differ in their response to corticosterone, cortisol, and cortisone
-
Bellows CG, Ciaccia A, Heersche JN. Osteoprogenitor cells in cell populations derived from mouse and rat calvaria differ in their response to corticosterone, cortisol, and cortisone. Bone. 1998;23:119-125.
-
(1998)
Bone.
, vol.23
, pp. 119-125
-
-
Bellows, C.G.1
Ciaccia, A.2
Heersche, J.N.3
-
193
-
-
0032588826
-
Characterization of 11β-hydroxysteroid dehydrogenase activity and corticosteroid receptor expression in human osteosarcoma cell lines
-
Bland R, Worker CA, Noble BS, et al. Characterization of 11β-hydroxysteroid dehydrogenase activity and corticosteroid receptor expression in human osteosarcoma cell lines. J Endocrinol. 1999;161:455-464.
-
(1999)
J Endocrinol.
, vol.161
, pp. 455-464
-
-
Bland, R.1
Worker, C.A.2
Noble, B.S.3
-
194
-
-
0035042608
-
Expression of 11 β-hydroxysteroid dehydrogenase in rat osteoblastic cells: pre-receptor regulation of glucocorticoid responses in bone
-
Eyre LJ, Rabbitt EH, Bland R, et al. Expression of 11 β-hydroxysteroid dehydrogenase in rat osteoblastic cells: pre-receptor regulation of glucocorticoid responses in bone. J Cell Biochem. 2001;81:453-462.
-
(2001)
J Cell Biochem.
, vol.81
, pp. 453-462
-
-
Eyre, L.J.1
Rabbitt, E.H.2
Bland, R.3
-
195
-
-
0033842430
-
Expression and functional consequences of 11β-hydroxysteroid dehydrogenase activity in human bone
-
Cooper MS, Walker EA, Bland R, FraserWD,HewisonM, Stewart PM. Expression and functional consequences of 11β-hydroxysteroid dehydrogenase activity in human bone. Bone. 2000;27:375-381.
-
(2000)
Bone.
, vol.27
, pp. 375-381
-
-
Cooper, M.S.1
Walker, E.A.2
Bland, R.3
Fraser, W.D.4
Hewison, M.5
Stewart, P.M.6
-
196
-
-
14844328091
-
11 β-Hydroxysteroid dehydrogenase expression and glucocorticoid synthesis are directed by a molecular switch during osteoblast differentiation
-
Eijken M, Hewison M, Cooper MS, et al. 11 β-Hydroxysteroid dehydrogenase expression and glucocorticoid synthesis are directed by a molecular switch during osteoblast differentiation. Mol Endocrinol. 2005;19:621-631.
-
(2005)
Mol Endocrinol.
, vol.19
, pp. 621-631
-
-
Eijken, M.1
Hewison, M.2
Cooper, M.S.3
-
197
-
-
20444436794
-
Circulating cortisone levels are associated with biochemical markers of bone formation and lumbar spine BMD: the Hertfordshire Cohort Study
-
Cooper MS, Syddall HE, Fall CH, et al. Circulating cortisone levels are associated with biochemical markers of bone formation and lumbar spine BMD: the Hertfordshire Cohort Study. Clin Endocrinol (Oxf). 2005;62:692-697.
-
(2005)
Clin Endocrinol (Oxf).
, vol.62
, pp. 692-697
-
-
Cooper, M.S.1
Syddall, H.E.2
Fall, C.H.3
-
198
-
-
0034743960
-
Modulation of 11β-hydroxysteroid dehydrogenase isozymes by proinflammatory cytokines in osteoblasts: an autocrine switch from glucocorticoid inactivation to activation
-
Cooper MS, Bujalska I, Rabbitt E, et al. Modulation of 11β-hydroxysteroid dehydrogenase isozymes by proinflammatory cytokines in osteoblasts: an autocrine switch from glucocorticoid inactivation to activation. J Bone Miner Res. 2001;16:1037-1044.
-
(2001)
J Bone Miner Res.
, vol.16
, pp. 1037-1044
-
-
Cooper, M.S.1
Bujalska, I.2
Rabbitt, E.3
-
199
-
-
77953704495
-
Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids: implications for inflammation associated bone loss
-
Kaur K, Hardy R, AhasanMM,et al. Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids: implications for inflammation associated bone loss. Ann Rheum Dis. 2010;69:1185-1190.
-
(2010)
Ann Rheum Dis.
, vol.69
, pp. 1185-1190
-
-
Kaur, K.1
Hardy, R.2
Ahasan, M.M.3
-
200
-
-
1642423643
-
Mice deficient in 11β-hydroxysteroid dehydrogenase type 1 lack bone marrow adipocytes, but maintain normal bone formation
-
Justesen J, Mosekilde L, Holmes M, et al. Mice deficient in 11β-hydroxysteroid dehydrogenase type 1 lack bone marrow adipocytes, but maintain normal bone formation. Endocrinology. 2004;145:1916-1925.
-
(2004)
Endocrinology.
, vol.145
, pp. 1916-1925
-
-
Justesen, J.1
Mosekilde, L.2
Holmes, M.3
-
201
-
-
33748107691
-
Impaired cortical bone acquisition and osteoblast differentiation in mice with osteoblast-targeted disruption of glucocorticoid signaling
-
Sher LB, Harrison JR, Adams DJ, Kream BE. Impaired cortical bone acquisition and osteoblast differentiation in mice with osteoblast-targeted disruption of glucocorticoid signaling. Calcif Tissue Int. 2006;79:118-125.
-
(2006)
Calcif Tissue Int.
, vol.79
, pp. 118-125
-
-
Sher, L.B.1
Harrison, J.R.2
Adams, D.J.3
Kream, B.E.4
-
202
-
-
0042387905
-
11β-Hydroxysteroid dehydrogenase type 1 activity predicts the effects of glucocorticoids on bone
-
Cooper MS, Blumsohn A, Goddard PE, et al. 11β-Hydroxysteroid dehydrogenase type 1 activity predicts the effects of glucocorticoids on bone. J Clin Endocrinol Metab. 2003;88:3874-3877.
-
(2003)
J Clin Endocrinol Metab.
, vol.88
, pp. 3874-3877
-
-
Cooper, M.S.1
Blumsohn, A.2
Goddard, P.E.3
-
203
-
-
0033304809
-
Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoidinduced osteoporosis
-
Hofbauer LC, Gori F, Riggs BL, et al. Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoidinduced osteoporosis. Endocrinology. 1999;140:4382-4389.
-
(1999)
Endocrinology.
, vol.140
, pp. 4382-4389
-
-
Hofbauer, L.C.1
Gori, F.2
Riggs, B.L.3
-
204
-
-
0035999432
-
Osteoblastic 11β-hydroxysteroid dehydrogenase type 1 activity increases with age and glucocorticoid exposure
-
Cooper MS, Rabbitt EH, Goddard PE, BartlettWA,Hewison M, Stewart PM. Osteoblastic 11β-hydroxysteroid dehydrogenase type 1 activity increases with age and glucocorticoid exposure. J Bone Miner Res. 2002;17:979-986.
-
(2002)
J Bone Miner Res.
, vol.17
, pp. 979-986
-
-
Cooper, M.S.1
Rabbitt, E.H.2
Goddard, P.E.3
Bartlett, W.A.4
Hewison, M.5
Stewart, P.M.6
-
205
-
-
33645882536
-
Enhancement of cortisol-induced 11 β-hydroxysteroid dehydrogenase type 1 expression by interleukin 1β in culturedhuman chorionic trophoblast cells
-
Li WJ, Gao L, Wang Y, Duan T, Myatt L, Sun K. Enhancement of cortisol-induced 11 β-hydroxysteroid dehydrogenase type 1 expression by interleukin 1β in culturedhuman chorionic trophoblast cells. Endocrinology. 2006;147: 2490-2495.
-
(2006)
Endocrinology.
, vol.147
, pp. 2490-2495
-
-
Li, W.J.1
Gao, L.2
Wang, Y.3
Duan, T.4
Myatt, L.5
Sun, K.6
-
206
-
-
84863207913
-
Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells
-
Ahasan MM, Hardy R, Jones C, et al. Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells. Arthritis Rheum. 2012;64:2404-2413.
-
(2012)
Arthritis Rheum.
