Synthesis of novel 3-amino and 29-hydroxamic acid derivatives of glycyrrhetinic acid as selective 11β-hydroxysteroid dehydrogenase 2 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 21, 2010, Pages 7522-7541

  Stanetty, Christian ^a   Czollner, Laszlo ^b   Koller, Iris ^a   Shah, Priti ^b   Gaware, Rawindra ^b   Cunha, Thierry Da ^c   Odermatt, Alex ^c   Jordis, Ulrich ^b   Kosma, Paul ^a   Claßen Houben, Dirk ^d  

^a UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^b VIENNA UNIVERSITY OF TECHNOLOGY   (Austria)

^c UNIVERSITY OF BASEL   (Switzerland)

^d Onepharm Research and Development GmbH   (Austria)

Author keywords

11 HSD1; 11 HSD2; 11 Hydroxysteroid dehydrogenase; Cancer; Carbenoxolone; Chronic inflammatory disease; Cortisone metabolism; Glucocorticoid metabolism; Glycyrrhetinic acid; Glycyrrhizin; Hydroxamic acid; Inflammation; Selective inhibitor

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; 11BETA HYDROXYSTEROID DEHYDROGENASE 2; ENZYME INHIBITOR; GLYCYRRHETINIC ACID DERIVATIVE; HYDROXAMIC ACID DERIVATIVE; TRITERPENE DERIVATIVE;

ARTICLE; CHRONIC INFLAMMATION; DIABETES MELLITUS; DRUG ACTIVITY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; MALIGNANT NEOPLASTIC DISEASE; METABOLIC DISORDER; OBESITY;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; ANIMALS; ENZYME INHIBITORS; GLYCYRRHETINIC ACID; HUMANS; HYDROXAMIC ACIDS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 77957997461     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.08.046     Document Type: Article

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