, vol.64
, pp. 2404-2413
-
-
Ahasan, M.M.1
Hardy, R.2
Jones, C.3
-
207
-
-
0035399825
-
11β-Hydroxysteroid dehydrogenase type 1 is induced in human monocytes upon differentiation to macrophages
-
Thieringer R, Le Grand CB, Carbin L, et al. 11β-Hydroxysteroid dehydrogenase type 1 is induced in human monocytes upon differentiation to macrophages. J Immunol. 2001;167:30-35.
-
(2001)
J Immunol.
, vol.167
, pp. 30-35
-
-
Thieringer, R.1
Le Grand, C.B.2
Carbin, L.3
-
208
-
-
24744446455
-
Expression of 11β-hydroxysteroid dehydrogenase type 1 permits regulation of glucocorticoid bioavailability by human dendritic cells
-
Freeman L, Hewison M, Hughes SV, et al. Expression of 11β-hydroxysteroid dehydrogenase type 1 permits regulation of glucocorticoid bioavailability by human dendritic cells. Blood. 2005;106:2042-2049.
-
(2005)
Blood.
, vol.106
, pp. 2042-2049
-
-
Freeman, L.1
Hewison, M.2
Hughes, S.V.3
-
209
-
-
11844282839
-
The expression of 11 β-hydroxysteroid dehydrogenase type I by lymphocytes provides a novel means for intracrine regulation of glucocorticoid activities
-
Zhang TY, Ding X, Daynes RA. The expression of 11 β-hydroxysteroid dehydrogenase type I by lymphocytes provides a novel means for intracrine regulation of glucocorticoid activities. J Immunol. 2005;174:879-889.
-
(2005)
J Immunol.
, vol.174
, pp. 879-889
-
-
Zhang, T.Y.1
Ding, X.2
Daynes, R.A.3
-
210
-
-
33744958894
-
Local amplification of glucocorticoids by 11 β-hydroxysteroid dehydrogenase type 1 promotes macrophage phagocytosis of apoptotic leukocytes
-
Gilmour JS, Coutinho AE, Cailhier JF, et al. Local amplification of glucocorticoids by 11 β-hydroxysteroid dehydrogenase type 1 promotes macrophage phagocytosis of apoptotic leukocytes. J Immunol. 2006;176:7605-7611.
-
(2006)
J Immunol.
, vol.176
, pp. 7605-7611
-
-
Gilmour, J.S.1
Coutinho, A.E.2
Cailhier, J.F.3
-
211
-
-
38449115958
-
Macrophages from 11β-hydroxysteroid dehydrogenase type 1-deficient mice exhibit an increased sensitivity to lipopolysaccharide stimulation due to TGF-β-mediated up-regulation of SHIP1 expression
-
Zhang TY, Daynes RA. Macrophages from 11β-hydroxysteroid dehydrogenase type 1-deficient mice exhibit an increased sensitivity to lipopolysaccharide stimulation due to TGF-β-mediated up-regulation of SHIP1 expression. J Immunol. 2007;179:6325-6335.
-
(2007)
J Immunol.
, vol.179
, pp. 6325-6335
-
-
Zhang, T.Y.1
Daynes, R.A.2
-
212
-
-
84455188599
-
11 β-Hydroxysteroid dehydrogenase type 1, but not type 2, deficiency worsens acute inflammation and experimental arthritis in mice
-
Coutinho AE, Gray M, Brownstein DG, et al. 11 β-Hydroxysteroid dehydrogenase type 1, but not type 2, deficiency worsens acute inflammation and experimental arthritis in mice. Endocrinology. 2012;153:234-240.
-
(2012)
Endocrinology.
, vol.153
, pp. 234-240
-
-
Coutinho, A.E.1
Gray, M.2
Brownstein, D.G.3
-
213
-
-
50249168853
-
Local and systemic glucocorticoid metabolism in inflammatory arthritis
-
Hardy R, Rabbitt EH, Filer A, et al. Local and systemic glucocorticoid metabolism in inflammatory arthritis. Ann Rheum Dis. 2008;67:1204-1210.
-
(2008)
Ann Rheum Dis.
, vol.67
, pp. 1204-1210
-
-
Hardy, R.1
Rabbitt, E.H.2
Filer, A.3
-
214
-
-
34347407061
-
11β-Hydroxysteroid dehydrogenase 1 and 2 expression in colon from patients with ulcerative colitis
-
ZbankovaS, Bryndova J, Leden P,KmentM,Svec A, Pacha J. 11β-Hydroxysteroid dehydrogenase 1 and 2 expression in colon from patients with ulcerative colitis. J Gastroenterol Hepatol. 2007;22:1019-1023.
-
(2007)
J Gastroenterol Hepatol.
, vol.22
, pp. 1019-1023
-
-
Zbankova, S.1
Bryndova, J.2
Leden, P.3
Kment, M.4
Svec, A.5
Pacha, J.6
-
215
-
-
60249085724
-
Expression profiles of human 11β-hydroxysteroid dehydrogenases type 1 and type 2 in inflammatory bowel diseases
-
Stegk JP, Ebert B, Martin HJ, Maser E. Expression profiles of human 11β-hydroxysteroid dehydrogenases type 1 and type 2 in inflammatory bowel diseases. Mol Cell Endocrinol. 2009;301:104-108.
-
(2009)
Mol Cell Endocrinol.
, vol.301
, pp. 104-108
-
-
Stegk, J.P.1
Ebert, B.2
Martin, H.J.3
Maser, E.4
-
216
-
-
80052733581
-
bone to therapeutic glucocorticoids in inflammatory bowel disease?
-
Can 11β-hydroxysteroid dehydrogenase activity predict the sensitivity of doi: 10.1210/er.2012-1050 edrv.endojournals.org 551 ,
-
Cooper MS, Kriel H, Sayers A, et al. Can 11β-hydroxysteroid dehydrogenase activity predict the sensitivity of doi: 10.1210/er.2012-1050 edrv.endojournals.org 551 bone to therapeutic glucocorticoids in inflammatory bowel disease? Calcif Tissue Int. 2011;89:246-251.
-
(2011)
Calcif Tissue Int.
, vol.89
, pp. 246-251
-
-
Cooper, M.S.1
Kriel, H.2
Sayers, A.3
-
218
-
-
20744442436
-
Reduced capacity for the reactivation of glucocorticoids in rheumatoid arthritis synovial cells: possible role of the sympathetic nervous system?
-
Schmidt M, Weidler C, Naumann H, Anders S, Scholmerich J, Straub RH. Reduced capacity for the reactivation of glucocorticoids in rheumatoid arthritis synovial cells: possible role of the sympathetic nervous system? Arthritis Rheum. 2005;52:1711-1720.
-
(2005)
Arthritis Rheum
, vol.52
, pp. 1711-1720
-
-
Schmidt, M.1
Weidler, C.2
Naumann, H.3
Anders, S.4
Scholmerich, J.5
Straub, R.H.6
-
219
-
-
77952951067
-
Local metabolism of glucocorticoids and its role in rat adjuvant arthritis
-
Ergang P, Leden P, Vagnerova K, et al. Local metabolism of glucocorticoids and its role in rat adjuvant arthritis. Mol Cell Endocrinol. 2010;323:155-160.
-
(2010)
Mol Cell Endocrinol.
, vol.323
, pp. 155-160
-
-
Ergang, P.1
Leden, P.2
Vagnerova, K.3
-
220
-
-
70449413778
-
Effects of glucocorticoids on mood, memory, and the hippocampus
-
Brown ES. Effects of glucocorticoids on mood, memory, and the hippocampus. Treatment and preventive therapy. Ann NY Acad Sci. 2009;1179:41-55.
-
(2009)
Treatment and preventive therapy. Ann NY Acad Sci.
, vol.1179
, pp. 41-55
-
-
Brown, E.S.1
-
221
-
-
0026463945
-
Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing's syndrome
-
Starkman MN, Gebarski SS, Berent S, Schteingart DE. Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing's syndrome. Biol Psychiatry. 1992;32:756-765.
-
(1992)
Biol Psychiatry.
, vol.32
, pp. 756-765
-
-
Starkman, M.N.1
Gebarski, S.S.2
Berent, S.3
Schteingart, D.E.4
-
222
-
-
0036266337
-
Glucocorticoids and hippocampal atrophy after heart transplantation
-
Wilner AP, de Varennes B, Gregoire PA, Lupien S, Pruessner JC. Glucocorticoids and hippocampal atrophy after heart transplantation. Ann Thorac Surg. 2002;73:1965-1967.
-
(2002)
Ann Thorac Surg.
, vol.73
, pp. 1965-1967
-
-
Wilner, A.P.1
de Varennes, B.2
Gregoire, P.A.3
Lupien, S.4
Pruessner, J.C.5
-
223
-
-
0034117178
-
Subtle shifts in the ratio between pro-and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate
-
Almeida OF, Conde GL, Crochemore C, et al. Subtle shifts in the ratio between pro-and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate. FASEB J. 2000;14:779-790.
-
(2000)
FASEB J.
, vol.14
, pp. 779-790
-
-
Almeida, O.F.1
Conde, G.L.2
Crochemore, C.3
-
224
-
-
0032539809
-
Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress
-
Gould E, Tanapat P, McEwen BS, Flugge G, Fuchs E. Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proc Natl Acad Sci USA. 1998;95:3168-3171.
-
(1998)
Proc Natl Acad Sci USA.
, vol.95
, pp. 3168-3171
-
-
Gould, E.1
Tanapat, P.2
McEwen, B.S.3
Flugge, G.4
Fuchs, E.5
-
225
-
-
0025005821
-
Glucocorticoid endangerment of hippocampal neurons is NMDA-receptor dependent
-
Armanini MP, Hutchins C, Stein BA, Sapolsky RM. Glucocorticoid endangerment of hippocampal neurons is NMDA-receptor dependent. Brain Res. 1990;532:7-12.
-
(1990)
Brain Res.
, vol.532
, pp. 7-12
-
-
Armanini, M.P.1
Hutchins, C.2
Stein, B.A.3
Sapolsky, R.M.4
-
226
-
-
45849092638
-
Effects of altered corticosteroid milieu on rat hippocampal neurochemistry and structure-an in vivo magnetic resonance spectroscopy and imaging study
-
Schubert MI, Kalisch R, Sotiropoulos I, et al. Effects of altered corticosteroid milieu on rat hippocampal neurochemistry and structure-an in vivo magnetic resonance spectroscopy and imaging study. J Psychiatr Res. 2008; 42:902-912.
-
(2008)
J Psychiatr Res.
, vol.42
, pp. 902-912
-
-
Schubert, M.I.1
Kalisch, R.2
Sotiropoulos, I.3
-
227
-
-
57249111794
-
Behavioral stress accelerates plaque pathogenesis in the brain of Tg2576 mice via generation of metabolic oxidative stress
-
Lee KW, Kim JB, Seo JS, et al. Behavioral stress accelerates plaque pathogenesis in the brain of Tg2576 mice via generation of metabolic oxidative stress. J Neurochem. 2009; 108:165-175.
-
(2009)
J Neurochem.
, vol.108
, pp. 165-175
-
-
Lee, K.W.1
Kim, J.B.2
Seo, J.S.3
-
228
-
-
58049202261
-
The amyloidogenic potential and behavioral correlates of stress
-
Catania C, Sotiropoulos I, Silva R, et al. The amyloidogenic potential and behavioral correlates of stress. Mol Psychiatry. 2009;14:95-105.
-
(2009)
Mol Psychiatry.
, vol.14
, pp. 95-105
-
-
Catania, C.1
Sotiropoulos, I.2
Silva, R.3
-
229
-
-
33748253471
-
Glucocorticoids increase amyloid-β and tau pathology in a mouse model of Alzheimer's disease
-
Green KN, Billings LM, Roozendaal B, McGaugh JL, LaFerla FM. Glucocorticoids increase amyloid-β and tau pathology in a mouse model of Alzheimer's disease. J Neurosci. 2006;26:9047-9056.
-
(2006)
J Neurosci.
, vol.26
, pp. 9047-9056
-
-
Green, K.N.1
Billings, L.M.2
Roozendaal, B.3
McGaugh, J.L.4
LaFerla, F.M.5
-
230
-
-
40849085658
-
Glucocorticoid receptor variant and risk of dementia and white matter lesions
-
van Rossum EF, de Jong FJ, Koper JW, et al. Glucocorticoid receptor variant and risk of dementia and white matter lesions. Neurobiol Aging. 2008;29:716-723.
-
(2008)
Neurobiol Aging.
, vol.29
, pp. 716-723
-
-
van Rossum, E.F.1
de Jong, F.J.2
Koper, J.W.3
-
231
-
-
0037379353
-
Serum-and glucocorticoid-regulated kinase isoform-1 and epithelial sodium channel subunits in human ocular ciliary epithelium
-
Rauz S, Walker EA, Hughes SV, et al. Serum-and glucocorticoid-regulated kinase isoform-1 and epithelial sodium channel subunits in human ocular ciliary epithelium. Invest Ophthalmol Vis Sci. 2003;44:1643-1651.
-
(2003)
Invest Ophthalmol Vis Sci.
, vol.44
, pp. 1643-1651
-
-
Rauz, S.1
Walker, E.A.2
Hughes, S.V.3
-
233
-
-
0013815909
-
Intraocular pressure response to topical corticosteroids
-
Armaly MF, Becker B. Intraocular pressure response to topical corticosteroids. Fed Proc. 1965;24:1274-1278.
-
(1965)
Fed Proc.
, vol.24
, pp. 1274-1278
-
-
Armaly, M.F.1
Becker, B.2
-
235
-
-
77951649692
-
Pseudotumor cerebri after surgical remission of Cushing's disease
-
Kiehna EN, Keil M, Lodish M, Stratakis C, Oldfield EH. Pseudotumor cerebri after surgical remission of Cushing's disease. J Clin Endocrinol Metab. 2010;95:1528-1532.
-
(2010)
J Clin Endocrinol Metab.
, vol.95
, pp. 1528-1532
-
-
Kiehna, E.N.1
Keil, M.2
Lodish, M.3
Stratakis, C.4
Oldfield, E.H.5
-
236
-
-
51649120020
-
Exploring the pathogenesis of IIH: an inflammatory perspective
-
Sinclair AJ, Ball AK, Burdon MA, et al. Exploring the pathogenesis of IIH: an inflammatory perspective. J Neuroimmunol. 2008;201-202:212-220.
-
(2008)
J Neuroimmunol.
, vol.201-202
, pp. 212-220
-
-
Sinclair, A.J.1
Ball, A.K.2
Burdon, M.A.3
-
237
-
-
79960560115
-
11β-Hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress
-
Wyrwoll CS, Holmes MC, Seckl JR. 11β-Hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress. Front Neuroendocrinol. 2011;32:265-286.
-
(2011)
Front Neuroendocrinol.
, vol.32
, pp. 265-286
-
-
Wyrwoll, C.S.1
Holmes, M.C.2
Seckl, J.R.3
-
238
-
-
0034907411
-
Expression and putative role of 11 β-hydroxysteroid dehydrogenase isozymes within the human eye
-
Rauz S, Walker EA, Shackleton CH, Hewison M, Murray PI, Stewart PM. Expression and putative role of 11 β-hydroxysteroid dehydrogenase isozymes within the human eye. Invest Ophthalmol Vis Sci. 2001;42:2037-2042.
-
(2001)
Invest Ophthalmol Vis Sci.
, vol.42
, pp. 2037-2042
-
-
Rauz, S.1
Walker, E.A.2
Shackleton, C.H.3
Hewison, M.4
Murray, P.I.5
Stewart, P.M.6
-
239
-
-
0029670812
-
11 β-Hydroxysteroid dehydrogenase in cultured hippocampal cells reactivates inert 11-dehydrocorticosterone, potentiating neurotoxicity
-
Rajan V, Edwards CR, Seckl JR. 11 β-Hydroxysteroid dehydrogenase in cultured hippocampal cells reactivates inert 11-dehydrocorticosterone, potentiating neurotoxicity. J Neurosci. 1996;16:65-70.
-
(1996)
J Neurosci.
, vol.16
, pp. 65-70
-
-
Rajan, V.1
Edwards, C.R.2
Seckl, J.R.3
-
240
-
-
38549142798
-
Hexose-6-phosphate dehydrogenase and 11β-hydroxysteroid dehydrogenase-1 tissue distribution in the rat
-
Gomez-Sanchez EP, Romero DG, de Rodriguez AF, Warden MP, Krozowski Z, Gomez-Sanchez CE. Hexose-6-phosphate dehydrogenase and 11β-hydroxysteroid dehydrogenase-1 tissue distribution in the rat. Endocrinology. 2008;149:525-533.
-
(2008)
Endocrinology.
, vol.149
, pp. 525-533
-
-
Gomez-Sanchez, E.P.1
Romero, D.G.2
de Rodriguez, A.F.3
Warden, M.P.4
Krozowski, Z.5
Gomez-Sanchez, C.E.6
-
241
-
-
84859811122
-
Prenatal excess glucocorticoid exposure and adult affective disorders: a role for serotonergic and catecholamine pathways
-
Wyrwoll CS, Holmes MC. Prenatal excess glucocorticoid exposure and adult affective disorders: a role for serotonergic and catecholamine pathways. Neuroendocrinology. 2012;95:47-55.
-
(2012)
Neuroendocrinology.
, vol.95
, pp. 47-55
-
-
Wyrwoll, C.S.1
Holmes, M.C.2
-
242
-
-
77958067558
-
Partial deficiency or short-term inhibition of 11β-hydroxysteroid dehydrogenase type 1 improves cognitive function in aging mice
-
Sooy K, Webster SP, Noble J, et al. Partial deficiency or short-term inhibition of 11β-hydroxysteroid dehydrogenase type 1 improves cognitive function in aging mice. J Neurosci. 2010;30:13867-13872.
-
(2010)
J Neurosci.
, vol.30
, pp. 13867-13872
-
-
Sooy, K.1
Webster, S.P.2
Noble, J.3
-
243
-
-
2342616297
-
11β-Hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics
-
Sandeep TC, Yau JL, MacLullich AM, et al. 11β-Hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics. Proc Natl Acad Sci USA. 2004;101:6734-6739.
-
(2004)
Proc Natl Acad Sci USA.
, vol.101
, pp. 6734-6739
-
-
Sandeep, T.C.1
Yau, J.L.2
MacLullich, A.M.3
-
244
-
-
0035836756
-
Lack of tissue glucocorticoid reactivation in 11β-hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments
-
Yau JL, Noble J, Kenyon CJ, et al. Lack of tissue glucocorticoid reactivation in 11β-hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments. Proc Natl Acad Sci USA. 2001;98:4716-4721.
-
(2001)
Proc Natl Acad Sci USA.
, vol.98
, pp. 4716-4721
-
-
Yau, J.L.1
Noble, J.2
Kenyon, C.J.3
-
245
-
-
34848923074
-
Enhanced hippocampal long-term potentiation and spatial learning in aged 11β-hydroxysteroid dehydrogenase type 1 knock-out mice
-
Yau JL, McNair KM, Noble J, et al. Enhanced hippocampal long-term potentiation and spatial learning in aged 11β-hydroxysteroid dehydrogenase type 1 knock-out mice. J Neurosci. 2007;27:10487-10496.
-
(2007)
J Neurosci.
, vol.27
, pp. 10487-10496
-
-
Yau, J.L.1
McNair, K.M.2
Noble, J.3
-
246
-
-
0038495546
-
Inhibition of 11β-hydroxysteroid dehydrogenase type 1 lowers intraocular pressure in patients with ocular hypertension
-
Rauz S, Cheung CM, Wood PJ, et al. Inhibition of 11β-hydroxysteroid dehydrogenase type 1 lowers intraocular pressure in patients with ocular hypertension.QJM. 2003; 96:481-490.
-
(2003)
QJM
, vol.96
, pp. 481-490
-
-
Rauz, S.1
Cheung, C.M.2
Wood, P.J.3
-
247
-
-
78650060011
-
Cerebrospinal fluid corticosteroid levels and cortisol metabolism in patients with idiopathic intracranial hypertension: a link between 11β-HSD1 and intracranial pressure regulation?
-
Sinclair AJ, Walker EA, Burdon MA, et al. Cerebrospinal fluid corticosteroid levels and cortisol metabolism in patients with idiopathic intracranial hypertension: a link between 11β-HSD1 and intracranial pressure regulation? J Clin Endocrinol Metab. 2010;95:5348-5356.
-
(2010)
J Clin Endocrinol Metab
, vol.95
, pp. 5348-5356
-
-
Sinclair, A.J.1
Walker, E.A.2
Burdon, M.A.3
-
248
-
-
0029941919
-
Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol
-
Van Cauter E, Leproult R, Kupfer DJ. Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol. J Clin Endocrinol Metab. 1996;81:2468-2473.
-
(1996)
J Clin Endocrinol Metab.
, vol.81
, pp. 2468-2473
-
-
Van Cauter, E.1
Leproult, R.2
Kupfer, D.J.3
-
249
-
-
0022763667
-
The neuroendocri-nology of stress and aging: the glucocorticoid cascade hypothesis
-
Sapolsky RM, Krey LC, McEwen BS. The neuroendocri-nology of stress and aging: the glucocorticoid cascade hypothesis. Endocr Rev. 1986;7:284-301.
-
(1986)
Endocr Rev.
, vol.7
, pp. 284-301
-
-
Sapolsky, R.M.1
Krey, L.C.2
McEwen, B.S.3
-
250
-
-
26244458148
-
Hypothalamuspituitary-adrenal hyperactivity in human aging is partially refractory to stimulation by mineralocorticoid receptor blockade
-
Giordano R, Bo M, Pellegrino M, et al. Hypothalamuspituitary-adrenal hyperactivity in human aging is partially refractory to stimulation by mineralocorticoid receptor blockade. J Clin Endocrinol Metab. 2005;90:5656-5662.
-
(2005)
J Clin Endocrinol Metab.
, vol.90
, pp. 5656-5662
-
-
Giordano, R.1
Bo, M.2
Pellegrino, M.3
-
251
-
-
0025787687
-
Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men
-
Iranmanesh A, Lizarralde G, Veldhuis JD. Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men. J Clin Endocrinol Metab. 1991;73:1081-1088.
-
(1991)
J Clin Endocrinol Metab.
, vol.73
, pp. 1081-1088
-
-
Iranmanesh, A.1
Lizarralde, G.2
Veldhuis, J.D.3
-
252
-
-
0027935871
-
Serum insulin-like growth factor I in a random population sample of men and women: relation to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid hormone and osteocalcin
-
Landin-Wilhelmsen K, Wilhelmsen L, Lappas G, et al. Serum insulin-like growth factor I in a random population sample of men and women: relation to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid hormone and osteocalcin. Clin Endocrinol (Oxf). 1994;41:351-357.
-
(1994)
Clin Endocrinol (Oxf).
, vol.41
, pp. 351-357
-
-
Landin-Wilhelmsen, K.1
Wilhelmsen, L.2
Lappas, G.3
-
253
-
-
0042333313
-
Insulin-like growth factor-1 and interleukin 6 predict sarcopenia in very old community-living men and women: the Framingham Heart Study
-
Payette H, Roubenoff R, Jacques PF, et al. Insulin-like growth factor-1 and interleukin 6 predict sarcopenia in very old community-living men and women: the Framingham Heart Study. J AmGeriatr Soc. 2003;51:1237-1243.
-
(2003)
J AmGeriatr Soc.
, vol.51
, pp. 1237-1243
-
-
Payette, H.1
Roubenoff, R.2
Jacques, P.F.3
-
254
-
-
0014739714
-
Atrophy of skeletal muscle in patients with Cushing's syndrome
-
Pleasure DE, Walsh GO, Engel WK. Atrophy of skeletal muscle in patients with Cushing's syndrome. Arch Neurol. 1970;22:118-125.
-
(1970)
Arch Neurol.
, vol.22
, pp. 118-125
-
-
Pleasure, D.E.1
Walsh, G.O.2
Engel, W.K.3
-
255
-
-
0015596693
-
Oxidative respiration of skeletal muscle in experimental corticosteroid myopathy
-
Vignos PJ Jr, Greene R. Oxidative respiration of skeletal muscle in experimental corticosteroid myopathy. J Lab Clin Med. 1973;81:365-378.
-
(1973)
J Lab Clin Med.
, vol.81
, pp. 365-378
-
-
Vignos Jr., P.J.1
Greene, R.2
-
256
-
-
0017685051
-
Ultrastructural observations in myopathy complicating Cushing's disease
-
Djaldetti M, Gafter U, Fishman P. Ultrastructural observations in myopathy complicating Cushing's disease.AmJ Med Sci. 1977;273:273-277.
-
(1977)
AmJ Med Sci.
, vol.273
, pp. 273-277
-
-
Djaldetti, M.1
Gafter, U.2
Fishman, P.3
-
257
-
-
0032941062
-
Measurement of body fat in healthy elderly men: a comparison of methods
-
Ravaglia G, Forti P, Maioli F, Boschi F, Cicognani A, Gasbarrini G. Measurement of body fat in healthy elderly men: a comparison of methods. J Gerontol A Biol Sci Med Sci. 1999;54:M70-M76.
-
(1999)
J Gerontol A Biol Sci Med Sci.
, vol.54
-
-
Ravaglia, G.1
Forti, P.2
Maioli, F.3
Boschi, F.4
Cicognani, A.5
Gasbarrini, G.6
-
259
-
-
77949495933
-
Tissue-specific increases in 11β-hydroxysteroid dehydrogenase type 1 in normal weight postmenopausal women
-
Andersson T, Simonyte K, Andrew R, et al. Tissue-specific increases in 11β-hydroxysteroid dehydrogenase type 1 in normal weight postmenopausal women. PLoS One. 2009; 4:e8475.
-
(2009)
PLoS One.
, vol.4
-
-
Andersson, T.1
Simonyte, K.2
Andrew, R.3
-
260
-
-
77953271453
-
Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice
-
Weinstein RS, Wan C, Liu Q, et al. Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice. Aging Cell. 2010;9:147-161.
-
(2010)
Aging Cell.
, vol.9
, pp. 147-161
-
-
Weinstein, R.S.1
Wan, C.2
Liu, Q.3
-
261
-
-
44249117598
-
Looking older: fibroblast collapse and therapeutic implications
-
Fisher GJ, Varani J, Voorhees JJ. Looking older: fibroblast collapse and therapeutic implications. Arch Dermatol. 2008;144:666-672.
-
(2008)
Arch Dermatol.
, vol.144
, pp. 666-672
-
-
Fisher, G.J.1
Varani, J.2
Voorhees, J.J.3
-
263
-
-
0028075339
-
Glucocorticoid action and the clinical features of Cushing's syndrome
-
Yanovski JA, Cutler GB Jr. Glucocorticoid action and the clinical features of Cushing's syndrome. Endocrinol Metab Clin North Am. 1994;23:487-509.
-
(1994)
Endocrinol Metab Clin North Am.
, vol.23
, pp. 487-509
-
-
Yanovski, J.A.1
Cutler, G.B.Jr.2
-
265
-
-
0035030336
-
Corticosteroid-induced atrophy and barrier impairment measured by non-invasive methods in human skin
-
Kolbe L, Kligman AM, Schreiner V, Stoudemayer T. Corticosteroid-induced atrophy and barrier impairment measured by non-invasive methods in human skin. Skin Res Technol. 2001;7:73-77.
-
(2001)
Skin Res Technol.
, vol.7
, pp. 73-77
-
-
Kolbe, L.1
Kligman, A.M.2
Schreiner, V.3
Stoudemayer, T.4
-
266
-
-
84884272182
-
11 β-Hydroxysteroid dehydrogenase type 1 increases with age and photoexposure in human skin ex vivo
-
Abstract 541
-
Tiganescu A, Walker EA, Mayes AE, Stewart PM. 11 β-Hydroxysteroid dehydrogenase type 1 increases with age and photoexposure in human skin ex vivo. J Invest Dermatol. 2011;131(suppl 1):S91 (Abstract 541).
-
(2011)
J Invest Dermatol.
, vol.131
, Issue.SUPPL 1
-
-
Tiganescu, A.1
Walker, E.A.2
Mayes, A.E.3
Stewart, P.M.4
-
267
-
-
4544265783
-
The prevalence of "cognitive impairment no dementia" in community-dwelling elderly: a pilot study
-
Low LF, Brodaty H, Edwards R, et al. The prevalence of "cognitive impairment no dementia" in community-dwelling elderly: a pilot study. Aust N Z J Psychiatry. 2004;38: 725-731.
-
(2004)
Aust N Z J Psychiatry.
, vol.38
, pp. 725-731
-
-
Low, L.F.1
Brodaty, H.2
Edwards, R.3
-
268
-
-
0029056548
-
Individual differences in hypothalamic-pituitary-adrenal activity in later life and hippocampal aging
-
Meaney MJ, O'Donnell D, Rowe W, et al. Individual differences in hypothalamic-pituitary-adrenal activity in later life and hippocampal aging. Exp Gerontol. 1995;30:229-251.
-
(1995)
Exp Gerontol.
, vol.30
, pp. 229-251
-
-
Meaney, M.J.1
O'Donnell, D.2
Rowe, W.3
-
269
-
-
0018263702
-
Hippocampal aging and adrenocorticoids: quantitative correlations
-
Landfield PW, Waymire JC, Lynch G. Hippocampal aging and adrenocorticoids: quantitative correlations. Science. 1978;202:1098-1102.
-
(1978)
Science.
, vol.202
, pp. 1098-1102
-
-
Landfield, P.W.1
Waymire, J.C.2
Lynch, G.3
-
270
-
-
13844297524
-
Plasma cortisol levels, brain volumes and cognition in healthy elderly men
-
MacLullich AM, Deary IJ, Starr JM, Ferguson KJ, Wardlaw JM, Seckl JR. Plasma cortisol levels, brain volumes and cognition in healthy elderly men. Psychoneuroendocrinology. 2005;30:505-515.
-
(2005)
Psychoneuroendocrinology.
, vol.30
, pp. 505-515
-
-
MacLullich, A.M.1
Deary, I.J.2
Starr, J.M.3
Ferguson, K.J.4
Wardlaw, J.M.5
Seckl, J.R.6
-
271
-
-
0025500122
-
Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats
-
Issa AM, Rowe W, Gauthier S, Meaney MJ. Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats. J Neurosci. 1990;10: 3247-3254.
-
(1990)
J Neurosci.
, vol.10
, pp. 3247-3254
-
-
Issa, A.M.1
Rowe, W.2
Gauthier, S.3
Meaney, M.J.4
-
272
-
-
77952625669
-
11β-Hydroxysteroid dehydrogenase type 1 expression is increased in the aged mouse hippocampus and parietal cortex and causes memory impairments
-
Holmes MC, Carter RN, Noble J, et al. 11β-Hydroxysteroid dehydrogenase type 1 expression is increased in the aged mouse hippocampus and parietal cortex and causes memory impairments. J Neurosci. 2010;30:6916-6920.
-
(2010)
J Neurosci.
, vol.30
, pp. 6916-6920
-
-
Holmes, M.C.1
Carter, R.N.2
Noble, J.3
-
273
-
-
0344844573
-
A rapid screening assay for inhibitors of 11β-hydroxysteroid dehydrogenases (11β-HSD): flavanone selectively inhibits 11β-HSD1 reductase activity
-
Schweizer RA, Atanasov AG, Frey BM, Odermatt A. A rapid screening assay for inhibitors of 11β-hydroxysteroid dehydrogenases (11β-HSD): flavanone selectively inhibits 11β-HSD1 reductase activity. Mol Cell Endocrinol. 2003; 212:41-49.
-
(2003)
Mol Cell Endocrinol.
, vol.212
, pp. 41-49
-
-
Schweizer, R.A.1
Atanasov, A.G.2
Frey, B.M.3
Odermatt, A.4
-
274
-
-
0034056308
-
In the search for specific inhibitors of human 11 β-hydroxysteroid-dehydrogenases (11 β-HSDs): chenodeoxycholic acid selectively inhibits 11 β-HSD-I
-
Diederich S, Grossmann C, Hanke B, et al. In the search for specific inhibitors of human 11 β-hydroxysteroid-dehydrogenases (11 β-HSDs): chenodeoxycholic acid selectively inhibits 11 β-HSD-I. Eur J Endocrinol. 2000;142: 200-207.
-
(2000)
Eur J Endocrinol.
, vol.142
, pp. 200-207
-
-
Diederich, S.1
Grossmann, C.2
Hanke, B.3
-
275
-
-
27644453205
-
Endogenous selective inhibitors of 11 β-hydroxysteroid dehydrogenase isoforms 1 and 2 of adrenal origin
-
Latif SA, Pardo HA, Hardy MP, Morris DJ. Endogenous selective inhibitors of 11 β-hydroxysteroid dehydrogenase isoforms 1 and 2 of adrenal origin. Mol Cell Endocrinol. 2005;243:43-50.
-
(2005)
Mol Cell Endocrinol.
, vol.243
, pp. 43-50
-
-
Latif, S.A.1
Pardo, H.A.2
Hardy, M.P.3
Morris, D.J.4
-
276
-
-
0037238379
-
Effects of the 11 β-hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes
-
Andrews RC, Rooyackers O, Walker BR. Effects of the 11 β-hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes. J Clin Endocrinol Metab. 2003;88:285-291.
-
(2003)
J Clin Endocrinol Metab.
, vol.88
, pp. 285-291
-
-
Andrews, R.C.1
Rooyackers, O.2
Walker, B.R.3
-
277
-
-
33947491197
-
Inhibition of 11β-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis
-
Tomlinson JW, Sherlock M, Hughes B, et al. Inhibition of 11β-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis. J Clin Endocrinol Metab. 2007; 92:857-864.
-
(2007)
J Clin Endocrinol Metab.
, vol.92
, pp. 857-864
-
-
Tomlinson, J.W.1
Sherlock, M.2
Hughes, B.3
-
278
-
-
84883783501
-
-
Thomson Reuters, International Year of Chemistry (IYC 200)
-
Thomson Reuters. The changing role of chemistry in drug discovery. International Year of Chemistry (IYC 2011) report. http:thomsonreuters.com/content/science/pdf/ls/iyc2011.pdf.
-
The changing role of chemistry in drug discovery
-
-
-
279
-
-
67649362287
-
11β-Hydroxysteroid dehydrogenase type 1 inhibitors: a review of recent patents
-
Boyle CD, Kowalski TJ. 11β-Hydroxysteroid dehydrogenase type 1 inhibitors: a review of recent patents. Expert Opin Ther Pat. 2009;19:801-825.
-
(2009)
Expert Opin Ther Pat.
, vol.19
, pp. 801-825
-
-
Boyle, C.D.1
Kowalski, T.J.2
-
280
-
-
54049098360
-
Colletoic acid, a novel 11β-hydroxysteroid dehydrogenase type 1 inhib itor from Colletotrichum gloeosporioides SANK 21404
-
Aoyagi A, Ito-Kobayashi M, Ono Y, et al. Colletoic acid, a novel 11β-hydroxysteroid dehydrogenase type 1 inhib itor from Colletotrichum gloeosporioides SANK 21404. J Antibiot (Tokyo). 2008;61:136-141.
-
(2008)
J Antibiot (Tokyo).
, vol.61
, pp. 136-141
-
-
Aoyagi, A.1
Ito-Kobayashi, M.2
Ono, Y.3
-
281
-
-
65949101862
-
Twoasymmetric syntheses ofAMG221, an inhibitor of 11β-hydroxysteroid dehydrogenase type 1
-
Caille S, Cui S, Hwang TL, Wang X, FaulMM.Twoasymmetric syntheses ofAMG221, an inhibitor of 11β-hydroxysteroid dehydrogenase type 1. J Org Chem. 2009;74: 3833-3842.
-
(2009)
J Org Chem.
, vol.74
, pp. 3833-3842
-
-
Caille, S.1
Cui, S.2
Hwang, T.L.3
Wang, X.4
Faul, M.M.5
-
282
-
-
77950862672
-
The development andSAR of pyrrolidine carboxamide 11β-HSD1 inhibitors
-
Cheng H, Hoffman J, Le P, et al. The development andSAR of pyrrolidine carboxamide 11β-HSD1 inhibitors. Bioorg Med Chem Lett. 2010;20:2897-2902.
-
(2010)
Bioorg Med Chem Lett.
, vol.20
, pp. 2897-2902
-
-
Cheng, H.1
Hoffman, J.2
Le, P.3
-
283
-
-
27144453386
-
Perhydroquinolylbenzamides as novel inhibitors of 11β-hydroxysteroid dehydrogenase type 1
-
Coppola GM, Kukkola PJ, Stanton JL, et al. Perhydroquinolylbenzamides as novel inhibitors of 11β-hydroxysteroid dehydrogenase type 1. JMedChem. 2005;48:6696-6712.
-
(2005)
JMedChem.
, vol.48
, pp. 6696-6712
-
-
Coppola, G.M.1
Kukkola, P.J.2
Stanton, J.L.3
-
284
-
-
79952452807
-
Synthesis of new glycyrrhetinic acid derived ring A azepanone, 29-urea and 29-hydroxamic acid derivatives as selective 11β-hydroxysteroid dehydrogenase 2 inhibitors
-
Gaware R, Khunt R, Czollner L, et al. Synthesis of new glycyrrhetinic acid derived ring A azepanone, 29-urea and 29-hydroxamic acid derivatives as selective 11β-hydroxysteroid dehydrogenase 2 inhibitors. Bioorg Med Chem. 2011;19:1866-1880.
-
(2011)
Bioorg Med Chem.
, vol.19
, pp. 1866-1880
-
-
Gaware, R.1
Khunt, R.2
Czollner, L.3
-
285
-
-
79955865247
-
Population pharmacokinetic/ pharmacodynamic model of subcutaneous adipose 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity after oral administration of AMG 221, a selective 11β-HSD1 inhibitor
-
Gibbs JP, Emery MG, McCaffery I, et al. Population pharmacokinetic/ pharmacodynamic model of subcutaneous adipose 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity after oral administration of AMG 221, a selective 11β-HSD1 inhibitor. J Clin Pharmacol. 2011;51: 830-841.
-
(2011)
J Clin Pharmacol.
, vol.51
, pp. 830-841
-
-
Gibbs, J.P.1
Emery, M.G.2
McCaffery, I.3
-
286
-
-
43949124158
-
2-Amino-1,3-thiazol-4(5H)-ones as potent and selective 11β-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structureanddemonstrationofpharmacodynamiceffects inC57Bl/6 mice
-
JohanssonL,FotschC,BartbergerMD,etal.2-Amino-1,3-thiazol-4(5H)-ones as potent and selective 11β-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structureanddemonstrationofpharmacodynamiceffects inC57Bl/6 mice. J Med Chem. 2008;51:2933-2943.
-
(2008)
J Med Chem.
, vol.51
, pp. 2933-2943
-
-
Johansson, L.1
Fotsch, C.2
Bartberger, M.D.3
-
287
-
-
78650810717
-
Identification of cyclic sulfonamide derivatives with an acetamide group as 11β-hydroxysteroid dehydrogenase 1 inhibitors
-
Kim SH, Kwon SW, Chu SY, et al. Identification of cyclic sulfonamide derivatives with an acetamide group as 11β-hydroxysteroid dehydrogenase 1 inhibitors. Chem Pharm Bull (Tokyo). 2011;59:46-52.
-
(2011)
Chem Pharm Bull (Tokyo).
, vol.59
, pp. 46-52
-
-
Kim, S.H.1
Kwon, S.W.2
Chu, S.Y.3
-
288
-
-
66349124660
-
Discovery and structure-guided drug design of inhibitors of 11β-hydroxysteroid-dehydrogenase type I based on a spirocarboxamide scaffold
-
Lepifre F, Christmann-Franck S, Roche D, et al. Discovery and structure-guided drug design of inhibitors of 11β-hydroxysteroid-dehydrogenase type I based on a spirocarboxamide scaffold. Bioorg Med Chem Lett. 2009;19: 3682-3685.
-
(2009)
Bioorg Med Chem Lett.
, vol.19
, pp. 3682-3685
-
-
Lepifre, F.1
Christmann-Franck, S.2
Roche, D.3
-
289
-
-
79953283569
-
Bicyclo[2.2.2]octyltriazole inhibitors of 11β-hydroxysteroid dehydrogenase type 1. Pharmacological agents for the treatment of metabolic syndrome
-
Maletic M, Leeman A, Szymonifka M, et al. Bicyclo[2.2.2]octyltriazole inhibitors of 11β-hydroxysteroid dehydrogenase type 1. Pharmacological agents for the treatment of metabolic syndrome. Bioorg Med Chem Lett. 2011;21:2568-2572.
-
(2011)
Bioorg Med Chem Lett.
, vol.21
, pp. 2568-2572
-
-
Maletic, M.1
Leeman, A.2
Szymonifka, M.3
-
290
-
-
33846228383
-
Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl)acetamide11β-hydroxysteroiddehydrogenasetype 1 inhibitors
-
Rohde JJ, Pliushchev MA, Sorensen BK, et al. Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl)acetamide11β-hydroxysteroiddehydrogenasetype 1 inhibitors. J Med Chem. 2007;50:149-164.
-
(2007)
J Med Chem.
, vol.50
, pp. 149-164
-
-
Rohde, J.J.1
Pliushchev, M.A.2
Sorensen, B.K.3
-
291
-
-
77957997461
-
Synthesis of novel 3-amino and 29-hydroxamic acid derivatives of glycyrrhetinic acid as selective 11β-hydroxysteroid dehydrogenase 2 inhibitors
-
Stanetty C, Czollner L, Koller I, et al. Synthesis of novel 3-amino and 29-hydroxamic acid derivatives of glycyrrhetinic acid as selective 11β-hydroxysteroid dehydrogenase 2 inhibitors. Bioorg Med Chem. 2010;18:7522-7541.
-
(2010)
Bioorg Med Chem.
, vol.18
, pp. 7522-7541
-
-
Stanetty, C.1
Czollner, L.2
Koller, I.3
-
292
-
-
79960013275
-
Small molecule 11β-hydroxysteroid dehydrogenase type 1 inhibitors
-
Sun D, Wang M, Wang Z. Small molecule 11β-hydroxysteroid dehydrogenase type 1 inhibitors. Curr Top Med Chem. 2011;11:1464-1475.
-
(2011)
Curr Top Med Chem.
, vol.11
, pp. 1464-1475
-
-
Sun, D.1
Wang, M.2
Wang, Z.3
-
293
-
-
77953182919
-
Discovery of a potent, orally active 11β-hydroxysteroid dehydrogenase type 1 inhibitor for clinical study: identification of (S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5 H)-one (AMG 221)
-
Veniant MM, Hale C, Hungate RW, et al. Discovery of a potent, orally active 11β-hydroxysteroid dehydrogenase type 1 inhibitor for clinical study: identification of (S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5 H)-one (AMG 221). J Med Chem. 2010;53: 4481-4487.
-
(2010)
J Med Chem.
, vol.53
, pp. 4481-4487
-
-
Veniant, M.M.1
Hale, C.2
Hungate, R.W.3
-
294
-
-
34250171175
-
Novel non-steroidal inhibitors of human 11β-hydroxysteroid dehydrogenase type 1
-
Vicker N, Su X, Ganeshapillai D, et al. Novel non-steroidal inhibitors of human 11β-hydroxysteroid dehydrogenase type 1. J Steroid Biochem Mol Biol. 2007;104:123-129.
-
(2007)
J Steroid Biochem Mol Biol.
, vol.104
, pp. 123-129
-
-
Vicker, N.1
Su, X.2
Ganeshapillai, D.3
-
295
-
-
80052138643
-
Synthesis of potent and orally efficacious 11β-hydroxysteroid dehydrogenase type 1 inhibitor HSD-016
-
Wan ZK, Chenail E, Li HQ, et al. Synthesis of potent and orally efficacious 11β-hydroxysteroid dehydrogenase type 1 inhibitor HSD-016. J Org Chem. 2011;76:7048-7055.
-
(2011)
J Org Chem.
, vol.76
, pp. 7048-7055
-
-
Wan, Z.K.1
Chenail, E.2
Li, H.Q.3
-
296
-
-
79959914089
-
Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1)
-
Wang H, Robl JA, Hamann LG, et al. Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1). Bioorg Med Chem Lett. 2011;21:4146-4149.
-
(2011)
Bioorg Med Chem Lett.
, vol.21
, pp. 4146-4149
-
-
Wang, H.1
Robl, J.A.2
Hamann, L.G.3
-
297
-
-
67651094103
-
Discovery of novel dual functional agent as PPARγ agonist and 11β-HSD1 inhibitor for the treatment of diabetes
-
Ye YL, Zhou Z, Zou HJ, et al. Discovery of novel dual functional agent as PPARγ agonist and 11β-HSD1 inhibitor for the treatment of diabetes. BioorgMedChem. 2009; 17:5722-5732.
-
(2009)
BioorgMedChem.
, vol.17
, pp. 5722-5732
-
-
Ye, Y.L.1
Zhou, Z.2
Zou, H.J.3
-
298
-
-
79957770534
-
The inhibition of human and rat 11β-hydroxysteroid dehydrogenase 2 by perfluoroalkylated substances
-
Zhao B, Lian Q, Chu Y, Hardy DO, Li XK, Ge RS. The inhibition of human and rat 11β-hydroxysteroid dehydrogenase 2 by perfluoroalkylated substances. J Steroid Biochem Mol Biol. 2011;125:143-147.
-
(2011)
J Steroid Biochem Mol Biol.
, vol.125
, pp. 143-147
-
-
Zhao, B.1
Lian, Q.2
Chu, Y.3
Hardy, D.O.4
Li, X.K.5
Ge, R.S.6
-
299
-
-
0037194658
-
rylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11β-hydroxysteroid dehydrogenase type 1
-
Barf T, Vallgarda J, Emond R, et al. Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11β-hydroxysteroid dehydrogenase type 1. J Med Chem. 2002; 45:3813-3815.
-
(2002)
J Med Chem.
, vol.45
, pp. 3813-3815
-
-
Barf, T.1
Vallgarda, J.2
Emond, R.3
-
300
-
-
0036432995
-
Selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice
-
Alberts P, Engblom L, Edling N, et al. Selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice. Diabetologia. 2002;45:1528-1532.
-
(2002)
Diabetologia.
, vol.45
, pp. 1528-1532
-
-
Alberts, P.1
Engblom, L.2
Edling, N.3
-
301
-
-
0242468543
-
Selective inhibition of 11 β-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains
-
Alberts P, Nilsson C, Selen G, et al. Selective inhibition of 11 β-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains. Endocrinology. 2003;144:4755-4762.
-
(2003)
Endocrinology.
, vol.144
, pp. 4755-4762
-
-
Alberts, P.1
Nilsson, C.2
Selen, G.3
-
302
-
-
77955828684
-
Emodin, a natural product, selectively inhibits 11β-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in dietinduced obese mice
-
Feng Y, Huang SL, Dou W, et al. Emodin, a natural product, selectively inhibits 11β-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in dietinduced obese mice. Br J Pharmacol. 2010;161:113-126.
-
(2010)
Br J Pharmacol.
, vol.161
, pp. 113-126
-
-
Feng, Y.1
Huang, S.L.2
Dou, W.3
-
303
-
-
79952992498
-
Anti-diabetic and antiadipogenic effects of a novel selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone (KR-66344)
-
Park JS, Rhee SD, Kang NS, et al. Anti-diabetic and antiadipogenic effects of a novel selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone (KR-66344). Biochem Pharmacol. 2011;81:1028-1035.
-
(2011)
Biochem Pharmacol.
, vol.81
, pp. 1028-1035
-
-
Park, J.S.1
Rhee, S.D.2
Kang, N.S.3
-
304
-
-
35148876079
-
11β-HSD1 inhibition improves triglyceridemia through reduced liver VLDL secretion and partitions lipids toward oxidative tissues
-
Berthiaume M, Laplante M, Festuccia WT, et al. 11β-HSD1 inhibition improves triglyceridemia through reduced liver VLDL secretion and partitions lipids toward oxidative tissues. Am J Physiol Endocrinol Metab. 2007; 293:E1045-E1052.
-
(2007)
Am J Physiol Endocrinol Metab.
, vol.293
-
-
Berthiaume, M.1
Laplante, M.2
Festuccia, W.T.3
-
305
-
-
34249775822
-
Depotspecific modulation of rat intraabdominal adipose tissue lipid metabolism by pharmacological inhibition of 11β-hydroxysteroid dehydrogenase type 1
-
Berthiaume M, Laplante M, Festuccia W, et al. Depotspecific modulation of rat intraabdominal adipose tissue lipid metabolism by pharmacological inhibition of 11β-hydroxysteroid dehydrogenase type 1. Endocrinology. 2007;148:2391-2397.
-
(2007)
Endocrinology.
, vol.148
, pp. 2391-2397
-
-
Berthiaume, M.1
Laplante, M.2
Festuccia, W.3
-
306
-
-
41449104843
-
Inhibition of 11βHSD1 with the S-phenylethylaminothiazolone BVT116429 increases adiponectin concentrations and improves glucose homeostasis in diabetic KKAy mice
-
Sundbom M, Kaiser C, Bjorkstrand E, et al. Inhibition of 11βHSD1 with the S-phenylethylaminothiazolone BVT116429 increases adiponectin concentrations and improves glucose homeostasis in diabetic KKAy mice. BMC Pharmacol. 2008;8:3.
-
(2008)
BMC Pharmacol.
, vol.8
, pp. 3
-
-
Sundbom, M.1
Kaiser, C.2
Bjorkstrand, E.3
-
307
-
-
67349178689
-
Additive action of 11β-HSD1 inhibition and PPAR-γ agonism on hepatic steatosis and triglyceridemia in diet-induced obese rats
-
Berthiaume M, Laplante M, Festuccia WT, Berger JP, Thieringer R, Deshaies Y. Additive action of 11β-HSD1 inhibition and PPAR-γ agonism on hepatic steatosis and triglyceridemia in diet-induced obese rats. Int J Obes (Lond). 2009;33:601-604.
-
(2009)
Int J Obes (Lond).
, vol.33
, pp. 601-604
-
-
Berthiaume, M.1
Laplante, M.2
Festuccia, W.T.3
Berger, J.P.4
Thieringer, R.5
Deshaies, Y.6
-
308
-
-
72049107460
-
Preliminary report: pharmaco-logic 11β-hydroxysteroid dehydrogenase type 1 inhibition increases hepatic fat oxidation in vivo and expression of related genes in rats fed an obesogenic diet
-
Berthiaume M, Laplante M, Festuccia WT, Berger JP, Thieringer R, Deshaies Y. Preliminary report: pharmaco-logic 11β-hydroxysteroid dehydrogenase type 1 inhibition increases hepatic fat oxidation in vivo and expression of related genes in rats fed an obesogenic diet. Metabolism. 2010;59:114-117.
-
(2010)
Metabolism.
, vol.59
, pp. 114-117
-
-
Berthiaume, M.1
Laplante, M.2
Festuccia, W.T.3
Berger, J.P.4
Thieringer, R.5
Deshaies, Y.6
-
309
-
-
84863628857
-
attenuates obesity and inflammation in diet-induced obese mice.
-
BVT.2733, a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor,
-
Wang L, Liu J, Zhang A, et al. BVT.2733, a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, attenuates obesity and inflammation in diet-induced obese mice. PLoS One. 2012;7:e40056.
-
PLoS One. 2012
, vol.7
-
-
Wang, L.1
Liu, J.2
Zhang, A.3
-
310
-
-
70449473618
-
Antidiabetic effects of 11β-HSD1 inhibition in a mouse model of combined diabetes, dyslipidaemia and atherosclerosis
-
Lloyd DJ, Helmering J, Cordover D, et al. Antidiabetic effects of 11β-HSD1 inhibition in a mouse model of combined diabetes, dyslipidaemia and atherosclerosis. Diabetes Obes Metab. 2009;11:688-699.
-
(2009)
Diabetes Obes Metab.
, vol.11
, pp. 688-699
-
-
Lloyd, D.J.1
Helmering, J.2
Cordover, D.3
-
311
-
-
77950808186
-
Effect of 11 β-hydroxysteroid dehydrogenase-1 inhibition on hepatic glucose metabolism in the conscious dog
-
Edgerton DS, Basu R, Ramnanan CJ, et al. Effect of 11 β-hydroxysteroid dehydrogenase-1 inhibition on hepatic glucose metabolism in the conscious dog. Am J Physiol Endocrinol Metab. 2010;298:E1019-E1026.
-
(2010)
Am J Physiol Endocrinol Metab.
, vol.298
-
-
Edgerton, D.S.1
Basu, R.2
Ramnanan, C.J.3
-
312
-
-
37349004141
-
Demonstration of proof of mechanism and pharmacokinetics and pharmacodynamic relationship with 4'-cyano-biphenyl-4-sulfonic acid (6-amino-pyridin-2-yl)-amide (PF-915275), an inhibitor of 11 -hydroxysteroid dehydrogenase type 1, in cynomolgus monkeys
-
Bhat BG, Hosea N, Fanjul A, et al. Demonstration of proof of mechanism and pharmacokinetics and pharmacodynamic relationship with 4'-cyano-biphenyl-4-sulfonic acid (6-amino-pyridin-2-yl)-amide (PF-915275), an inhibitor of 11 -hydroxysteroid dehydrogenase type 1, in cynomolgus monkeys. J Pharmacol Exp Ther. 2008;324:299-305.
-
(2008)
J Pharmacol Exp Ther.
, vol.324
, pp. 299-305
-
-
Bhat, B.G.1
Hosea, N.2
Fanjul, A.3
-
314
-
-
77955630861
-
The 11-β-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemiainpatientswithtype2diabetesinadequatelycontrolled by metformin monotherapy
-
Rosenstock J, Banarer S, Fonseca VA, et al. The 11-β-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemiainpatientswithtype2diabetesinadequatelycontrolled by metformin monotherapy. Diabetes Care. 2010;33: 1516-1522.
-
(2010)
Diabetes Care.
, vol.33
, pp. 1516-1522
-
-
Rosenstock, J.1
Banarer, S.2
Fonseca, V.A.3
-
315
-
-
79955046317
-
Effects of an 11 β-hydroxysteroid dehydrogenase type 1 inhibitor, MK-0916, in patients with type 2 diabetes mellitus and metabolic syndrome
-
Feig PU, Shah S, Hermanowski-Vosatka A, et al. Effects of an 11 β-hydroxysteroid dehydrogenase type 1 inhibitor, MK-0916, in patients with type 2 diabetes mellitus and metabolic syndrome. Diabetes Obes Metab. 2011;13: 498-504.
-
(2011)
Diabetes Obes Metab.
, vol.13
, pp. 498-504
-
-
Feig, P.U.1
Shah, S.2
Hermanowski-Vosatka, A.3
-
316
-
-
79955639922
-
Efficacy and safety of the selective 11β-HSD-1 inhibitors MK-0736 and MK-0916 in overweight and obese patients with hypertension
-
Shah S, Hermanowski-Vosatka A, Gibson K, et al. Efficacy and safety of the selective 11β-HSD-1 inhibitors MK-0736 and MK-0916 in overweight and obese patients with hypertension. J Am Soc Hypertens. 2011;5:166-176.
-
(2011)
J Am Soc Hypertens.
, vol.5
, pp. 166-176
-
-
Shah, S.1
Hermanowski-Vosatka, A.2
Gibson, K.3
-
317
-
-
39049131253
-
Modulation of 11 β-hydroxysteroid dehydrogenase (11 β HSD) activity biomarkers and pharmacokinetics of PF-00915275, a selective 11 β HSD1 inhibitor
-
Courtney R, Stewart PM, Toh M, Ndongo MN, Calle RA, Hirshberg B. Modulation of 11 β-hydroxysteroid dehydrogenase (11 β HSD) activity biomarkers and pharmacokinetics of PF-00915275, a selective 11 β HSD1 inhibitor. J Clin Endocrinol Metab. 2008;93:550-556.
-
(2008)
J Clin Endocrinol Metab.
, vol.93
, pp. 550-556
-
-
Courtney, R.1
Stewart, P.M.2
Toh, M.3
Ndongo, M.N.4
Calle, R.A.5
Hirshberg, B.6
-
318
-
-
84859540710
-
Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization
-
Nixon M, Wake DJ, Livingstone DE, et al. Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization. Diabetes. 2012;61:790-796.
-
(2012)
Diabetes.
, vol.61
, pp. 790-796
-
-
Nixon, M.1
Wake, D.J.2
Livingstone, D.E.3
|